C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents
Keywords: C21-steroidal pregnane steroids; Anti-inflammation; TLR; NF-κB; TRAF6;
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Ethanol extract of Atractylodis macrocephalae Rhizoma ameliorates insulin resistance and gut microbiota in type 2 diabetic db/db mice
Keywords: T2DM; Type 2 diabetes mellitus; IR; insulin resistance; PI3K; phosphatidylinositol-3-kinase; AKT; protein kinase B; TNF-α; tumor necrosis factor-alpha; IL-1β; interleukin 1-beta; NF-κB; nuclear factor-kappa B; AMK; Atractylodes macrocephala Koidz; IL-6
CQMUH-011, a novel adamantane sulfonamide compound, inhibits lipopolysaccharide- and D-galactosamine-induced fulminant hepatic failure in mice
Keywords: Fulminant hepatic failure; CQMUH-011; Lipopolysaccharide; Toll-like receptor 4; NF-κB;
Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome
Keywords: PSGL-1; P-selectin glycoprotein ligand-1; JNK; c-Jun N-terminal kinases; NF-κB; nuclear factor-κB; ACE-I; angiotensin converting enzyme inhibitors; TLR2; toll-like receptor 2; SPM; specialized pro-resolving mediator; PPAR-α; peroxisome proliferator-act
Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice
Keywords: Diclofenac; Acute kidney injury; NF-κB; Vinpocetine; Proteinuria; Reactive oxygen species;
Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice
Keywords: Transmembrane activator and calcium modulator ligand interactor; common variable immunodeficiency; natural antibodies; pneumococcal susceptibility; BÂ cells; APRIL; A proliferation-inducing ligand; BAFF; BÂ cell-activating factor; CRD; Cysteine-rich dom
CD11b regulates antibody class switching via induction of AID
Keywords: ITGAM; integrin subunit alpha M; SLE; systemic lupus erythematosus; CSR; class switch recombination; AID; activation induced cytidine deaminase; TLR; Toll-like receptor; BCR; B cell receptors; SHM; somatic hypermutation; CFSE; carboxyfluorescein succinimi
Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G
Keywords: NLRP3; NF-κB; P2X7; Liver inflammation;
Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-κB
Keywords: Acute lung injury; Digitoflavone; Oxidative stress; Inflammation; TXNIP; NF-κB;
Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats
Keywords: Hesperetin; Gold nanoparticles; Mast cells; Glycoconjugates; TNF-α; NF-κB; PCNA;
Identification and functional analysis of a TEP gene from a crustacean reveals its transcriptional regulation mediated by NF-κB and JNK pathways and its broad protective roles against multiple pathogens
Keywords: Litopenaeus vannamei; Thioester-containing protein; Innate immunity; NF-κB; AP-1;
Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-κB pathways
Keywords: Membranous nephropathy; Oxidative stress; Betulinic acid; MN; Membranous nephropathy; PHN; Passive Heymann nephritis; BA; betulinic acid; DEX; dexamethasone; MAC; membrane attack complex; NF-κB; nuclear transcription factor-kB; ROS; reactive oxygen speci
Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex
Keywords: JAK; Janus kinase; STAT; signal transducer and activator of transcription; SOCS; suppressor of cytokine signaling; TYK2; tyrosine kinase 2; NF-κB; nuclear factor kappa B; C/EBP; CCAAT-enhancer-binding proteins; GATA-1; GATA-binding factor 1; AP-1; Activa
Integrin linked kinase regulates the transcription of AQP2 by NFATC3
Keywords: AQP2; Aquaporin-2; AP-1; Activator protein-1; b.w.; Body weight; CH2O; Free H2O clearance; cKD-ILK; ILK conditional-knockdown mice; Cn; Calcineurin; Col I; Calf skin collagen type I; Cosm; Osmolar clearance; CRE; BALB/cJ mice carrying a CMV-driven tamoxif
Geniposide attenuates Staphylococcus aureus-induced pneumonia in mice by inhibiting NF-κB activation
Keywords: Geniposide; Staphylococcus aureus; Pneumonia; NF-κB;
PERK and XBP1 differentially regulate CXCL10 and CCL2 production
Keywords: Chemokine; ER stress; Photoreceptor; NF-κB; STAT3;
Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes
Keywords: Nuclear factor κ light-chain enhancer of activated B cells; hypogammaglobulinemia; autoinflammation; Behçet disease; NFKB1; p50; p105; B cell; IκBα; NF-κB inhibitor α; IKK; Inhibitor of κB kinase; NEMO; NF-κB essential modulator; NF-κB; Nuclear f
MicroRNA-29a regulates lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages through the Akt1/ NF-κB pathway
Keywords: Inflammatory; Macrophage; MiR-29a; Akt1; NF-κB;
Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
Keywords: Lysosome; Mitochondrial Dysfunction; Macrophage; Cytokine; AP; acute pancreatitis; ATG; autophagy-related (gene or protein); CCL; chemokines C-C motif ligand; CP; chronic pancreatitis; CypD; cyclophilin D; DAMP; damage-associated molecular pattern; DC; de
The Ï-carboxyl group of 7-ketocholesteryl-9-carboxynonanoate mediates the binding of oxLDL to CD36 receptor and enhances caveolin-1 expression in macrophages
Keywords: 7-Ketocholesteryl-9-carboxynonanoate; Oxidized low-density lipoprotein; CD36; Caveolin-1; NF-κB;
Sodium butyrate improved intestinal immune function associated with NF-κB and p38MAPK signalling pathways in young grass carp (Ctenopharyngodon idella)
Keywords: Sodium butyrate; Intestinal immune; NF-κB; p38MAPK; Grass carp (Ctenopharyngodon idella);
Celecoxib induced apoptosis against different breast cancer cell lines by down-regulated NF-κB pathway
Keywords: Celecoxib; NF-κB; Apoptosis;
Inhibition of NF-κB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion
Keywords: PEDV; Porcine epidemic diarrhea virus; Coronavirus; Immune evasion; Interferon suppression; NF-κB; Nsp1; Interferon signaling; Proinflammatory cytokines;
Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Keywords: ADP; adenosine 5â²-diphosphate; AgRP; agouti-related peptide; AMPK; 5â²-AMP-activated protein kinase; ApnA; diadenosine polyphosphate; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATP; adenosine 5â²-triphosphate; BN-PAGE; blue native-p
Taxifolin enhances osteogenic differentiation of human bone marrow mesenchymal stem cells partially via NF-κB pathway
Keywords: Taxifolin; Flavonoid; Osteogenesis; MSC; NF-κB; hBMSCs; human bone marrow-derived mesenchymal stem cells; MAPK; mitogen-activated protein kinase; DMSO; dimethyl sulfoxide; NF-κB-Luc; NF-κB-luciferase reporter plasmid; ALP; alkaline phosphatase; OPN; os
Targeting vasa vasorum dysfunction to prevent atherosclerosis
Keywords: Vasa vasorum; Atherosclerosis; Neoangiogenesis; Endothelial metabolism; Epigenetic regulation; microRNA; 5-aza-2â²-dC; 5-aza-2â²-deoxycytidine; BRD4; bromodomain-containing protein 4; BET; bromodomain and extra terminal domain; CAMs; cell adhesion molec
The IL-1RI Co-Receptor TILRR (FREM1Â Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease
Keywords: heparan sulfate proteoglycan; interleukin-1 receptor; IL-1RI; NF-κB; TILRR; ApoE; apolipoprotein E; DK; double knockout; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; iBALT; inducible bronchus-associated lymphoid tissue; IgG; immunoglobulin G; IκBα;
The roles of NF-κB and ROS in regulation of pro-inflammatory mediators of inflammation induction in LPS-stimulated zebrafish embryos
Keywords: Zebrafish embryos; Inflammation; Pro-inflammatory mediator; ROS; NF-κB;
Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation
Keywords: ARE; antioxidant response element; BSCB; blood-spinal cord barrier; CXCL1; C-X-C motif ligand 1; GFAP; glial fibrillary acidic protein; GSH; glutathione; GSSG; glutathione disulfide; HO-1; heme oxygenase-1; H2O2; hydrogen peroxide; Iba-1; ionized calcium-
Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress
Keywords: CCL5; chemokine (C-C motif) ligand 5; RANTES; regulated upon activation normal T-cell expressed and secreted; CCR5; C-C chemokine receptor type 5; NAFLD; nonalcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; HFD; high-fat-diet; α-SMA; al
Antiâinflammatory and antiâarthritic properties of naringenin via attenuation of NFâκB and activation of the heme oxygenase ï´¾HOï´¿â1/related factor 2 pathway
Keywords: Naringenin; Complete Freund's adjuvant; NF-κB; Nrf-2/HO-1 pathway;
NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells
Keywords: Monobutyl phthalate; Steroidogenesis; NF-κB; Vimentin;
Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-κB signaling
Keywords: CLP; cecal ligation and puncture; HLJDD; Huang-Lian-Jie-Du-Decoction; TCM; Traditional Chinese Medicine; TNF-α; tumor necrosis factor alpha; NO; nitric oxide; IL; interleukin; ACh; acetylcholine; ChAT; choline acetylase; NF-κB; Nuclear factor-κappa B;
The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation
Keywords: Extracellular matrix; Gelatin zymography; HaCat keratinocytes; MAP kinases; NF-κB, skin inflammation; AKBA; 3-O-acetyl-11-keto-β-boswellic acid; ERK; extracellular signal-regulated kinase; IL; interleukin; JNK; c-Jun N-terminal kinase; KBA; 11-keto-β
Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors
Keywords: Imidazopyrazine; Imidazoquinoxaline; Pyrazoloquinoxaline; IKK; NF-κB;
Apamin inhibits TNF-α- and IFN-γ-induced inflammatory cytokines and chemokines via suppressions of NF-κB signaling pathway and STAT in human keratinocytes
Keywords: Apamin; Atopic dermatitis; Type 2 helper T lymphocyte chemokine; NF-κB; STAT;
Inhibition of constitutive NF-κB activity induces platelet apoptosis via ER stress
Keywords: Platelet; Apoptosis; NF-κB; ER stress; SERCA;
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase
Keywords: 26S; proteasome; RP; regulatory particle; CP; proteolytic core particle; DUBs,; deubiquitinating enzymes; Ub-AMC; ubiquitin 7-amido-4-methylcoumarin; TNFα; tumor necrosis factor α; ER; endoplasmic reticulum; NF-κB; nuclear factor κB; IκB; inhibitor o
Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-κB activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy
Keywords: NF-κB; Gastric cancer; Curcuminoid analog; Irinotecan;
Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway
Keywords: MUC1; Membrane-tethered mucin; Macrophage; Inflammation; Pseudomonas aeruginosa; aa; amino acid; AEC; airway epithelial cell; AM; alveolar macrophage; CF7; control peptide 7; EGFR; epidermal growth factor receptor; ERK1/2; extracellular signal-regulated k
Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling
Keywords: Harmin; Peganum harmala L.; Inflammation; NF-κB; TNF-α; IL-1β; IL-6;
Cinnamon extracts exert intrapancreatic cytoprotection against streptozotocin in vivo
Keywords: STZ; streptozotocin; GTT; glucose tolerance testing; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; ELISA; enzyme-linked immunosorbent assay; NF-κB; nuclear-factor kappa B; RT-PCR; polymerase chain reaction; T1D; type 1 diabetes; CTMs; Chinese Tr
Expression of glial CBP in steroid mediated neuroprotection in male and female zebra finches
Keywords: Astrocytes; Songbird; Estrogens; Neuroprotection; Inflammation; Coactivators; NF-κB;
The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation
Keywords: Kaposi's sarcoma; KSHV; HHV-8; Herpesvirus; vFLIP; RTA; Ubiquitin; Itch; AIP4; NF-κB;
The regulation of Jmjd3 upon the expression of NF-κB downstream inflammatory genes in LPS activated vascular endothelial cells
Keywords: H3K27; Jmjd3; NF-κB; Inflammation; Vascular endothelial cell;
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Keywords: Astrocytes; Aging; HIV-associated neurocognitive disorders; Neuroinflammation; ER/Nucleolar/Oxidative stress; Excitotoxicity; Aβ; amyloid beta; AEG-1; astrocyte elevated gene-1; AD; Alzheimer's disease; AIDS; acquired immune deficiency syndrome; ARE; a
DNA Methylation Regulates Gene Expression in Intracranial Aneurysms
Keywords: DNA methylation; Gene expression profile; Intracranial aneurysm; Microarray analysis; AAA; Abdominal aortic aneurysm; DEG; Differentially expressed gene; FC; Fold change; GO; Gene Ontology; JAK-STAT; Janus kinase/signal transducer and activator of transcr
Rifampin suppresses osteoclastogenesis and titanium particle-induced osteolysis via modulating RANKL signaling pathways
Keywords: Osteolysis; Rifampin; NF-κB; P38; Wear particles;
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1
Keywords: NR4A1; nuclear receptor subfamily 4, group A member 1; 8-OHdG; 8-hydroxy deoxyguanosine; DAPI; 4,6-diamidino-2-phenyindole; ROS; reactive oxygen species; Caspase 3; cysteinyl aspartate specific proteinase 3; WT1; Wilms' tumor gene 1; SIRT1; Sirtuin type 1
The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition
Keywords: LPS; lipopolysaccharide; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; BALF; bronchoalveolar lavage fluid; W/D; lung wet/dry ratio; IL-1β; interleukin-1β; IL-6; interleukin-6; TNF-α; necrosis factor-α; MPO; myeloperoxidase; TLR4;