کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8547065 | 1561727 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of Mucuna pruriens on the renal oxidative stress and transcription factors in high-fructose-fed rats
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کلمات کلیدی
NF-κBMDAheme-oxygenase 1Nrf2kelch like-ECH-associated protein 1HO-1IKKkeap1 - buy1IκB kinase - IkB kinasetumor necrosis factor-α - تومور نکروز عامل αMetabolic syndrome - سندرم متابولیکantioxidant response element - عنصر پاسخ آنتی اکسیدانTranscription factors - عوامل رونویسیTNF-α - فاکتور نکروز توموری آلفاnuclear factor (erythroid-derived 2)-like 2 - فاکتور هسته ای (erythroid-derived 2) -like 2nuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استmalondialdehyde - مالون دی آلدهیدMucuna pruriens - مگنوس دندانARE - هستند
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, we evaluated the effects of M. pruriens administration on metabolic parameters, oxidative stress and kidney nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathways in high-fructose fed rats. Male rats (nâ¯=â¯28) were divided into 4 groups as control, M. pruriens, fructose, and M. pruriens plus fructose. All rats were fed a standard diet supplemented or no supplemented with M. pruriens (200â¯mg/kg/d by gavage). Fructose was given in drinking water for 8 weeks. High fructose consumption led to an increase in the serum level of glucose, triglyceride, urea and renal malondialdehyde (MDA) levels. Although M. pruriens treatment reduced triglyceride and MDA levels, it did not affect other parameters. M. pruriens supplementation significantly decreased the expression of NF-Ò¡B and decreased expression of Nrf2 and HO-1 proteins in the kidney. This study showed that the adverse effects of high fructose were alleviated by M. pruriens supplementation via modulation of the expression of kidney nuclear transcription factors in rats fed high fructose diet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 526-531
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 526-531
نویسندگان
Ramazan Ulu, Nevzat Gozel, Mehmet Tuzcu, Cemal Orhan, Ä°rem Pembegül YiÄit, Ayhan Dogukan, Hafize Telceken, Ãzlem Ãçer, Zeki Kemeç, Dilara Kaman, Vijaya Juturu, Kazim Sahin,