کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10748566 | 1050275 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway
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کلمات کلیدی
PPPTCAOXPHOSmTORHIF6-AN6-aminonicotinamide - 6-آمینونیکوتامینیدDMSO - DMSOAutophagy - اتوفاژیtricarboxylic acid - اسید تری کربوکسیلیکDimethyl sulfoxide - دیمتیل سولفواکسیدLeukemia cells - سلولهای لوسمیHypoxia-inducible factor - فاکتور القاء کننده هیپوکسیOxidative phosphorylation - فسفوریلاسیون اکسیداتیوpentose phosphate pathway - مسیر پنتوز فسفاتmammalian target of rapamycin - هدف پستانداران رپامایسینchloroquine diphosphate - کلروفین دی فسفاتGlycolysis - گلیکولیز یا قندکافت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway](/preview/png/10748566.png)
چکیده انگلیسی
Most cancer cells predominantly produce energy by glycolysis, even in the presence of adequate oxygen. Therefore, inhibition of glycolysis is a promising cancer treatment target. Recently, it has been recognized that to conduct thorough treatment of cancer, comprehensive understanding of cancer metabolism is essential, not only focusing on glycolysis. Here, we investigated the supporting mechanism of autophagy, which is a catabolic process that recycles intracellular components, for energy supply in the glycolysis-inhibited condition. Autophagy is thought to be highly activated in cancers and to promote their growth or progression by adapting to the harsh surrounding microenvironment. We found that cancer cells positively promoted autophagy to overcome the energy shortage from glycolysis by maintaining mitochondrial activity for ATP production essential for survival. Conclusively, autophagy plays a role in determining whether cancer cells live or die, and autophagic ability in cancer cells is a promising target for therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 474, Issue 1, 20 May 2016, Pages 188-192
Journal: Biochemical and Biophysical Research Communications - Volume 474, Issue 1, 20 May 2016, Pages 188-192
نویسندگان
Moemi Kawaguchi, Shigeki Aoki, Takuya Hirao, Michie Morita, Kousei Ito,