Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs
Keywords: Neurosteroids; Steroids; Neurosteroids; γ-Aminobutyric acid; GABA; GABAA receptor
مقالات ISI Neurosteroids (ترجمه نشده)
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Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways
Keywords: Neurosteroids; Neurosteroids; Midbrain; 5α-Pregnan-3α-ol-20-one; Allopregnanolone; Ventral tegmental area
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration
Keywords: Neurosteroids; neurosteroids; neurodevelopment; hippocampus; passive avoidance; elevated plus maze; finasterideAlloP, allopregnanolone; EPM, elevated plus maze; N-K, Newman-Keuls; PregS, pregnenolone sulfate
The role of GABAA receptors in the development of alcoholism
Keywords: Neurosteroids; GABA; Ethanol; Neurosteroids; Benzodiazepines; Tolerance; Withdrawal; Reward; VTA; Stress; Anxiety; Genes; GABRA2
The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production
Keywords: Neurosteroids; Clozapine; Translocator protein (TSPO); Peripheral-type benzodiazepine receptor (PBR); Neurosteroids; Antipsychotics
Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
Keywords: Neurosteroids; Alzheimer’s disease; Allopregnanolone; Hippocampus; Cortex; Learning and memory; Neurosteroids
One-year therapy with 10Â mg/day DHEA alone or in combination with HRT in postmenopausal women: Effects on hormonal milieu
Keywords: Neurosteroids; DHEA replacement therapy; HRT; Postmenopausal women; Sex steroids; Androgenic deficiency; Neurosteroids;
Neuroprogesterone: Key to estrogen positive feedback?
Keywords: Neurosteroids; Estrogen positive feedback; Progesterone receptor; Neurosteroids; Neurosteroid; Lordosis; Membrane estrogen receptor; mGluR1a; Calcium; Brain; Luteinizing hormone; Astrocytes; Glial; LH; Reproduction; 3beta-HSD; Estradiol; Rapid; Non-genomic; Hypothalamus
Regenerative potential of allopregnanolone
Keywords: Neurosteroids; Neurosteroids; Neurodegenerative disease; Alzheimer's disease; Neurogenesis; Triple transgenic AD mouse; Neuroregenerative therapeutics
The neurosteroid system: Implication in the pathophysiology of hepatic encephalopathy
Keywords: Neurosteroids; Hepatic encephalopathy; Neurosteroids; PTBR; GABA-A receptors; Neurotransmission; Gene expression
Ganaxolone
Keywords: Neurosteroids; Ganaxolone; neurosteroids; epilepsy; infantile spasms; catamenial epilepsy; partial-onset seizures;
Heightened seizure susceptibility associated with brain dermoid cyst and the administration of human chorionic gonadotropin (hCG)
Keywords: Neurosteroids; hCG; Neurosteroids; Seizure; Motor cortical excitability; Magnetic stimulation;
Androgens and the brain
Keywords: Neurosteroids; Androgens; Brain; Neurosteroids
Circulatory neurosteroid levels in smoking and non-smoking chronic schizophrenia patients
Keywords: Neurosteroids; Schizophrenia; Addiction; Neurosteroids; PANSS; Smoking; Nicotine
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells
Keywords: Neurosteroids; NMDA receptor; NR2B subunit; Neurosteroids; Ifenprodil; Pregnenolone sulphate (PS); Pregnanolone sulphate (3α5βS); NG108-15; Neurite outgrowth; Cell adhesion
Cerebellum progesterone concentration decreased in canine distemper virus infection
Keywords: Neurosteroids; Canine distemper virus; Cerebellum; Demyelination; Neurosteroids; Progesterone
3β-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: Effect of pseudopregnancy and traumatic brain injury
Keywords: Neurosteroids; Neurosteroids; 3β-Hydroxysteroid dehydrogenase; Brain; In situ hybridization; Traumatic brain injury; Progesterone
Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects
Keywords: Neurosteroids; Pregnenolone; Dehydroepiandrosterone; Neurosteroids; Schizophrenia; Anxiety; Emotional distress
A new meaning for “Gin & Tonic”: tonic inhibition as the target for ethanol action in the brain
Keywords: Neurosteroids; GABAARs; Ethanol; Inhibition; Tonic inhibition; Neurosteroids
Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: A study in an animal model of childhood depression
Keywords: Neurosteroids; monoamines; FSL rats; neurosteroids; animal models of depressionACTH, adrenocorticotropic hormone; ANOVA, analysis of variance; DA, dopamine; DHEA, dehydroepiandrosterone; DOPAC, dihydroxyphenylacetic acid; FSL, Flinders sensitive line; HVA, homovanillic
Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
Keywords: Neurosteroids; Estrous cycle; Allopregnanolone; Neurosteroids; SERMs; Estrogen receptor; Learning and memory
Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells—A possible interaction with psychotropic drugs
Keywords: Neurosteroids; Neurosteroids; Antipsychotics; GR-mediated gene transcription; Protein kinase C; Mitogen-activated protein kinase; Fibroblast cells
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
Keywords: Neurosteroids; Etifoxine; Neurosteroids; Allopregnanolone; Anxiety
Obstetric risks for women with epilepsy during pregnancy
Keywords: Neurosteroids; Women; Epilepsy; Pregnancy; Outcome; Nutrition; Neurosteroids; Seizures; Antiepileptic drugs; Stillbirth; Small for dates; Abruptio; Eclampsia; Imaging; Ultrasound
Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats
Keywords: Neurosteroids; Alcohol consumption; Allopregnanolone; Hippocampus; Neurosteroids
The neuroactive steroids alphaxalone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons
Keywords: Neurosteroids; GABAA receptors; Neurosteroids; Single channel conductance; Cultured hippocampal neurons
Enzyme-assisted synthesis and characterization of glucuronide conjugates of neuroactive steroids
Keywords: Neurosteroids; Neuroactive steroids; Neurosteroids; Glucuronidation; Conjugation; Liquid chromatography–mass spectrometry; Biosynthesis
Circulating levels of pregnanolone isomers during the third trimester of human pregnancy
Keywords: Neurosteroids; Pregnanolone isomers; Neurosteroids; Steroid sulfates; Human pregnancy; GC-MS;
Reversal of lindane-induced impairment of step-down passive avoidance and oxidative stress by neurosteroids in rats
Keywords: Neurosteroids; Lindane; Neurosteroids; Pregnenolone sulfate; Progesterone; 4′-Chlorodiazepam
Studies on neurosteroids XIX
Keywords: Neurosteroids; Neurosteroids; LC-ESI-MS-MS; Derivatization; Rat brain; Immobilization stress; Ethanol administration;
Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients
Keywords: Neurosteroids; Lithium; Carbamazepine; Mirtazapine; Neuroactive steroids; Neurosteroids; Depressive disorder
Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats
Keywords: Neurosteroids; Neurosteroids; Allopregnanolone; DHEAS; GABAA receptor; Ethanol tolerance; Withdrawal anxiety
Neurosteroids in the context of stress: Implications for depressive disorders
Keywords: Neurosteroids; Neurosteroids; Allopregnanolone; Stress; Premenstrual dysphoric disorder; Depressive disorders3α,5α-THP, allopregnanolone; 3α,5α-THDOC, allotetrahydroDOC; HPA, hypothalamic-pituitary-adrenal; PMDD, premenstrual dysphoric disorder
Steroid modulation of GABAA receptor-mediated transmission in the hypothalamus: Effects on reproductive function
Keywords: Neurosteroids; Neurosteroids; GABAA receptors; Anabolic androgenic steroids; Reproduction; Supraoptic nucleus; Medial preoptic area; GnRH; Oxytocin
In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABAA receptors
Keywords: Neurosteroids; Midbrain; Allopregnanolone; Neurosteroids; Non-genomic; Sexual receptivity; Bicuculline; SKF38393; Reinforcing behavior; Dopamine; GABA
Impaired reduction of enhanced levels of dehydroepiandrosterone by oral dexamethasone in anorexia nervosa
Keywords: Neurosteroids; Allopregnanolone; Anorexia nervosa; Cortisol; Dehydroepiandrosterone; Dexamethasone; Neurosteroids
Effects of early-life stress on behavior and neurosteroid levels in the rat hypothalamus and entorhinal cortex
Keywords: Neurosteroids; Early life; Stress; Behavior; Neurosteroids;
Neuroactive steroids: Old players in a new game
Keywords: Neurosteroids; neurosteroids; brain; spinal cord; peripheral nerves; steroid receptors; non-classical steroid receptorsDOC, deoxycorticosterone; EDC, endocrine disrupting chemical; ER, estrogen receptor; PBR, Peripheral Benzodiazepine Receptor; SERM, selective estrogen
Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin
Keywords: Neurosteroids; Deoxycorticosterone; Infant rats; Finasteride; Indomethacin; DHDOC; THDOC; Neurosteroids; Seizures; Anticonvulsant
The protective effect of frontal cortex dehydroepiandrosterone in anxiety and depressive models in mice
Keywords: Neurosteroids; Dehydroepiandrosterone (DHEA); Neurosteroids; Depression; Anxiety; Mice; Forced Swim Test (FST); Elevated Plus Maze (EPM); Behavioral disorders
Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell
Keywords: Neurosteroids; Neurosteroids; Neuronal growth; Synaptogenesis; Purkinje cell; Cerebellar development
Progestins’ effects on sexual behaviour of female rats and hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent
Keywords: Neurosteroids; Neurosteroids; Non-genomic; Lordosis; Muscimol; SKF38393
Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area
Keywords: Neurosteroids; Neurosteroids; Non-genomic; Lordosis; Muscimol; SKF38393; 2′,5′-Dideoxyadenosine; cAMP; Protein kinase A; Midbrain; Signal transduction; Membrane-bound receptors; 5α-Pregnan-3α-ol-20-one
Comparative non-radioactive RT-PCR assay: An approach to study the neurosteroids biosynthetic pathway in humans
Keywords: Neurosteroids; RT-PCR; PBR; 5α-Reductase 1; 3α-HSOR 1–2; Parkinson's disease; Neurosteroids; GC–MS
Plastic neuronal changes in GABAA receptor gene expression induced by progesterone metabolites: In vitro molecular and functional studies
Keywords: Neurosteroids; Neurosteroids; GABAA receptor; Gene expression; Cell culture; Patch-clamp; Synaptic plasticity;
Alterations in DHEA metabolism in schizophrenia: Two-month case-control study
Keywords: Neurosteroids; Dehydroepiandrosterone; Progesterone; Androstenedione; Neurosteroids; Prolactin; Schizophrenia; Prospective study
Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system
Keywords: Neurosteroids; multidrug resistance proteins; neurosteroids; dehydroepiandrosterone 3-sulfate; gliomas; paroxysmal kinesigenic choreoathetosis; GABAA receptor modulationABC, ATP-binding cassette; ABCC, subfamily C of ATP-binding cassette transporters; cDNA, complementar
Neuroactive steroids and affective disorders
Keywords: Neurosteroids; Antidepressants; CCK-4; Electroconvulsive therapy; GABAA-receptor; Ligand-gated ion channel; Neurosteroids; Panic disorder; Partial sleep deprivation; Transcranial magnetic stimulation;
Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats
Keywords: Neurosteroids; Cocaine; Dehydroepiandrosterone (DHEA); Neurosteroids; Self-administration; Cocaine seeking behavior
Neurosteroids, neuroactive steroids, and symptoms of affective disorders
Keywords: Neurosteroids; Neurosteroids; Neuroactive steroids; Depression; Panic disorders; Anxiety; Glia; 5α-reductase; Tetrahydroprogesterone; Tetrahydrodeoxycorticosterone; Dehydroepiandrosterone