Effects of pentachlorophenol on the quail (Coturnix japonica) liver detoxification pathway
Keywords: Pentachlorophenol; Cytochrome P450; NF-κB; Nrf2; Coturnix japonica;
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RhoB induces the production of proinflammatory cytokines in TLR-triggered macrophages
Keywords: RhoB; MHC class II molecule; NF-κB; Macrophage; Toll-like receptors;
IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma
Keywords: Muc5ac; IL-1β; HIF-1α; NF-κB; Asthma;
Src and Syk contribute to the anti-inflammatory activities of Achyranthes aspera ethanolic extract
Keywords: Achyranthes aspera L.; Anti-inflammatory effect; NF-κB; Src; Syk;
IRF9 as a negative regulator involved in TRIF-mediated NF-κB pathway in a teleost fish, Miichthys miiuy
Keywords: IRF9; TRIF; Negative regulation; NF-κB; Teleost;
Salvianolic acid B inhibits IL-1β-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model
Keywords: Salvianolic acid B; Osteoarthritis; Chondrocyte; NF-κB; Interleukin-1β;
Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation
Keywords: NF-κB; Immunoproteasome; LMP2; LMP7; Inflammation;
Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice
Keywords: Cryptotanshinone; Osteoarthritis; Chondrocytes; NF-κB; IL-1β; Inflammation;
Alpha-Mangostin suppresses interleukin-1β-induced apoptosis in rat chondrocytes by inhibiting the NF-κB signaling pathway and delays the progression of osteoarthritis in a rat model
Keywords: Alpha-Mangostin; Osteoarthritis; Interleukin-1β; Chondrocyte; Apoptosis; NF-κB;
The immune-enhancing activity of Cervus nippon mantchuricus extract (NGE) in RAW264.7 macrophage cells and immunosuppressed mice
Keywords: Lipopolysaccharide (PubChem CID: 11970143); Cyclophosphamide (PubChem CID: 2907); Cervus nippon mantchuricus Extract; Deer bone; Immunosuppressed mice; Macrophages; Immune-enhancing activity; MAPK; NF-κB;
Litsenolide A2: The major anti-inflammatory activity compound in Litsea japonica fruit
Keywords: Litsea japonica fruit; Litsenolide A2 (LNA2); Anti-inflammatory; NF-κB; MAPK; Marker compound;
Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells
Keywords: AUR; auranofin; CA9; carbonic anhydrase IX; CDKN1B; cyclin-dependent kinase inhibitor 1B (p27); CSC; cancer stem cell; DMOG; dimethyloxalylglycine; GSH; glutathione; HIF; hypoxia inducible factor; MUC2; mucin2; NCL; nucleolin; NFE2L2 or Nrf2; nuclear fact
The archaic roles of the lamprey NF-κB (lj-NF-κB) in innate immune responses
Keywords: NF-κB; nuclear factor-kappa B; RHD; Rel homology domain; ANKs; ankyrin repeats; NLS; nuclear localization signals; TAD; transactivation domain; GRR; glycine-rich region; IMD; immune deficiency; AMPs; antimicrobial peptides; IPT; immunoglobulin-plexin-tra
TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response
Keywords: Diabetic retinopathy; TLR7; Inflammation; NF-κB; MAPKs;
Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway
Keywords: Inflammation; RAW264.7 cells; Ginsenoside Rk1; Jak2/Stat3; NF-κB;
The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population
Keywords: TLR3; toll-like receptor 3; TRIF; TIR-domain-containing adapter-inducing interferon-β; TRAF3; tumor necrosis factor receptor-associated factor 3; IFN-β; type I interferon -β; NF-κB; nuclear factor-κB; IRF-3/7; interferon regulatory factor 3/7; SN
Research articleDexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway
Keywords: Inflammation; Dexmedetomidine; Neuroprotection; TLR-4; NF-κB;
NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation
Keywords: ALI; acute lung injury; LPS; lipopolysaccharide; BALF; bronchoalveolar lavage fluid; NE; neutrophil elastase; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; MCP-1; monocyte chemoattra
Newly identified PcToll4 regulates antimicrobial peptide expression in intestine of red swamp crayfish Procambarus clarkii
Keywords: TLR; Toll-like receptor; LRR; leucine-rich repeat; LRR TYP; Leucine-rich repeats, typical (most populated) subfamily; LRR CT; Leucine rich repeat C-terminal; LRR NT; Leucine rich repeat N-terminal; WSSV; white spot syndrome virus; S2; Drosophila Schneider
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
Full Length ArticleActivation of mTOR is involved in anti-β2GPI/β2GPI-induced expression of tissue factor and IL-8 in monocytes
Keywords: mTOR; mammalian target of rapamycin; ECs; endothelial cells; APS; antiphospholipid syndrome; aPL; antiphospholipid antibodies; TF; tissue factor; β2GPI; β2-glycoprotein I; IL-8; interleukin-8; TLR4; toll-like receptor 4; NF-κB; nuclear factor kappa B;
Research articleNF-κB dependent up-regulation of TRPC6 by Aβ in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage
Keywords: TRPC6; Aβ; BV-2 microglia; NF-κB; COX-2; Alzheimer's disease;
Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation
Keywords: PXR; pregnane X receptor; PCN; pregnenolone 16α-carbonitrile; Con A; concanavalin A; DSS; dextran sulfate sodium; TNF; tumor necrosis factor; LPS; lipopolysaccharide; NF-κB; nuclear factor κB; MPO; myeloperoxidase; SOCS1; suppressor of cytokine signali
Peroxisome proliferator-activated receptor-γ-mediated polarization of macrophages in Neospora caninum infection
Keywords: Neospora caninum; Macrophages; Polarization; PPAR-γ; NF-κB;
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide
Keywords: Microglial priming; Aging; Parkinson's disease; MMP-8 inhibitor; Systemic inflammation; Neuroinflammation; CSF; macrophage colony-stimulating factor; EMSA; electrophoretic mobility shift assay; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium
DPP-4 inhibition protects human umbilical vein endothelial cells from hypoxia-induced vascular barrier impairment
Keywords: Dipeptidyl peptidase-4; Hypoxia; Endothelial cell; Adherens junctions; NF-κB;
Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis
Keywords: ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); AP-1; activator protein-1; Aq.F; aqueous fraction; BCB; β-carotene bleaching activity; Bu.F; butanol fraction; CEE; crude alcoholic extract; Cr.F; crude fraction; CVD; cardiovascular diseas
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways
Keywords: LPS/D-GalN; Morin; Nrf2; NF-κB;
Standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza prevents murine ulcerative colitis by regulation of inflammation
Keywords: Curcuma xanthorrhiza; Ulcerative colitis; Dextran sulfate sodium; Gene expression; NF-κB; S100a8;
A novel whey tetrapeptide IPAV reduces interleukin-8 production induced by TNF-α in human intestinal Caco-2 cells
Keywords: CaSR; calcium sensing receptor; ESI; electric spray ionization; HPLC; high-performance liquid chromatography; IBD; inflammatory bowel disease; IL; interleukin; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; JN
Protective effects of coumestrol on lipopolysaccharide-induced acute lung injury via the inhibition of proinflammatory mediators and NF-κB activation
Keywords: ALI; LPS; Coumestrol; TNF-α; IL-6; NF-κB; Coumestrol (PubChem CID: 5281707);
Pilose antler peptide potentiates osteoblast differentiation and inhibits osteoclastogenesis via manipulating the NF-κB pathway
Keywords: Pilose antler peptide; Inflammation; Osteoblasts; Osteoclasts; NF-κB;
STAT3 and NF-κB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema
Keywords: NF-κB; STAT3; Kaempferol; Polyphenol; Inflammation; Paw edema;
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells
Keywords: BCL; B cell lymphoma; CLL; chronic lymphatic leukemia; DSB; DNA double strand break; HDAC; histone deacetylase; HDACi; histone deacetylase inhibitor; MS-275; entinostat; NF-κB; nuclear factor 'kappa-light-chain-enhancer' of activated B cells; PDAC; p
Osthole inhibits intimal hyperplasia by regulating the NF-κB and TGF-β1/Smad2 signalling pathways in the rat carotid artery after balloon injury
Keywords: Osthole (PubChem CID: 10228); Osthole; Intimal hyperplasia; Inflammation; NF-κB; TGF-β1/Smad2;
Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-κB mediated IL-2 secretion
Keywords: Contact dermatitis; IL-2; NF-κB; T cell; Tetradecanol;
Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells
Keywords: Berberine; Inflammation; Macrophage; Sirt1; NF-κB;
LncRNA HOTAIR alleviates rheumatoid arthritis by targeting miR-138 and inactivating NF-κB pathway
Keywords: HOTAIR; Rheumatoid arthritis; Proliferation; Inflammation; miR-138; NF-κB signaling pathway; RA; rheumatoid arthritis; miR; microRNA; lncRNA; long non-coding RNA; PCNA; proliferating cell nuclear antigen; IL; interleukin; NF-κB; nuclear transcription fa
Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats
Keywords: Stachydrine; Cardiac hypertrophy; Myocardial fibrosis; NF-κB; JAK/STAT;
3-Methoxy-catalposide inhibits inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages
Keywords: NF-κB; nuclear factor-kappaB; AP-1; activator protein-1; e.g.; exempli gratia; ELISA; enzyme-linked immunosorbent assay; eNOS; endothelial NOS; iNOS; inducible nitric oxide synthase; nNOS; neuronal nitric oxide synthase; PCNA; proliferating cell nuclear
Lithospermum erythrorhizon extract inhibits Der p2-induced inflammatory response through alleviation of thymic stromal lymphopoietin, nuclear factor Kappa B, and inflammasome expression in human bronchial epithelial cells
Keywords: Lithospermum erythrorhizon; Angelica sinensis; Thymic Stromal Lymphopoietin; NF-κB; Inflammasome; Signal transducer and activator of transcription 3;
Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-like receptors
Keywords: Paraquat; Epigallocatechin-3-gallate; Acute lung injury; Toll-like receptor; NF-κB;
SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway
Keywords: SIRT1; CD40; TLR4; NF-κB; Inner medullary collecting duct cells; Inflammation;
Antimalarial agent artesunate protects Concanavalin A-induced autoimmune hepatitis in mice by inhibiting inflammatory responses
Keywords: Artesunate; Concanavalin A-induced hepatitis; Mouse; NF-κB; MAPK;
Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-κB signals
Keywords: MEHP; Wilms' tumor; Migration; Invasion; NF-κB;
Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression
Keywords: PM2.5; microRNA; Reactive oxygen species; Lipopolysaccharide; NF-κB; Inflammation;
Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation
Keywords: Cadmium; Sinapic acid; Nephrotoxicity; Oxidative/nitrosative stress; NF-κB;
Immune response mechanism of mouse monocytes/macrophages treated with κ-carrageenan polysaccharide
Keywords: κ-carrageenan polysaccharide; Mouse monocyte/macrophage cell; Immunomodulatory; TNF-α; NF-κB;
Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) differentially modulate angiotensin II effects on vascular smooth muscle cells
Keywords: ACE; angiotensin converting enzyme; AngII; angiotensin II; BrDU; bromodeoxyuridine; DHE; dihydroethidium; ERK1/2; extracellular signal regulated kinases 1 and 2; IPP; Ile-Pro-Pro; NF-κB; nuclear factor kappa B; RAS; renin-angiotensin system; ROS; reactiv
MicroRNA-34a targets regulator of calcineurin 1 to modulate endothelial inflammation after fetal cardiac bypass in goat placenta
Keywords: MicroRNAs; Placental insufficiency; Endothelial cells; Inflammation; Fetus; Cardiopulmonary bypass; miRNA; microRNA; miR-34a; miRNA-34a; mRNA; messenger RNA; 3'-untranslated regions (UTRs); untranslated region; RCAN1; regulator of calcineurin 1; NFATC1;