کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
319281 | 539271 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats](/preview/png/319281.png)
The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.
Journal: European Neuropsychopharmacology - Volume 16, Issue 5, July 2006, Pages 329–339