Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines
Keywords: P-glycoprotein; ABC protein; Disulfide cross-linking; Molecular spring; Drug-stimulated ATPase activity; ABC; ATP-binding cassette; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; human embryonic kidney; TM; transmembrane; TMD; transmembrane do