Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; neonatal cholestasis; ABCC2; MRP2; black liver; molecular genetic analysis; ABCC2; ATP-binding cassette sub-family C member 2; BSEP; Bile salt export pump; D Bil; Direct bilirubin; GGT; γ-glutamyltransferase; MRP2; Multidrug resistance-associated protein
مقالات ISI پروتئین مرتبط با مقاومت چند دارویی 2 (ترجمه نشده)
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Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Bee pollen; Phytometabolites; Nutrition; Therapeutic benefits; Food safety; GC-MS; gas chromatography-mass spectrometry; LC-ESI/MS; liquid chromatography-electrospray ionization mass spectrometry; TLC; thin layer chromatography; HPLC-DAD-ESI/MS; high-pe
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; BS; bile salts; BSEP; bile salt export pump; MRP2; multidrug resistance-associated protein 2; E17G; estradiol 17 β-d-glucuronide; EE; 17α-ethynylestadiol; IRHC; isolated rat hepatocyte couplets; CME; clathrin mediated endocytosis; MDC; monodansylcadaver
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ADMET; absorption, distribution, metabolism, excretion, toxicity; AHR; aryl hydrocarbon receptor; AUC; area under the curve; BVU; (E)-5-(2-bromovinyl) uracil; CAR; constitutive androstane receptor; cMOAT; Canalicular multispecific organic anion transporte
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; DILI; drug-induced liver injury; ALT; alanine aminotransferase; ALP; alkaline phosphatase; BBW; black box warning; WDN; withdrawn; BC; bile canalicular; BSEP; bile salt export pump; MRP2; multidrug resistance-associated protein 2; SCHs; sandwich cultured
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Tyrosine kinase inhibitors; Drug transporter; Drug interaction; Therapeutic drug monitoring; Skin disorders; ADR; Adverse drug reaction; AUC; Area under the curve; BBB; Blood-brain barrier; BCRP/ABCG2; Breast cancer resistance protein; CNS; Central nerv
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; AhR; aryl hydrocarbon receptor; ARE; antioxidant response element; BT; black tea; CYP; cytochrome P450; DME; drug-metabolizing enzymes; DR4; direct repeat with 4Â bp spacer; DRE; dioxin response elements; GT; green tea beverage; EC; epicatechin; EGC; epig
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; AD; Decoction of processed aconite root; ALD; Decoction of processed aconite root and honey-processed liquorice; AP; Apical; BCRP; Breast cancer resistance protein; BL; Basolateral; DDAs; Diester-diterpenoid alkaloids; EIC; Extracted ion chromatogram; ER;
Reduced Hepatocellular Expression of Canalicular Transport Proteins in Infants with Neonatal Cholestasis and Congenital Hypopituitarism
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; cholestasis; congenital hypopituitarism; septo-optic dysplasia; canalicular ectoenzymes; canalicular transport proteins; ACTH; Adrenocorticotropic hormone; BSEP; Bile salt export pump; CD13; Alanyl aminopeptidase; FIC1; Familial intrahepatic cholestasis t
Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Quercetin; Hepatocellular carcinoma; Multiple drug resistance; ATP-binding cassette transporters, FZD7/β-catenin pathway; 5-FU; 5-fluorouracil; ABC; ATP-binding cassette; ATP; adenosine triphosphate; ADR; doxorubicin; FZD7; Frizzled homolog protein 7; GV
Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Nomegestrol acetate; Multidrug resistance-associated protein 2; Drug-drug interactions; HepG2 cells; Caco-2 cells;
The HLA-B*15:02 polymorphism and Tegretol®-induced serious cutaneous reactions in epilepsy: An updated systematic review and meta-analysis
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ADRs; adverse drug reactions; cADRs; cutaneous adverse drug reactions; CBZ; carbamazepine; CI; confidence interval; DNA; deoxyribonucleic acid; DRESS; drug reaction with eosinophilia and systemic symptoms; GABRA1; gamma-aminobutyric acid type A receptor a
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Bile canaliculi; Collagen; Hepatic drug disposition; Methods; Sandwich-cultured rat hepatocytes; AUC; Area Under the Curve; BEI; biliary excretion index; CDF; 5-(6)-carboxy-2-dichlorofluorescein; CDFDA; 5-(6)-carboxy-2-dichlorofluorescein diacetate; Clint
Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Fasiglifam (TAK-875); Drug-induced liver injury (DILI); Microarray; Comparative hepatic transcriptome analysis; Gene set enrichment analysis; ALT; Alanine aminotransferase; Bsep; Bile salt export pump; CCl4; Carbon tetrachloride; ConA; Concanavalin A; DAM
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Cisplatin; Regeneration; Apoptosis; Oct2; p53; AKI; acute kidney injury; MDM2; murine double minute 2; Oct2; organic cation transporter 2; Mrp2; multidrug resistance-associated protein 2; BrdU; 5-bromo-2-deoxyuridine;
Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Hepatocyte polarization; Bile acid homeostasis; Tight junctions; Cholestatic hepatotoxicity; Alpha-naphthylisothiocyanate; ANIT; α-naphthylisothiocyanate; NTCP; Na+-dependent taurocholate cotransporter; MRP2; multidrug resistance-associated protein 2; MR
Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Multidrug resistance-associated protein 2; Endogenous substrates; ABCC2; Single nucleotide polymorphisms; Metabolomics;
Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Cyclosporin (PubChem CID: 122172945); Atazanavir (PubChem CID: 86601659); Nelfinavir (PubChem CID: 122130496); Itraconazole (PubChem CID: 86611782); Amphotericin B (PubChem CID: 122130047); Ciprofloxacin (PubChem CID: 92135222); Clopidogrel (PubChem CID:
Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC transporters; P-glycoprotein; multidrug resistance-associated proteins; pharmacokinetics; biliary excretion; ABC; ATP-binding cassette; Bcrp; breast cancer resistance protein; BMAL1; brain and muscle arnt-like protein-1; CLOCK; circadian locomotor out
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro-In Vivo Discrepancy in Its Drug Interaction Potential in Rats
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; drug interactions; in vitro/in vivo correlations; pharmacokinetics; protein binding; transporters; CYP enzymes; hepatocytes; organic anion-transporting polypeptide transporters; multidrug resistance transporters; solute transporters; ABT; 1-aminobenzotr
P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Res; resveratrol; MTX; methotrexate; P-gp; P-glycoprotein; MRP2; multidrug resistance-associated protein 2; MDR1; multidrug resistance 1; OATs; organic anion transporters; DDIs; drug-drug interactions; Papp; apparent permeability coefficients; ER; Efflux
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ANIT; alpha-naphthylisothiocyanate; A1AR; A1 adenosine receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; Bsep; bile salt export pump; Mrp2; multidrug resistance-associated protein 2; Ntcp; Na+-dependent taurocholate cotransporter; Oatp2
Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Drug transport; Drug-drug interactions; Intestinal chemical barrier; Multidrug resistance-associated protein 2; Nutrient-drug interaction; Pregnane-X-receptor
Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Res; resveratrol; Mdr1; multidrug resistance 1; Pept1; peptide transporter 1; Mrp2; multidrug resistance-associated protein 2; IGF-1R; insulin-like growth factor 1 receptor; ERK; extracellular signal-regulated kinase; AKT; protein kinase B; ABC; ATP-bindi
Simultaneous determination of lopinavir and three ester prodrugs by LC-MS/MS in lysates of BeWo cells
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; BSA; bovine serum albumin; DLPV; diglycolic acid monoester of lopinavir; DPBS; Dulbecco's phosphate buffered saline; GLPV; glutaric acid monoester of lopinavir; LPV; lopinavir; MRP2; multidrug resistance-associated protein 2; Pgp; P-glycoprotein; RTV; rit
Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Calculus Bovis Sativus; Traditional Chinese medicine; Cholestasis; Multidrug resistance-associated protein 2; Breast cancer resistance protein
Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; MRP2; multidrug resistance-associated protein 2; MDR1; multidrug resistance protein 1; BCRP; breast cancer resistance protein; EE; ethynylestradiol; GNT; genistein; ER; estrogen receptor; AP-1; activating protein-1; Sp1; specificity protein-1; PQ; paraqua
The Combination of MK-5172, Peginterferon, and Ribavirin Is Effective in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection Without Cirrhosis
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Response-Guided Therapy; Sustained Virologic Response; Chronic HCV; Protease Inhibitor; ADME; absorption, distribution, metabolism, and excretion; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BOC; boceprevir; cEVR; complete early virolo
Potential role of ATP-binding cassette transporters in the intestinal transport of rhein
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC; ATP-binding cassettet; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; MRP2; multidrug resistance-associated protein 2; B; basolateral; A; apical; MDCKII; Mardin-Darby canine kidney II; Rhein; ATP-binding cassette transporters; Rat in
Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood-brain barrier after CITCO activation
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC-transporter; ATP-binding cassette transporter; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BMDP; brain multidrug resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P450; pgCAR; porcine CAR; CITCO; 6-(4-c
Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: Role of Mrp2
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; CH3Hg+; methylmercury; CH3HgCl; methylmercury chloride; CH3[203Hg+]; radioactive methylmercury; Cys; cysteine; Cys-S-CH3Hg; cysteine-thiol-conjugates of methylmercury; Mrp; multidrug resistance-associated transporter; OAT; organic anion transporter; DCM;
Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; JBP485; cyclo-trans-4-l-hydroxyprolyl-l-serine; ARF; acute renal failure; Oat; organic anion transporters; Mrp2; multidrug resistance-associated protein 2; BUN; blood urea nitrogen; IS; indoxyl sulfate; PAH; para-aminohippurate; MDA; malondialdehyde; SOD;
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC; ATP-binding cassette; AED; antiepileptic drug; ANOVA; analysis of variance; BBB; blood-brain barrier; BSP; bromosulfophthalein; CT; control rats; ESI; electrospray ionization; i.p.; intraperitoneal; Mrp2; multidrug resistance-associated protein 2;
Modulation of cytochrome P450 gene expression in primary hepatocytes on various artificial extracellular matrices
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ASGPR; asialoglycoprotein receptor; BAL; bioartificial liver; BSA; bovine serum albumin; CYP; cytochrome P450; DAPI; 4â²,6-diamidino-2-phenylindole; E-cad-Fc; E-cadherin-IgG Fc; ECM; extracellular matrix; EGF; epidermal growth factor; Mrp2; multidrug res
Quantification of coproporphyrin isomers I and III in urine by HPLC and determination of their ratio for investigations of Multidrug Resistance Protein 2 (MRP2) function in humans
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Coproporphyrins; High-performance liquid chromatography; ATP-binding cassette transporters; Multidrug Resistance-associated Protein 2; Biological markers
Hepatic Metabolism and Biliary Excretion of Valerenic Acid in Isolated Perfused Rat Livers: Role of Mrp2 (Abcc2)
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; valerenic acid; hepatic metabolism; hepatic clearance; biliary excretion; multidrug resistance-associated protein 2; HPLC;
Function of multidrug resistance-associated protein 2 in acute hepatic failure rats
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Multidrug resistance-associated protein 2; 2,4-Dinitrophenyl-S-glutathione; CCl4-induced acute hepatic failure; Hyperbilirubinemia; Intestinal efflux
Expression and function of efflux drug transporters in the intestine
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; ABC transporter; P-glycoprotein; Multidrug resistance-associated protein 2; Breast cancer resistance protein; Oral bioavailability; Transporter-mediated drug interactionABC, ATP-binding cassette; AUC, area under the plasma concentration–time curve; BCRP,
Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; food interactions; oral absorption; transporters; organic anion-transporting polypeptide; p-glycoprotein; bioavailability; API:; atmospheric pressure ionization; AUC0n:; area under the concentration vs. time curve from 0 to time of the last measurable con
Hyperbilirubinemia in the setting of antiviral therapy
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; AIDS; acquired immunodeficiency syndrome; CMV; cytomegalovirus; HIV; human immunodeficiency virus; MRP2; multidrug resistance-associated protein 2; NIAID; National Institute of Allergy and Infectious Diseases; NRTI; nucleoside reverse transcriptase inhibi
Mechanisms involved in spironolactone-induced choleresis in the rat
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; AE2; anionic exchanger 2; BSDF; bile salt-dependent bile flow; Bsep; bile salt export pump; BSIF; bile salt-independent bile flow; CDNB; 1-chloro-2,4-dinitrobenzene; DNP-SG; dinitrophenyl S-glutathione; GSH; reduced glutathione; GSSG; oxidized glutathione
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
Keywords: پروتئین مرتبط با مقاومت چند دارویی 2; Akt; protein kinase B; ERKs; extracellular signal-regulated kinases; ITCs; isothiocyanates; JNK; c-Jun N-terminal kinase; MAPKs; mitogen-activated protein kinases; MRP2; multidrug resistance-associated protein 2; NF-κB; nuclear factor-kappa B; NQO1; NADP