Keywords: bFGF; basic fibroblast growth factor; BJ-iPSC; BJ fibroblast-derived induced pluripotent stem cell; CRISPR/Cas9; clustered regularly interspaced palindromic repeats/CRISPR-associated; DAPI; 4â²,6-diamidino-2-phenylindole; EB; epidermolysis bullosa; EBKC-
مقالات ISI (ترجمه نشده)
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Keywords: DSC1; desmocollin 1; EV; extracellular vesicle; FLG; filaggrin; KRT10; keratin 10; MAPK; mitogen-activated protein kinase; NHEK; normal human epidermal keratinocyte; PBMC; peripheral blood mononuclear cell; PEV; P. acnes-derived EV; siRNA; small interferi
Keywords: AD; atopic dermatitis; ARTN; artemin; HSD11β1; 11β-hydroxysteroid dehydrogenase-1; GC; glucocorticoid; GR; glucocorticoid receptor; HC; healthy control individual; Hsd11b1KC-/-; keratinocyte-specific Hsd11b1-knockout; NHEK; normal human epidermal ke
Keywords: BM; bone marrow; BMSC; bone marrow stem cells; BSA; body surface area; CTACK; cutaneous T cell-attracting chemokine; DDEB; dominant dystrophic epidermolysis bullosa; DEJ; dermo-epidermal junction; EB; epidermolysis bullosa; EBK; epidermolysis bullosa kera
Keywords: NHEK; normal human epidermal keratinocyte; SAA; serum amyloid A; Th; T helper; TNF; tumor necrosis factor;
Keywords: RSV; resveratrol (3,5,4â²-trihydroxy-trans-stilbene); SIRT1; sirtuin 1; PDE4; phosphodiesterase 4; ROS; reactive oxygen species; HNE; 4-hydroxy-2-nonenal; GSH; glutathione; KBM; keratinocyte basal medium; KGM; keratinocyte growth medium; NHEK; neonatal n
Keywords: BPE; bovine pituitary extract; CIA; chemotherapy-induced alopecia; EGF; epidermal growth factor; FBS; fetal bovine serum; HaCaTa; adapted HaCaT; HHFK; human hair follicular keratinocytes; 4-OH-CP; 4-hydroxycyclophosphamide; KSFM; keratinocyte serum-free m
A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin
Keywords: ACD; Allergic contact dermatitis; COMT; catechol-O-methyl transferases; GST; glutathione-S-transferases; HaCaT; Immortalised keratinocytes “Human Adult Low Calcium High Temperature”; NAT; N-acetyltransferases; NHEK; Normal Human Epidermal Keratinocyte
The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes
Keywords: α-MEM; alpha minimum essential medium; bFGF; basic fibroblast growth factor; BIO; 6-bromoindirubin-3â²-oxime; BM-MSCs; bone marrow-derived MSCs; BMP4; bone morphogenetic protein 4; C57BL/6; C57BL/6 mouse; CM; conditioned medium; DAPI; 4â²,6-diamidino-2
Pre-malignant transformation by senescence evasion is prevented by the PERK and ATF6alpha branches of the Unfolded Protein Response
Keywords: Endoplasmic reticulum; Unfolded protein response; ATF6α; PERK; Senescence; Post-senescence neoplastic emergence; Normal human epidermal keratinocyte; PSNE; Post-Senescence Neoplastic Emergence; UPR; Unfolded Protein Response; NHEK; Normal Human Epidermal
β-1,3/1,4-Glucan Lichenan from Cetraria islandica (L.) ACH. induces cellular differentiation of human keratinocytes
Keywords: Lichenan; Keratinocytes; Differentiation; Involucrin; Keratin; Microarray; CLSM; Confocal laser scanning microscopy; CK; Cytokeratin 10; CREB; Transcription factor cAMP response element-binding protein; DP; Degree of polymerization; EGFR; Epidermal growth
A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation
Keywords: NHEK; normal human epidermal keratinocyte;
EphA2 Transmembrane Domain Is Uniquely Required for Keratinocyte Migration by Regulating Ephrin-A1 Levels
Keywords: ANOVA; analysis of variance; NHEK; normal human epidermal keratinocyte; RHE; reconstituted human epidermis; RTK; receptor tyrosine kinase; TMD; transmembrane domain;
CCN1/Cyr61 Stimulates Melanogenesis through Integrin α6β1, p38 MAPK, and ERK1/2 Signaling Pathways in Human Epidermal Melanocytes
Keywords: NHEK; normal human epidermal keratinocyte; NHEM; normal human epidermal melanocyte; siRNA; small interfering RNA;
Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes
Keywords: 2-APB; 2-aminoethoxydiphenyl-borate; NHEK; normal human cultured keratinocyte; RNAi; RNA interference; TRP; transient receptor potential;
High Expression of Collagen XVII Compensates for its Depletion Induced by Pemphigoid IgG in the Oral Mucosa
Keywords: BMZ; basement membrane zone; BP; bullous pemphigoid; COL17; collagen XVII; COL7; collagen VII; Dsg; desmoglein; ECM; extracellular matrix; MMP; mucous membrane pemphigoid; NC; noncollagenous; NHEK; normal human epidermal keratinocyte; NHOM; normal human o
CON4EI: EpiOcular⢠Eye Irritation Test (EpiOcular⢠EIT) for hazard identification and labelling of eye irritating chemicals
Keywords: DBALM; Database of Alternative Methods at the European Commission's Joint Research Centre; Cat 1; UN GHS/EU CLP classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS/EU CLP classification for chemica
CON4EI: CONsortium for in vitro Eye Irritation testing strategy - EpiOcular⢠time-to-toxicity (EpiOcular ET-50) protocols for hazard identification and labelling of eye irritating chemicals
Keywords: DBALM; Database of Alternative Methods at the European Commission's Joint Research Centre; Cat 1; UN GHS/EU CLP classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS/EU CLP classification for chemica
Integrin-β4-TNS4-Focal Adhesion Kinase Signaling Mediates Keratinocyte Proliferation in Human Skin
Keywords: ERK; extracellular signal-regulated kinases; GFP; green fluorescent protein; FAK; focal adhesion kinase; ITGB; integrin β; NHEK; normal human epidermal keratinocyte; siRNA; small interfering RNA;
Topically Delivered Tumor Necrosis Factor-α-Targeted Gene Regulation for Psoriasis
Keywords: 3D; three dimensional; IMQ; imiquimod; L-SNA; liposomal-cored spherical nucleic acid; NHEK; normal human epidermal keratinocyte; Scr; scrambled liposomal-cored spherical nucleic acid control sample; SNA; spherical nucleic acid; TNF-α; tumor necrosis fact
Palladium and Platinum Nanoparticles Activate AHR and NRF2 in Human Keratinocytes-Implications in Vitiligo Therapy
Keywords: AHR; aryl hydrocarbon receptor; CYP1A1; cytochrome P450 family 1 subfamily A member 1; CXCL; chemokine (C-X-C motif) ligand; NHEK; normal human epidermal keratinocyte; NRF2; nuclear factor (erythroid-derived 2)-like 2; NQO1; NAD(P)H quinone dehydrogen
The silymarin composition⦠and why does it matter???
Keywords: ADME; absorption, distribution, metabolism, and excretion; ASTM; American Society for Testing and Materials; NHDF; normal human dermal fibroblasts; NHEK; normal human epidermal keratinocytes; PE; petroleum ether; LC-MS; liquid chromatography-mass spectr
IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A
Keywords: NHEK; neonatal human epidermal keratinocyte; poly(I:C); polyinosinic:polycytidylic acid; TLR; toll-like receptor; TNF-α; tumor necrosis factor-α; TRIF; TIR-domain-containing adapter-inducing IFN-β; VDR; vitamin D receptor;
After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration
Keywords: dsRNA; double-stranded RNA; HPGD; 15-hydroxyprostaglandin dehydrogenase; NHEK; normal human epidermal keratinocyte; PGE2; prostaglandin E2; poly(I:C); polyinosinic:polycytidylic acid; PTGS; prostaglandin-endoperoxide synthase 2; PWD; post-wounding day; si
Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1
Keywords: PAH; polycyclic aromatic hydrocarbons; UFP; ultrafine particles; PM; particulate matter; PME; particulate matter extract; d-UV; daily ultraviolet; BaP; benzo[a]pyrene; IcdP; indeno[1,2,3-cd]pyrene; GSH; reduced glutathione; BSO; buthionine sulfoximine; Ph
Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility
Keywords: AS; antisense oligonucleotide; GCS; glucosylceramide synthase; GCSI; glucosylceramide synthase inhibitor; GM3S; ganglioside GM3 synthase; IGF-1; insulin-like growth factor-1; IGF1R; insulin-like growth factor-1 receptor; IR; insulin receptor; M2D3; GM2/GD
Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation
Keywords: ATP; adenosine triphosphate; BMDC; bone marrow-derived dendritic cell; CrO42-; potassium chromate; Cr2O72-; potassium dichromate; Cr3+; chromium chloride; chromium (III); trivalent chromium; chromium (VI); hexavalent chromium; DAMP; damage-associated
SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol
Keywords: LPS; lipopolysaccharide; MMP-9; matrix metalloproteinase; NHEK; normal human epidermal keratinocyte; PGE2; prostaglandin E2; siRNA; small interfering RNA; TNF-α; tumor necrosis factor-α;
Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus
Keywords: CDLE; chronic discoid lupus erythematosus; CLE; cutaneous lupus erythematosus; eNA; endogenous nucleic acid; LE; lupus erythematosus; NHEK; normal human epidermal keratinocyte; PRR; pattern recognition receptor; TLR; toll-like receptor;
Adenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis
Keywords: AR; adenosine receptors; BAY; BAY60-6583; CGS; CGS-21680; iCa2+; intracellular calcium; MRS; MRS-1706; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NECA; 5'-N-ethylcarboxamidoadenosine; NHEK; normal human epidermal keratinocyte; SC
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes
Keywords: 2-DG; 2-deoxyglucose; ChIP; chromatin immunoprecipitation; ECAR; extracellular acidification rate; GFP; green fluorescent protein; nHEK; neonatal human epidermal keratinocyte; PFK1; phosphofructokinase-1; siRNA; small interfering RNA;
Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes
Keywords: AD; atopic dermatitis; DSG-1; desmoglein-1; FLG; filaggrin; KLK; kallikrein; MMP; matrix metalloproteinase; NHEK; normal human epidermal keratinocyte; Pro-FLG; profilaggrin; RT; room temperature; siRNA; small interfering RNA; TSB; tryptic soy broth;
Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity
Keywords: AK; actinic keratosis; cSCC; cutaneous squamous cell carcinoma; cSCCIS; cSCC in situ; DUSP; dual-specificity phosphatase; ERK; extracellular signal-regulated kinase; FC; fold change; lncRNA; long noncoding RNA; JNK; c-Jun N-terminal kinase; MAPK; mitogen-
The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease
Keywords: AKR1B10; aldo-keto reductase family 1, member B10; ALDH; aldehyde dehydrogenase; CRABP; cellular retinoic acid binding protein; CYP26; cytochrome P450, family 26; KD; keloid disease; KE; keloid epidermis; KF; keloid fibroblast; LCM; laser capture microdis
The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation
Keywords: Ca2+; calcium; [Ca2+]i; intracellular calcium; ER; endoplasmic reticulum; FLG; filaggrin; KRT14; keratin-14; NHEK; normal human epidermal keratinocytes; PCNA; proliferating cell nuclear antigen; PTH; parathyroid hormone; PTHrP; PTH-related peptide; PTH2R;
Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation
Keywords: ITAM; immunoreceptor tyrosine-based activation motif; NHEK; normal human epidermal keratinocytes; PMA; phorbol 12-myristate 13-acetate; siRNA; small interfering RNA; Syk; spleen tyrosine kinase; TGase; transglutaminase;
Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation
Keywords: BSTFA-TMS; N,O-bis(trimethylsilyl)trifluoracetamide-trimethylsilylether; CLSM; confocal laser scanning microscopy; EtOH; ethanol; EtOAc; ethyl acetate; HPLC; high pressure liquid chromatography; LDH; lactate dehydrogenase; MeOH; methanol; NHEK; natural hu
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
Keywords: Sirtuin 1 (SIRT1); skin barrier; filaggrin; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; ARNT; Aryl hydrocarbon receptor nuclear translocator; BaP; Benzo(a)pyrene; cHet; Epidermis-specific heterozygous SIRT1 deletion; cKO; Epidermis-specific hom
Nrf2-A regulator of keratinocyte redox signaling
Keywords: AHR; Aryl hydrocarbon receptor; ARE; antioxidant response element; DMBA; 7,12-dimethylbenz[a]anthracene; HO-1; heme oxygenase 1; NHEK; normal human epidermal keratinocytes; NQO1; NAPD(H) dehydrogenase, quinone 1; Nrf2; nuclear factor erythroid 2-like 2; S
Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells
Keywords: B2M; β-2 microglobulin; CAIX; carbonic anhydrase IX; CYPA; cyclophilin A; DFO; desferrioxamine; NHEK; normal human epidermal keratinocytes; HIF; hypoxia-inducible factor; H/R; hypoxia/reoxygenation; HRE; hypoxia-response element; HSP; heat shock protein;
Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions
Keywords: MicroRNA; apoptosis; drug eruption; keratinocyte; serum; BCL2L10; B-cell lymphoma/leukemia-2-like protein 10; BSA; Body surface area; Ct; Cycle threshold; EM; Erythema multiforme; miRNA; MicroRNA; NHEK; Normal human epidermal keratinocyte; siRNA; Small in
Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects
Keywords: AEOL 10150; Mn(III) tetrakis(N,Nâ²-diethylimidizolium-2-yl)porphyrin; BrdU; 5-bromo-2â²-deoxyuridine; CEES; 2-chloroethylethyl sulfide; DHE; dihydroethidium; GSH; reduced glutathione; 16HBE cells; human bronchial epithelial cells; SAE cells; primary sma
Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis
Keywords: α-ENO; α-enolase; AD; atopic dermatitis; CAIII; carbonic anhydrase III; Cu,Zn-SOD; copper and zinc-containing superoxide dismutase; NHEK; normal human epidermal keratinocyte; KTII; keratin type II; 6-NO2Trp; 6-nitrotryptophan; 3-NO2Tyr; 3-nitrotyrosine;
Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard
Keywords: SM; sulfur mustard; NHEK; normal human epidermal keratinocytes; MAPK; mitogen activated protein kinase; siRNA; small interfering RNA; MK2/MAPKAPK2; MAPK activated kinase 2; MK3/MAPKAPK3; MAPK activated kinase 3; MK5/MAPKAPK5; MAPK activated kinase 5; TNF-
An insight into the role of barrier related skin proteins
Keywords: NHEK; normal human-derived epidermal keratinocytes; SC; stratum corneum; EI; electrical impedance; ER; enhancement ratio; IP; irritation potential; DID; diisopropyl adipate; DS; diethyl sebacate; IS; diisopropyl sebacate; IM; isopropyl myristate; NMP; n-m
Typha latifolia L. fruit polysaccharides induce the differentiation and stimulate the proliferation of human keratinocytes in vitro
Keywords: AGP; arabinogalactan protein; AEC; anion exchange chromatography; CK; cytokeratin; FCS; fetal calf serum; HaCaT; human adult low calcium high temperature keratinocyte; NaPB; sodium phosphate buffer; NHDF; normal human dermal fibroblasts; NHEK; normal huma
CCL27 expression is regulated by both p38 MAPK and IKKβ signalling pathways
Keywords: MAPK; mitogen-activated protein kinase; MSK; mitogen- and stress-activated protein kinase; Mnk; mitogen-activated protein kinase (MAPK)-interacting kinase; IκB; inhibitory κB; IKK; IκB kinase; NF-κB; nuclear factor-κB; NHEK; normal human epidermal ke
Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation - A novel paradigm for Gq/11 linked GPCRs
Keywords: PAR-2; proteinase-activated receptor-2; PAR-2 AP; PAR-2 activating peptide; 2f-LIGKV-OH; 2-furoyl-LIGKV-hydroxyl; JNK; c-jun N-terminal protein kinase; NFκB; nuclear factor kappa B; PKC; protein kinase C; MAP kinase; mitogen-activated protein kinase; PMA
Skin cells and tissue are capable of using l-ergothioneine as an integral component of their antioxidant defense system
Keywords: ROS; reactive oxygen species; EGT; l-ergothioneine; NHDF; normal human dermal fibroblasts; NHEK; normal human epidermal keratinocytes; ssUV; solar-simulating UV; PBS; phosphate-buffered saline; BSA; bovine serum albumin; HRP; horseradish peroxidase; l-Erg
Vitamin D3 inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis
Keywords: BP; bullous pemphigoid; BPAG; bullous pemphigoid antigen; ELISA; enzyme-linked immunosorbent assay; NHEK; normal human epidermal keratinocytes; VD3; vitamin D3; Keratinocyte; Basement membrane zone; Promoter; Gene;