Resveratrol: An overview of its anti-cancer mechanisms
Keywords: Resveratrol; Cancer metabolism; Nrf2; NLRP3; MAPK; NFkB; MKP-1; Autophagy;
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Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release
Keywords: NAFLD; Non-alcoholic fatty liver disease; NLRP3; NACHT, LRR, and PYD domains-containing protein 3; NAFL; Non-alcoholic fatty liver; NASH; non-alcoholic steatohepatitis; FFA; free fatty acid; PA; palmitic acid; KCs; Kupffer cells; MCD; methionine choline d
MiR-223-3p overexpression inhibits cell proliferation and migration by regulating inflammation-associated cytokines in glioblastomas
Keywords: MiR-223-3p; NLRP3; GBM; Inflammation;
Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease
Keywords: atherosclerosis; clinical trial; inflammation; interleukin-1; CI; confidence interval; CKD; chronic kidney disease; eGFR; estimated glomerular filtration rate; HR; hazard ratio; hsCRP; high sensitivity C-reactive protein; IL; interleukin; NLRP3; (NOD)-lik
DNA damage, metabolism and aging in pro-inflammatory T cells
Keywords: EC; endothelial cell; ROS; reactive oxygen species; ATP; adenosine 5â²-triphosphate; ER; endoplasmic reticulum; mtDNA; mitochondrial DNA; ETC; electron transport chain; mROS; mitochondrial ROS; NADPH; nicotinamide adenine dinucleotide phosphate; TNF-α;
Synthesis of 1,5-Anhydro-d-fructose derivatives and evaluation of their inflammasome inhibitors
Keywords: Carbohydrates; 1,5-Anhydro-d-fructose derivatives; Enones; Inflammasome; NLRP3;
Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages
Keywords: ANOVA; analysis of variance; BMM; bone marrow-derived macrophages; BSA; bovine serum albumin; CVD; cardiovascular diseases; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulphoxide; DHE; dihydroethidium; EDTA; ethylenediaminetetraacetic acid; FBS;
The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β
Keywords: Naringenin; Gout arthritis; Pain; Inflammation; NFκB; Inflammasome; ABTS; 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate; ALT; alanine transaminase; ASC; apoptosis-associated speck-like protein containing a CARD; AST; aspartate transaminase; BMDMs; bone
Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation
Keywords: LPS; lipopolysaccharide; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; NLRP3; nucleotide-binding oligomerization domain-like receptor with pyrin domain 3; ASC; apoptosis-associated speck-like protein containing a caspase-recruiting do
Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice
Keywords: Apoptosis-Inflammation-Ischemic stroke-tPA-SMTP-7; BSA; bovine serum albumin; CBF; cerebral blood flow; CCA; common carotid artery; d; days; DAB; 3,3â²-diaminobenzidine; ECA; external carotid artery; ECL; enhanced chemiluminescent; EET; epoxyeico
Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis
Keywords: ALP; alkaline phosphatase; BI-RADS; Breast Imaging Reporting and Data System; BMP2; bone morphogenetic protein 2; BSP; bone sialoprotein; CA1; carbonic anhydrase I; COX2; cyclooxygenase-2; DCIS; ductal carcinoma in situ; EMT; epithelial-mesenchymal transi
Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations
Keywords: Sjögren's syndrome; Inflammasome; DNase-I; DNase-II; Peripheral blood; Salivary glands; SS-LR; SS patients with low risk for lymphoma development; SS-HR; SS patients with high risk for lymphoma development; SS-Ly; SS patients complicated with mucosa-asso
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome
Keywords: 10-11 translocation 2; clonal hematopoiesis; heart failure; interleukin-1beta; myocardial infarction; pressure overload hypertrophy; ANOVA; analysis of variance; BMT; bone marrow transplantation; CVD; cardiovascular disease; HSPC; hematopoietic stem or pr
Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice
Keywords: Compound K; Nox1; TXNIP; NLRP3; Diabetic nephropathy; p38;
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Keywords: ASC; apoptosis-associated speck-like protein; CPT-1; carnitine palmitoyl transferase-1; GST; glutathione S-transferase; HO-1; hemeoxygenase-1; H2O2; hydrogen peroxide; IL; interleukin; Keap1; Kelch-like ECH-associated protein 1; MDA; malondialdehyde; miR-
ATP/P2X7-NLRP3 axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion
Keywords: Th; type helper; IL; interleukin; AHR; hyper-responsiveness; HMGB1; high mobility protein 1; DCs; dendritic cells; BMDCs; bone marrow-derived mononuclear cells; DAMPs; damage-associated molecular patterns; PAMP; pathogen-associated molecular patterns; RAG
Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis
Keywords: Blood-brain barrier; Cerebral venous thrombosis; MMP9; NLRP3; Neuroinflammation; Sinus thrombosis;
Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway
Keywords: LPS; lipopolysaccharide; NO; nitric oxide; TNF-α; tumor necrosis factor; IL-1β; interleukin; ROS; reactive oxygen species; iNOS; inducible nitric oxide synthase; NLRP3; NLR family pyrin domain-containing protein 3; NF-κB; NF-KappaB; CNS; central nervou
3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates NLRP3 inflammasome-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglial cells
Keywords: Inflammasome; NLRP3; Proinflammatory cytokines; Microglia; Azetidine derivative;
An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes
Keywords: Procaspase-1; Inflammasome; Whole blood assay; NLRP3; AIM2; NLRC4;
NLRP3 inflammasome activation by mycobacterial ESAT-6 and dsRNA in intraocular tuberculosis
Keywords: Intraocular tuberculosis; Inflammasome; NLRP3; ESAT-6; RNA;
The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia
Keywords: NLRP3; Inflammasome; Polymorphisms; Chronic myeloid leukemia;
Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C
Keywords: CS; Complement System; C7; Complement Component 7; MAC; Membrane Attack Complex; HCC; Hepatocellular Carcinoma; PCR; Polymerase Chain Reaction; OR; Odds Ratio; CI; Confidence Interval; HCV; Hepatitis C Virus; SNP; Single Nucleotide Polymorphism; RNA; Ribo
Darunavir alleviates irinotecan-induced intestinal toxicity in Vivo
Keywords: Darunavir; Irinotecan; Inflammation; HMGB1; NLRP3;
NLRP3 inflammasome is involved in the recognition of Paracoccidioides brasiliensis by human dendritic cells and in the induction of Th17 cells
Keywords: NLRP3; IL-1beta; IL-18; Dendritic cells; Paracoccidioidomycosis; Th17;
Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice
Keywords: Pancreatic Inflammation; Mechanisms; Immune Response; Mouse Model; ATP; adenosine triphosphate; BMDM; bone marrow-derived macrophages; CCK; cholecystokinin; CTSB; cathepsin B; CTSL; cathepsin L; DAMP; damage-associated molecular pattern; IL; interleukin;
TNFAIP3 haploinsufficiency is the cause of autoinflammatory manifestations in a patient with a deletion of 13Mb on chromosome 6
Keywords: Autoinflammatory diseases; Behçet's disease; TNFAIP3; Comparative Genomic Hybridization (CGH); Chromosome deletion; Oral ulcer; ESID; European Society for Immunodeficiencies; ENT; Ear-nose-throat; NF-kB; Nuclear factor kappa-light-chain-enhancer of act
Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain
Keywords: Electroacupunture; CB2 receptor; Inflammasome; NLRP3; ASC; Caspase-1; Inflammatory pain;
Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia
Keywords: Estrogen; Progesterone; Astrocytes; BV-2; Neuroprotection; Neuroinflammation; NLRP3;
NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model
Keywords: Parkinson's disease; Thymus; MPTP; Inflammasome; NLRP3; α-Synuclein;
Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages
Keywords: AA; arachidonic acid; ATM; adipose tissue macrophages; BMDM; bone marrow-derived macrophages; Cer; ceramide; COX2; cyclooxygenase 2; DAG; diacylglycerol; DAMP; damage-associated molecular pattern; Des; dihydroceramide desaturase; FFA; free fatty acid; γT
Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review
Keywords: NCBI; National Centre for Biotechnology Information; SARS; Severe acute respiratory syndrome; NO; Nitric Oxide; LPS; Lipopolysaccharide; NF-κB; Nuclear factor kappa B; ROS; Reactive Oxygen Species; TNF-α; Tumor Necrosis Factor-α; IL; Interleukin; MCP-1
Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway
Keywords: lncRNAs; long noncoding RNAs; LPS; lipopolysaccharide; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NLRP3; nod-like receptor protein 3; PD; Parkinson's disease; SNHG1; small nucleolar RNA host gene 1; SNpc; substantia nigra pars compacta; TNF; tu
The enigmatic role of IL-38 in inflammatory diseases
Keywords: IL-1F; interleukin 1 family; RA; rheumatoid arthritis; AS; ankylosing spondylitis; PsA; psoriatic arthritis; CRP; C-reactive protein; TH; T Helper; PBMCs; peripheral blood mononuclear cells; SLE; systemic lupus erythematous; IL-1RacP; IL-1 receptor access
Weicao capsule ameliorates renal injury through increasing autophagy and NLRP3 degradation in UAN rats
Keywords: Weicao; Autophagy; NLRP3; Inflammation; UAN;
Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression
Keywords: Dexmedetomidine; Acute pancreatitis; Inflammatory response; NLRP3; Sympathetic activation;
The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation
Keywords: SGK1; serum-glucocorticoid regulated kinase 1; Ang II; Angiotension II; IL; interleukin; TGF-β; transforming growth factor-β; CTGF; connective tissue growth factor; TNF-α; tumor necrosis factor-α; IFN-γ; Interferon-γ; ASC; apoptosis associated speck
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Keywords: AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Keywords: Organelle communication; Mitochondria-associated membranes; Nutrients; Microbiome; Innate immunity; Insulin sensitivity; Metabolic diseases; Ca2+; calcium; CLRs; C-type lectin receptors; CypD; cyclophilin D; DAMPs; Danger-Associated Molecular patterns; ER
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
Keywords: NLRP3; Nod-like receptor family, pyrin domain-containing 3; HAECs; human aortic endothelial cells; MCM; macrophage-conditioned medium; MnSOD; manganese superoxide dismutase; mtROS; mitochondrial reactive oxygen species; PMA; phorbol-12-myristate-13-acetat
Glucocorticoid Upregulates Thioredoxin-interacting Protein in Cultured Neuronal Cells
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; CORT; corticosterone; DMEM; Dulbecco's Modified Eagle Media; GR; glucocorticoid receptor; HPA; hypothalamicpituitary-adrenal; IL; interleukin; MMTS; methyl methaneth
Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway
Keywords: Intervertebral disc degeneration; Honokiol; TXNIP; NLRP3; ROS;
An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes' extracts traditionally used in Rwanda for asthma treatment
Keywords: FETAX; Frog Embryo Teratogenesis Assay - Xenopus; WHO; World Health Organization; COPD; Chronic Obstructive Pulmonary Disease; Th2; T helper 2; Th17; T helper 17; IL-1β; Interleukin one beta; TNF-α; Tumor necrosis factor alpha; NLRP3; NOD-Like Recepto
Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target
Keywords: Omega-3 fatty acids; Soluble epoxide hydrolase; Lipidomics; Depression; Drug development; ER stress; NLRP3; Inflammasome; Metabolism; Mitochondrial dysfunction; Dementia; Neuroprogression; Neurodegeneration; Obesity; Diabetes; Heart disease; Stroke;
Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; BBB; blood-brain barrier; HT; hemorrhagic transformation; IgG; immunoglobulin G; IL-1β; interleukin-1β; i.p.; intraperitoneally; MPO; myeloperoxidase; NLRP3; Nod-lik
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a
Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells
Keywords: AS; atherosclerosis; CVD; cardiovascular diseases; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; LPS; lipopolysaccharide; MTT; 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide; DMSO; dimethyl sulfoxide; NAC;
Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition
Keywords: miR-200a; microRNA-200a; TXNIP; thioredoxin interacting protein; NLRP3; NOD-like receptor pyrin domain containing 3; ASC; adaptor apoptosis-associated speck-like protein containing CARD; caspase1; cysteinyl aspartate specific proteinase 1; NAFLD; nonalcoh
Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
Keywords: cardiovascular disease; diabetes; inflammation; randomized trial; CI; confidence interval; HbA1c; glycosylated hemoglobin; HR; hazard ratio; hsCRP; high-sensitivity C-reactive protein; IL; interleukin; IQR; interquartile range; NF-κB; nuclear factor kapp