کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10759331 | 1050420 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells
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کلمات کلیدی
N-acetyl-lactosamineMMPLacNAcLPSPam3CSK4PVDFNHBEGAGGlcNAcFlagellinEGFRHRPTLRs - TLR هاEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدnormal human bronchial epithelial - اپیتلیال طبیعی انسانی برونشInterleukin-8 - اینترلوکین -8Chronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهAirway epithelial cells - سلول های اپیتلیال هواییKeratan sulfate - سولفات برشlipopolysaccharide - لیپوپلی ساکاریدMatrix metalloprotease - ماتریکس متیل پروتئازایN-acetylglucosamine - نیتستیگلوکوزامینHyaluronan - هیالورونانHorseradish peroxidase - پراکسیداز هوررادیشpoly(I:C) - پلی (I: C)Polyinosinic:polycytidylic acid - پلی سونیک: پلیسییدیدیل اسیدChondroitin sulfate - کندرویتین سولفاتGlycosaminoglycans - گلیکوز آمینو گلیکان هاEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمالToll-like receptors - گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells](/preview/png/10759331.png)
چکیده انگلیسی
Bacterial or viral infection of the airway plays a critical role in the pathogenesis and exacerbation of chronic obstructive pulmonary disease (COPD) which is expected to be the 3rd leading cause of death by 2020. The induction of inflammatory responses in immune cells as well as airway epithelial cells is observed in the disease process. There is thus a pressing need for the development of new therapeutics. Keratan sulfate (KS) is the major glycosaminoglycans (GAGs) of airway secretions, and is synthesized by epithelial cells on the airway surface. Here we report that a KS disaccharide, [SO3--6]Galβ1-4[SO3--6]GlcNAc, designated as L4, suppressed the production of Interleukin-8 (IL-8) stimulated by flagellin, a Toll-like receptor (TLR) 5 agonist, in normal human bronchial epithelial (NHBE) cells. Such suppressions were not observed by other L4 analogues, N-acetyllactosamine or chondroitin-6-sulfate disaccharide. Moreover, treatment of NHBE cells with L4 inhibited the flagellin-stimulated phosphorylation of epidermal growth factor receptor (EGFR), the down stream signaling pathway of TLRs in NHBE cells. These results suggest that L4 specifically blocks the interaction of flagellin with TLR5 and subsequently suppresses IL-8 production in NHBE cells. Taken together, L4 represents a potential molecule for prevention and treatment of airway inflammatory responses to bacteria infections, which play a critical role in exacerbation of COPD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 435, Issue 3, 7 June 2013, Pages 460-465
Journal: Biochemical and Biophysical Research Communications - Volume 435, Issue 3, 7 June 2013, Pages 460-465
نویسندگان
Ken Shirato, Congxiao Gao, Fumi Ota, Takashi Angata, Hidehiko Shogomori, Kazuaki Ohtsubo, Keiichi Yoshida, Bernd Lepenies, Naoyuki Taniguchi,