دانلود مقالات ISI درباره موتاژنز + ترجمه فارسی

Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region

Keywords: موتاژنز; Propofol; Kv1.5; Mutagenesis; Pore region; Amino acid; Open channel block

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Bypass of a 5′,8-cyclopurine-2′-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks

Keywords: موتاژنز; 5′,8-Cyclopurine-2′-deoxynucleoside; DNA polymerase β; Lesion bypass synthesis; Base excision repair; DNA replication; Mutagenesis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo functional analysis of the Drosophila melanogaster nicotinic acetylcholine receptor Dα6 using the insecticide spinosad

Keywords: موتاژنز; Nicotinic acetylcholine receptor; Spinosad; Insecticide resistance; Drosophila melanogaster; CRISPR; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Point mutations in Escherichia coli DNA pol V that confer resistance to non-cognate DNA damage also alter protein-protein interactions

Keywords: موتاژنز; N2-furfuryl-dG; UmuC; UmuD; DinB (DNA pol IV); Mutagenesis; Ultraviolet light;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state

Keywords: موتاژنز; Ankyrin receptor subtype 1; Transient receptor potential; S4-S5-linker; Mutagenesis; Homology modeling; Molecular dynamics; AITC; allyl isothiocyanate; CA; cinnamaldehyde; HEK293T cell; human embryonic kidney-293 cell expressing the large T-antigen of S

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Alleles of newly identified barley gene HvPARP3 exhibit changes in efficiency of DNA repair

Keywords: موتاژنز; Barley; DNA repair; Double-strand breaks; PARP3; Mutagenesis; Telomere; TILLING

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors

Keywords: موتاژنز; Heteromeric P2X receptors; P2X2/3 receptors; Subunit stoichiometry; Mutagenesis; 2-MeSATP; 2-methylthio ATP; ASIC; acid-sensing ion channel; BN-PAGE; blue native PAGE; DRG; dorsal root ganglion; EC50; half maximal effective concentration; FR; fluorescent

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of nuclear localization signals within the human BCOR protein

Keywords: موتاژنز; BCL-6 corepressor; Oculofaciocardiodental syndrome; X-linked dominant hereditary; Nuclear localization; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

Eukaryotic DNA polymerase ζ

Keywords: موتاژنز; DNA polymerase; Mutagenesis; Translesion synthesis; PCNA;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

Whole genome sequencing and the transformation of C. elegans forward genetics

Keywords: موتاژنز; Whole genome sequencing; C. elegans; Forward genetics; Mutagenesis; Mapping

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Exclusive induction of G:C to A:T transitions by 3-azido-1,2-propanediol in yeast

Keywords: موتاژنز; Azide, sodium azide (NaN3); AZG, 3-azido-1,2-propanediol; E. coli, Escherichia coli; CAN1, yeast membrane arginine permease geneAzide; Mutagenesis; Yeast

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Ribonucleotide incorporation by yeast DNA polymerase ζ

Keywords: موتاژنز; Ribonucleotides; Mutagenesis; DNA polymerase; Translesion synthesis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement

Keywords: موتاژنز; zfP2X4R; zebrafish P2X4 receptor; rP2X6R; rat P2X6 receptor; rP2X6R In284; mutant rat P2X6 receptor containing an insertion of residues 285-293 of zfP2X4R after position 284; TMD; transmembrane domain; MTSES−; sodium (2-sulfonatoethyl) methanethiosulf

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Efficient Mutagenesis Independent of Ligation (EMILI)

Keywords: موتاژنز; Mutagenesis; Inverse PCR; T4 DNA polymerase; Fast mutagenesis; Plasmid-based mutagenesis; Large deletion

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions

Keywords: موتاژنز; INSL5; RXFP4; Ligand-receptor interaction; Electrostatic interaction; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Cytotoxic, mutagenic and genotoxic evaluation of crude extracts and fractions from Piper jericoense with trypanocidal action

Keywords: موتاژنز; Chagas; Mutagenesis; Genotoxicity; Cytotoxicity; Chemotherapy; Antiprotozoal;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Mutagenesis in the lacI gene target of E. coli: Improved analysis for lacId and lacO mutants

Keywords: موتاژنز; Mutagenesis; lacI spectra; lacO, lacId mutants;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions

Keywords: موتاژنز; KAZ; the catalytic 19 kDa protein of Oplophorus luciferase; nanoKAZ; a KAZ mutant substituted with 16 amino acid residues; eKAZ; a triple mutant of KAZ with V44I, A54I and Y138I; CTZ; coelenterazine; GLase; Gaussia luciferase; GLsp; the signal peptide se

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

An improved method to obtain novel mutants in Cucurbita pepo by pollen viability

Keywords: موتاژنز; EMS; Mutagenesis; FCR test; Zucchini; Fertility;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

A simple TALEN-based protocol for efficient genome-editing in Drosophila

Keywords: موتاژنز; Drosophila; Mutagenesis; Genome-editing; TALEN; T7 endonuclease I; Method;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Enhancing the Activity of Glutamate Decarboxylase from Lactobacillus brevis by Directed Evolution

Keywords: موتاژنز; Directed evolution; Recombinant DNA; Mutagenesis; Enzyme activity; Kinetic parameter; Bio-synthesis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells

Keywords: موتاژنز; Prox1; prospero homeobox 1; PDPN; podoplanin; LEC; lymphatic endothelial cell; BEC; blood vessel endothelial cell; VEGFR-3; vascular endothelial growth factor receptor 3; Lyve-1; lymphatic vessel endothelial hyaluronan receptor 1; COUP-TFII; COUP transcri

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z

Keywords: موتاژنز; PZ; protein Z; ZPI; protein Z-dependent protease inhibitor; RCL; reactive center loop; ZPI-Y387A; a ZPI mutant in which Tyr-387 has been replaced with an Ala; FXa; activated factor X; Gla; γ-carboxyglutamic acid; EGF; epidermal growth factor; PZ/FX-LC; a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Titanium Dioxide-Montmorillonite Nanocomposite as Photoprotective Agent Against Ultraviolet B Radiation-Induced Mutagenesis in Saccharomyces cerevisiae: A Potential Candidate for Safer Sunscreens

Keywords: موتاژنز; titanium dioxide; montmorillonite; UVB; nanocomposite; mutagenesis; cerevisiae; nanostructures, nanotechnology; clays; X-ray diffraction; layered compounds;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The inter-monomer interface of the major light-harvesting chlorophyll a/b complexes of photosystem II (LHCII) influences the chlorophyll triplet distribution

Keywords: موتاژنز; Light-harvesting chlorophyll a/b complexes; Conformation; Chlorophyll triplet; Lutein; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Having a direct look: Analysis of DNA damage and repair mechanisms by next generation sequencing

Keywords: موتاژنز; C. elegans; Mutagenesis; Whole-genome sequencing; Mutation profiles; DNA repair pathway analysis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

TALEN-mediated mutagenesis in zebrafish reveals a role for r-spondin 2 in fin ray and vertebral development

Keywords: موتاژنز; R-spondin2; Mutagenesis; Zebrafish; TALEN; Fin ray; Skeletogenesis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase

Keywords: موتاژنز; M. tuberculosis AHAS, Mycobacterium tuberculosis acetohydroxyacid synthase; CSU, catalytic subunit; ThDP, thiamine diphosphate; BCAA, branched-chain amino acids; MD, molecular dynamicsAcetohydroxyacid synthase; ThDP dependent enzymes; Mutagenesis; Molecul

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Continuous colorimetric screening assay for detection of d-amino acid aminotransferase mutants displaying altered substrate specificity

Keywords: موتاژنز; Transaminases; Coupled enzyme assay; High-throughput screening; Mutagenesis; Substrate specificity; Enzyme kinetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Natural competence in Histophilus somni strain 2336

Keywords: موتاژنز; Histophilus somni; Competence; Transformation; Mutagenesis; Shuttle vector;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Highly efficient multiplex targeted mutagenesis and genomic structure variation in Bombyx mori cells using CRISPR/Cas9

Keywords: موتاژنز; CRISPR/Cas9; Bombyx mori; Mutagenesis; Chromosomal deletion; Chromosomal inversion; Multiplex genome editingCRISPR/Cas, clustered regulatory interspaced short palindromic repeat/CRISPR associated; th, tyrosine hydroxylase gene; re, red egg gene; fl, fluge

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Enhancement of hydrolytic activity of thermophilic alkalophilic α-amylase from Bacillus sp. AAH-31 through optimization of amino acid residues surrounding the substrate binding site

Keywords: موتاژنز; Amylase; Starch; Enzyme activity; Enzyme production; Mutagenesis; Glycoside hydrolase family 13GH, glycoside hydrolase family; aa, amino acid; AmyL, Bacillus sp. AAH-31 α-amylase; NPLA, neopullulanase-like α-amylase; CBM20, carbohydrate binding module fam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae

Keywords: موتاژنز; As(III); arsenite; As(V); arsenate; Sb(III); antimonite; ER; endoplasmic reticulum; TM; transmembrane segment; Yeast; Arsenite transporter; Mutagenesis; Plasma membrane; Acr3 permease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Mutagenesis and molecular dynamics simulations revealed the chitooligosaccharide entry and exit points for chitinase D from Serratia proteamaculans

Keywords: موتاژنز; Chitinases; Chitooligosaccharides; SpChiD; Transglycosylation; Mutagenesis; Molecular Dynamics Simulations

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The PCNA binding domain of Rad2p plays a role in mutagenesis by modulating the cell cycle in response to DNA damage

Keywords: موتاژنز; RAD2; PCNA; Cell cycle; Mutagenesis; DNA damage;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Tracing the fates of site-specifically introduced DNA adducts in the human genome

Keywords: موتاژنز; TATAM; tracing DNA adducts in targeted mutagenesis; 8-oxoG; 8-oxo-7,8-dihydroguanine; TK; thymidine kinase gene; HR; homologous recombination; DSB; double-strand break; MYH; human MutY homolog; DNA adducts; Mutagenesis; Gene targeting; 8-Oxoguanine (8-oxo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The contribution of Nth and Nei DNA glycosylases to mutagenesis in Mycobacterium smegmatis

Keywords: موتاژنز; Mycobacterium tuberculosis; Base excision repair; Formamidopyrimidine DNA glycosylase; EndonucleaseVIII; Endonuclease III; Mutagenesis; DNA repair;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Neuropharmacology and analgesiaAllosteric modulation of alpha4beta2 nicotinic acetylcholine receptors by HEPES

Keywords: موتاژنز; Alpha4beta2; Alpha7; Nicotinic acetylcholine receptor; Ligand gated ion channels; Positive allosteric modulation; HEPES; desformylflustrabromine; dFbr; Two-electrode voltage clamp; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Convallatoxin: A new P-glycoprotein substrate

Keywords: موتاژنز; NMQ; N-methyl quinidine; DLCs; Digitalis-like compounds; P-gp; P-glycoprotein; HEK293 cells; human embryonic kidney cells; LC-MS; liquid chromatography-mass spectrometry; ABC transporter; ATP-binding cassette transporter; eYFP; enhanced yellow fluores

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Functional insight into development of positive allosteric modulators of AMPA receptors

Keywords: موتاژنز; Electrophysiology; Mutagenesis; Deactivation; Desensitization; Allosteric modulation; AMPAkine; Ion channel gating; Neuropharmacology; AMPA; alpha-amino-3-hydroxy-5-methyl-isoxazole-propionic acid; CTZ; cyclothiazide - 2,4-benzothiadiazine-3-bicyclo[2.2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors

Keywords: موتاژنز; EDTA; Ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; DMEM; Dulbecco's modified Eagle medium; BES; N,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid; kainate receptors; mutagenesis; patch-clamp; glutamate;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana

Keywords: موتاژنز; NCS2; Nucleobase ascorbate transporter; Homology model; Mutagenesis; Arabidopsis thaliana; Uracil;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Improvement of stability and enzymatic activity by site-directed mutagenesis of E. coli asparaginase II

Keywords: موتاژنز; E. coli; Asparaginase; Activity; Stability; Mutagenesis

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

MutY-glycosylase: An overview on mutagenesis and activities beyond the GO system

Keywords: موتاژنز; MutY-glycosylase; DNA damage; DNA repair; GO system; Mutagenesis; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Role of polymerase η in mitochondrial mutagenesis of Saccharomyces cerevisiae

Keywords: موتاژنز; DAPI; 4′,6-diamidino-2-phenylindole; GFP; green fluorescent protein; PBS; phosphate-buffered saline; YPD; yeast extract/peptone/dextrose medium; YPG; yeast extract/peptone/glycerol medium; Yeast; Mitochondria; Mutagenesis; DNA damage; DNA polymerase η;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Drosophila MagT1 is upregulated by PKC activation

Keywords: موتاژنز; dMagT1; PKC; Phorsphorylation; Mutagenesis; Patch-clamping;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Amino acid residues in the N-terminal region of the BinB subunit of Lysinibacillus sphaericus binary toxin play a critical role during receptor binding and membrane insertion

Keywords: موتاژنز; Lysinibacillus sphaericus; Binary toxin; BinB; Mutagenesis; Receptor binding; Membrane penetration;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

A voltage-gated pore for translocation of tRNA

Keywords: موتاژنز; tRNA; Translocation; Membrane potential; AFM; Mutagenesis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase

Keywords: موتاژنز; Acetohydroxyacid synthase; ThDP dependent enzyme; ThDP binding; Mutagenesis; Homology modeling;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The genetically modified suilysin, rSLYP353L, provides a candidate vaccine that suppresses proinflammatory response and reduces fatality following infection with Streptococcus suis

Keywords: موتاژنز; CDC; cholesterol-dependent cytolysin; rSLY; recombinant suilysin; STSS; streptococcal toxic shock syndrome; IL-6; interleukin 6; IL-1β; interleukin 1β; TNF-α; tumor necrosis factor alpha; PBS; phosphate buffered saline; HUs; hemoagglutination units; i.

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه