کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10737858 | 1046630 | 2015 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nrf2-A regulator of keratinocyte redox signaling
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کلمات کلیدی
AHRHO-1DMBANQO1NHEK7,12-Dimethylbenz[a]anthracene - 7،12-Dimethylbenz [a] آنتراسنantioxidant response element - عنصر پاسخ آنتی اکسیدانARE - هستندheme oxygenase 1 - همای اکسیژناز 1normal human epidermal keratinocytes - کراتینوسیت های اپیدرمی طبیعی انسانaryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals, and mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging, and even cancer development. Therefore, an efficient antioxidant defense strategy is of major importance in this tissue. Since the Nrf2 transcription factor regulates a battery of genes involved in the defense against reactive oxygen species and in compound metabolism, it plays a key role in skin homeostasis, repair, and disease. In this review we summarize current knowledge on the expression and function of Nrf2 in normal skin and its role in the acute and chronic UV response as well as in the pathogenesis of epithelial skin cancer and of different inflammatory skin diseases. Finally, we discuss the potential of Nrf2-activating compounds for skin protection under stress conditions and for the treatment of major human skin disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 88, Part B, November 2015, Pages 243-252
Journal: Free Radical Biology and Medicine - Volume 88, Part B, November 2015, Pages 243-252
نویسندگان
Matthias Schäfer, Sabine Werner,