دانلود مقالات ISI درباره Mtor + ترجمه فارسی

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma

Keywords: AMPK; AMP-activated kinase; BRAFi; BRAF inhibitor; ERK; extracellular signal-regulated kinase; ERKi; ERK inhibitor; PGC1α; peroxisome proliferator-activated receptor gamma, coactivator 1-α; MEK; MAPK/ERK kinase; MEKi; MEK inhibitor; mTOR; mechanistic ta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Blockade of CCR5 receptor prevents M2 microglia phenotype in a microglia-glioma paradigm

Keywords: Microglia; Glioblastoma; iNOS; Arginase; AKT; mTOR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

Keywords: Ischemic stroke; Sirt3; Autophagy; AMPK; mTOR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Sirtuin 1 independent effects of resveratrol in INS-1E β-cells

Keywords: Sirt1; Resveratrol; mTOR; Rapamycin; Cell size; Hypertrophy;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production

Keywords: Palmitic acid; Insulin resistance; Mitochondrial ROS; mTOR; Human neuroblastoma cells; Cortical neurons; Energy metabolism;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Intracorneal melatonin delivery using 2-hydroxypropyl-β-cyclodextrin ophthalmic solution for granular corneal dystrophy type 2

Keywords: MT; melatonin; GCD-2; granular corneal dystrophy type 2; CDs; cyclodextrins; HPβCD; 2-hydroxypropyl βCD; αCD; α-cyclodextrin; βCD; β-cyclodextrin; γCD; γ-cyclodextrin; TGFβIp; transforming growth factor beta-induced protein; mTOR; mechanistic tar

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy

Keywords: LCD; licoricidin; LCDG; the glycosylated product of licoricidin; AMPK; adenosine 5′-monophosphate (AMP)-activated protein kinase; Caspase; cysteinyl aspartate specific proteinase; Akt; protein kinase B; mTOR; mammalian target of rapamycin; PGE2; prostag

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Staphylococcal enterotoxin C2 mutant drives T lymphocyte activation through PI3K/mTOR and NF-ĸB signaling pathways

Keywords: Staphylococcal enterotoxin C2; PI3K; mTOR; NF-ĸB; Proliferation; IL-2;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Autophagy as a potential therapeutic target during epithelial to mesenchymal transition in renal cell carcinoma: An in vitro study

Keywords: mTOR; Autophagy; Epithelial to mesenchymal transition; TGF-β;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy

Keywords: Urate; Macroautophagy; mTOR; SNCA/α-synuclein; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer

Keywords: Antrodia cinnamomea; Tamoxifen; Anti-angiogenesis; ER+ T47D breast cancer; Dehydroeburicoic acid; Akt; protein kinase B; CAM; chorioallantoic membrane; COX-2; cyclooxygenase-2; ER; estrogen receptor; Jak1; Janus kinase 1; mTOR; mammalian target of rapamyc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14++CD16−) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

Keywords: DCs; dendritic cells; HA; hyaluronan; IRF; interferon regulatory factor; MOI; multiplicity of infection; PKB; protein kinase B; RNI; reactive nitrogen intermediates; ROI; reactive oxygen species; mTOR; mammalian target of rapamycin; TIM; tumor-infiltratin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, antifungal and antitumor activity of two new types of imidazolin-2-ones

Keywords: Benzimidazolones; Imidazopyridines; Antifungal activity; Antitumor activity; mTOR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells

Keywords: BCR; B-cell receptor; CLL; chronic lymphocytic leukemia; ECAR; extracellular acidification rate; ETC; electron transport chain; MM; mitochondrial mass; MOMP; mitochondrial outer membrane potential; MRC; maximum respiration capacity; mtDNA; mitochondrial D

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Structural analysis of ribosomal RACK1 and its role in translational control

Keywords: RACK1; Receptor for activated C-Kinase 1; rRNA; Ribosomal RNA; mRNA; Messenger RNA; PKC; Protein kinase C; eIF6; Eukaryotic initiation factor 6; eIF3; Eukaryotic initiation factor 3; eIF4E; Eukaryotic initiation factor 4E; Src; Sarcoma family kinase; Scp1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex

Keywords: Autophagy; TSC; mTOR; Rapamycin; Pigmentation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2 +

Keywords: Akt; protein kinase B; AMPK; AMP-activated protein kinase; BAPTA-AM; 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid acetoxymethyl ester; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol tetraacetic acid; ER; endoplasmic reticu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Keywords: GABA; gamma-aminobutyric acid; Tor 1; Torin 1; Tor 2; Torin 2; SSADH; succinic semialdehyde dehydrogenase; SSADHD; succinic semialdehyde dehydrogenase deficiency; aldh5a1; aldehyde dehydrogenase 5a1 (identical to succinic semialdehyde dehydrogenase); GABA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Neuronal zinc-α2-glycoprotein is decreased in temporal lobe epilepsy in patients and rats

Keywords: AD; Alzheimer's disease; AED; anti-epileptic drug; BSA; bovine serum albumin; cDNA; complementary deoxyribonucleic acid; Co-IP; co-immunoprecipitation; CSF; cerebrospinal fluid; DAB; 3,3-diaminobenzidine; DAPI; 4,6-diamidino-2-phenylindole; FITC; fluore

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Tackling endocrine resistance in ER-positive HER2-negative advanced breast cancer: A tale of imprecision medicine

Keywords: Breast cancer; CDK 4/6; Endocrine; Metastatic; mTOR; PI3K; Resistance;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation

Keywords: Niclosamide; Epstein-Barr virus; Kaposi's sarcoma-associated herpesvirus; mTOR; Lytic replication;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction

Keywords: mTOR; DEPTOR; Multiple myeloma; Cytotoxicity; SAR study;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Different functions of DEPTOR in modulating sensitivity to chemotherapy for esophageal squamous cell carcinoma

Keywords: ESCC; esophageal squamous cell carcinoma; DEPTOR; DEP domain-containing mTOR-interacting protein; S6K; S6 kinase; mTOR; mammalian target of rapamycin; TNBC; triple negative breast cancer; NC; negative control; HE; hematoxylin and eosin; IHC; immunohistoch

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleFBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma

Keywords: FBX8; miR-223; mTOR; Ubiquitin degradation; Colorectal carcinoma;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleAspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition

Keywords: Aspirin; mTORC1; AMPK; Sorafenib; Proliferation; AMPK; Adenosine 5'-monophosphate (AMP)-activated protein kinase; mTOR; mammalian target of rapamycin; MEF; mouse embryonic fibroblast; TSC2; Tuberous sclerosis 1; NSAID; non-steroidal anti-inflammatory dr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress

Keywords: S6K1; Exercise; Glycemic control; Metabolic phenotyping; Reactive oxidative species; HFD; high-fat diet; ROS; reactive oxygen species; TCA; tricarboxylic acid cycle; mTOR; mammalian target of rapamycin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Functional consequences of chemically-induced β-arrestin binding to chemokine receptors CXCR4 and CCR5 in the absence of ligand stimulation

Keywords: βArr; β-arrestin; AP2; adaptor protein 2; Dmr A/C; dimer A/C; FKBP12; 12 kDa FK506-binding protein; FRB; FKBP12-rapamycin-binding; GPCR; G protein-coupled receptor; MCF; mean channel fluorescence; mTOR; mechanistic target of rapamycin; p38; p38 mitogen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Bisphenol A and estrogen induce proliferation of human thyroid tumor cells via an estrogen-receptor-dependent pathway

Keywords: Bisphenol A; Estrogen receptor; Thyroid cancer; mTOR; AKT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Keywords: Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin-Sensitive Late-LTP is Enhanced in the Hippocampus of IL-6 Transgenic Mice

Keywords: ANOVA; analysis of variance; ACSF; artificial cerebral-spinal fluid; CNS; central nervous system; DNA; deoxyribonucleic acid; ERK; extracellularly regulated kinase; fEPSP; field excitatory postsynaptic potential; HFS; high-frequency stimulation; I/O; inpu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma

Keywords: Akt; protein kinase B; DMSO; dimethyl sulfoxide; ESCC; esophageal squamous cell carcinoma; FBS; fetal bovine serum; IC50; half maximal inhibitory concentration; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3 kinase; Rapa; rapamycin; Rap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

Keywords: Cancer-associated fibroblast; Cytokines; Intermediate metabolite; Autophagy; Tumor relapse; Radiation therapy; CAFs; cancer-associated fibroblasts; IGF1/2; insulin-like growth factor 1/2; CXCL12; C-X-C motif chemokine ligand 12; ROS; reactive oxygen speci

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation

Keywords: Microtopography; Peripheral nerve; Tissue engineering; mTOR;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin suppresses Aβ25-35- or LPS-induced neuronal inflammation via modulation of NF-κB signaling

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; BSA; bovine serum albumin; DMSO; dimethyl sulphoxide; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharides; mTOR; mammalian target of rapamycin; NF-κB; nuclear factor kappa B; PD; Parkinson's disea

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Loss of hepatic DEPTOR alters the metabolic transition to fasting

Keywords: DEPTOR; mTOR; Liver; Glucose; Fasting;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways

Keywords: HIF-1; hypoxia-inducible factor-1; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; MAPK; mitogen-activated protein kinase; VEGF; vascular endothelial growth factor; EPO; erythropoietin; Topo-I; topoisomerase-I; eIF4E; eukaryotic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

The role of interleukin-17A in the pathogenesis of kidney diseases

Keywords: Interleukin-17A; inflammation; kidney disease; AHR; aryl hydrocarbon receptor; AKI; acute kidney injury; ANCA; antineutrophil cytoplasmic antibody; APOE; apolipoprotein E; ASC; apoptosis-associated speck-like protein containing a carboxy-terminal CARD; Ct

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

Keywords: TFEB; mTOR; The autophagic-lysosomal pathway; Proteotoxicity; Misfolded proteins; Cardiomyocytes;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

Keywords: Autophagy; Insulin receptors; IGF-1 receptors; Akt; mTOR; Cardiac function;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewReappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique

Keywords: mTOR; 4E-BP; eIF4E; Rapamycin; Post-translational modification;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum

Keywords: PDMP; mTOR; Subcellular localization; Lysosome; ER; Osteoblast;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

Keywords: ACQ; acquisition; ACh; acetylcholine; DMSO; dimethyl sulfoxide; IA; inhibitory avoidance; i.c.v.; intracerebroventricular; i.p.; intraperitoneal; mTOR; mammalian Target of Rapamycin; mAChR; muscarinic acetylcholine receptors; mTORC1,2; mammalian Target of

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis

Keywords: Zebrafish; Tuberous sclerosis complex; Transcriptomics; mTOR;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats

Keywords: Lipopolysaccharide; mTOR; rpS6; Hypotension; Inflammation; Rat;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice

Keywords: 3MA; 3-methyladenine; ACTB; actin, beta; ATG4B; autophagy related 4B cysteine peptidase; GFP; green fluorescent protein; LC3B; microtubule-associated protein light chain 3B; GST; glutathione-S-transferase; mTOR; mechanistic target of rapamycin; p70S6K; ri

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer

Keywords: Eriocalyxin B; Autophagy; Apoptosis; mTOR; Reactive oxygen species; Breast cancer; Eriocalyxin B (Pubchem CID: 367620); Chloroquine (Pubchem CID); 3-Methyladenine (Pubchem CID: 1673); AVOs; acidic vesicular organelles; ATG; autophagy-related genes; CQ; ch

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Elevated expression of neuropeptide signaling genes in the eyestalk ganglia and Y-organ of Gecarcinus lateralis individuals that are refractory to molt induction

Keywords: Crustacea; Ecdysteroid; Y-organ; Molting; mTOR; Autotomy; Molt-inhibiting hormone; Cyclic nucleotide; cAMP; cGMP; Nitric oxide synthase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation

Keywords: AMPK; 5′ adenosine monophosphate-activated protein kinase; BSA; bovine serum albumin; CQ; chloroquine; EC; endothelial cell; eIF2α; eukaryotic translation initiation factor 2α; ER; endoplasmic reticulum; Erk1/2; extracellular signal-regulated kinase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Everolimus for the Treatment of Tuberous Sclerosis Complex-Related Cardiac Rhabdomyomas in Pediatric Patients

Keywords: cardiac tumors; hamartomas; mTOR inhibition; infants; cRHM; Cardiac rhabdomyoma; mTOR; Mammalian target of rapamycin; SEGA; Subependymal giant cell astrocytoma; TSC; Tuberous sclerosis complex;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه