Keywords: LPS binding protein; Neutrophil; Pam3CSK4; Priming; Respiratory burst; Serum;
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Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2
Keywords: TLR2; toll-like receptor 2; P-NF-κBp65; phosphorylated nuclear factor -κBp65; NLRP3; NOD-like receptor pyridine containing 3; OVA; ovalbumin; Lidocaine; Allergic airway inflammation; TLR2; Pam3CSK4; NLRP3;
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Keywords: TLR; Toll-like receptor; TRIF; Toll/IL-1R domain-containing adaptor inducing IFN-β; LPS; lipopolysaccharide; KD; kinase-dead; IRAK; IL-1R-associated kinase; ISG; interferon stimulated gene; PIP3; phosphatidylinositol (3,4,5) trisphosphate; PH; pleckstrin
Research paperAdhesion attenuates respiratory burst induced by different modes of triggering in resting or LPS-primed neutrophils
Keywords: BSA; bovine serum albumin; fMLP; N-formyl-methionyl-leucyl-phenylalanine; IL-8; interleukin-8; LPS; lipopolysaccharide; O2â; superoxide anion; Pam3CSK4; tripalmitoyl-S-glyceryl-l-Cys-Ser-(Lys)4; PBS; phosphate buffered saline; poly HEMA; polyhydroxyl-et
Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants
Keywords: APC; antigen presenting cell; CFA; Complete Freunds' Adjuvant; CFSE; 5,6-carboxy-succinimidyl-fluoresceine-ester; CL; contralateral; DC; dendritic cell; DDA; dimethyldioctadecylammonium bromide; dLN; draining lymph node; hPG; human proteoglycan; hpi; ho
Research PaperThe toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury
Keywords: 2PE; Two-photon excitation; CNPase; 2â²-3â²-cyclic nucleotide 3â²-phosphodiesterase; Pam3CSK4; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-[R]-cysteinyl-[S]-seryl-[S]-lysyl-[S]-lysyl-[S]-lysyl-[S]- lysine; SCI; Spinal cord injury; TLR; Toll-like
A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells
Keywords: IL-1β; interleukin 1-beta; IL-18; interleukin-18; LPS; lipopolysaccharide; MSU; monosodium urate crystals; Pam3CSK4; synthetic triacylated lipopeptide; BMDM; bone marrow-derived macrophage; PBMC; peripheral blood mononuclear cell; DAMP; damage-associated
Enhanced immunostimulatory activity of in silico discovered agonists of Toll-like receptor 2 (TLR2)
Keywords: AG; agonist; BMDMs; bone marrow-derived macrophages; DC; dendritic cell; LPS; lipopolysaccharide; NF-kB; nuclear factor-kB; Pam3CSK4; S-[2,3-Bis(palmitoyloxy)propyl]-N-palmitoyl-l-cysteinyl-l-seryl-l-lysyl-l-lysyl-L-lysyl-l-lysine; Pam2CSK4; S-[(2R)-2,3-B
House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling
Keywords: AD; atopic dermatitis; DFE; Dermatophagoides farinae extract; DN; dominant negative; FSL-1; TLR2/TLR6 agonist, synthetic diacylated lipoprotein; HDM; house dust mite; IKK; IκB kinase; ILC; innate lymphoid cell; LPS; lipopolysaccharide; NOD2; nucleotide-b
Molecular and functional characterization of Toll-like receptor (Tlr)1 and Tlr2 in common carp (Cyprinus carpio)
Keywords: Toll-like receptor; Innate immunity; Heterodimer; TLR signalling; Teleost; BSA; bovine serum albumin; GFP; green fluorescent protein; IRAK1; interleukin-1 receptor-associated kinase 1; LRR; leucine-rich repeat; LTA; lipoteichoic acid; MYD88; myeloid diffe
Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a phosphatidylinositol-3-kinase dependent manner
Keywords: Akt; Echinacea; Polysaccharide; Pam3Csk4; PI3K; THP-1;
In vitro innate immune cell based models to assess whole cell Bordetella pertussis vaccine quality: A proof of principle
Keywords: Bordetella pertussis; Vaccines; In vitro; Innate immunity; Consistency approach; Alternatives to animal experiments; B. pertussis; Bordetella pertussis; wP; whole cell Bordetella pertussis; APC; antigen presenting cells; moDC; monocyte derived dendritic
The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade
Keywords: Human platelets; TLR2; Pam3CSK4; Syk; LAT; PLCγ2;
Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production
Keywords: APBTs; activated peripheral blood T cells; APC; antigen presenting cells; IFN-γ; interferon-γ; PAM; PAM3CSK4; Toll-like receptor 5; T cell receptor; T cells; Signal transduction;
Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells
Keywords: #COPD; chronic obstructive pulmonary disease; TLRs; Toll-like receptors; GAG; glycosaminoglycans; NHBE; normal human bronchial epithelial; KS; keratan sulfate; HA; hyaluronan; CS; chondroitin sulfate; MMP; matrix metalloprotease; LPS; lipopolysaccharide;
Calpastatin is upregulated in non-immune neuronal cells via toll-like receptor 2 (TLR2) pathways by lipid-containing agonists
Keywords: LPP; lipoproteins; LPS; lipopolysaccharide; LTA; lipoteichoic acid; MALP-2; macrophage activating lipopeptide 2; NDMh; neuroblastoma derived Mycoplasma hyorhinis; PAM3CSK4; synthetic bacterial lipopeptide Pam3-Cys-Ser-Lys4; PGN; peptidoglycan; TDE; synthe
The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
Keywords: BMDCs; bone marrow-derived dendritic cells; BMDMs; bone marrow-derived macrophages; CpG; CpG motif containing oligonucleotide 1826; DC; dendritic cell; E. coli; Escherichia coli O18; HDAC; histone deacetylase; LPS; lipopolysaccharide; MKP; MAPK phosphatas
Pam3CSK4/TLR2 signaling elicits neutrophil recruitment and restricts invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine mastitis model
Keywords: Mastitis; Neutrophils; Murine model; Toll-like receptor; Pam3CSK4
Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo
Keywords: GRK5; TLR4; TLR2; TLR3; Inflammatory cytokines; Poly(I:C); Pam3CSK4
Major Stress Hormones Suppress the Response of Macrophages Through Down-Regulation of TLR2 and TLR4
Keywords: Toll-like receptors; glucocorticoids; catecholamines; macrophages; Pam3CSK4; lipopolysaccharide
High-density lipoprotein phospholipids interfere with dendritic cell Th1 functional maturation
Keywords: VLDL; very low density lipoprotein; IDL; intermediate density lipoprotein; LDL; low density lipoprotein; HDL; high density lipoprotein; oxLDL; oxidized LDL; Apo; apolipoprotein; DC; dendritic cells; IL; interleukin; IFN; interferon; TLR; Toll-like recepto
Functional consequences of CD36 downregulation by TLR signals
Keywords: FSL1; Pam2CGDPKHPKSF; LPS; Lipopolysaccharide; OxLDL; Oxidized low-density lipoprotein; Pam3CSK4; Pam3CysSerLys4; PPAR-γ; Peroxisome proliferator-activated receptor gamma; Scavenger receptor; Phagocytosis; Monocytes;
Shock/Sepsis/Trauma/Critical CareSystemic inflammation after aortic cross clamping is influenced by Toll-like receptor 2 preconditioning and deficiency
Keywords: Toll-like receptor 2; Ischemia/reperfusion; Aortic cross clamping; Systemic inflammation; Cytokines; Pam3CSK4; Organ dysfunction;
Avian-specific TLRs and downstream effector responses to CpG-induction in chicken macrophages
Keywords: LPS; lipopolysaccharide; TLR; toll-like receptor; MyD88; myeloid differentiation primary response gene 88; ODN; oligonucleotide; NLR; nod-like receptor; PRR; pattern recognition receptor; PAMP; pathogen associated molecular patterns; RLR; RIG-I like recep
Alendronate augments interleukin-1β release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1
Keywords: Bisphosphonates (BPs); Porphyromonas gingivalis; Tannerella forsythia; Interleukin-1β (IL-1β); Tumor necrosis factor α (TNFα); Alendronate; Clodronate; Pam3CSK4; Lipid A; Caspase-1;
Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
Keywords: Toll-like receptor 2; Pam3CSK4; Cerebral ischemia; Blood-brain barrier; Mouse
Stimulation of mast cells via FcɛR1 and TLR2: The type of ligand determines the outcome
Keywords: FcɛR1; MALP-2; Pam3CSK4; TLR2; Antigen; Lipopeptides; Calcium mobilization; Degranulation; IL-6