NF-κB independent signaling pathway is responsible for LPS-induced GDNF gene expression in primary rat glial cultures
Keywords: GDNF; LPS; NF-κB; JNK; Astrocyte; Microglia;
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Xenogeneic interaction between human CD40L and porcine CD40 activates porcine endothelial cells through NF-κB signaling
Keywords: Porcine CD40; Human CD40L; Chemokine; NF-κB; Xenotransplantation;
IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
Keywords: NEMO; Toll-like receptors; IκB; Inhibitor of nuclear factor-κB; IKK; Inhibitor of nuclear factor-κB kinase; NEMO; Nuclear factor-κB essential modulator; NF-κB; Nuclear factor-κB; NK; Natural killer; TCR; T-cell receptor; TLR; Toll-like receptor;
The anti-apoptotic activity associated with phosphatidylinositol transfer protein α activates the MAPK and Akt/PKB pathway
Keywords: PI-TP; phosphatidylinositol transfer protein; PI; phosphatidylinositol; PC; phosphatidylcholine; PLA; phospholipase A; MAPK; mitogen-activated protein kinase; ERK; extracellular signalling related kinase; IAP; inhibitor of apoptosis protein; PKB; protein
The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice
Keywords: Brassinosteroid; HSV-1; Murine herpetic stromal keratitis; Immunomodulatory activity; NF-κB; TNF-α; IL-6;
17β-Estradiol attenuates cardiac dysfunction and decreases NF-κB binding activity in mechanically stretched rat hearts
Keywords: Estrogen; Stretching; Heart; NF-κB; Signaling;
Innate immune responses of epididymal epithelial cells to Staphylococcus aureus infection
Keywords: Epididymal epithelial cells; Staphylococcus aureus; Toll-like receptors; Innate immune responses; p38 MAPK; NF-κB;
Inhibition of the promotion of hepatocarcinogenesis by 2,2â²,4,4â²,5,5â²-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-κB in mice
Keywords: PCBs; NF-κB; Carcinogenesis; Cell proliferation;
The α1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-κB signalling to induce breast cancer cell apoptosis
Keywords: Doxazosin; Breast cancer; Apoptosis; EGFR; NF-κB;
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway
Keywords: NF-κB; nuclear factor-κB; TNF; tumor necrosis factor α; EMSA; electrophoretic mobility shift assay; Simvastatin; Nuclear factor-kappaB; Chemotherapeutic agents; Apoptosis;
Fenofibrate reduces lipoprotein associated phospholipase A2 mass and oxidative lipids in hypertriglyceridemic subjects with the metabolic syndrome
Keywords: [3H]-PAF; platelet activating factor; DIACOR; Diabetes and Combined Lipid Therapy Regimen; FIELD; Fenofibrate Intervention and Event Lowering in Diabetes; HDL-C; high-density lipoprotein cholesterol; HRP; horseradish-peroxidase; ICAM-1; intercellular adhe
GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of ICAD and IAP2 and activation of caspase activities
Keywords: BCR; B cell receptor; HAT; histone acetyltransferase; PMA; phorbol 12-myristate 13-acetate; PVDF; polyvinyliden difluoride.; Caspase; DT40; Gene targeting; NF-κB; PKC;
Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
Keywords: Bromelain; Mouse skin; Apoptosis; Cox-2; NF-κB; MAPK;
Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline
Keywords: Aniline; Spleen; Oxidative stress; NF-κB; AP-1; IKK; MAPK; Cytokines;
Protective effect of Ginkgolids (A + B) is associated with inhibition of NIK/IKK/IκB/NF-κB signaling pathway in a rat model of permanent focal cerebral ischemia
Keywords: GKAB; Ginkgolid A and B, Ginkgolids (A + B); IKK; IκBα kinase; NIK; NF-κB-inducing kinase; NF-κB; nuclear factor kappaB; LPS; lipopolysaccharide; pMCAO; permanent middle cerebral artery occlusion; p-NIK,; phosphorylated NIK; p-IKKα,; phosphorylated
In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-α converting enzyme/tumor necrosis factor-α/nuclear factor-κB
Keywords: ischemic preconditioning; ischemic tolerance; normobaric hyperoxia; NF-κB; TNF-a; TACE; AP; activator protein; BBB; blood-brain barrier; BIT; brain ischemic tolerance; DW; dry weight; EB; Evans Blue; HO; hyperoxia; InRA; intermittent room air; IPC; isc
On interaction of activated protein C with human aortic smooth muscle cells attenuating the secretory group IIA phospholipase A2 expression
Keywords: APC; activated protein C; BSA; bovine serum albumin; C/EBP; CCAAT box enhancer binding protein; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunoassay; EPCR; endothelial protein C receptor; ERK 1/2; extracellular signal-regulated kinase; FCS; fetal ca
Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro
Keywords: PrP106-126; Microglia; Neuron; NF-κB; Cytokines; Aspirin;
Pioglitazone attenuates neointimal thickening via suppression of the early inflammatory response in a porcine coronary after stenting
Keywords: Thiazolidinediones; Neointimal hyperplasia; Coronary stenting; NF-κB; MCP-1;
NF-κB-dependency and consequent regulation of IL-8 in echinomycin-induced apoptosis of HT-29 colon cancer cells
Keywords: Echinomycin; NF-κB; IL-8; HT-29 cells;
NUMBL interacts with TAB2 and inhibits TNFα and IL-1β-induced NF-κB activation
Keywords: NF-κB; nuclear factor kappa B; IL-1β; interleukin-1β; TNF; tumor necrosis factor; NUMBL; homologous protein of numb like; TAK1; TGF-β activated kinase1; TAB2; TAK1-binding protein 2; TRAF6; TNF receptor-associated factor 6; TRAF2; TNF receptor-associa
Amitriptyline induces nuclear transcription factor-κB-dependent glutamate transporter upregulation in chronic morphine-infused rats
Keywords: amitriptyline; nuclear transcription factor-kB; glutamate transporters; excitatory amino acids; microdialysis; morphine tolerance; CSF; cerebrospinal fluid; EAAC1; excitatory amino acid carrier 1; GLAST; glutamate-aspartate transporter; GLT-1; glutamate t
Salmonella enterica serovar Enteritidis dam mutant induces low NOS-2 and COX-2 expression in macrophages via attenuation of MAPK and NF-κB pathways
Keywords: Salmonella enterica serovar Enteritidis; Macrophages; Inflammation; NOS-2; COX-2; MAPK; NF-κB;
Preventive and curative effects of cyclophosphamide in an animal model of Guillain Barrè syndrome
Keywords: Cyclophosphamide; Experimental allergic neuritis; Immunotherapy; NF-κB;
Role of HLA-G in innate immunity through direct activation of NF-κB in natural killer cells
Keywords: HLA-G; Natural killer cells; Signal transduction; NF-κB;
Molecular cloning and expression analysis of the ASC gene from mandarin fish and its regulation of NF-κB activation
Keywords: mfASC; PYRIN domain; CARD domain; Gene structure; mRNA expression; NF-κB;
Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-κB activation and COX-2 expression in human breast epithelial cells
Keywords: Human breast epithelial cells; Cyclooxygenase-2; NF-κB; Mitogen-activated protein kinase; Chemoprevention; Phorbol ester;
Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts
Keywords: Licochalcone A; Osteoclast formation; Bone resorption; ERK; NF-κB; Fra-2; AP; activator protein; ATP6v0d2; v-ATPase V0 subunit d2; BMM; bone marrow-derived macrophage; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GAPDH; glyceralde
Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-κB
Keywords: Obovatol; NF-κB; Apoptotic cell death; Colon cancer; Prostate cancer;
The Sodium Pump α1 Subunit as a Potential Target to Combat Apoptosis-Resistant Glioblastomas
Keywords: AMOG; adhesion molecule on glia; MGMT; methylguanine-DNA methyltransferase; mTOR; mammalian target of rapamycin; NF-κB; nuclear factor-kappa B; P13K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog on chromosome ten;
1-Bromopropane induces macrophage activation via extracellular signal-regulated kinase 1/2 MAPK and NF-κB pathways
Keywords: 1-Bromopropane; Inducible nitric oxide synthase; NF-κB; MAP kinase;
Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8
Keywords: c-FLIP; Cycloheximide; Ectodomain shedding; NF-κB; TNF receptor;
NF-κB p52, RelB and c-Rel are transported into the nucleus via a subset of importin α molecules
Keywords: Nuclear translocation; NF-κB; Importin; p52; RelB; c-Rel;
Effects of Antidiabetic and Antihyperlipidemic Agents on C-Reactive Protein
Keywords: A1c; glycated hemoglobin; CRP; C-reactive protein; DM; diabetes mellitus; HDL-C; high-density lipoprotein cholesterol; hsCRP; high-sensitivity CRP; ICAM-1; intercellular adhesion molecule 1; IL; interleukin; LDL-C; low-density lipoprotein cholesterol; MCP
Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-κB translocation
Keywords: Atherosclerosis; Nitric oxide; Inducible nitric oxide synthase; Glutathione-S-transferase; NF-κB;
The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-κB
Keywords: Epstein-Barr virus; LMP1; Bcl-3; NF-κB;
The pharmokinetic limitations of antioxidant treatment for COPD
Keywords: COPD; chronic obstructive pulmonary disease; FEV1; forced expiratory volume in 1 s; IL-1β; interleukin-1-beta; GM-CSF; granulocyte monocyte colony stimulating factor; NF-κB; nuclear factor kappa B; MAPK; mitogen activated protein kinase; EGCG; epigallo
PKCθ cooperates with atypical PKCζ and PKCι in NF-κB transactivation of T lymphocytes
Keywords: CA; constitutive active; DN; dominant negative; I-κB; inhibitor of NFκB; IKK; I-κB-kinase; NFκB; nuclear factor of κB; PMA; phorbol myristate acetate; PH; pleckstrin homology domain; (PI)3K; phosphatidylinositol 3-kinase; PKC; protein kinase C; PTEN;
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Keywords: cIAP-2; cellular inhibitor of apoptosis protein 2; DAI; disease activity index; DMOG; dimethyloxalylglycine; DSS; dextran-sodium sulfate; HIF; hypoxia inducible factor; IL; interleukin; MPO; myeloperoxidase; NF-κB; nuclear factor κB; TNF; tumor necrosis
Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis
Keywords: AP-1; activator protein-1; AIDS; acquired immune deficiency syndrome; ANOVA; analysis of variance; CBP; cAMP binding protein; ChIP; chromatin immunoprecipitation; ERK; extracellular regulated kinase; GCL; glutamate cysteine ligase; NF-κB; nuclear factor
The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-κB pathway
Keywords: TLRs; Toll-like receptors; PRR; pattern recognition receptors; LRR; leucine-rich repeat domain; Nod; the nucleotide-binding oligomerization domain family; NF-κB; nuclear factor-κB; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PG
Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-κB, AP-1, and Sp1 activation
Keywords: Nobiletin; Tissue factor; LPS; NF-κB; AP-1; Sp1;
Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFκB activation
Keywords: ARPE-19 cells; herpes simplex virus vector (hrR3); IL-6; ACV; NF-κB;
Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-α. Effects dependent on activation of NF-κB and MAP kinases
Keywords: AP-1; activator protein-1; BCA; bicinchoninic acid; BK; bradykinin; BSA; essentially fatty acid free fetal bovine serum albumin; CASE; Cellular Activation of Signalling ELISA; COX-2; cyclooxygenase-2; CRE; cyclic AMP responsive element; DALBK; des-Arg10-L
Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis
Keywords: Psychoneuroimmunology; Neuroimmunology; HPA axis; ACTH; CRF; Endorphin; NF-κB; Neuroendocrine; Leukocytes;
Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus
Keywords: HO-1; heme oxygenase-1; SE; status epilepticus; PPARγ; peroxisome proliferator-activated receptor gamma; ROS; reactive oxygen species; ARE; antioxidant response elements; CNS; central nervous system; TZDs; thiazolidinediones; PPREs; PPAR responsive eleme
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
Keywords: AID; activation-induced cytidine deaminase; IKK; IκB kinase; IL; interleukin; NF-κB; nuclear factor κB; PCR; polymerase chain reaction; siRNA; small interfering RNA; STAT; signal transducers and activators of transcription; TCR; T-cell receptor; TNF; t
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
Keywords: Apaf-1; apoptosis protease-activating factor-1; ROS; reactive oxygen species; ERK; extracellular signal-regulated kinase; NF-κB; nuclear factor-κB; IGFBP; insulin-like growth factor binding protein; PARP; poly(ADP)ribose polymerase; MDM; murine double m
Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation
Keywords: ASMase; acidic sphingomyelinase; FD-70; fluorescein-isothiocyanate-labeled dextrans of 70 kDa; FLIP; FLICE (FADD [Fas-associated death domain]-like interleukin-1 β-converting enzyme)-inhibitory protein; HP; 3-hydroxy-4-pentenoate; IAP; inhibitor of
Inhibition of GSK3 differentially modulates NF-κB, CREB, AP-1 and β-catenin signaling in hepatocytes, but fails to promote TNF-α-induced apoptosis
Keywords: TNF-α; Wnt; NF-κB; AP-1; CREB; β-catenin; Glycogen synthase kinase-3; Hepatocyte; Liver; Apoptosis;