دانلود مقالات ISI درباره Mtor + ترجمه فارسی

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; ConA; concanavalin A; eEF2; eukaryotic elongation factor 2; eIF; eukaryotic initiation factor; ERK; extracellular-signal-regulated

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue

Keywords: ACM; Adipocyte-conditioned medium; BET; Bromodomain and extraterminal; Brd2; Bromodomain-containing protein 2; WT; Wild-type; SWI/SNF; Switch mating type/sucrose non-fermenting; Deptor; DEP domain containing mTOR-interacting protein; mTOR; Mechanistic tar

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism

Keywords: Pancreas cancer; Uncoupling proteins; UCP2; mTOR; Everolimus; GAPDH; Cell death;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular neurobiology of mTOR

Keywords: 4E-BPs; 4E-binding proteins; Atg13; autophagy-related protein 13; BDNF; brain-derived neurotrophic factor; CGG; trinucleotide; EGF; epidermal growth factor; FXS; Fragile X syndrome; Hif1α; hypoxia-inducible factor 1-α; LTD; long-term depression; LTP; lo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Systemic application of sirolimus prevents neointima formation not via a direct anti-proliferative effect but via its anti-inflammatory properties

Keywords: α-SMA; α-smooth muscle actin; BMPC; bone marrow-derived progenitor cells; BMTx; bone marrow transplantation; CFSE; carboxyfluorescein succinimidyl ester; DES; drug-eluting stents; EC; endothelial cells; ICAM-1; intercellular adhesion molecule 1; mTOR; m

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture

Keywords: AD; Alzheimer's disease; EA; electroacupuncture; 18F-FDG; 18F-Fluoro-2-deoxy-D-Glucose; PET; positron emission tomography; AMPK; adenosine monophosphate-activated protein kinase; mTOR; mammalian target of rapamycin; Aβ; amyloid-beta; ThS; Thioflavin stai

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway

Keywords: Indomethacin; Glioma; Apoptosis; AMPK; mTOR;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells

Keywords: Leucine; Reactive oxygen species; Oxidative phosphorylation; Glycolysis; mTOR; HIF-1α;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells

Keywords: 3-MA; 3-methyladenine; ADCX; 25-O-acetyl-7,8-didehydrocimigenol 3-O-beta-D-xylopyranoside; TCM; traditional Chinese medicine; HCC; hepatocellular carcinoma; ABC; ATP-binding cassette; ULK1; unc-51-like kinase 1; HCQ; hydroxychloroquine; CTSB; cathepsin B;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress

Keywords: βRicKO; β-cell-specific knockout of Rictor; GIIS; glucose-induced insulin secretion; HFD; high-fat diet; NCD; normal chow diet; mTOR; mechanistic target of rapamycin; mTORC2; mTOR complex 2; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; R

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects

Keywords: A1; Bcl-2-related protein A1; AIF; apoptosis-inducing factor; AKT; protein kinase B; AMPK; 5′AMP-activated protein kinase; Bad; Bcl-2-associated death promoter; Bak; Bcl-2-associated killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

Keywords: SIRT1; AMPK; mTOR; Nutraceutical modulators; Synergistic effect;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2017 سفارش ترجمه

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

Keywords: Autophagy; eosinophil cytolysis; eosinophilic disease; necrosis; necroptosis; non-apoptotic cell death; mixed lineage kinase-like; RIP kinase; reactive oxygen species; cfeg; Cluster of free eosinophil granules; CR3; Complement receptor 3; DPI; Diphenylene

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy

Keywords: ROS; reactive oxygen species; ER; endoplasmic reticulum; PDT; photodynamic therapy; HY-PDT; hypericin-mediated photodynamic therapy; mTOR; mammalian target of rapamycin; CHOP; CCAAT/enhancer-binding protein homologous protein; Endoplasmic reticulum (ER);

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1

Keywords: BAG3; BCL2-associated athanogene; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis; CASA; chaperone-assisted selective autophagy; CMA; chaperone-mediated autophagy; RE; maximal eccentric resista

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2017 سفارش ترجمه

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of 1-(3-aryl-4-chlorophenyl)-3-(p-aryl)urea derivatives against breast cancer by inhibiting PI3K/Akt/mTOR and Hedgehog signalings

Keywords: Breast cancer; Drug design; Antitumor activity; PI3K; mTOR; Hedgehog;

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus

Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; FTDP-17; frontotemporal dementia and Parkinsonism linked to chromosome 17; GVD; granulovacuolar degeneration; mTOR; mammalian target of rapamycin; NFTs; neurofibrillary tangles; p70S6K; S6 kinases; PI3K;

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2017 سفارش ترجمه

1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the β-catenin/TCF4/GSK-3β/mTOR pathway

Keywords: 1,25D3; 1,25-dihydroxyvitamin D3; VDR; vitamin D receptor; 25(OH)D; 25-dihydroxyvitamin D; DCM; diabetic cardiomyopathy; CQ; chloroquine; STZ; streptozotocin; lenti-shVDR; lentiviral vectors expressing a short hairpin RNA against VDR; TSC; tuberous sclero

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2017 سفارش ترجمه

Src-family tyrosine kinases and the Ca2 + signal

Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs

Keywords: LAT; L-type amino acid transporters 1; SLC; solute carrier; CD98; cluster of differentiation 98; ASCT2; AlaSerCys Transporter 2; mTOR; mammalian target of rapamycin; BBB; blood brain barrier; AdiC; l-arginine/agmatine antiporter; C12E8; octaethylene glyco

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2017 سفارش ترجمه

Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

Modifications to the composition of the hyphal outer layer of Aspergillus fumigatus modulates HUVEC proteins related to inflammatory and stress responses

Keywords: AiP; programed cell death 6-interacting protein; AKT; protein kinase B; ASK1; mitogen-activated protein kinase 5; BAD; BLC2-associated agonist of cell death; BAX; BCL2-associated X protein; CD-142; tissue factor; cFOS; FBJ Murine osteosarcoma viral oncoge

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies

Keywords: ACE; angiotensin converting enzyme; ADAM; a disintegrin and metalloproteinase; AKI; acute kidney injury; ANGII; angiotensin II; AT1; angiotensin II receptor type 1; AMPKα; AMP-activated protein kinase α; α-SMA; α-smooth muscle actin; CKD; chronic kidn

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of autophagy by mitochondrial phospholipids in health and diseases

Keywords: ALCAT1; lysocardiolipin acyltransferase 1; ALE1; lysophospholipid acyltransferase (yeast); AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATGL; adipose triglyceride lipase; AVT1; amino acid vacuolar transport; BNIP3; BCL2/adenovirus E1B

دانلود رایگان متن کامل مقاله ISI 84 صفحه سال انتشار : 2017 سفارش ترجمه

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review

Keywords: Aβ42; β-amyloid42; ABCA1; ATP-Binding Cassette Transporter A1; AD; Alzheimers disease; ADAM; AD-related disintegrin and metalloprotease; AICD; APP- intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE; ApolipoproteinE;

دانلود رایگان متن کامل مقاله ISI 175 صفحه سال انتشار : 2017 سفارش ترجمه

Autophagy in allografts rejection: A new direction?

Keywords: Autophagy; Transplantation; Allograft; T lymphocyte; Tolerance; TCR; T cell receptor; I/R; Ischemia-reperfusion; PI3K; Phosphatidylinosito 3-kinase; mTOR; Mammalian target of rapamycin; CNI; Calcineurin inhibitor;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy

Keywords: Endomyocardial biopsy; mTOR; Ribosomal protein S6; Heart failure; Angiotensin; Dilated cardiomyopathy;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway

Keywords: Autophagy; Glycolysis; Oxidative phosphorylation; Pentose phosphate pathway; Leukemia cells; Cancer energy metabolism; 6-AN; 6-aminonicotinamide; CQ; chloroquine diphosphate; DMSO; dimethyl sulfoxide; HIF; hypoxia-inducible factor; mTOR; mammalian target

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Research paperHypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis

Keywords: Tuberous sclerosis complex; mTOR; HIF1; Dendrite; Brain development; Cognitive disease; Hypoxia; Cognition;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Perivascular epithelioid cell tumor of the gastrointestinal tract

Keywords: Perivascular epithelioid cell tumor; PEComa; Gastrointestinal; Sarcoma; mTOR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact

Keywords: RSV; respiratory syncytial virus; BMDC; bone marrow derived dendritic cells; DC; dendritic cells; mTOR; mechanist target of rapamycin; Respiratory syncytial virus; Rapamycin; Dendritic cells; CD8 T cells;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression

Keywords: Rapamycin; mTOR; p53; Hepatocellular carcinoma cells; ERK signal;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway

Keywords: FXR; mTOR/S6K; Liver cancer cells; Proliferation; AP; Ammonium peroxydisulfate; Acr-Bis; Acrylamide-bisacrylamide; BCA; Bicinchoninic acid; BLAST; Basic Local Alignment Search Tool; BSA; Bovine serum albumin; DEPC; Diethypyrocarbonate; DMSO; Dimethyl sulf

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Safety of Everolimus in Patients Younger than 3 Years of Age: Results from EXIST-1, a Randomized, Controlled Clinical Trial

Keywords: AE; Adverse event; EXIST-1; EXamining everolimus In a Study of Tuberous Sclerosis Complex-1; mTOR; Mammalian target of rapamycin; SAE; Serious AE; SEGA; Subependymal giant cell astrocytoma; TSC; Tuberous sclerosis complex;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum

Keywords: REDD1; mTOR; Transcriptional/translational regulation; Amino acids;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis

Keywords: Autophagy; Lysosome; Vacuolar-ATPase; Rapamycin; Analysis of variance; ANOVA; mammalian target of rapamycin; mTOR; nonalcoholic fatty liver disease; NAFLD; nonalcoholic steatohepatitis; NASH; endoplasmic reticulum; ER; green fluorescent protein; GFP; micr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Autophagy induction contributes to GDC-0349 resistance in head and neck squamous cell carcinoma (HNSCC) cells

Keywords: Head and neck squamous cell carcinoma (HNSCC); GDC-0349; mTOR; Autophagy; ATG-7;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling

Keywords: PRKCI; Autophagy; MTOR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent

Keywords: Acute myeloid leukemia; mTOR; WYE-687; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway

Keywords: Radix bupleuri; Epilepsy; Anticonvulsant; Hippocampus; mTOR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of Bcl-2 potentiates AZD-2014-induced anti-head and neck squamous cell carcinoma cell activity

Keywords: Head and neck squamous cell carcinoma (HNSCC); mTOR; AZD-2014; Bcl-2; ABT-737;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat

Keywords: Hepatocellular carcinoma; HDACs; Resminostat; mTOR; Mitochondrial apoptosis pathway; Chemo-sensitization;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration

Keywords: MTOR; Skeletal muscle; Regeneration; Leucine supplementation; Aging;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice

Keywords: mTOR; Neural stem cell; Proliferation; Differentiation; Aging;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A Randomised Phase 2 Study of AZD2014 Versus Everolimus in Patients with VEGF-Refractory Metastatic Clear Cell Renal Cancer

Keywords: Renal cancer; mTOR; TORC2; Survival;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

MHY1485 activates mTOR and protects osteoblasts from dexamethasone

Keywords: Dexamethasone; Osteoblasts; MHY1485; mTOR; Mitochondrial death pathway;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats

Keywords: AAR; area at risk; antimiR; antimicroRNA; C; control; DR; diabetic rat; GLUT4; glucose transporter type 4; IGF-1R; insulinlike growth factor-1 receptor; InsR; insulin receptor; IS; infarct size; L; lentivirus vectors with let-7 antimiR; LY; LY294002; miRN

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells

Keywords: Metformin; Oxidative stress; Akt; mTOR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه