کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8438548 | 1401526 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy
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کلمات کلیدی
mTORPP2A3-MACXCL12CAFsC-X-C motif chemokine ligand 123-methyladenine - 3-متیل آدنینROS - ROSAutophagy - اتوفاژیCytokines - سیتوکین هاTumor relapse - عود تومورCancer-associated fibroblasts - فیبروبلاست های مرتبط با سرطانcancer-associated fibroblast - فیبروبلاست وابسته به سرطانMechanistic target of rapamycin - هدف مکانیکی رپامایسینRadiation therapy - پرتودرمانی یا رادیوتراپیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Tumor relapse after radiotherapy is a significant challenge to oncologists, even after recent the advances in technologies. Here, we showed that cancer-associated fibroblasts (CAFs), a major component of cancer stromal cells, promoted irradiated cancer cell recovery and tumor relapse after radiotherapy. We provided evidence that CAFs-produced IGF1/2, CXCL12 and β-hydroxybutyrate were capable of inducing autophagy in cancer cells post-radiation and promoting cancer cell recovery from radiation-induced damage in vitro and in vivo in mice. These CAF-derived molecules increased the level of reactive oxygen species (ROS) post-radiation, which enhanced PP2A activity, repressing mTOR activation and increasing autophagy in cancer cells. Consistently, the IGF2 neutralizing antibody and the autophagy inhibitor 3-MA reduce the CAF-promoted tumor relapse in mice after radiotherapy. Taken together, our findings demonstrated that CAFs promoted irradiated cancer cell recovery and tumor regrowth post-radiation, suggesting that targeting the autophagy pathway in tumor cells may be a promising therapeutic strategy for radiotherapy sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 17, March 2017, Pages 45-56
Journal: EBioMedicine - Volume 17, March 2017, Pages 45-56
نویسندگان
Yongbin Wang, Guifang Gan, Bocheng Wang, Jinliang Wu, Yuan Cao, Dan Zhu, Yan Xu, Xiaona Wang, Hongxiu Han, Xiaoling Li, Ming Ye, Jiangmin Zhao, Jun Mi,