Newcastle disease virus infection induces activation of the NLRP3 inflammasome
Keywords: Inflammasome; NDV; NLRP3; Caspase-1; THPâ1 cells;
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Casticin inhibits lipopolysaccharide-induced acute lung injury in mice
Keywords: Casticin; LPS; Acute lung injury; NF-κB; NLRP3
The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-кB/NLRP3 activation in rats
Keywords: Curculigoside A; Arthritis; NF-кB; NLRP3
Probenecid protects against oxygen–glucose deprivation injury in primary astrocytes by regulating inflammasome activity
Keywords: Cerebral ischemia/reperfusion injury; Pannexin 1; Inflammasome; NLRP3; HMGB1
A translocator protein 18Â kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation
Keywords: TSPO; Ro5-4864; NLRP3; Inflammasome; Mitochondria;
Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation
Keywords: NLRP3; Bipolar disorder; Complex I; Oxidative stress; Post-mortem brain; Frontal cortex;
Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome
Keywords: Sulforaphane; NLRP3; NLRC4; AIM2; Inflammasome
Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes
Keywords: IL-1β; interlekine-1β; UCP1; uncoupling protein 1; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; JNK; c-jun N-terminal kinase; LPS; lipopolysaccharide; WAT; white adipose tissue; BAT; brown adipose tissue; NLRP3; nu
Protective mechanisms of wogonoside against Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice
Keywords: Wogonoside; LPSNrf2; NLRP3
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
Keywords: Biochanin A; LPS; Nrf2; NLRP3; TXNIP;
Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner
Keywords: Rheumatoid arthritis; Neutrophils; Disease activity; NLRP3; Caspase-1; Interleukin-18
Determination of NLRP3 (rs4612666) and IL-1B (rs1143634) genetic polymorphisms in periodontally diseased and healthy subjects
Keywords: Chronic periodontitis; Genetic polymorphisms; NLRP3; IL-1B; Saliva
RNase L and the NLRP3-inflammasome: An old merchant in a new trade
Keywords: RNase L; OAS; 2-5A; IAV; NLRP3;
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury
Keywords: TLR4; Inflammasome; Proinflammatory cytokines; (+)-Naltrexone; Interleukin-1β; NLRP3; Tumor necrosis factor; Neuropathic pain; Rats;
Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells
Keywords: Cholesterol crystals; Inflammation; Syk; PI3K; S100 proteins; CHC; cholesterol crystals; Syk; spleen tyrosine kinase; PI3K; phosphoinositide-3 kinase; MMP; matrix metalloprotease; NLRP3; Nod-like receptor related protein 3; DAMPs; damage associated molecu
Reviews and feature articleInterferons and inflammasomes: Cooperation and counterregulation in disease
Keywords: Interferon; IL-1β; IL-18; gram-negative bacteria; inflammasome; NLRP3; caspase-1; caspase-11; guanylate-binding protein; pyroptosis; AIM2; tuberculosis; multiple sclerosis; experimental autoimmune encephalomyelitis; AIM2; Absent in melanoma 2; ALR; AIM2-
The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Keywords: NLRP3; Inflammasome; Alloimmunization; Conventional dendritic cells (cDCs); Red blood cell (RBC) storage
Therapeutic effect of methyl salicylate 2-O-β-d-lactoside on LPS-induced acute lung injury by inhibiting TAK1/NF-kappaB phosphorylation and NLRP3 expression
Keywords: Methyl salicylate 2-O-β-d-lactoside; Acute lung injury; Lipopolysaccharide; TAK1; NF-κB; NLRP3
Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell
Keywords: AA-PBMC; peripheral blood mononuclear cells freshly isolated from healthy individuals; AA-RBC; red blood cell from healthy individuals; ASC; apoptosis-associated speck-Like protein containing card; DAMPs; damage-associated molecular pattern molecules (DAM
Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome
Keywords: Endothelial senescence; Flavonoids; High glucose; NLRP3 inflammasome; Reactive oxygen species; Quercetin (PubChem CID: 5280343); Puerarin (PubChem CID: 5281807); Troxerutin (PubChem CID: 5486699); ASC; apoptotic speck-like protein containing a CARD domain
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; Atg; autophagy-related gene; α-SMA; alpha smooth muscle actin; Cat; catalase; DHA; dihydroartemisinin; ERK1/2; extracellular regulated kinase1/2; GSH; glutathione;
The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS
Keywords: Peritoneal mesothelial cells; Mitophagy/autophagy; Resveratrol; ROS; NLRP3
Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells
Keywords: Kupffer cells; BMSCs; NLRP3; PGE2; Acute liver injury;
CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation
Keywords: Quantum dots; Hepatocyte pyroptosis; Liver inflammation; NLRP3; Reactive oxygen species; Calcium mobilizationQDs, quantum dots; NLRP3, NLR pyrin domain containing 3; mtROS, mitochondrial reactive oxygen species; ASC, apoptotic speck-like protein containin
Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome
Keywords: Cepharanthine; Piperine; Diabetes; Renal injury; NF-κB; TXNIP; NLRP3
Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy
Keywords: NLRP3; nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3; IL; interleukin; DN; diabetic nephropathy; ESRD; end-stage renal disease; TNF; tumor necrosis factor; NF-κB; nuclear factor κB; TLRs; Toll-like receptor
Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
Keywords: AMPK; ER stress; NLRP3 inflammasome; Quercetin; Quercetin-3-O-glucuronide; Tau phosphorylation; Compound C (PubChem CID: 11524144); Metformin (PubChem CID: 14219); Okadaic acid (PubChem CID: 446512); Quercetin (PubChem CID: 5280343); Quercetin-3-O-glucuro
Autoinflammatory Skin Disorders: The Inflammasomme in Focus
Keywords: inflammasome; NLRP3; IL-1; CAPS; FMF; Ptpn6; Sharpin; inflammatory; autoimmune
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Keywords: NLRP3; ASC; Inflammasome; Ischemia-reperfusion; Heart; Inflammation; Acute coronary syndrome; Revascularization;
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Keywords: ALI; acute lung injury; APCs; antigen-presenting cells; ARE; antioxidant responsive element; Bach1; Broad complex-Tramtrack-Bric-a-brac (BNB) and Cap'n'collar (CNC) homolog 1; BAL; bronchoalveolar lavage; BR; bilirubin-IXα; BV; biliverdin-IXα; BVR;
Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit
Keywords: EMT; epithelial-mesenchymal transition; HSCs; hepatic stellate cells; MET; mesenchymal-epithelial transition; ECM; extracellular matrix; ACE2; angiotensin converting enzyme 2; Ang II; angiotensin II; Ang-1-7; angiotensin-(1-7); ASC; apoptosis associat
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation
Keywords: Histone deacetylase 6; NLRP3; Inflammasome;
Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor
Keywords: P2X7 receptor; ATP; Inflammasome; Interleukin 1β; Silica; NLRP3
HDL functionality and crystal-based sterile inflammation in atherosclerosis
Keywords: HDL; high-density lipoprotein; oxLDL; oxidized-low density lipoprotein; PON 1; paraoxonase 1; ARE; arylesterase; CBSI; crystal-based sterile inflammation; NLRP3; nucleotide binding domain leucine-rich repeat receptor protein 3; IL-1β; interleukin 1 beta;
Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats
Keywords: NLRP3; Endothelial dysfunction; Obesity; Vessel inflammation; OLETF;
Interactions between differential fatty acids and inflammatory stressors-impact on metabolic health
Keywords: Fatty acids; Inflammation; Metabolic health; Inflammatory stressors; Obesity; NLRP3; nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3; IR; insulin resistance; MUFA; monounsaturated fatty acids; PUFA; polyunsaturated fat
Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production
Keywords: Oxygen and glucose deprivation; dsRNA; B1 RNA; NLRP3; Cerebral ischemia;
Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models
Keywords: ALI; Anti-inflammasome; Danger-associated molecules; IL-1β; NLRP3;
Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients
Keywords: Dry eye; Tear film hyperosmolarity; Reactive oxygen species; NLRP3; Inflammasomes; Inflammation; Caspase-1; IL-1β; APCs; antigen presenting cells; ASC; apoptosis-associated speck-like protein containing CARD domain; DE; dry eye; HCEC; human corneal epith
Research ArticleInvariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice
Keywords: NLRP3; nucleotide-binding domain, leucine-rich-containing family pyrin domain containing-3; IL; interleukin; iNKT; invariant natural killer T; rh(m)IL-1Ra; recombinant human(murine) IL-1 receptor antagonist; WT; wild-type; ALD; alcohol liver disease; MN
Inflammasomes of the intestinal epithelium
Keywords: innate immunity; intestinal epithelial cell (IEC); caspase-1; NLRP3; extrusion; mucus;
A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants
Keywords: CAPS; Autoinflammation; NLRP3; Variants; IL-1β; TNF-α;
Mitochondria: diversity in the regulation of the NLRP3 inflammasome
Keywords: mitochondria; NLRP3; inflammasome; metabolic disease
Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis
Keywords: NLRP3; Inflammasome; T helper cells; Th17; Multiple sclerosis
Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome
Keywords: NLRP3; MI injury; JAK2-STAT3 inflammatory pathway; Insulin signaling pathway; PPAR-α;
MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage
Keywords: MicroRNA-223; Inflammation; Brain injury; NLRP3; Intracerebral hemorrhage
The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry
Keywords: Inflammasome; RT-PCR; Immunohistochemistry; NLRP3; NLRP1; AIM2;
DAMPs as mediators of sterile inflammation in aging-related pathologies
Keywords: DAMP; TLR; NLRP3; Sterile-inflammation; Aging; Inflammasome