Sixty-day repeated dose toxicity of sinafloxacin in rats and dogs
Keywords: Sinafloxacin; Repeated dose toxicity; NOAEL; Rats; Dogs
مقالات ISI (ترجمه نشده)
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Permissible level of toxaphene residues in fish from the German market based on in vivo and in vitro effects to tumor promotion
Keywords: RfD; reference dose; PL; permissible level; CLE; cod liver extract; NOAEL; no observed adverse effect levels; AHF; altered hepatic foci; GSTp-AHF; placental glutathion-S-transferase; LOEC; lowest observed effect concentration; HRGC-MS; high resolution g
Twenty-eight-day oral toxicity study of lycopene from recombinant Escherichia coli in rats
Keywords: Lycopene; Recombinant Escherichia coli; Subacute oral toxicity; NOAEL;
Safety evaluation to support first-in-man investigations II: Toxicology studies
Keywords: Single dose; Repeat dose; Rodent; Non-rodent; MTD; NOAEL; Genotoxicity
The new tapestry of risk assessment
Keywords: Chemical intolerance; Early development; Intervention; Lifetime exposure; NOAEL; Risk assessment; Threshold
90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats
Keywords: APTT, activated partial thromboplastin time; LFO, licorice flavonoid oil; MCT, medium-chain triglycerides; PT, prothrombin timeLicorice flavonoid oil; Glycyrrhiza glabra; Rat; Subchronic toxicity; NOAEL
Comment on: “A retrospective analysis of the two-generation study: What is the added value of the second generation?” by G. Janer, B.C. Hakkert, W. Slob, T. Vermeire, A.H. Piersma [Reprod. Toxicol. 24 (2007) 97-102]
Keywords: Two-generation study; One-generation study; Reproductive toxicity; Developmental toxicity; Fertility; NOAEL; Classification and labelling; Risk assessment; OECD TG 416;
The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level”
Keywords: LOAEL; NOAEL; Hazard identification; Risk assessment; Developmental toxicity bioassay; Fetal; Rat; Mouse; Rabbit; Teratology
A retrospective analysis of developmental toxicity studies in rat and rabbit: What is the added value of the rabbit as an additional test species?
Keywords: Developmental toxicity; Rat; Rabbit; Risk assessment; NOAEL; Classification and labeling
A retrospective analysis of the two-generation study: What is the added value of the second generation?
Keywords: Two-generation study; One-generation study; Reproductive toxicity; Developmental toxicity; Fertility; NOAEL; Classification and labeling; Risk assessment
A benchmark dose analysis for sodium monofluoroacetate (1080) using dichotomous toxicity data
Keywords: Benchmark dose; NOAEL; 1080; Cardiomyopathy; Testicular; Teratogen; TDI
A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats
Keywords: Curcumin; Turmeric; Reproductive toxicity; Generation; NOAEL
The use of myocardial and testicular end points as a basis for estimating a proposed tolerable daily intake for sodium monofluoroacetate (1080)
Keywords: Sodium monofluoroacetate (1080); Tolerable daily intake (TDI); Cardiomyopathy; Testicular effects; BMDL; NOAEL
A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study
Keywords: Two-generation study; Subchronic study; Reproductive toxicity; Developmental toxicity; NOAEL; Classification and labeling; Risk assessment
Evaluation of acute inhalation toxicity for chemicals with limited toxicity information
Keywords: Acute; Inhalation; Threshold of concern; Globally Harmonized System; LC50; Cramer; Air permit review; NOAEL
Safety evaluation studies on argemone oil through dietary exposure for 90 days in rats
Keywords: Epidemic dropsy; Argemone oil; Sanguinarine; Anemia; NOAEL
Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows
Keywords: Recombinant human lactoferrin; Oral administration; Rats; Repeated dose toxicity study; LF; lactoferrin; hLF; human LF; rhLF; recombinant hLF; bLF; bovine LF; NOAEL; no-observed-adverse-effect level;
Thresholds of allergenic proteins in foods
Keywords: ACE; Angiotensin converting enzyme; DBPCFC; Double-blind, placebo-controlled food challenge; EED; Estimated eliciting dose; IRBs; Institutional Review Boards; LOAEL; Lowest observed adverse event level; NOAEL; No observed adverse event level; OAS; Oral al
Evaluation of developmental toxicity of 1-butanol given to rats in drinking water throughout pregnancy
Keywords: NOAEL; no observed adverse effect level; 1-Butanol; Developmental toxicity; Teratogenicity; Fetal abnormality; Rat;
Risk assessment of dietary acrylamide intake in Flemish adolescents
Keywords: IARC; International Agency for Research on Cancer; SNFA; Swedish National Food Administration; FAO/WHO; Food and Agriculture Organisation/World Health Organisation; LC-MS-MS; Liquid chromatography-mass spectrometry-mass spectrometry; US FDA; Unite
Dietary toxicity of calcium β-hydroxy-β-methyl butyrate (CaHMB)
Keywords: ANOVA; analysis of variance; BW; body weight; CaHMB; calcium β-hydroxy-β-methyl butyrate; CFR; Code of Federal Regulations; CK; creatine phosphokinase; EPA; eicosapentaenoic acid; FDA; Food and Drug Administration; GLP; good laboratory practices; HMB; Î
The role of the benchmark dose in a regulatory context
Keywords: Benchmark dose; NOAEL; Chemical regulation; Risk assessment;
Evaluation of biochemical effects related to perfluorooctane sulfonic acid exposure in organohalogen-contaminated great tit (Parus major) and blue tit (Parus caeruleus) nestlings
Keywords: PFOS; perfluorooctane sulfonic acid; ww; wet weight; ALT; alanine aminotransferase; OCP; organochlorine pesticide; PCB; polychlorinated biphenyl; PBDE; polybrominated biphenyl ether; HCH; hexachlorocyclohexane; HCB; hexachlorobenzene; OxC; oxychlordane; T
Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review
Keywords: ADI; acceptable daily intake; BMD; benchmark dose; CSAF; chemical-specific adjustment factor; LOAEL; low observed adverse effect level; NOAEL; no observed adverse effect level; RfD; reference dose; TDI; tolerable daily intake; AUC; area under the plasma-c
Guidance on setting of acute reference dose (ARfD) for pesticides
Keywords: ADI; Acceptable daily intake; ARfD; Acute reference dose; AUC; Area-under-the-curve; bw; Body weight; CSAF; Chemical-specific adjustment factor; EHC; Environmental Health Criteria; FAO; Food and Agriculture Organisation of the United Nations; IPCS; Intern
Safety assessment of esters of p-hydroxybenzoic acid (parabens)
Keywords: DNCB; dinitrochlorobenzene; FEMA; flavor and extract manufacturers' association; GRAS; generally recognized as safe; MIC; minimum inhibitory concentration; NOAEL; no observed adverse effect level; NOEL; no observed effect level; OTC; over the counter; P
Criteria for the safety evaluation of flavoring substances
Keywords: ABS; chromosomal aberration; ADH; alcohol dehydrogenase; ALD; aldehyde dehydrogenase; AE; anethole epoxide; CYP450; Cytochrome P450; CHO; Chinese hamster ovary; CoA; coenzyme A; CoE; Council of Europe; CCK; cholecystokinin; DDA; detailed dietary analysis;