Keywords: absorption; computational ADME; efflux pumps; in vitro models; organic cation transporters; P-glycoprotein; peptide transporters; pulmonary delivery/absorption; ABC transporters; organic anion-transporting polypeptide transporters; BAL; bronchoalveolar l
مقالات ISI (ترجمه نشده)
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Keywords: Mechanical strain; Mechanical stimulation; A549; RLE-6TN; NHBE; IMR-90; Mechanical integrity of cellular monolayers;
Keywords: DEP; diesel exhaust particle; TEM; transmission electron microscopy; NHBE; normal human bronchial epithelial; GM-CSF; colony stimulating factor; IL-6; interleukin-6; IL-1β; interleukin-1β; ALI; air liquid interface; PM; particulate matter; EGFR; epide
Quantification of membrane transporter proteins in human lung and immortalized cell lines using targeted quantitative proteomic analysis by isotope dilution nanoLC-MS/MS
Keywords: BCRP; breast cancer resistant protein; BEAS; bronchial epithelium and adenovirus; MDCK; madin darby canine kidney; MDR1; multidrug resistance protein 1 (also known as P-gp); MRM; multiple reaction monitoring; MRP; multidrug resistance-associated protein;
Assessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approaches
Keywords: Tobacco heating products; In vitro; Lung epithelial; Cigarette smoke; High content screening; Reporter assay; ARE; antioxidant response element; DMSO; dimethyl sulphoxide; HCI; Health Canada intense smoking regimen; HCIm; modified Health Canada Intense s
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress
Keywords: COPD; chronic obstructive pulmonary disease; ROS; reactive oxygen species; GSH; glutathione; GPx; GSH peroxidase; PPARγ; Peroxisome proliferator-activated receptor γ; NF-κB; nuclear factor-κB; CSE; cigarette smoke extract; HBE; human bronchial epithel
Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival
Keywords: INPP4A; inositol polyphosphate 4 phosphatase type I enzyme; LMB; leptomycin B; PtdIns(P); phosphatidyl inositol phosphate; Ins(1,4,5)P3; Inositol 1,4,5 tris-phosphate; PDK-1; phosphoinositide-dependent kinase-1; mTORC2; mammalian target of rapamycin compl
Airway Goblet Cells Secrete Pro-Inflammatory Cytokines, Chemokines, and Growth Factors
Keywords: airway inflammation; allergic asthma; asthma; cilia; immunology asthma; ALI; air-liquid interface; bFGF; basic fibroblast growth factor; CCL; cysteine-cysteine motif chemokine; CXCL; cysteine-X-cysteine chemokine; MIP; macrophage inflammatory protein; NHB
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Keywords: ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC
Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway
Keywords: TMHM,; Taraxacum mongolicum Hand.-Mazz; OAC; organic acid component; LPS; lipopolysaccharide; IKK; inhibitor of nuclear factor kappa-B kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; NHBE; Normal Human Bronchial Epithelial; IF; Immunofluorescence
Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells
Keywords: #COPD; chronic obstructive pulmonary disease; TLRs; Toll-like receptors; GAG; glycosaminoglycans; NHBE; normal human bronchial epithelial; KS; keratan sulfate; HA; hyaluronan; CS; chondroitin sulfate; MMP; matrix metalloprotease; LPS; lipopolysaccharide;
Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection
Keywords: Ab; antibody; AEC; airway epithelial cells; Ag; antigen; AGTR1; angiotensin II type 1 receptor; AMR; antibody mediated rejection; APC; antigen presenting cell; BOS; bronchiolitis obliterans syndrome; CAN; chronic allograft nephropathy; CAV; cardiac allogr
Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials
Keywords: Ag; silver; ALI; air-liquid interface; ASL; airway surface liquid; BAL; bronchoalveolar lavage; CMD; count median diameter; Cu; copper; EDTA; ethylenediamine tetraacetic acid; EDS; energy dispersive spectroscopy; FBS; fetal bovine serum; GM; geometric m
An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules
Keywords: NHBE; normal human bronchial epithelial; B-LCL; EBV-transformed B lymphoblastoid cell line; aAPC; artificial antigen-presenting cell; A24-293T; HLA-A24 expressing HEK-293T;
Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro
Keywords: OCT; organic cation transporters; PKPD; pharmacokinetic/pharmacodynamic; NHBE; normal human bronchial epithelial; RT-PCR; reverse transcriptase polymerase chain reaction; TEER; transepithelial electrical resistance; ASP+; 4-(4-(diethylamino)styryl)-N-meth
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
Keywords: Cigarette smoke; nicotine; nicotinic acetylcholine receptors; γ-aminobutyric acid receptors; acetylcholine; airway mucus; AB/PAS; Alcian blue/periodic acid-Schiff; ALI; Air-liquid interface; GABAAR; γ-Aminobutyric acid type A receptor; GAPDH; Glycera
Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells
Keywords: Influenza A; Tubulin; Acetylation; Histone deacetylase 6; Rho; AcMTs; acetylated microtubules; AcTub; acetylated α-tubulin; BIM; bisindolylmaleimide; CdTB; Clostridium difficile toxin B; HDAC6; histone deacetylase 6; hpi; hour post-infection; IAV; influe
Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells
Keywords: COX; cyclooxygenase; EGFR; epidermal growth factor receptor; EGFR-P; EGFR phosphorylation; EP; E-prostanoid; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; IL; interleukin; NHBE; normal human bronchial epithelial; PG; prosta
Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism
Keywords: Transient receptor potential melastatin 8; mucus hypersecretion; MUC5AC; cold air; myristoylated alanine-rich C kinase substrate; Ca2+; phosphatidylinositol 4,5-bisphosphate; BCTC; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide;
Leptin and leptin receptor expression in asthma
Keywords: Leptin; leptin receptor; severe asthma; epithelium; TGF-β; remodeling; BECs; Bronchial epithelial cells from brushings; FP; Fluticasone propionate; C; Healthy control volunteer; ICS; Subject with mild asthma controlled with inhaled corticosteroids; NHBE;
Differentiation and functional analysis of human TH17 cells
Keywords: IL-17; regulatory T cells; differentiation; primary bronchial epithelial cells; airway inflammation; transcription factor; TGF-β; ActD; Actinomycin D; BFA; Brefeldin A; FOXP3; Forkhead box protein 3; hROR; Human retinoic acid receptor-related orphan re
Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack
Keywords: Amphiregulin; bronchial asthma; bronchial epithelial cells; epidermal growth factor; tissue remodeling; ADAM17/TACE; A membrane disintegrin and metallopeptidase 17/TNF-alpha converting enzyme; ALI; Air-liquid interface; BSMC; Bronchial smooth muscle cells
Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation
Keywords: Lung epithelial cells; Nicotine; nAChR; EGFR; NF-kB; NHBE;
Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis
Keywords: Pollen NAD(P)H oxidase; oxidative stress; epithelium; conjunctivitis; H2DCF-DA; 2â²-7â²-Dihydro-dichlorofluorescein diacetate; NADH; nicotinamide adenine dinucleotide, reduced; NADPH; nicotinamide adenine dinucleotide phosphate, reduced; NAD(P)H; NADH o
Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation
Keywords: NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NHBE; normal human bronchial epithelial cell; SAEC; small airway epithelial cell; nAchR; nicotinic acetylcholine receptor; DHβE; dihydro-β-erythroidine; α-BTX; α-bungarotoxin; MLA; methyllycaconitin