Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry
Keywords: موتاژنز; Filovirus; Ebolavirus; Glycoprotein; Viral entry; Mutagenesis
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Location and characterization of the O-GlcNAcase active site
Keywords: موتاژنز; Post-translational modification; Mutagenesis
Thermodynamic and mutational studies of l-N-carbamoylase from Sinorhizobium meliloti CECT 4114 catalytic centre
Keywords: موتاژنز; l-N-carbamoylase; Mutagenesis; l-Amino acids; Modelling; Isothermal titration calorimetry;
A genetic model to investigate drug–target interactions at the ribosomal decoding site
Keywords: موتاژنز; Ribosome; Structure; Mutagenesis; Aminoglycoside; Resistance
The mouse gcd2 mutation causes primordial germ cell depletion
Keywords: موتاژنز; Mutagenesis; Germ cells; Primordial germ cells; Stem cells; Gametogenesis
Tyrosine residues 654 and 670 in β-catenin are crucial in regulation of Met–β-catenin interactions
Keywords: موتاژنز; Wnt/beta-catenin; Liver growth; Liver cancer; HGT/Met; Proliferation; Mutagenesis
Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase
Keywords: موتاژنز; Benzoylformate; Phenylpyruvate; Pyruvate; 2-Keto acid; Mutagenesis; Homology model
Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell–cell fusion but does not affect virion entry
Keywords: موتاژنز; Coronavirus; Envelope (spike) glycoprotein; Membrane fusion; Furin protease; SARS; Pseudotyped virion; Mutagenesis
Efficient gene transfer and targeted mutagenesis in Fusobacterium nucleatum
Keywords: موتاژنز; Fusobacterium nucleatum; Shuttle plasmid; Transformation; Mutagenesis
Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor
Keywords: موتاژنز; Corticotropin releasing factor; Non-peptide antagonist; Mutagenesis; Allosteric; Depression; Ligand binding
Production of a d-glycero-d-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and functionality of antibodies to this LPS structure
Keywords: موتاژنز; Mannheimia haemolytica; Actinobacillus pleuropneumoniae; Pasteurella multocida; LPS; Vaccine; Mutagenesis; Antibodies
Cis and Trans-acting Effects on a Mutational Hotspot Involving a Replication Template Switch
Keywords: موتاژنز; replication; inverted repeat; exonuclease; mutagenesis; translesion polymeraseORF, open reading frame; Ap, ampicillin; Cm, chloramphenicol; Km, kanamycin; Tc, tetracycline; Tmp, trimethoprim
Crystal Structure of d-Psicose 3-epimerase from Agrobacterium tumefaciens and its Complex with True Substrate d-Fructose: A Pivotal Role of Metal in Catalysis, an Active Site for the Non-phosphorylated Substrate, and its Conformational Changes
Keywords: موتاژنز; DPEase, d-psicose 3-epimerase; DTEase, d-tagatose 3-epimerase; RMSD, root-mean-square deviationd-psicose 3-epimerase; Agrobacterium tumefaciens; crystal structure; metal-dependent catalysis; mutagenesis
Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)
Keywords: موتاژنز; Mismatch repair; Mlh1; PhIP; Mutagenesis; Colon
Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay
Keywords: موتاژنز; Mutagenesis; Mutation; Mutation assay; Flow cytometry; CD59; CHO AL; Radiation; MNNG; EMS; UV; ENU; Benzo(a)pyrene; Chlorpheniramine maleate; Ethidium bromide; Hydrogen peroxide; Lead; Mitomycin C; Arsenic; Thalidomide; Tetrachloroethane; Asbestos; Colchi
Translesion DNA synthesis across non-DNA segments in cultured human cells
Keywords: موتاژنز; Translesion replication; Mutagenesis; Carcinogenesis; TLR; TLS; DNA polymerase; Error-prone repair
Specific amino acid residues in the β sliding clamp establish a DNA polymerase usage hierarchy in Escherichia coli
Keywords: موتاژنز; dnaN alleles; β sliding clamp; DNA polymerase selection/switching; Mutagenesis; Translesion DNA synthesis
Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination
Keywords: موتاژنز; Ionizing radiation; Translesion synthesis; SUMOylation; Ubiquitination; Mutagenesis; PCNA; DNA repair; Homologous recombination; Non-homologous end joining; Nuclotide excision repair; REV3; REV7; REV1; RAD30; Polymerase zeta; Polymerase eta; Deoxycytidyl
Melatonin as antioxidant, geroprotector and anticarcinogen
Keywords: موتاژنز; Melatonin; Free radicals; Gene activity; Mutagenesis; Life span; Longevity; Tumorigenesis; Mouse; Rat; Fruit fly
A reporter-assisted mutagenesis screen using α1-tubulin-GFP transgenic zebrafish uncovers missteps during neuronal development and axonogenesis
Keywords: موتاژنز; Tubulin; Transgenic; Mutagenesis; Neurogenesis; Cell cycle exit; Axonal branching; Zebrafish
Protein engineering of formate dehydrogenase
Keywords: موتاژنز; Formate dehydrogenase; Protein engineering; Pseudomonas sp.101; Candida boidinii; Stability; Mutagenesis
Unifying evolutionary dynamics: From individual stochastic processes to macroscopic models
Keywords: موتاژنز; Adaptive evolution; Individual-based model; Birth and death point process; Body size scaling; Timescale separation; Mutagenesis; Density-dependent selection; Frequency-dependent selection; Invasion fitness; Adaptive dynamics; Canonical equation; Nonlinear
Effect of ENU (ethylnitrosourea) mutagenesis in cleft lip and/or palate pathogenesis in mice
Keywords: موتاژنز; ENU (ethylnitrosourea); mutagenesis; cleft lip and palate; mouse; gene; point mutation;
Involvement in K+ access of Leu318 at the extracellular domain flanking M3 and M4 of the Na+,K+-ATPase α-subunit
Keywords: موتاژنز; Na+,K+-ATPase; K+; Access path; Extracellular domain; Mutagenesis;
Different tau epitopes define Aβ42-mediated tau insolubility
Keywords: موتاژنز; Alzheimer's disease; Tau; Neurofibrillary tangles; β-Amyloid; SH-SY5Y neuroblastoma cells; Phospho-epitope; Mutagenesis;
Angiotensin II AT1 receptor mutants expressed in CHO cells caused morphological change and inhibition of cell growth
Keywords: موتاژنز; AT1 receptor; Mutagenesis; Cyclic AMP; Ca+2 signaling; Cell proliferation; Morphology regulation;
Mutational analysis of the role of calcium ions in the Lactobacillus reuteri strain 121 fructosyltransferase (levansucrase and inulosucrase) enzymes
Keywords: موتاژنز; Fructosyltransferase; Levansucrase; Inulosucrase; Mutagenesis; Calcium ion; Lactobacillus reuteri;
Portraits of a Y-family DNA polymerase
Keywords: موتاژنز; Structure; Mechanism; Y-family polymerase; Mutagenesis; Translesion (CPD, BPDE, AP);
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium
Keywords: موتاژنز; Ad-RPE65, adenovirus expressing RPE65; CHX, cycloheximide; LRAT, lecithin retinol acyl transferase; MOI, multiplicity of infection; RPE, retinal pigment epithelium11-cis Retinal; Isomerase; Mutagenesis; Retinal dystrophy; Vitamin A; Visual cycle
Role of Escherichia coli DnaK and DnaJ chaperones in spontaneous and induced mutagenesis and their effect on UmuC stability
Keywords: موتاژنز; DnaK; DnaJ; Mutagenesis; UmuC protein; Escherichia coli;
Ser475, Glu272, Asp276, Asp327, and Asp360 are involved in catalytic activity of human tripeptidyl-peptidase I
Keywords: موتاژنز; Tripeptidyl-peptidase I; CLN2 protein; Active site; Mutagenesis; Serine-carboxyl peptidase; Sedolisin;
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit
Keywords: موتاژنز; Neurotransmitters, modulators, transporters and receptors; GABAA receptors; γ-Aminobutyric type-A receptor; Mutagenesis; Isoflurane;
Mutation in the flexible loop of 1-deoxy-d-xylulose 5-phosphate reductoisomerase broadens substrate utilization
Keywords: موتاژنز; Deoxyxylulose; Isoprenoids; Methylerythritol; MEP pathway; Mutagenesis; Reductoisomerase; Synechocystis;
Anesthetic sites on GABAA receptors
Keywords: موتاژنز; Affinity label; Allosteric; Mutagenesis;
Transition state stabilization by six arginines clustered in the active site of creatine kinase
Keywords: موتاژنز; Creatine kinase; Active site; Mutagenesis; MgATP binding; Fluorescence quenching;
Changing the metal ion selectivity of rabbit muscle enolase by mutagenesis: effects of the G37A and G41A mutations
Keywords: موتاژنز; PGA; 2-phosphoglyceric acid; PEP; phosphoenolpyruvate; PEG; polyethylene glycol; CD; circular dichroism; k.i.e.; kinetic isotope effect; Enolase; Mutagenesis; Divalent cation;
Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli
Keywords: موتاژنز; Mutagenesis; Deoxyribonucleoside triphosphate; Escherichia coli;
Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks
Keywords: موتاژنز; DNA crosslinks; Escherichia coli; Mutagenesis;
The role of alternative splicing and C-terminal amino acids in thromboxane receptor stabilization
Keywords: موتاژنز; Thromboxane; ER-associated degradation; Isoprostane; Protein turnover; Mutagenesis; Oxidative stress;
The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
Keywords: موتاژنز; Sox9; Ubiquitin-proteasome system; Mutagenesis;
Structural requirements of the unique disulphide bond and the proline-rich motif within the α4-α5 loop for larvicidal activity of the Bacillus thuringiensis Cry4Aa δ-endotoxin
Keywords: موتاژنز; Bacillus thuringiensis; Disulphide bond; δ-Endotoxin; Larvicidal activity; Mutagenesis; Proline-rich motif;
Repair of psoralen interstrand cross-links in Xenopus laevis egg extracts is highly mutagenic
Keywords: موتاژنز; Interstrand cross-links; DNA repair; Xenopus laevis extract; Mutagenesis;
First steps towards the genetic manipulation of Mycoplasma agalactiae and Mycoplasma bovis using the transposon Tn4001mod
Keywords: موتاژنز; Mycoplasma; Transformation; Transposon; Genetics; Mutagenesis;
Radiation-induced damage to cellular DNA: measurement and biological role
Keywords: موتاژنز; Ionizing radiation; Base lesions; OH radical; One-electron oxidation; Cyclonucleosides; Oxidized guanine; Tandem lesion; DNA repair; Oligonucleotide synthesis; Mutagenesis;
Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin
Keywords: موتاژنز; Thrombin; Thrombomodulin; Protein C; Antithrombin; Factor Xa; Mutagenesis;
Diesel emissions significantly influence composition and mutagenicity of ambient particles: a case study in São Paulo, Brazil
Keywords: موتاژنز; Diesel emissions; Mutagenesis; Air pollution; Environmental toxicology; Ambient particles;
Genetic analysis of heptad-repeat regions in the G2 fusion subunit of the JunÃn arenavirus envelope glycoprotein
Keywords: موتاژنز; Arenavirus; JunÃn virus or Argentine hemorrhagic fever virus; Envelope glycoprotein; GP-C; Membrane fusion; Six-helix bundle; Mutagenesis;
Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli
Keywords: موتاژنز; Transposon; Mutagenesis; Drug tolerance; Escherichia coli;
C-terminus mutations of Acremonium chrysogenum deacetoxy/deacetylcephalosporin C synthase with improved activity toward penicillin analogs
Keywords: موتاژنز; DAOC; DAC; Deacetoxy/deacetylcephalosporin C synthase; C-terminus; Mutagenesis; Acremonium chrysogenum; Kinetics;
Error-prone replication of West Nile virus caused by ribavirin
Keywords: موتاژنز; West Nile virus; Error catastrophe; Ribavirin; Antiviral; Mutagenesis;