Keywords: cytochrome P450; drug interaction; OATP1B1; pharmacokinetics; red ginseng;
مقالات ISI (ترجمه نشده)
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Keywords: Microcystins; OATP1B1; OATP1B3; Cell culture model; Aggregate; Cyanotoxins;
Keywords: BCRP; breast cancer resistance protein; BSEP; bile salt export pump; BSP; bromosulfophtalein; CYP; cytochrome P450; day 29 or 36; hepatocyte cultures 29 or 36 days respectively after start of the hepatic differentiation protocol; E17βG; estradiol-17β-d-
BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications
Keywords: ABC; ATP-binding cassette; AUC; area under the time-concentration curve; BCRP; breast cancer resistance protein; Cmax; maximum concentration; CYP; cytochrome P450; DOAC; direct oral anti-coagulant; GI; gastrointestinal; MRP1; multidrug resistance protei
Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case
Keywords: Cyclosporin (PubChem CID: 122172945); Atazanavir (PubChem CID: 86601659); Nelfinavir (PubChem CID: 122130496); Itraconazole (PubChem CID: 86611782); Amphotericin B (PubChem CID: 122130047); Ciprofloxacin (PubChem CID: 92135222); Clopidogrel (PubChem CID:
Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s
Keywords: Curcumin; Docetaxel; Pharmacokinetics; OATP1B1; OATP1B3; Human liver microsomes;
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice
Keywords: ABC; ATP-binding cassette; AUC; area under the concentration-time curve; DDI; drug-drug interactions; E2G; estradiol 17β-d-glucuronide; i.v.; intravenous; OATP; organic anion-transporting polypeptide; TKI; tyrosine kinase inhibitor; UGT1A1; UDP-glucuro
Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3
Keywords: Hepatotoxicity; Microcystin-LR; OATP1B1; OATP1B3; Okadaic acid; BSP; bromosulfophthalein; DHEAS; dehydroepiandrosterone sulfate; DMF; dose modifying factor; FCS; fetal calf serum; MC-LR; microcystin-LR; IC50; half maximal inhibitory concentration; MEM; mi
Naringin attenuates the cytotoxicity of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells
Keywords: FCS; fetal calf serum; MC-LR; microcystin-LR; IC50; half maximal inhibitory concentration; Km; Michaelis constant; MEM; minimum essential medium; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; OATP; organic anion transporting polypept
Muscle symptoms in statin users, associations with cytochrome P450, and membrane transporter inhibitor use: A subanalysis of the USAGE study
Keywords: Statins; Drug interactions; Myopathy; Cytochrome P450; P-glycoprotein; OATP1B1; Discontinuation; Muscle pain
Research ArticleA phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1
Keywords: HCV; hepatitis C virus; CYP3A4; cytochrome P450 isoform 3A4; RNA; ribonucleic acid; IL28B; interleukin-28B; LiPA; Versant® HCV Genotype Inno-LiPA Assay, version 2.0; MedDRA; Medical Dictionary for Regulatory Activities; OATP1B1; organic anion transportin
Consumption of baby kale increased cytochrome P450 1A2 (CYP1A2) activity and influenced bilirubin metabolism in a randomized clinical trial
Keywords: BHNRC; Beltsville Human Nutrition Research Center; CYP1A2; cytochrome P450 family 1 subfamily A member 2; CYP2A6; cytochrome P450 family 2 subfamily A member 6; CV; control vegetables; GST; glutathione S-transferase; GSTA; glutathione S-transferase alpha;
A LC–MS/MS method to evaluate the hepatic uptake of the liver-specific magnetic resonance imaging contrast agent gadoxetate (Gd-EOB-DTPA) in vitro and in humans
Keywords: Gadoxetate; Gd-EOB-DTPA; LC–MS/MS; OATP1B1
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
Keywords: Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch
Prediction of the in vivo OATP1B1-mediated drug–drug interaction potential of an investigational drug against a range of statins
Keywords: Transporters; Drug–drug interactions (DDI); In vitro; OATP1B1; Statins; US Food and Drug Administration (US FDA)
Pediatric Pharmacogenomics
Keywords: Pharmacogenomics; Ontogeny; HMG-CoA reductase inhibitors; Statins; Low-density lipoprotein cholesterol; OATP1B1; Cytochrome P450; Pediatrics;
Cytotoxicity of atorvastatin and simvastatin on primary rainbow trout (Oncorhynchus mykiss) hepatocytes
Keywords: HMGR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; PEC; predicted environmental concentration; MVA; mevalonic acid; CYP; cytochrome P-450; AB; alamar blue; CFDA-AM; 5-carboxyfluorescein diacetate, actetoxymethyl ester; GLM; general linear model; OAT
Fluorescence-based assays for the assessment of drug interaction with the human transporters OATP1B1 and OATP1B3
Keywords: Transporter; Transport; Fluorescence; OATP1B1; OATP1B3
Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition
Keywords: Microcystin LR; OATP1B1; HSP27; KCC transporters; DIOA
Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer
Keywords: UGT1A; ABCB1; ABCC2; ABCG2; OATP1B1; Irinotecan; NSCLC
Interaction of porphyrins with human organic anion transporting polypeptide 1B1
Keywords: BSP; bromosulfophthalein; HEK293; human embryonic kidney; ICG; indocyanine green; OATP1B1; organic anion transporting polypeptide 1B1; OATP1B1 inhibitor; Porphyria; Bilirubin; Porphyrin;
BacMam recombinant baculovirus in transporter expression: A study of BCRP and OATP1B1
Keywords: BCRP; ABCG2; MXR; Efflux transporter; OATP1B1; OATP-C; OATP2; SLC21A6; Influx transporter; BacMam; ADME; Pharmacokinetics