Keywords: HCV; 3a; HVR1; NS3; NS5B; Phylogentic; Analysis; Quasispecies; NGS;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: 5/15-LOX; 5/15-lipoxygenase; AChE; acetylcholinesterase; AUF-MS; affinity-ultrafiltration mass spectrometry; BFA; bound fraction analysis; COX-2; cyclooxygenase-2; GST; glutathione S-transferase; HPLC-DAD-MS; high performance liquid chromatography-dio
Keywords: Ultrafiltration-LC/MS; Multiple ligand detection; Affinity measurement; Fragment library screening; NS5B
5â² UTR and NS5B-based genotyping of hepatitis C virus in patients from Damietta governorate, Egypt
Keywords: HCV; Genotypes; NS5B; 5â² UTR; Phylogenetic tree; Sofosbuvir;
Epidemiological investigation and analysis of the NS5B gene and protein variability of non-primate hepacivirus in several horse cohorts in Rio de Janeiro state, Brazil
Keywords: Equine hepacivirus; Horse; Prevalence; Risk factors; NS5B; Brazil;
Efficacy of Sofosbuvir and Velpatasvir, With and Without Ribavirin, in Patients With Hepatitis C Virus Genotype 3 Infection and Cirrhosis
Keywords: Direct-Acting Antiviral Agent; Outcome; Drug Resistance; AE; adverse event; HCV; hepatitis C virus; HIV; human immunodeficiency virus; NS5A; nonstructural protein 5A; NS5B; nonstructural protein 5B; RAS; resistance-associated substitution; SAE; serious ad
Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir
Keywords: Hepatitis C virus; Drug resistance; NS5A; NS5B; DAA; Ledipasvir; Sofosbuvir; Ribavirin;
In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Keywords: Hepatitis C virus; NS3 protein; Stable Huh-7Â cell culture system; RNA interference; NS5B; HCV therapeutics;
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase
Keywords: HCV; NS5B; Tricyclic Indole; Pyridone; Replicon;
Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection
Keywords: T/F; Transmitted founder; HCV; Hepatitis C virus; NS5B; Non-structural protein 5B; BNAbs; Broadly neutralizing antibodies; AR; Antigenic region; HVR; Hypervariable region; Broadly neutralizing antibodies; Hepatitis C; Epitopes; Glycoprotein E2; InC3 colla
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase
Keywords: HCV; NS5B; Replicase; Inhibitors; Cyclopropylindolobenzazepine; Direct-acting; Antiviral agent
NS5A resistance leading to failure of 24-week therapy with sofosbuvir/ledipasvir and ribavirin for the treatment of hepatitis C genotype 1a infection in a HIV-1 co-infected patient
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; cART; combination antiretroviral therapy; DAA; direct-acting antiviral; DDI; drug-drug interaction; EOTR; end-of-treatment response; GT; genotype; HCV; hepatitis C virus; HIV-1; human immun
ReviewThe importance of resistance to direct antiviral drugs in HCV infection in clinical practice
Keywords: HCV; hepatitis C virus; DAA; direct-acting antiviral agent; NS3; non-structural protein 3; NS5A; non-structural protein 5A; NS5B; non-structural protein 5B; RAVs; resistance associated variants; IP-10; interferon-gamma-inducible protein 10; IFNL4; interfe
Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation
Keywords: Fbw7; NS5B; Ubiquitination; Degradation; HCV replication;
Effectiveness of Simeprevir Plus Sofosbuvir, With or Without Ribavirin, in Real-World Patients With HCV Genotype 1 Infection
Keywords: Chronic Hepatitis; Direct-Acting Agent; NS3/4A Protease Inhibitor; NS5B; AASLD; American Association for the Study of Liver Disease; AE; adverse event; CI; confidence interval; FDA; Food and Drug Administration; HCV; hepatitis C virus; IDSA; Infectious Di
Previous failure of interferon-based therapy does not alter the frequency of HCV NS3 protease or NS5B polymerase inhibitor resistance-associated variants: longitudinal analysis in HCV/HIV co-infected patients
Keywords: HCV; Direct-acting antivirals; Resistance-associated variants (RAVs); NS3; NS5B; Peg-IFN;
Phosphorylation at the N-terminal finger subdomain of a viral RNA-dependent RNA polymerase
Keywords: Hepatitis C virus; Phosphorylation; RNA-dependent RNA polymerase; Fingers; NS5B;
A molecular phylogenetics-based approach for identifying recent hepatitis C virus transmission events
Keywords: HCV; hepatitis C virus; PWID; people who inject drugs; BC; British Columbia; NS5B; non-structural protein-5B; E1; Envelope-1; HVR1; hypervariable region-1; cDNA; complementary DNA; RT-PCR; reverse transcriptase polymerase chain reaction; E2; Envelope-2; I
NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release
Keywords: Hepatitis C virus (HCV); BIK; NS5B;
Accurate genotyping of hepatitis C virus through nucleotide sequencing and identification of new HCV subtypes in China population
Keywords: Genotype; hepatitis C virus; ns5b; sequencing; subtype;
Research ArticleHLA-Bâ27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope
Keywords: HLA; human leukocyte antigen; HCV; hepatitis C virus; NS5B; non-structural protein 5B; PBMC; peripheral blood mononuclear cell; EBV; Epstein Barr virus; B-LCL; B-lymphoblastoid cell lines; IFN-γ; interferon-gamma; Hepatitis C virus; CD8+ T cell response;
Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a
Keywords: Hepatitis C virus; Genotype 3; Replicon; NS5A; NS5B; chimera;
Hepatitis C virus polymerase-polymerase contact interface: Significance for virus replication and antiviral design
Keywords: HCV; NS5B; Protein-protein interactions; Antiviral drugs;
In vitro selection of the 3â²-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B
Keywords: HCV; NS5B; LGALS1 (GAL-1); mRNA 3â²-UTR; RPS4X;
No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing
Keywords: HCV; NS5B; Resistance; S282T; Deep sequencing;
Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods
Keywords: HTQMVQVXFRQIKW-UHFFFAOYSA-N; GHOSNRCGJFBJIB-UHFFFAOYSA-N; QUWPELVBLLLYGL-UHFFFAOYSA-N; AYBCFPXLXOLPIZ-JIPXPUAJSA-N; DWNLKPNALZNWCU-UHFFFAOYSA-N; UVECAUSNPDCAPG-UHFFFAOYSA-N; NS5B; RdRp; HCV; SAR; HCV-796; RDKit; Random Forest; k Nearest Neighbor Simulated
Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase
Keywords: HCV; NS5B; Inhibitor; Kinetics; Chemodynamics; Thermodynamics;
Evaluation of 2′-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase
Keywords: Hepatitis C; HCV; Nucleosides; NS5b; Polymerase; HCV NS5b polymerase
Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound
Keywords: Bovine viral diarrhea virus; Antiviral; NS5B; Cattle
Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity
Keywords: HCV; NS5B; Oleanolic acid; Ursolic acid; Antivirals
β-d-2â²-α-F-2â²-β-C-Methyl-6-O-substituted 3â²,5â²-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure-activity relationship study
Keywords: PSI-352938; PSI-353661; HCV; Nucleoside; Nucleotide; Antiviral; Prodrug; NS5B; Cyclic phosphate; Hepatitis C virus;
Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a
Keywords: HCV; NS5B; GS-9190; Tegobuvir; Chimeric; Replicon
Research ArticleHepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation
Keywords: HCV; hepatitis C virus; NS5A; non-structural 5A; NS5B; non-structural 5B; HCC; hepatocellular carcinoma; CycA2; cyclin A2; CDK1&2; cyclin-dependent kinase 1&2; GST; glutathione S-transferase; PBS; phosphate-buffered saline; TRITC; tetramethylrhodamine iso
Classical swine fever virus NS5A protein interacts with 3′-untranslated region and regulates viral RNA synthesis
Keywords: Classical swine fever virus; NS5A; NS5B; 3′UTR
Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors
Keywords: Hepatitis C virus; RNA polymerase; NS5B; Non-nucleoside polymerase inhibitors; Resistance; Genotype coverage
Identification and evaluation of anti Hepatitis C virus phytochemicals from Eclipta alba
Keywords: HCV; Hepatitis C virus; NS5B; non-structural protein 5B of hepatitis C virus; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; Poly (rA).(dT)18; polyriboadenylic acid annealed with (oligodeoxythymidylic acid)18; RdRp; RNA-dependant RNA
Classical swine fever virus NS5A regulates viral RNA replication through binding to NS5B and 3′UTR
Keywords: Classical swine fever virus; NS5A; NS5B; Viral replication; NS5A–NS5B interaction
Second generation direct antivirals and the way to interferon-free regimens in chronic HCV
Keywords: Hepatitis C virus; Direct acting antiviral agents; NS3/4A protease inhibitor; NS5A; NS5B; Nucleotide inhibitors; Non-nucleotide inhibitors; Cyclophilin inhibitor
Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus
Keywords: Carbocyclic nucleoside; Anti-HCV; NS5B; X-ray structure
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase
Keywords: HCV; NS5B; Co-crystal; Structure; Antiviral; Inhibitor; Polymerase
The Synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors
Keywords: Hepatitis; Polymerase; NS5B; Inhibitors; Pyrazoles
Phylogenetic analysis of recent classical swine fever virus (CSFV) isolates from Assam, India
Keywords: Classical swine fever virus; E2; India; NS5B; Phylogenetic analysis; 5′ UTR
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Keywords: NS5B; HCV; Indolo-fused heterocyclic inhibitors
Dual pro-drugs of 2′-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus
Keywords: HCV; ProTide; Phosphoramidate; Nucleoside; Nucleotide; Polymerase; NS5B
Discovery of novel HCV polymerase inhibitors using pharmacophore-based virtual screening
Keywords: HCV; NS5B; Polymerase; Virtual screening; Molecular docking; Pharmacophore
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons
Keywords: Hepatitis C virus; Antiviral; HCV; NS5B; Polymerase; Inhibitor; SAR
SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Keywords: HCV; NS5B; Allosteric inhibitors; SAR
RNA-dependent RNA polymerases from different hepatitis C virus genotypes reveal distinct biochemical properties and drug susceptibilities
Keywords: HCV, hepatitis C virus; GT, genotype; NS5B, non-structure protein 5B (RNA-dependent RNA polymerase); NNI, non-nucleoside polymerase inhibitorHCV; NS5B; Genotype; RNA polymerase; Non nucleoside inhibitor
Characterisation of interaction between NS3 and NS5B protein of classical swine fever virus by deletion of terminal sequences of NS5B
Keywords: Classical swine fever virus; NS5B; NS3; NS3-NS5B interaction;
Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors
Keywords: Hepatitis C; HCV; NS5B; Polymerase; Benzothiadiazine; Benzothiazine; Benzoisothiazole; Tetramic acid; Review;