Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1
Keywords: GlyT1; NMDAr; NMDA; Glycine; Transporter; Inhibitor; Schizophrenia
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The temporal specificity of the switch from NMDAr-dependent extinction to NMDAr-independent re-extinction
Keywords: Extinction; Re-extinction; NMDAr; Fear; MK801; Rats
Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case–control study
Keywords: Parkinson's disease; Single nucleotide polymorphism; NMDAR; GRIN1; GRIN2B
Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction
Keywords: Orexin/hypocretin; CRF; VTA; synaptic plasticity; AMPAR; NMDAR; LTP
The efficacy of physiological and pharmacological N-methyl-d-aspartate receptor block is greatly reduced under hyperbaric conditions
Keywords: hippocampus; magnesium; AP5; NMDAR; HPNS; synaptic transmissionAP5, dl-2-amino-5-phosphonopentanoic acid; DNQX, 6,7–dinitroquinoxaline -2,3-dione; fEPSP, field excitatory post-synaptic potential; HPNS, high pressure neurological syndrome; IC50, antagonist
Dynamic and interacting profiles of â
NO and O2 in rat hippocampal slices
Keywords: NMDA; N-methyl-d-aspartate; NMDAr; NMDA receptor; â
NO; nitric oxide; CcO; cytochrome oxidase; CA1/3; cornus ammon 1/3; NOS; nitric oxide synthase; DG; dentate gyrus; CNS; central nervous system; PSD-95; postsynaptic density protein 95; aCSF; artificial
A plasma membrane Ca2+ ATPase isoform at the postsynaptic density
Keywords: calcium extrusion; calcium pump; immunohistochemistry; dendritic spine; postsynaptic density; EM; electron microscopy; LM; light microscopy; NDS; normal donkey serum; NMDAR; N-methyl-d-aspartic acid receptor; nNOS; neuronal nitric oxide synthase; PB; phos
Cellular and Molecular NeuroscienceResearch PaperSpecific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-d-aspartate receptors
Keywords: conantokins; NMDAR subtypes; NMDAR antagonists; electrophysiology; ion channels; con; conantokin; GFP; green fluorescent protein; HEK; human embryonic kidney; NMDAR; N-methyl-D-aspartate receptor; NR1; N-methyl-d-aspartate receptor subunit 1, with its 8 s
Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-d-aspartate receptor-triggered neurotoxicity
Keywords: N-methyl-d-aspartate receptors; PSD-93; Ca2+ loading; neuronal nitric oxide synthase; cGMP; cyclic guanosine 3â²,5â²-monophosphate; chapsyn; channel-associated protein of synapses; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; KO; knockout; l-NAME; N-Nitr
Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus
Keywords: sphingosine kinase; sphingosine 1-phosphate; S1P receptor; long-term potentiation; hippocampus; memory; ACSF; artificial cerebrospinal fluid; eEPSC; evoked excitatory postsynaptic current; fEPSP; field excitatory postsynaptic potentials; HACPT; 2-(p-hydro
Differential NR2B subunit expression at dorsal root and ventrolateral funiculus synapses on lumbar motoneurons of neonatal rat
Keywords: MK-801; EPSP; NMDA receptor; ifenprodil; NR2B; ACSF; artificial cerebrospinal fluid; CGP 46381; Ciba Geigy Product 46381; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DR; dorsal root; EPSP; excitatory postsynaptic potential; MK-801; (5R,10S)-(+)-5-methyl-1
Characterization of developing rat cortical neurons after epileptiform discharges
Keywords: PSD, postsynaptic density; NMDAR, N-methyl-d-aspartate receptor; PSD-95, postsynaptic density-95; CD, cortical dysplasia; DIV, days in vitro; MGF, magnesium-free; PS, physiological solutionDevelopment; NMDAR; PSD-95; Dendrotoxicity; Spine; Epileptic insul
Castration and training in a spatial task alter the number of immature neurons in the hippocampus of male mice
Keywords: GCL; granule cell layer of the hippocampus; DMTP; delayed matching to place task; DCX; doublecortin; NMDAR; N-methyl-d-aspartate receptor; Hippocampus; Spatial memory; Irradiation; Androgens; Neurogenesis;
Aluminium interferes with hippocampal calcium signaling in a species-specific manner
Keywords: Toxicity; Ligand; Hippocampal culture; Signaling; NMDAR; VDCC
D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration
Keywords: cocaine; self-administration; reinstatement; d-serine; NMDA receptor; ANOVA; analysis of variance; CS; conditioned stimulus; FR; fixed ratio; LgA; long access; NMDAR; N-methyl, d-aspartate receptor; ShA; short access; US; unconditioned stimulus;
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats
Keywords: MIF; macrophage migration inhibitory factor; NMDAR; NMDA receptor; CSF; cerebrospinal fluid; rMIF; recombinant rat MIF; MAPK; mitogen-activated protein kinase; p-p38 MAPK; phosphorylated p38 MAPK; ERK; extracellular signal regulated kinase; PI3K; phosphoi
Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region
Keywords: platelet-activating factor; CaMKII; PKC; ERK; synaptic facilitation; ACSF; artificial cerebrospinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid receptor; CaMKII; calcium/calmodulin-dependent protein kinase II; ERK; extracellular sig
N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure
Keywords: NR1; NR2A; NR2B; alcohol withdrawal; hippocampus; frontal cortex; ANOVA; analysis of variance; BALs; blood alcohol levels; BCA assay; bicinchoninic acid assay; C; degree Celsius; CET; chronic ethanol treatment; ERP; event-related potential; FAS; fetal alc
Is age-dependent, ketamine-induced apoptosis in the rat somatosensory cortex influenced by temperature?
Keywords: glutamate; rat; anesthesia; neonatal; cooling; cell death; AC3; activated caspase-3; CBT; core body temperature; IHC; immunohistochemistry; K2; 2 mg/kg ketamine; K5; 5 mg/kg ketamine; K10; 10 mg/kg ketamine; K20; 20 mg/kg ketamine; K20-25C; K20 placed in
Influence of Alcohol on Mortality in Traumatic Brain Injury
Keywords: GCS; Glasgow Coma Score; TBI; traumatic brain injury; NMDar; N-methyl-D-aspartic acid receptors;
Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus
Keywords: Neuropsychiatric SLE; Cognitive impairment; Emotional impairment; NMDAR; Anti-NR2 antibody;
CASK point mutation regulates protein–protein interactions and NR2b promoter activity
Keywords: CASK; CINAP; Mental retardation; NMDAR; NR2b; Tbr-1; Transcription regulation
Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats
Keywords: CNS; central nervous system; iGluRs; ionotropic glutamate receptors; NMDAR; N-methyl-d-aspartic acid receptor; NR1; NMDA-R1 subunit; mGluRs; metabotropic glutamate receptors; mGluR1; mGlu receptor subtype 1; mGluR5; mGlu receptor subtype 5; AIDA; (RS)-1-A
Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats
Keywords: Arsenic; Morris water maze; Ultra-structure; NMDAR; Hippocampus
Exomic sequencing of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia
Keywords: Schizophrenia; NMDAR; NR3A; GRIN3A; Rare mutations; Pathogenesis
Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR
Keywords: N-Acetylaspartylglutamate (NAAG); mGluR2; mGluR3; NMDAR
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus
Keywords: chemically-induced late phase of LTP; NR2B antagonist; protein kinase A; protein synthesis; hippocampus; ACSF; artificial cerebrospinal fluid; AP5; 2-amino-5-phosphonovaleric acid; BDNF; brain-derived neurotrophic factor; CREB; cAMP-responsive element bin
In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
Keywords: apoptosis; necrosis; extrasynaptic; neuroprotection; NR2A; mEPSC; miniature excitatory postsynaptic current; NMDA; N-methyl-d-aspartate; NMDAR; N-methyl-d-aspartate receptor; NR2A-NMDAR; NR2A-containing N-methyl-d-aspartate receptor; SGG; salt-glucoseâ
Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus
Keywords: glutamate; circadian clock; rhythm; light entrainment; ontogeny; in situ hybridization; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; CT; circadian time; DD; constant darkness; E; embryonic day; LD 12:12; 12-h light/dark cycle; NMD
Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons
Keywords: HIV-1 Tat; Neuronal cell culture; Toxicity; Caspases; MCP-1; NMDAR
Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-d-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits
Keywords: glutamate receptor; heroin; learning and memory; opiate addiction; synaptic plasticity; ACSF; artificial cerebrospinal fluid; EDTA; ethylenediamine tetraacetic acid; EGTA; ethylene glycol tetraacetic acid; ERK; extracellular signal-regulated kinase; LTP;
Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics
Keywords: neurogenesis; odorant receptor; NMDA receptor; 5-HT receptor; dopamine receptor; neuronal cell culture; 5-HT; serotonin; ACIII; adenylate cyclase type 3; DIG; digoxigenin; D2R; dopamine receptor; EDTA; ethylene diamine tetraacetic acid; EGTA; ethylene gly
Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3–CA1 synapses
Keywords: Long-term potentiation; LTP; NR2B; NMDA receptor; NMDAR; AMPA receptor; AMPAR; Spine density; Glutamate synapses; Estradiol; Estrogen; ERα; ERβ
Sensory activity differentially modulates N-methyl-d-aspartate receptor subunits 2A and 2B in cortical layers
Keywords: ferret; glutamate receptors; immunoelectron microscopy; ocular dominance plasticity; NMDAR; ANOVA; analysis of variance; DAB; diaminobenzidine; DR; dark rearing; EEO; early eyelid opening; EEO21; early eyelid opening surgery at postnatal day 21; EEO28; ea
Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats
Keywords: prenatal ethanol; addiction; vulnerability; sensitization; reward; ANOVA; analysis of variance; BEL; blood ethanol level; CPA; conditioned place aversion; CPP; conditioned place preference; DAT; dopamine transporter; LORR; loss of righting reflex; NMDA; N
Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats
Keywords: IBS; irritable bowel syndrome; LUT; lower urinary tract; NMDA; N-methyl-d-aspartate; NMDAR; N-methyl-d-aspartate receptor; Cdk5; cyclin-dependent kinase-5; DRG; dorsal root ganglion; PSD95; postsynaptic density 95; MO; mustard oil; SRP; spinal reflex pote
Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1
Keywords: GlyT1; NMDA receptor; latent inhibition; learning; psychopharmacology; schizophrenia; aCSF; artificial cerebrospinal fluid; ALX5407; (R)-N[3-(4-fluorophenyl)-3-(4-phenyl-phenoxy)propyl]-sarcosine; AMPAR; AMPA receptor; ANCOVA; analysis of covariance; ANOV
Regulation of AMPA receptors and synaptic plasticity
Keywords: long-term potentiation; long-term depression; glutamate; receptor trafficking; receptor phosphorylation; ABP; AMPA receptor-binding protein; AMPAR; AMPA receptor; Arc; activity-regulated cytoskeleton-associated protein; Aβ; beta-amyloid; BAR; Bin/amphyph
Endogenous reductions in N-methyl-d-aspartate receptor activity inhibit nitric oxide production in the anoxic freshwater turtle cortex
Keywords: APV; dl-2-amino-5-phosphonopentanoic acid; CBF; cerebral blood flow; DAF-FM; 4-amino-5-methylamino-2â²,7â²-difluorofluorescein; ECD; excitotoxic cell death; l-NAME; NG-nitro-l-arginine methyl ester; NMDAR; N-methyl-d-aspartate receptor; nNOS; neuronal n
The visceromotor response to colorectal distention fluctuates with the estrous cycle in rats
Keywords: nociception; visceral pain; gonadal hormone; estrogen; spinal cord; estradiol; AUC; area under the curve; CRD; colorectal distention; DRG; dorsal root ganglia; EMG; electromyogram; IBS; irritable bowel syndrome; NMDAR; N-methyl-d-aspartate receptor; TMJ;
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
Keywords: Calcium; NMDAR; Huntington's disease; Transgenic mouse; Mitochondria; Apoptosis; Excitotoxicity
Neural differentiation and the attenuated heat shock response
Keywords: dibutyryl cAMP; N6,2â²-O-dibutyryl adenosine 3â²:5â²-cyclic mono-phosphate; FBS; fetal bovine serum; HSF1; heat shock factor 1; HSR; heat shock response; HSP; heat shock protein; HSP70; the 72Â kDa heat shock protein; HSC70; the 73Â kDa constitutively
Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death
Keywords: S-nitrosylation; phosphorylation; GluR6; nNOS; cerebral ischemia; neuroprotection; AMT; 2-amion-5,6-dihydro-6-methyl-4H-1,3-thiazine; CaMK II; Ca2+/calmodulin-dependent kinase II; COXIV; cytochrome c oxidase subunit IV; DMSO; dimethyl sulfoxide; DTT; dith
Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury
Keywords: AGA; 18α-glycyrrhetinic acid; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; Cx; connexin; FRIL; freeze-fracture replica immunogold labeling
Environmental enrichment selectively increases glutamatergic responses in layer II/III of the auditory cortex of the rat
Keywords: behavior; AI; patch-clamp; perforated patch; excitation/inhibition balance; neuronal modeling; ACSF; artificial cerebrospinal fluid; AEP; auditory evoked potential; AMPAR; AMPA receptor; APV; d-2-amino-5-phosphonopentanoic acid; DNQX; 6,7-dinitroquinoxali
Chronic membrane depolarization-induced morphological alteration of developing neurons
Keywords: filopodia; synaptogenesis; spine; GFP; development; NMDA receptor; AMPAR; AMPA receptor; APV; (d)-2-amino-5-phosphonovaleric acid; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent protein kinase; CREB; cyclic AMP response-element
Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo
Keywords: hippocampus; nucleus accumbens; NMDA receptors; long-term potentiation; long-term depression; withdrawal; AMPAR; AMPA receptor; A-WD; acute withdrawal; C-WD; prolonged withdrawal; EPSP; excitatory postsynaptic potential; GCs; glucocorticoids; GR; glucocor
Loss of calcium and increased apoptosis within the same neuron
Keywords: AC3; activated caspase-3; BAPTA-AM; 1,2-bis(2-Amino-5-fluorophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid-(acetoxymethyl) ester; CaBP; calcium binding protein; CB; calbindin; CG-1; Calcium Green-1; CR; calretinin; DIV; days in vitro; EDAC; N-(3-Dimeth
The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty
Keywords: immediate early gene; LTP; LTD; corticosterone; stress; ACSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; ASR; acoustic startle responses; CN; calcineurin; Egr; early growth response; Egr3; early growth response gene 3; EPSP; excitatory p
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures
Keywords: voltage-sensitive dye; field potential; optically-recorded EPSP; NMDAR; NR2B; developmentACSF, artificial cerebrospinal fluid; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; CS, corticospinal; d-APV, d-2-amino-5-phosphonovalerate; DIV, days in vitro; EPSC, e