Keywords: NAC، N-acetyl-cysteine; Cx43, connexin43; DMEM, Dulbecco's modified Eagle's medium; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; NAC, N-acetyl cysteine; PSNL, partial sciatic nerve ligation; RAR, retinoic acid receptor; RARE, retinoic acid response element; TNF, tumor necro
مقالات ISI NAC، N-acetyl-cysteine (ترجمه نشده)
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Keywords: NAC، N-acetyl-cysteine; BHA, butylated hydroxyanisol; DMSO, dimethyl sulfoxide; FITC, fluorescein isothiocyanate; H2O2, hydrogen peroxide; ΔΨm, mitochondrial membrane potential; MPTP, mitochondrial permeability transition pore; NAC, N-acetyl cysteine; NAO, nonyl acridine orange;
Keywords: NAC، N-acetyl-cysteine; AqPM, aqueous PM suspension; COX, cyclooxygenase; DEP, diesel exhaust particles; HO-1, heme oxygenase-1; MAPK, mitogen activated protein kinase; NAC, N-acetyl cysteine; OC, organic carbon; OE, organic extract; PAH, polycyclic aromatic hydrocarbon; PG, pro
Induction of IL-8(CXCL8) and MCP-1(CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell
Keywords: NAC، N-acetyl-cysteine; BCA, Bicinchoninic acid assay; DGF, delayed graft function; IRI, Ischaemia reperfusion injury; GM, growth media; GPx, glutathione peroxidase; IFN-γ, Interferon – gamma; IL-1β, Interleukin 1 beta; NAC, N-acetyl cysteine; NF-κB, Nuclear factor kappa-light-c
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells
Keywords: NAC، N-acetyl-cysteine; Paris Saponin II; Autophagy; Apoptosis; ROSAVOs, acidic vesicular organelles; CQ, chloroquine; GA, gallic acid; NAC, N-acetyl cysteine; p-AKT, Phospho-AKT (phospho-S473); p-ERK1/2, Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204); p-JNK, phospho-SAPK/JNK (Thr
Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cells
Keywords: NAC، N-acetyl-cysteine; Curcumin; Vinblastine; Microtubule; Mitochondrial membrane potential; ROS, Antitumor activityROS, Reactive oxygen species; MMP, Mitochondrial membrane potential; NAC, N-acetyl cysteine; PI, Propidium iodide; DAPI, 6-diamidino-2-phenylindole; DCF-DA, 2′,7′
Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches
Keywords: NAC، N-acetyl-cysteine; CYP450, cytochrome P450; HLM, human liver microsomes; AGM, agomelatine; KCZ, ketoconazole; NF, α-naphthoflavone; GSH, reduced glutathione; NAc, N-acetyl cysteine; OPLS-DA, orthogonal projection to latent structures-discriminant analysis; UHPLC, ultra-high
CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo
Keywords: NAC، N-acetyl-cysteine; CHNQ; Quercetin; Colon cancer; Oxidative stress; AutophagyCHNQ, 3,7-dihydroxy-2-[4-(2-chloro-1,4-naphthoquinone-3-yloxy)-3-hydroxyphenyl]-5-hydroxychromen-4-one; Qc, quercetin; ROS, reactive oxygen species; NAC, n-acetyl cysteine; 3-MA, 3-methyladenine; P
Cynaropicrin attenuates UVB-induced oxidative stress via the AhR–Nrf2–Nqo1 pathway
Keywords: NAC، N-acetyl-cysteine; AhR, aryl hydrocarbon receptor; BaP, benzo[a]pyrene; Cyn, cynaropicrin; CYP1A1, cytochrome P450 subfamily A polypeptide 1; DMSO, dimethyl sulfoxide; IL-6, interleukin 6; NAC, N-acetyl cysteine; NHEKs, normal human epidermal keratinocytes; Nqo1, NAD(P)H:qu
Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia
Keywords: NAC، N-acetyl-cysteine; NAC, N-acetyl cysteine; GSH, glutathione; NMDA, N-methyl-d-aspartate receptor (NMDA receptor or NMDAR); DSM-IV, Diagnostic and Statistical Manual of Mental Disorders IV version; PANSS, Positive and Negative Symptoms Scale; CGI-S, Clinical Global Impressio
Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin
Keywords: NAC، N-acetyl-cysteine; ARE, antioxidant responsive element; BR, bilirubin; CoPP, cobalt protoporphyrin; FePP, heme; H2DCFDA, 2′,7′-dicholoro-fluorescin diacetate; HO-1, heme oxygenase-1; IRE, iron responsive element; NAC, N-acetyl cysteine; PI, propidium iodide; ROS, reactive o
Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage
Keywords: NAC، N-acetyl-cysteine; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; DCFDA, 2,7-dichlorodihydrofluorescein diacetate; DMSO, dimethyl sulfoxide; GSTP1, glutathione S-transferase P1; HO1, heme oxygenase 1; NAC, N-acetyl cysteine; PPLGM, piperlongumine; pChk1, phospho checkpoint kinase 1;
The PacC-family protein Rim101 prevents selenite toxicity in Saccharomyces cerevisiae by controlling vacuolar acidification
Keywords: NAC، N-acetyl-cysteine; CCA, concanamycin A; GSH, reduced glutathione; NAC, N-acetyl cysteine; t-BOOH, tert-butyl hydroperoxideESCRT machinery; Oxidative stress; PacC family; Rim101; Selenite; Vacuole
Consequences of tributyltin chloride induced stress in Leydig cells: An ex-vivo approach
Keywords: NAC، N-acetyl-cysteine; ROS, reactive oxygen species; GSH, glutathione; TBARS, thiobarbituric acid reactive substances; BAPTA-AM, (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid); EGTA, ethylene glycol tetraacetic acid; NAC, N-acetyl cysteine; ERK1/2, extracellular sig
Rosiglitazone inhibits chlorpyrifos-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells
Keywords: NAC، N-acetyl-cysteine; COX-2, cyclooxygenase-2; CPF, chlorpyrifos; ERK, extracellular signal-regulated kinase 1/2; HO-1, heme oxigenase-1; JNK, c-Jun N-terminal kinase; NAC, N-acetyl cysteine; NF-κB, nuclear transcription factor kappa-B; p38, p38 MAP kinase; ROS, reactive oxida
Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells
Keywords: NAC، N-acetyl-cysteine; GSE, grape seed extract; TEM, transmission electron microscopy; ROS, reactive oxygen species; DHE, Dihydroethidium; MDC, monodansylcadaverine; NAC, N-acetyl cysteine; MnTBAP, metalloporphyrin: Mn(III)tetrakis (4-Benzoic acid) porphyrin chloride; BAFA1, Ba
Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway
Keywords: NAC، N-acetyl-cysteine; Cyp-D, cyclophilin D; Cs-A, cyclosporine A; H2O2, hydrogen peroxide; mPTP, mitochondrial permeability transition pore; ROS, reactive oxygen species; NAC, N-acetyl cysteine; TNF-α, tumor-necrosis factor-α; UVB, ultraviolet BUVB radiation; Cyclophilin D; Sk
Differential effects of α-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells
Keywords: NAC، N-acetyl-cysteine; NAC, N-acetyl cysteine; AGEs, advanced glycation end products; MDA, malondialdehyde; PUFA, polyunsaturated fatty acids; RA, retinoic acid; α-T, α-tocopherolAdvanced glycation end product; Diabetes; Oxidative stress; Vitamin E; Neuropathy; N-acetyl cystein
High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol
Keywords: NAC، N-acetyl-cysteine; ECM, extracellular matrix; H2DCF-DA, 2′ 7′-dichlorodihydrofluorescein diacetate; HG, high glucose; MAP, mitogen-activated protein; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetyl cysteine; NG, normal glucose; ROS, reactive
Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling
Keywords: NAC، N-acetyl-cysteine; ADAM-17, a disintegrin and metalloproteinase 17; PPIase, peptidyl-prolyl cis/trans isomerase; CsA, cyclosporin A; ERK, extracellular signal-regulated kinase; MAPK, mitogen activated protein kinase; MC, mesangial cells; NAC, N-acetyl cysteine; ROS, reactiv
Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B
Keywords: NAC، N-acetyl-cysteine; BIAM, biotin conjugated IAM; DCFH-DA, 2’, 7’–dichlorofluorescein diacetate; DTT, dithiothreitol; GSH, glutathione; IAM, iodoacetamide; IR, irradiation; NAC, N-acetyl cysteine; PTEN, phosphatase and tensin homolog; ROS, reactive oxygen species; s.d., stand
Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos
Keywords: NAC، N-acetyl-cysteine; CPF, chlorpyrifos; NAC, N-acetyl cysteine; ROS, reactive oxidative species; MAPK, mitogen‐activated protein kinase; JNK, c-Jun N-terminal kinase, p38, p38 MAP kinase; ERK, extracellular signal-regulated kinase 1/2; SOD, superoxide dismutase; HO-1, Heme ox
N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder
Keywords: NAC، N-acetyl-cysteine; CHX, 2-cyclohexene-1-one; NAC, N-acetyl cysteine; S.E.M, standard error of the mean; RCF, relative centrifugal forceGlutathione; Schizophrenia; Bipolar disorder; Acetyl cysteine; 2-Cyclohexene-1-one (CHX); Amphetamine
Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin
Keywords: NAC، N-acetyl-cysteine; APO, apocynin; BALF, bronchoalveolar lavage fluid; DMSO, dimethyl sulfoxide; DPI, diphenyleneiodonium chloride; GSH, glutathione; IL, interleukine; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; NAC, N-acetyl cysteine; NF-κB, nuclear fact
Effects of lipoic acid on antiapoptotic genes in control and ethanol-treated fetal rhombencephalic neurons
Keywords: NAC، N-acetyl-cysteine; DCF, dye 2′,7′-dichlorofluorescein (DCF); DIV, day in vitro; H2DCFDA, 2′7′-dichlorodihydrofluorescein diacetate; IKK, I-kappa B kinase; LA, (±)-alpha lipoic acid; MAPKK, mitogen activated protein kinase kinase; NAC, N-acetyl cysteine; PKC, protein kinase
The Roles of Stress-Activated Sty1 and Gcn2 Kinases and of the Protooncoprotein Homologue Int6/eIF3e in Responses to Endogenous Oxidative Stress during Histidine Starvation
Keywords: NAC، N-acetyl-cysteine; eIF, eukaryotic initiation factor; eIF2K, eIF2α kinase; ISR, integrated stress response; MAPK, mitogen-activated protein kinase; MAP2K, MAPK kinase; 3AT, 3-aminotriazole; MMTV, mouse mammary tumor virus; NAC, N-acetyl cysteine; CFU, colony-forming units;
Peroxynitrite Elevation in Exhaled Breath Condensate of COPD and Its Inhibition by Fudosteine
Keywords: NAC، N-acetyl-cysteine; BSA, bovine serum albumin; DCDHF, 2′,7′-dichlorofluorescein; EBC, exhaled breath condensate; EC50, median effective concentration; FDS, fudosteine; IC50, median inhibitory concentration; IL, interleukin; HRP, horseradish peroxidase; NAC, N-acetyl cysteine
A reducing environment stabilizes HIF-2α in SH-SY5Y cells under hypoxic conditions
Keywords: NAC، N-acetyl-cysteine; BSO, l-buthionine sulfoximine; h, hours; HIF-2, hypoxia inducible factor 2; NAC, N-acetyl cysteine; ROS, reactive oxygen speciesHIF-2α; Hypoxia; Redox status; SH-SY5Y; Stroke; Brain tumor
Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes—An NMR study
Keywords: NAC، N-acetyl-cysteine; BHP, t-butylhydroxyperoxide; MP, microparticles; NAC, N-acetyl cysteine; NEM, N-ethylmaleimide; NMR, Nuclear Magnetic Resonance; PBS, phosphate buffered saline; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PE-plas, phosphatidylethanolamine-plasm
Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells
Keywords: NAC، N-acetyl-cysteine; Apaf-1, apoptotic protease-activating factor-1; DiOC6(3), 3,3â²-dihexyloxacarbocyanine iodide; H2DCF-DA, 2â²,7â²-dichlorofluorescein diacetate; HL-60, human promyelocytic leukemia cells; NAC, N-acetyl cysteine; IC50, 50% inhibitory concentration; PI,
Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: Attenuation by N-acetyl cysteine
Keywords: NAC، N-acetyl-cysteine; PVL, periventricular leukomalacia; CP, cerebral palsy; PPAR-α, peroxisome proliferators activated receptor-α; OL, oligodendrocyte; ROS, reactive oxygen species; NAC, N-acetyl cysteine; CAT, catalase; AOX, acyl-CoA oxidase; DHAP-AT, dihydroxyacetonephospha
Relationship between reactive oxygen species and heme metabolism during the differentiation of Neuro2a cells
Keywords: NAC، N-acetyl-cysteine; ALAS-1, 5-aminolevulinic acid synthase-1; 3-AT, 3-aminotriazole; CPG, coproporphyrinogen; DSP, downstream primer; HO, heme oxygenase; NAC, N-acetyl cysteine; PMP70, peroxisomal membrane protein 70; RA, retinoic acid; ROS, reactive oxygen species; SA, succ
PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562
Keywords: NAC، N-acetyl-cysteine; cal c, calphostin c; DEVD-CHO, N-acetyl–Asp–Glu–Val–Asp aldehyde; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; NAC, N-acetyl cysteine; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; PS, phospholipidserine; RIP, ribosome-inactivating
Redox regulation of human estrogen sulfotransferase (hSULT1E1)
Keywords: NAC، N-acetyl-cysteine; SULT, sulfotransferase; SULT1E1, estrogen sulfotransferase; NAC, N-acetyl cysteine; BSO, buthionine sulfoxamine; PAPS, adenosine 3′-phosphate 5′-phosphosulfate; E2, 17β-estradiol; ER, estrogen receptor; ROS, reactive oxygen species; RNS, reactive nitrogen
Inhibiting pollen reduced nicotinamide adenine dinucleotide phosphate oxidase–induced signal by intrapulmonary administration of antioxidants blocks allergic airway inflammation
Keywords: NAC، N-acetyl-cysteine; Allergy; inflammation; antioxidants; eosinophils; TH2AA, Ascorbic acid; BAL, Bronchoalveolar lavage; H2DCF-DA, 2′-7′-Dihydro-dichlorofluorescein diacetate; 4-HNE, 4-Hydroxynonenal; ID50, Inhibitory dose 50; NAC, N-acetyl cysteine; OVA, Ovalbumin; PAS, Per
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: Implication for cytotoxicity
Keywords: NAC، N-acetyl-cysteine; GSH, reduced glutathione; MNU, methylnitrosourea; MNNG, 1-methyl-3-nitro-1-nitrosoguanidine; NAC, N-acetyl cysteine; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; SDS, sodium-dodecyl-sulfate; STZ, streptozotocin1-Methyl-3-nitro-1-nitrosoguanidi
Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum
Keywords: NAC، N-acetyl-cysteine; CMFDA, chloro-methyl-fluorescein-diacetate; DHE, dihydroethidium; GSH, glutathione; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; PI, propidium iodide; NAC, N-acetyl cysteine; TTFA, thenoyltrifluoroacetone; SOD, superoxide dismutase; ROS, reactive
Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects
Keywords: NAC، N-acetyl-cysteine; DPPH, 2,2-diphenyl-1-picrylhydrazyl; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SOD, superoxide dismutase; FBS, fetal bovine serum; BSA, bovine serum albumin; NAC, N-acetyl cysteine; CFSE, carboxyfluorescein diacetate succinimidyl
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression
Keywords: NAC، N-acetyl-cysteine; BE, baicalein; BI, baicalin; ERK, extracellular regulated kinases; JNK, c-Jun N-terminal kinases; HO-1, heme oxygenase 1; NAC, N-acetyl cysteine; CHX, cycloheximide; Act D, actinomycin D; H2O2, hydrogen peroxide; ROS, reactive oxygen species; MTT, (3-(4,5
Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt
Keywords: NAC، N-acetyl-cysteine; CEP, cepharanthine; JNK, c-Jun N-terminal kinase; MAPK, mitogen activated protein kinase; ROS, reactive oxygen species; NAC, N-acetyl cysteine; PARP, poly-(ADP-ribose)-polymeraseCepharanthine; Apoptosis; MAPK; PARP; SP600125
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition
Keywords: NAC، N-acetyl-cysteine; BQ, 1,4-benzoquinone; DFO, deferoxamine; DMNQ, 2,3-dimethoxy-1,4-naphthoquinone; DPI, diphenyleneiodonium chloride; GSH, reduced glutathione; GSSG, glutathione disulfide; LDH, lactate dehydrogenase; NAC, N-acetyl cysteine; ROS, reactive oxygen species; SK
ROS-triggered caspase 2 activation and feedback amplification loop in β-carotene-induced apoptosis
Keywords: NAC، N-acetyl-cysteine; ANT, adenosine nucleotide transferase; BH domain, baculovirus homology domain; DIDS, 4,4″-diisothiocyanostilbene-2,2′-disulfonic acid; NAC, N-acetyl cysteine; PARP, poly(ADP) ribose polymerase; PTP, permeability transition pore; ROS, reactive oxygen speci