Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions

- INSL5 regulates glucose homeostasis by activating its receptor RXFP4.
- Oppositely charged residues in INSL5 and RXFP4 are important for activity.
- We proposed probable electrostatic interactions between INSL5 and RXFP4.
- This work reveals the interactions of relaxin family peptides with their receptors.