Acetylcholine receptor and behavioral deficits in mice lacking apolipoprotein E
Keywords: Acetylcholine; Apolipoprotein E; Alzheimer's disease; Muscarinic; Stress; Attention
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The cholinergic system and hippocampal plasticity
Keywords: Acetylcholine; Hippocampus; Slice; Synaptic plasticity; LTP; Muscarinic; Nicotinic
Comparison of the kinetics and extent of muscarinic M1–M5 receptor internalization, recycling and downregulation in Chinese hamster ovary cells
Keywords: Muscarinic; Internalization; Recycling; Downregulation; Carbachol
Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats
Keywords: Diabetes; Muscarinic; Curcumin; Insulin and cerebral cortex
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells
Keywords: VEGF; Muscarinic; VEGFR2; mTOR; Crosstalk; PKC; Phosphatase
Cholinergic systems mediate action from movement to higher consciousness
Keywords: Muscarinic; Nicotinic; Motor actions; Muscle; Intracellular skeleton; Cortex
Localization of pre- and postsynaptic cholinergic markers in rodent forebrain: A brief history and comparison of rat and mouse
Keywords: Cholinergic; Cholinoceptive; Muscarinic; Species comparison; Rat; Mouse
The cholinergic system and neostriatal memory functions
Keywords: Cognitive strategy; T-maze; Set-shifting; Reversal learning; Place navigation; Nicotinic; Muscarinic; Striatum; Aging; Basal ganglia
Research reportThe double-H maze test, a novel, simple, water-escape memory task: Acquisition, recall of recent and remote memory, and effects of systemic muscarinic or NMDA receptor blockade during training
Keywords: Automatism; Declarative-like memory; Hippocampus; Learning; Maze; Muscarinic; N-methyl-d-aspartate; Procedural memory; Rat; Spatial; Striatum;
Involvement of the cholinergic system in conditioning and perceptual memory
Keywords: Muscarinic; Nicotinic; Learning; Memory; Conditioning
N-Heterocyclic derived M1 positive allosteric modulators
Keywords: M1; Muscarinic; Allosteric; Modulator; GPCR; Alzheimer’s; Quinolone
The discovery of new spirocyclic muscarinic M3 antagonists
Keywords: Muscarinic; Antagonist
Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists
Keywords: Muscarinic; Antagonist; Dystonia; Parkinson’s disease
Hydroxy cycloalkyl fused pyridone carboxylic acid M1 positive allosteric modulators
Keywords: M1; Muscarinic; Alzheimer’s; Quinolone; Allosteric
Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators
Keywords: M1; Muscarinic; Quinolone; Allosteric; Alzheimer’s
Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding
Keywords: M1; Muscarinic; Allosteric modulator; PAM; Alzheimer’s
Aequorin functional assay for characterization of G-protein-coupled receptors: Implementation with cryopreserved transiently transfected cells
Keywords: Aequorin; Transient transfection; Muscarinic; G-protein-coupled receptor; Cryopreserved cells
Nicotinic modulation of auditory attentional shift in the rat
Keywords: Cholinergic hypothesis; Adaptability; Auditory; Muscarinic; Atropine
The Inhibitory Role of Acetylcholine and Muscarinic Receptors in Bladder Afferent Activity
Keywords: Acetylcholine; Afferent; Antimuscarinic; Bladder; Distension; Mechanosensitivity; Muscarinic; Nerve; Sensory
Temporal Morphological and Functional Impact of Complete Urinary Diversion on the Bladder: A Model of Bladder Disuse in Rats
Keywords: urinary bladder; urinary diversion; atrophy; vagina; models; animal; CMG; cystometry; M; muscarinic; P2X; ligand gated purinergic; UD; urinary diversion;
Receptor changes in brain tissue of rats treated as neonates with capsaicin
Keywords: Capsaicin; Muscarinic; Serotonin; Dopamine; Cannabinoid; TRPV1
Enhanced cholinergic transmission promotes recall in honeybees
Keywords: Cholinergic system; Organo-phosphates; Apis mellifera; Discrimination learning; Associative learning; Nicotinic; Muscarinic; Pesticide; Non-target species; Anticholinesterase; Ecotoxicology
Muscimol, AP5, or scopolamine infused into perirhinal cortex impairs two-choice visual discrimination learning in rats
Keywords: Acetylcholine; Acquisition; Muscarinic; NMDA; Object recognition memory; Rat
N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor
Keywords: Muscarinic; M1; N-desmethylclozapine; Human tissue; AntagonistBacmam, recombinant Baculovirus under the control of a mammalian promoter; Carbachol, CCh; CHO, chinese hamster ovary; DTT, dithiothreitol; DMEM, Dulbecco's modified Eagle's medium; FBS, foetal
Sleep, activity, temperature and arousal responses of mice deficient for muscarinic receptor M2 or M4
Keywords: Muscarinic; Receptor; Acetylcholine; Brain; Sleep; Prepulse inhibition; Startle; Temperature; Locomotor activity; Candida albicans; Influenza; Sleep deprivation
Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens μ-opiate-mediated feeding behavior
Keywords: Accumbens; Muscarinic; Opioid; Feeding; Scopolamine; Eating; Acetylcholine
Identification of an Ascaris G protein-coupled acetylcholine receptor with atypical muscarinic pharmacology
Keywords: Nematode; G protein-coupled receptor; Acetylcholine; Muscarinic; Ascaris; Yeast
Catalpol ameliorates beta amyloid-induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors
Keywords: Aβ25-35; learning and memory; muscarinic receptor; BDNF; cholinergic neurons; catalpol; AChE; acetylcholinesterase; AcTC; acetylthiocholine ester; AD; Alzheimer's disease; Aβ; beta-amyloid peptide; BDNF; brain-derived neurotrophic factor; ChAT; cholin
Scopolamine impairs auditory delayed matching-to-sample performance in monkeys
Keywords: Sounds; Acetylcholine; Rhesus; Working memory; Recognition memory; Muscarinic;
Neutering affects urinary bladder function by different mechanisms in male and female dogs
Keywords: Neutered; Bitch; Canine; Urinary incontinence; Collagen; Muscarinic; Bladder
Ventilatory effects of low-dose paraoxon result from central muscarinic effects
Keywords: Paraoxon; Atropine; Methylatropine; Rats; Plethysmography; Receptors; Muscarinic; Organophosphates
Research ReportTaste novelty induces intracellular redistribution of NR2A and NR2B subunits of NMDA receptor in the insular cortex
Keywords: Detergent; Resistant Membrane (DRM); muscarinic; Acetylcholine Receptor (mAChR); N-Methyl-d-Aspartate; (NMDA); Taste recognition memory; Detergent resistant membranes; Learning;
M1/M3 and M2/M4 muscarinic receptor double-knockout mice present distinct respiratory phenotypes
Keywords: Control of breathing; Chemosensory afferents; Muscarinic receptors; Hypoxia; Ventilatory response; Mammals; Mouse; Mediators acetylcholine; Pattern of breathing; Acetylcholine; Receptors; Muscarinic; Techniques; Muscarinic receptor knockout mouse
Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtype
Keywords: Acetylcholine; Muscarinic; Memory; Knockout; M2; Passive avoidance; Habituation; Holeboard
Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: Can a single model explain disparate results?
Keywords: Mathematical model; Adrenergic; Opioid; Cannabinoid; Muscarinic
Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine
Keywords: Xanomeline; Sabcomeline; Muscarinic; Risperidone; Acetylcholine; Schizophrenia; Microdialysis
Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood-brain barrier permeability
Keywords: extracellular potassium; limbic cortex; muscarinic; BBB; blood-brain barrier; DAD; diode array; dpc; disynaptic population component; EC; entorhinal cortex; HPLC; high pressure liquid chromatography; LOT; lateral olfactory tract; mpc; monosynaptic popul
Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system
Keywords: muscarinic; gabazine; bicuculline; intracerebral injection; nucleus pontis oralis; sublaterodorsal nucleus; BMI; bicuculline methiodide; GABAA; GABA-type A; GBZ; gabazine; PnO; nucleus pontis oralis; REM; rapid eye movement; SLD; sublaterodorsal nucleus;
The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins
Keywords: Muscarinic; Endocytosis; Small G-proteins; GPCR; Trafficking; Vesicle
Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching
Keywords: Acetylcholine; Basal ganglia; Muscarinic; Learning; Attention
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases
Keywords: Acetylcholinesterase; Butyrylcholinesterase; Muscarinic; Organophosphate; Insecticides; Age-related
Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others
Keywords: CCK2; GABAB; Neuronal rhythms; Endocannabinoid; Muscarinic; LY225910;
Synthesis and evaluation of xanomeline analogs—Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor
Keywords: Xanomeline; Alzheimer’s disease; Muscarinic; Plasmalemma diffusion microkinetic model; Long-acting; Drug design; M1 receptor; Wash-resistant binding
Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists
Keywords: Muscarinic; Antagonists; Quaternary; Ammonium; Salts
Comparative Evaluation of Central Muscarinic Receptor Binding Activity by Oxybutynin, Tolterodine and Darifenacin Used to Treat Overactive Bladder
Keywords: bladder; mice; receptors; muscarinic; cholinergic antagonists; cerebral cortexBBB, blood-brain barrier; Bmax, maximal number of binding sites; CNS, central nervous system; DEOB, N-desethyl-oxybutynin; 5-HM, 5-hydroxymethyl metabolite; [3H]NMS, [N-methyl-3
Cholinergic modulation of intrinsic fibre-evoked excitatory transmission contains a nicotinic component in immature but not adult rat piriform cortex, in vitro
Keywords: Piriform cortex (PC); Acetylcholine (ACh); Extracellular field potentials (EFPs); Anticholinesterase; Muscarinic; Nicotinic
Whither vagal tone
Keywords: Cardiac vagal control; Cardiac vagal tone; Re-representation; Nucleus ambiguous; Dorsal motor nucleus; Respiration; Nicotinic; Muscarinic; Parasympathetic; Atropine; Vagal tone; Respiratory sinus arrhythmia; Polyvagal
Cortical cholinergic deficiency enhances amphetamine-induced dopamine release in the accumbens but not striatum
Keywords: Cholinergic; Saporin; Accumbens; Muscarinic; Schizophrenia; Nucleus basalis magnocellularis; Cortex
Carbachol injections into the intergeniculate leaflet induce nonphotic phase shifts
Keywords: IGL; Nonphotic; Cholinergic; Thalamus; Reward; Arousal; Acetylcholine; Muscarinic; Atropine
Effects of antimuscarinics on voiding function after cerebral infarction in a rat model of overactive bladder
Keywords: Cerebral infarction; Muscarinic; Micturition; Overactive bladder; Tolterodine; (Rat)