Keywords: CA IX; Carbonic anhydrase IX; CAFs; Cancer associated fibroblasts; TAMs; Tumor-associated macrophages; HIF-1; Hypoxia-inducible factor 1; EGFR; Epidermal growth factor receptor; ALDH1; Aldehyde dehydrogenase 1; HSF-1; Heat shock factor-1; PD-L1; Pro
مقالات ISI (ترجمه نشده)
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Keywords: CAFs; cancer-associated fibroblasts; CLCs; CAF-like cells; EMT; epithelial-to-mesenchymal transition; FDR; false discovery rate; IRDS; interferon-related DNA damage resistance signature; LC; liquid chromatography; LFQ; label free quantification; MRM; mult
Keywords: 3D-MCTS; Three-dimensional Multicellular Tumor Spheroids; Tumor-ECM; Tumor Extracellular Matrix; 3D; Three-Dimensional; TME; Tumor Microenvironment; MSCs; Mesenchymal Stem Cells; PLL; Poly-L-Lysine; hADSCs; Human Adipose-derived Stem Cells; ALP; Alkaline
Keywords: ALK1; activin receptor-like kinase1; ANG/Ang; angiopoietin; Bcl-xL; b-cell lymphoma-extra large; BM; bone marrow; BMDCs; bone marrow derived cells; BMP; bone morphogenetic protein; Bv8; bombina variagata peptide 8; CAFs; cancer/carcinoma associated fibrob
Keywords: Bio-based; Bioflocculant; Biopolymer; Colloids; Flocculant; Flocculation; Grafting; Polymerization; Polysaccharide; Wastewater treatment; ADAC; Anionic dialdehyde cellulose derivatives; Alg; Alginate; AM; Acrylamide; APTAC; 3-(acrylamidopropyl) trimethyl
Keywords: Microenvironment; Resistance; Target therapy; AML; acute myeloid leukemia; ATRA; all-trans retinoic acid; bFGF; basic fibroblast growth factor; CAFs; cancer-associated fibroblasts; CAM-DR; cell adhesion-mediated drug resistance; CCL2; chemokine (C-C motif
Keywords: CAFs; Cancer associated fibroblasts; NFs; normal fibroblasts; OC; Oral cancer or (OCC), oral cancer cells; C-C motif; Chemokine ligand 2 (CCL2); IL-8; Interleukin 8; OSCC; Oral squamous cell carcinoma; CM; Conditional medium; IHC; Immunohistochemistry; Ca
Keywords: Epithelial-mesenchymal transition; Cancer-associated fibroblasts; Fibroblast-dependent cancer invasion; Extracellular matrix remodeling; Platelet-derived growth factor B; CAFs; cancer-associated fibroblasts; ECM; extracellular matrix; EGF; epidermal gro
Keywords: Cell reorientation; NAFs; CAFs; Stress fiber; Energy minimization;
Keywords: APC; adenomatous polyposis coli; AR; androgen receptor; CAFs; cancer-associated fibroblasts; CTL; cytotoxic T cells; EMT; epithelial-mesenchymal transition; EPCs; endothelial progenitor cells; FSP1; fibroblast specific protein 1; HNSCC; head and neck sq
Keywords: ADAM; a disintegrin and metalloprotease; ADEX; aberrantly differentiated endocrine exocrine; ALDH1; aldehyde dehydrogenase 1; CAFs; cancer associated fibroblasts; CDKN2A; cyclin dependent kinase inhibitor 2A; CSC; cancer stem cell; CTC; circulating tumor
Keywords: EV(s); extracellular vesicle(s); MV(s); microvesicle(s); AB(s); apoptotic bodie(s); TME; tumor microenvironment; TfRs; transferrin receptors; MVE; multivesicular endosomes; MHC; major histocompatibility complex; miRNAs; microRNAs; PCa; prostate cancer; ES
Keywords: Tumor Stroma; Inflammation; Stomach Cancer; Tumor Cells; α-SMA; alpha-smooth muscle actin; CAFs; cancer-associated fibroblasts; CM; conditioned medium; DGC; diffuse-type gastric cancer; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition
Keywords: BCL-2; B-cell lymphoma 2; CA-125; cancer antigen-125; CAFs; cancer-associated fibroblasts; CCL17; chemokine (C-C motif) ligand 17; CCL2; chemokine (C-C motif) ligand 2; CXCL12; chemokine (C-X-C motif) ligand 12; DFS; disease-free survival; DNMT; DNA methy
Keywords: COPD; chronic obstructive pulmonary disease; RS; replicative senescence; SIPS; stress induced premature senescence; OIS; oncogene induced senescence; SASP; senescence associated secretory phenotype; TNF-a; tumor necrosis factor-a; TNFR1; TNFa receptor 1;
Keywords: Protease; Live-cell imaging; Breast cancer; Tumor microenvironment; 3D models; ABPs; activity-based probes; CAFs; carcinoma-associated fibroblasts; DCIS; ductal carcinoma in situ; DQ; dye quenched; ECM; extracellular matrix; FRET; fluorescence resonance e
Keywords: CAFs; cancer-associated fibroblasts; CCA; cholangiocarcinoma; DAPI; 4â²-6-diamidino-2-phenylindole; FBS; fetal bovine serum; Hh; Hedgehog; Gli; glioma-associated transcriptional factor; Ptch1; Patched-1; PTX; pertussis toxin; qRT-PCR; quantitative revers
Keywords: EPR; enhanced permeability and retention; CAFs; cancer associated fibroblasts; TAMs; tumor-associated macrophages; PDGFRβ; platelet-derived growth factor receptor beta; αSMA; alpha smooth muscle actin; TGFβ; transforming growth factor beta; 5-FU; 5-flu
Keywords: Colon cancer; Proliferation; Glucagon-like peptide 2; Cancer therapy; (5-FU); 5-Fluorouracil; Akt; protein kinase B; APC; adenomatous polyposis coli; CAFs; carcinoma-associated fibroblasts; CDK; cyclin-dependent kinase; DPP-IV; dipeptidyl peptidase IV; GL
Keywords: AKT; another kinase of transcription; AP-1; activator protein-1; bcl2; B-cell lymphoma-2; BDNF; brain-derived neurotrophic factor; CAFs; carcinoma-associated fibroblasts; COX-2; prostaglandin-endoperoxide synthase 2; DMSO; dimethyl sulfoxide; ECM; extrace
Keywords: CSCs; cancer stem cells; CRC; colorectal cancer; EMT; epithelial mesenchymal transition; ECM; extracellular matrix; ROS; reactive oxygen species; MMPs; matrix metalloproteinase; CAFs; cancer-associated fibroblasts; CAMs; cancer-associated macrophages; GSH
Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1
Keywords: IL-11; Interleukin 11; GC cells; gastric cancer cells; CAFs; cancer associated fibroblasts; STAT3; Signal Transducer and Activator of Transcription3; ERK; extracellular regulated protein kinases; KM-Plotter; Kaplan-Meier Plotter; EMT; epithelial to mesenc
Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
Keywords: α-SMA; alpha-smooth-muscle actin; AFM; atomic force microscopy; DAPI; 4â²,6-Diamidino-2-Phenylindole; DMSO; dimethylsulfoxide; EMT; epithelial to mesenchymal transition; ECM; extracellular matrix; FBs; fibroblasts; PBS; phosphate buffered saline; PCR; p
Emerging roles and mechanisms of FOXC2 in cancer
Keywords: FOXC2; Forkhead box protein C2; EMT; epithelial-mesenchymal transition; NSCLC; non-small cell lung cancer; EGFR; epidermal growth factor receptor; siRNA; small (or short) interfering RNA; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinosito
FOXOs in cancer immunity: Knowns and unknowns
Keywords: 2B4; CD244 molecule; AKT or PKB; protein kinase B; APCs; antigen-presenting cells; ARG1; arginase 1; BEC; blood endothelial cell; BLNK; B cell Linker protein; BMP; bone morphogenetic protein; BTK; Bruton tyrosine kinase; C/EBP; CCAAT/enhancer-binding prot
Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts
Keywords: CAFs; FXR; Tumor microenvironment; Breast cancer; Nuclear receptors;
Original ArticleLoss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis
Keywords: Exosomes; miR-320a; CAFs; PBX3; Tumourigenesis;
Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy
Keywords: Cancer-associated fibroblast; Cytokines; Intermediate metabolite; Autophagy; Tumor relapse; Radiation therapy; CAFs; cancer-associated fibroblasts; IGF1/2; insulin-like growth factor 1/2; CXCL12; C-X-C motif chemokine ligand 12; ROS; reactive oxygen speci
Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy
Keywords: CAFs; cancer-associated fibroblasts; CIS; carcinoma in situ; CSCs; cancer stem cells; CXCL12; CXC ligand 12; CXCR4; CXC chemokine receptor 4; EMT; epithelial mesenchymal transition; HMGB1; high mobility group box 1; MDSCs; myeloid-derived suppressor cells
Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth
Keywords: ECM; extracellular matrix; HA; hyaluronic acid; AFM; atomic force microscopy; CAFs; cancer-associated fibroblasts; MMFs; mouse mammary fibroblasts; TFM; traction force microscopy; LSL; lox-STOP-lox; H&E; hematoxylin and eosin;
Original ArticleAsporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms
Keywords: Asporin; Pancreatic cancer; Invasion; Migration; EMT; PSCs; pancreatic stellate cells; ECM; extracellular matrix; CAFs; cancer-associated fibroblasts; PCC; pancreatic cancer cell; ASC; the American Cancer Society; SLRP; small leucine-rich proteoglycan; α
FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells
Keywords: BCa; breast cancer; CAFs; cancer associated fibroblasts; ER; estrogen receptor α; FGF; fibroblast growth factor; OHT; 4-hydroxytamoxifen; PR; progesterone receptor;
HtrA3 stromal expression is correlated with tumor budding in stage II colorectal cancer
Keywords: APC; adenomatous polyposis coli; BMP; bone morphogenetic protein; CAFs; cancer-associated fibroblasts; CK; pan-keratin (AE1/AE3); CRC; colorectal cancer; DAB; diaminobenzidine hydrochloride; DFS; disease-free survival; EMT; epithelial-to-mesenchymal trans
Development of novel avenues to overcome challenges facing CAR T cells
Keywords: AICD; activation-induced cell death; AMP; adenosine monophosphate; APC; antigen-presenting cells; ATP; adenosine triphosphate; CAFs; cancer-associated fibroblasts; CAR; chimeric antigen receptor; CEA; carcinoembryonic antigen; CTLA4; cytotoxic T-lymphocyt
The ILK-MMP9-MRTF axis is crucial for EndMT differentiation of endothelial cells in a tumor microenvironment
Keywords: MRTFs; ILK; EndMT; CAFs; MMP9; Tumor microenvironments;
Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours
Keywords: Paediatric cancer; Neuroblastoma; Tumour microenvironment; Tumour stroma; Patient-derived xenograft (PDX); Metastasis; αSMA; α-smooth muscle actin; CAFs; cancer-associated fibroblasts; ECM; extracellular matrix; huCD31; human-specific CD31; IHC; immunoh
Enhancement of fibroblast activation protein α-based vaccines and adenovirus boost immunity by cyclophosphamide through inhibiting IL-10 expression in 4T1 tumor bearing mice
Keywords: Fibroblast activation protein α; Interleukin-10; Cyclophosphamide; Prime-boost strategy; Immunosuppression; Cancer vaccine; Ad; adenovirus; CAFs; cancer-associated fibroblasts; CpVR-FAP; a recombinant plasmid encoding human FAPα; CY; cyclophosphamide; E
Original ArticleVascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma
Keywords: CAFs; VM; Noncoding RNA; miR-101; TGF-β; SDF1;
IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment
Keywords: HCC; hepatocellular carcinoma; IL-6; interleukin-6; STAT3; Signal transducer and activator of transcription 3; PCAF; P300/CBP-associated factor; HATs; histone acetyltransferases; ELISA; enzyme-linked immunosorbent assay; Co-IP; co-immunoprecipitation; ChI
Dynamic monitoring of GPER-mediated estrogenic effects in breast cancer associated fibroblasts: An alternative role of estrogen in mammary carcinoma development
Keywords: α-SMA; α-smooth muscle actin; CAF; cancer associated fibroblast; Ca2+; calcium; E2; 17-β-estradiol; ECM; extracellular matrix; EC50; concentration for 50% of maximal effect; EGFR; epidermal growth factor receptor; ER; estrogen receptor; ERK; extracellu
Research paperN-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations
Keywords: AJ; adherens junction; CAFs; cancer-associated fibroblasts; CNS; central nervous system; DN; dominant negative; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; FA; focal adhesion; FGF; fibro
A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets
Keywords: Cancer-associated fibroblasts; Myofibroblasts; Pan-cancer; Therapeutic targets; Tumor microenvironment; αSMA; α-smooth muscle actin; CAFs; cancer-associated fibroblasts; CSPG4; chondroitin sulfate proteoglycan 4; ECM; extracellular matrix; LOX; lysyl ox
Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations
Keywords: FAPα; CAFs; Secretome; Degradome; Angiogenesis; TGFβ;
miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12
Keywords: CAFs; miR-101; CXCL12; Lung cancer
Regulation of prostate stromal fibroblasts by the PIM1 protein kinase
Keywords: PIM1; Proviral Insertion site of the Moloney murine leukemia virus; CAFs; cancer associated fibroblasts; BM; bone marrow; COL1A1; collagen type I alpha 1; PDGFR; platelet-derived growth factor receptors; CCL5; chemokine (C-C motif) ligand 5; BPH; benign p
ReviewPeriostin in intrahepatic cholangiocarcinoma: Pathobiological insights and clinical implications
Keywords: ICC; intrahepatic cholangiocarcinoma; CAFs; cancer-associated fibroblasts; α-SMA; α-smooth muscle actin; EMT; epithelial-mesenchymal transition; Postn; periostin; OSF-2; osteoblast specific factor-2; BMP-1; bone morphogenic protein-1; Tnc; tenascin-C;
Matrikines from basement membrane collagens: A new anti-cancer strategy
Keywords: ECM; extracellular matrix; MMP; matrix metalloproteinases; SDF-1; Stroma-Derived Factor 1; CAFs; cancer-Associated Fibroblasts; ROS; reactive oxygen species; EMT; epithelial-mesenchymal transition; NC domain; non-collagenous domain; FACIT; fibril associ
Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
Keywords: ER; estrogen receptor; PgR; progesterone receptor; HER2/erbB2; human epidermal growth factor receptor-2; E2; estradiol; RTK; receptor tyrosine kinase; IGF-IR; insulin-like growth factor I receptor; EGFR; epidermal growth factor receptor; MAPK; mitogen act
GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts
Keywords: CAFs; cancer-associated fibroblasts; MSCs; mesenchymal stem cells; ER; endoplasmic reticulum; α-SMA; α-smooth muscle actin; HBMSCs; human bone marrow mesenchymal stem cells; BMMSCs; murine bone marrow mesenchymal stem cells; SDF-1; stromal cell-derived
Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
Keywords: Tumor microenvironment; CAFs; Inflammation; Breast cancer; Ovarian cancer;