MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells
Keywords: MicroRNA; Aging; Senescence; NRF2; Endothelial cell;
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Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice
Keywords: Esculin; LPS; Liver injury; Nrf2;
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease
Keywords: AGEs; advanced glycation end-products; ARE; antioxidant-response element; AP; argpyrimidine (Náº-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine); BBB; blood-brain barrier; Casp-3; Caspase-3; CCM; Cerebral Cavernous Malformation; CNS; central nervous
Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures
Keywords: Oxidative stress; Olive oil; Total polyphenolic fraction; Cell lines; OO; olive oil; TPF; total phenolic fraction; EVOO; extra virgin olive oil; ROS; reactive oxygen species; GSH; glutathione; HT; hydroxytyrosol; EFSA; european food safety authority; DMEM
Activation of KGFR-Akt-mTOR-Nrf2 signaling protects human retinal pigment epithelium cells from Ultra-violet
Keywords: Ultra-violet (UV); Retinal pigment epithelium (RPE) cells; Keratinocyte growth factor (KGF); Nrf2; Akt-mTORC1;
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Keywords: 5α-DHP; 5α-dihydroprogestrone; ABC; ATP-binding cassette; AF6; ALL-1-fused gene from chromosome 6; ALL; acute lymphoblastic leukemia; AMPAR; amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor; Ang-1; angiopoietin-1; AP-1; activator protein-1; BBB;
Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathway
Keywords: Curcumin; Traumatic brain injury; Nrf2; Neuroprotection;
Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita
Keywords: DPN; diarylpropionitrile; ER; estrogen receptor; GSH; glutathione; NRF2; nuclear factor erythroid-derived 2 related factor 2; PC; pachyonychia congenital; PPK; palmar-plantar keratoderma; SF; sulforaphane; WT; wild type;
Untimely oxidative stress in β-cells leads to diabetes - Role of circadian clock in β-cell function
Keywords: Circadian clock; Islet; β-cell; Insulin; Oxidative stress; Diabetes; Bmal1; Nrf2;
Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin - Thioredoxin system. 1. Understanding commonalities and differences among cell types
Keywords: ASK1; apoptosis signal-regulating kinase 1; Cat; catalase; GSH; glutathione; GPx1; glutathione peroxidase 1; Grx; glutaredoxin; KEAP1; Kelch-like ECH-associated protein 1; NRF2; nuclear factor erythroid 2-related factor 2; Prx; typical 2-Cys peroxiredoxin
The long non-coding RNA MALAT1 activates Nrf2 signaling to protect human umbilical vein endothelial cells from hydrogen peroxide
Keywords: HUVECs; Oxidative stress; MALAT1; Nrf2; Keap1;
The dichotomous role of H2S in cancer cell biology? Déjà vu all over again
Keywords: 1400 W; N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide; 3-MP; 3-Mercaptopyruvate; 3-MST; 3-Mercaptopyruvate sulfurtransferase; ADT-OH; 5-(4-hydroxyphenyl)-3H-1, 2-dithiole-3-thione; AG; Aminoguanidine; AOAA; Aminooxyacetic acid; CAT; Cysteine aminotra
Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
Keywords: AD; Alzheimer's Disease; ADP; Adenosine diphosphate; Aβ; β-amyloid; CAW; Water extract of Centella asiatica; CFR; Conditioned fear response; ETC; Electron transport chain; FCCP; Carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone; GAPDH; Glyceraldehyde
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2
Keywords: Pulmonary fibrosis; MRC-5; Salvianolic acid B; Oxidative stress; Nrf2;
NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells
Keywords: Astragaloside IV; Inflammatory; Microglial; NRF2; HO-1;
Chronic exposure of the RAW246.7 macrophage cell line to H2O2 leads to increased catalase expression
Keywords: ROS; reactive oxygen species; GSH; glutathione; SOD; superoxide dismutase; PTPs; protein tyrosine phosphatases; NEM; N-ethylmaleimide; DTNB; 5,5-dithio-bis-(2-nitrobenzoic acid); PMA; phorbol 12-myristate 13-acetate; ASK1; apoptosis signal-regulating kina
Suppression of Nrf2 attenuates adipogenesis and decreases FGF21 expression through PPAR gamma in 3T3-L1 cells
Keywords: NRF2; PPARγ; C/EBPα; Adipocyte differentiation; FGF-21;
Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway
Keywords: Myocardial infarction; Ischaemia-reperfusion injury; Nrf2-ARE pathway; Azafrin; Oxidative stress; ARE; antioxidant response element; AST; aspartate aminotransferase; CK-MB; MB isoenzyme of creatine kinase; cTnI; cardiac troponin I; CVD; cardiovascular dis
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice
Keywords: AEL; aqueous extract of L. chuanxiong rhizome; ARE; antioxidant response element; COX-2; cyclooxygenase-2; DI; didox; DN; diabetic nephropathy; EEL; ethanol extract of L. chuanxiong rhizome; ELISA; enzyme linked immunosorbent assay; ESRD; end stage renal
The effects of Mucuna pruriens on the renal oxidative stress and transcription factors in high-fructose-fed rats
Keywords: Mucuna pruriens; High-fructose; Transcription factors; ARE; antioxidant response element; HO-1; heme-oxygenase 1; IKK; IκB kinase; Keap1; Kelch like-ECH-associated protein 1; MDA; malondialdehyde; NF-κB; nuclear factor kappa-light-chain-enhancer of acti
Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE(2)-M17 cells
Keywords: Neurological diseases; Heme oxygenase-1; Palmitic acid; Reactive oxygen species; BE(2)-M17 cells; AD; Alzheimer's disease; ARE; antioxidant response elements; BSA; bovine serum albumin; DHE; dihydroethidium; DCFH-DA; 2â²,7â²-Dichlorofluorescein diacetat
Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway
Keywords: Tan C; Tanshindiol C; oxLDL; oxidized low-density lipoprotein; Nrf2; NF-E2-related factor 2; ARE; antioxidant-response element; Sirt1; Sirtuin 1; Prdx1; peroxiredoxin 1; ABCA1; adenosine triphosphate-binding cassette (ABC) transporter A1; ABCG1; ATP-bindi
Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation
Keywords: KEAP1; Nrf2; Antioxidant response; Autophagy; P62; Beclin-1; ATG7;
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
Keywords: Isoflavone; 7-O-methylbiochanin A; Oxidative stress; Nrf2 activator; ARE; antioxidant response element; COPD; chronic obstructive pulmonary disease; γ-GCS; γ-glutamyl cysteine synthetase; GSH; glutathione; HO-1; heme oxygenase-1; Keap1; Kelch-like ECH-a
Functional regulation of large conductance Ca2+-activated K+ channels in vascular diseases
Keywords: AT1R; Angiotensin II type 1 receptors; AA; arachidonic acid; CaN; calcineurin; DHA; docosahexaenoic acid; FBXO-9; F-box only protein 9; HR; heart rate; H2O2; hydrogen peroxide; HS; hydrophobic segment; IBTX; iberiotoxin; I/R; ischemia/reperfusion; BK chan
Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction
Keywords: Homoeriodictyol; Nrf2; Reactive oxygen stress; Mitochondrial dysfunction; Apoptosis;
Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells
Keywords: AO; acridine orange; ARE; antioxidant response element; As(III); sodium arsenite; CC; column chromatography; CHX; cycloheximide; COPD; chronic obstructive pulmonary disease; DAPI; 6-diamidino-2-phenylindole; EB; ethidium bromide; γ-GCS; γ-glutamylcystei
The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: The demonstration of Nrf2-dependent anti-oxidative action using a zebrafish model
Keywords: CDDO; 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid; dpf; days post-fertilization; Keap1; Kelch-like ECH-associated protein 1; Nrf2; nuclear factor erythroid 2-related factor 2; Arsenite toxicity; Auranofin-induced protection; Heavy metal; Nrf2 pathw
Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy
Keywords: BrdU; 5-Bromo-2â²-Deoxyuridine; CuZnSOD; copper zinc superoxide dismutase; DAT; dopamine transporter; DG; dentate gyrus; EE; endurance exercise; GPX; glutathione peroxidase; HO-1; heme oxygenase I; MnSOD; manganese superoxide dismutase; MPTP; 1-methyl-4-
ETS-domain containing protein (Elk1) suppression protects cortical neurons against oxygen-glucose deprivation injury
Keywords: Elk1; ETS-domain containing protein; OGD; oxygen-glucose deprivation; Fra-1; Fos-related antigen 1; Nrf2; Nuclear factor erythroid 2-related factor; ARE; antioxidant responsive element; ROS; reactive oxygen species; SD; Sprague-Dawley; FBS; fetal bovine s
Amentoflavone-induced oxidative stress activates NF-E2-related factor 2 via the p38 MAP kinase-AKT pathway in human keratinocytes
Keywords: Amentoflavone; Nrf2; ROS; p38; AKT;
Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma
Keywords: HCC; Chemoresistance; Nrf2; Sensitivity; Regulation;
Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Keywords: AKR1C1; aldo-keto reductase family 1 member C1; DMEM; sodium pyruvate free Dulbecco's modified Eagle's medium; DMNQ; 2,3-dimethoxy-1,4-naphthoquinone; dtBHQ; 2,5-di-tert-butylhydroquinone; EGCG; epigallocatechin-3-gallate; FBS; fetal bovine serum; HEPES;
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
Keywords: Akt; protein kinase B; CTGF; connective tissue growth factor; DMF; dimethyl fumarate; EDN1; endothelin 1; GSK-3; glycogen kinase 3; HC; healthy control; MMP; matrix metalloproteinase; NRF2; nuclear factor (erythroid-derived 2)-like 2; PAAm; polyacrylamide
Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway
Keywords: Ozone; Oxidative stress; Nrf2; Keap1; Transcription;
Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart
Keywords: Rosuvastatin; Cardiac hypertrophy; TGF-βl; Smad; Nrf2;
A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats
Keywords: ANOVA; analysis of variance; GLP; good laboratory practice; ITC; isothiocyanate; MIC-1; moringa isothiocyanate-1; MICs; moringa isothiocyanates; MSE; moringa seed extract; NF-κB; nuclear factor kappa B; NO; nitric oxide; NOAEL; no observed adverse effect
Persimmon vinegar polyphenols protect against hydrogen peroxide-induced cellular oxidative stress via Nrf2 signalling pathway
Keywords: PVP; persimmon vinegar polyphenols; ROS; reactive oxygen species; Nrf2; nuclear factor (erythroid-2-derived) related factor 2; Keap 1; kelch-like ECH-associated protein 1; ARE; antioxidant-response element; HO-1; heme oxygenase-1; NQO1; NAD(P)H: quinone o
Crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer
Keywords: Glutathione; Nrf2; YAP; FOXM1; Chemoresistance; Bladder cancer cells;
Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity
Keywords: Nrf2; Chemoresistance; Triptolide; NSCLC;
NRF2 facilitates breast cancer cell growth via HIF1É-mediated metabolic reprogramming
Keywords: NRF2; HIF1α; Breast cancer cells; Glycolysis;
LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress
Keywords: AKT; protein kinase B (PKB); AMPK; protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1); HOTAIR; HOX transcript antisense RNA; Keap1; kelch like ECH associated protein 1; mTOR; mammalian target of rapamycin; NBR2; neighbor of BRCA1 gene 2; Nrf2
Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training paradigms in mice
Keywords: Regular exercise; Pain perception; Nrf2; Hippocampus; Cortex;
Anti-inflammatory activity of the decoction of Forsythia suspensa (Thunb.) Vahl is related to Nrf2 and A20
Keywords: WFF; the water extract of Forsythiae Fructus; TNFAP3 A20; tumor necrosis factor α-induced protein 3; HPLC; high-performance liquid chromatography; ROS; reactive oxygen species; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; FACS; Flu
Deregulation of Nrf2/ARE signaling pathway causes susceptibility of dystrophin-deficient myotubes to menadione-induced oxidative stress
Keywords: DMD; Duchenne muscular dystrophy; DysKD; Dystrophin knock-down cells; Nrf2; nuclear erythroid 2-related factor 2; SFN; sulforaphane; ARE; antioxidant response element; NQO1; NAD(P)H:quinone dehydrogenase 1; SOD; superoxide dismutase; HO-1; heme oxygenase-
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway
Keywords: ARE; antioxidant response element; Bcl-2; B-cell lymphoma 2; CA; caffeic acid; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GCLC; glutamate-cysteine ligase catalytic subunit; GCLM; gl
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; HO-1; heme oxygenase-1; NQO1; NADP(H): quinine oxidoreductase 1; GSTs; glutathione S-transferases; TXNRD; thioredoxin reducta
Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway
Keywords: ARE; antioxidant-responsive element; CM-H2DCFDA; chloromethyl 2â²,7â²-dichlorodihydrofluorescein diacetate; COX-2; cyclooxygenase-2; HO-1; heme oxygenase-1; iNOS; inducible nitric oxide synthase; IRAK; interleukin-1 receptor-associated kinase; LPS; lipo
Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats
Keywords: Insulin resistance; Phosphorylated insulin receptor; p-Akt; GLUT2; Wnt pathway; Nrf2; Glutathione; UCP2;
Curcumin enhances LXRα in an AMP-activated protein kinase-dependent manner in human macrophages
Keywords: LXR; liver X receptor; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; SREBP1c; sterol response element binding protein 1c; AMPK; AMP-activated protein kinase; PMA; phorbol myristate acetate; fMLP; formyl-Met-Leu-Ph