Keywords: OPN، osteopontin; NAFLD, nonalcoholic fatty liver disease; OPN, osteopontin; TGF-β, transforming growth factor β; αSMA, alpha smooth muscle actin; MCD diet, methionine choline deficient diet; FFPE, formalin-fixed, paraffin embedded; HPF, high-powered field; shScr, short-ha
مقالات ISI OPN، osteopontin (ترجمه نشده)
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Keywords: OPN، osteopontin; OPN, osteopontin; MFI, mean fluorescence intensity; mOPN, milk osteopontin; rmOPN, recombinant mammalian OPN; rbOPN, recombinant bacterial OPN; RAA OPN, N-terminal OPN half with RGD mutated to RAA; SVV-BSA, CGGSVVYGLR peptide cross-linked to BSA; LDV-BSA,
Keywords: OPN، osteopontin; ACTH, adrenocorticotrophic stimulating hormone; BMC, bone mineral content; BMD, bone mineral density; BV/TV, bone volume density; CT, computed tomography; DEXA, Dual Energy X-ray Absorptiometry; HE, hematoxylin eosin; OCN, osteocalcin; OPN, osteopontin; O
Keywords: OPN، osteopontin; kidney; ureteral obstruction; aliskiren; bredinin; drug synergismα-SMA, α-smooth muscle actin; Ang, angiotensin; MCP-1, monocyte chemotactic protein-1; MZR, mizoribine; OPN, osteopontin; RAS, renin-angiotensin system; RT-PCR, reverse transcription-polymer
Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways
Keywords: OPN، osteopontin; VSMC, vascular smooth muscle cell; OPN, osteopontin; HNE, 4-hydroxynonenal; WT, wild type; EGFR, epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; ChIP, chromatin immunoprecipitation; RTK, receptor tyrosine kinases; PCNA, p
Role of β-catenin in development of bile ducts
Keywords: OPN، osteopontin; APC, adenomatous polyposis coli; CK19, cytokeratin 19; E, embryonic day; HNF, Hepatocyte Nuclear Factor; OPN, Osteopontin; Muc1, Mucin-1; P, postnatal day; Sox9, SRY-related HMG box transcription factor 9; ZO1, Zonula Occludens-1Liver development; Biliary
A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins
Keywords: OPN، osteopontin; Fam20C, Family with Sequence Similarity 20, Member C; G-CK, Golgi-Casein Kinase or Genuine Casein Kinase; DMP-4, Dentin Matrix Protein-4; OPN, Osteopontin; BMP15, Bone Morphogenetic Protein 15; IGFBP, Insulin-like Growth Factor-Binding Protein; FGF23, Fib
The small chemical enzyme inhibitor 5-phenylnicotinic acid/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase/ACP5-overexpressing MDA-MB-231 breast cancer cells
Keywords: OPN، osteopontin; TRAP, tartrate-resistant acid phosphatase; CD13, 5-phenylnicotinic acid; OPN, osteopontin; PP1, mammalian serine/threonine protein phosphatase type 1; PP2A, protein phosphatase type 2A; KRT(p)IRR, phospho-threonine peptide; 1WAR, human TRAP 5a; 1QHW, rat
High preoparative levels of serum periostin are associated with poor prognosis in patients with hepatocellular carcinoma after hepatectomy
Keywords: OPN، osteopontin; Periostin; Hepatocellular carcinoma; PrognosisAFP, alpha-fetoprotein; DFS, disease-free survival; ECM, extracellular matrix; HBV, hepatitis B viral; HCC, hepatocellular carcinoma; NSCLC, non-small cell lung cancer; OPN, osteopontin; OS, overall survival;
Prognostic values of osteopontin-c, E-cadherin and β-catenin in breast cancer
Keywords: OPN، osteopontin; CAMs, cell adhesion molecules; DFS, disease-free survival; ER, estrogen receptor; HER-2/neu, human epidermal growth factor receptor 2; OS, overall survival; OPN, osteopontin; pN, positive lymph node; PR, progesterone receptorBreast cancer; Osteopontin-c;
Osteopontin Up-Regulates Critical Epithelial-Mesenchymal Transition Transcription Factors to Induce an Aggressive Breast Cancer Phenotype
Keywords: OPN، osteopontin; APT, aptamer; Bmi-1, B lymphoma Mo-MLV insertion region 1 homolog; ChIP, chromatin immunoprecipitation; EMT, epithelial-mesenchymal transition; mRNA, messenger RNA; OPN, osteopontin; PCR, polymerase chain reaction; TF, transcription factor; TGF, transform
Locally administered prostaglandin E2 prevents aeroallergen-induced airway sensitization in mice through immunomodulatory mechanisms
Keywords: OPN، osteopontin; PGE2, prostaglandin E2; HDM, house dust mite; pDC, plasmacytoid DC; mDC, myeloid DC; OPN, osteopontin; AHR, airway hyperresponsiveness; MC, mast cell; mMCP-1, mouse mast cell protease-1; WBP, whole body plethysmographyAeroallergen sensitization; Immunomod
The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells
Keywords: OPN، osteopontin; mDCs, mature dendritic cells; iDCs, immature DCs; H-mDCs, hypoxic mDCs; pO2, partial oxygen pressure; OPN, osteopontin; VEGF, vascular endothelial growth factor; IL-1, interleukin-1; MDMs, monocyte-derived macrophages; PBMCs, peripheral blood mononuclear
Bone morphogenetic protein-2 will be a novel biochemical marker in urinary tract infections and stone formation
Keywords: OPN، osteopontin; UTI, urinary tract infection; BMP-2, bone morphogenetic protein-2; THP, Tamm–Horsfall protein; OPN, osteopontin; GGT, gamma glutamyl transferaseBone morphogenetic protein; Tamm–Horsfall protein; Osteopontin; UTI; Renal stone
Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population
Keywords: OPN، osteopontin; IAV, influenza A virus; OPN, osteopontin; rOPN, recombinant osteopontin; TNF-α, tumor necrosis factor-α; IL, interleukin; IFN, interferon; Con-A, concanavalin A; KO, knockout; Tg, transgenic; NK cells, natural killer cells; WT, wild type; DAB, 3,3′-diamin
Ultra-sensitive DNA assay based on single-molecule detection coupled with fluorescent quantum dot-labeling and its application to determination of messenger RNA
Keywords: OPN، osteopontin; BSA, bovine serum albumin; DEPC, diethypyrocarbonate; DNase, deoxyribonuclease; dNTP, deoxy-ribonucleoside triphosphate; DSC, decidual stromal cell; GOPS, 3-glycidoxypropyltrimethoxysilane; mRNA, messenger RNA; OPN, osteopontin; PBS, physiological buffer
Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts
Keywords: OPN، osteopontin; Ang II, angiotensin II; CSA, cyclosporine A; DMEM, Dulbecco's modified Eagle's medium; ET-1, endothelin-1; MAPK, mitogen-activated protein kinase; OPN, osteopontin; PBS, phosphate-buffered saline; PKC, protein kinase C; TGF-β1, transforming growth factor-
Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells
Keywords: OPN، osteopontin; OPN, osteopontin; CM, conditioned media; EPCs, endothelial progenitor cells; RT-PCR, reverse-transcription polymerase chain reaction; VEGF, vascular endothelial growth factor; VEGFR-1, vascular endothelial growth factor receptor 1; VEGFR-2, vascular endot
Plasma osteopontin concentration correlates with the severity of hepatic fibrosis and inflammation in HCV-infected subjects
Keywords: OPN، osteopontin; HCV, HBV, viral hepatitis B and C; HCC, hepatocellular carcinoma; OPN, osteopontin; HAI, histological activity index; HSC, hepatic satellite cell; ECm, extracellular matrixOsteopontin; Hepatic fibrosis; Hepatic inflammation; Hepatitis C virus
Gene-Gene-Sex Interaction in Cytokine Gene Polymorphisms Revealed by Serum Interferon Alpha Phenotype in Juvenile Dermatomyositis
Keywords: OPN، osteopontin; IFN-α, Interferon alpha; IRF5, Interferon regulatory factor 5; JDM, Juvenile dermatomyositis; OPN, Osteopontin; PTPN22, Protein tyrosine phosphatase non-receptor type 22; SLE, Systemic lupus erythematosus; SNP, Single nucleotide polymorphism; TNF-α, Tumor
Oxidized low-density lipoprotein increases osteopontin expression by generation of oxidative stress
Keywords: OPN، osteopontin; LDL, low-density lipoprotein; OxLDL, Cu2+-oxidized LDL; OPN, osteopontin; ROS, reactive oxygen species; TBARS, thiobarbituric acid-reactive substances (lipid peroxidation products); BSO, buthionine sulfoximineOxidized LDL; Osteopontin; Inflammation; Oxida
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
Keywords: OPN، osteopontin; 9; 10; 10.1; 29BCE, bovine capillary endothelial; bp, base pair; DMEM, Dulbecco's Modified Eagle Medium; ELISA, enzyme-linked immunosorbent assay; NSCLC, non–small-cell lung cancer; OPN, osteopontin; RT-PCR, reverse transcriptase-polymerase chain reaction
Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress
Keywords: OPN، osteopontin; Pi, Inorganic phosphate; OxLDL, Cu2+-oxidized low density lipoprotein; OPN, osteopontin; RANKL, Receptor Activator of NFkappaB ligand; ERK, Extracellular signal-regulated kinase; JNK, Jun kinase; AP1, Activator Protein 1; CREB, cAMP Response Element Bindi
Effects of inorganic polyphosphate on bone sialoprotein gene expression
Keywords: OPN، osteopontin; BSP, bone sialoprotein; OPN, osteopontin; FGF2, fibroblast growth factor 2; FRE, FGF response element; bp, base pair(s); nts, nucleotides; PKC, protein kinase C; PKA, cAMP dependent protein kinase; LUC, luciferase; AP1, activator protein 1; CRE, cAMP resp
Drynaria fortunei J. Sm. promotes osteoblast maturation by inducing differentiation-related gene expression and protecting against oxidative stress-induced apoptotic insults
Keywords: OPN، osteopontin; ALP, alkaline phosphatase; BMP, bone morphogenetic protein; DMEM, Dulbecco's modified Eagle's medium; IGF-1, insulin-like growth factor-1; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; OCN, osteocalcin; OPN, osteopontin; PBS, phosphat
Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase
Keywords: OPN، osteopontin; OPN, osteopontin; bmOPN, bovine milk osteopontin; hrOPN, human recombinant osteopontin; hmOPN, human milk osteopontin; PTM, post-translational modification; TRAP, tartrate-resistant acid phosphatase; RGD, Arg-Gly-Asp; pNPP, p-nitrophenyl phosphate, 4-nitr
Hard tissue-forming potential of stem/progenitor cells in human dental follicle and dental papilla
Keywords: OPN، osteopontin; DFCs, dental follicle cells; DPCs, dental papilla cells; AIST, Advanced Industrial Science and Technology; FITC, fluorescein isothiocyanate; ALP, alkaline phosphatase; CP23, cementum protein-23; DSPP, dentin sialophosphoprotein; OPN, osteopontin; GAPDH, d
Markers of bone remodeling and skeletal morbidity in patients with solid tumors metastatic to the skeleton receiving the biphosphonate zoledronic acid
Keywords: OPN، osteopontin; ECOG, eastern co-operative oncology group; OPN, osteopontin; NTX, N-telopeptide, collagen type I; CTX, C-telopeptide, collagen type I; TRACP-5b, 5b isoenzyme of tartrate-resistant acid phosphatase; bALP, alkaline phosphatase, bone isoenzyme; sRANKL, solub
Osteopontin induces β-catenin signaling through activation of Akt in prostate cancer cells
Keywords: OPN، osteopontin; OPN, osteopontin; αvβ3, vitronectin receptor; RGD, cell adhesion sequences containing arginine–glycine–aspartic acid amino acids; siRNA, small interfering RNA; WM, wortmannin; PDK1, phosphoinositide-dependent kinase, PC3, human epithelial prostate cancer
B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways
Keywords: OPN، osteopontin; BCR, B cell receptor; Opn, osteopontin; FO, follicular; MZ, marginal zone; ELISA, enzyme-linked immunosorbent assay; IL-4, interleukin-4; ETA-1, early T lymphocyte activator 1; SPP1, secreted phosphoprotein 1; EAE, experimental autoimmune encephalomyeliti
Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis
Keywords: OPN، osteopontin; BMI, body mass index; CI, confidence interval; DM, diabetes mellitus; MetS, metabolic syndrome; OPN, osteopontin; OR, odds ratio; SNPs, single nucleotide polymorphisms
Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(β-hydroxybutyrate-co-β-hydroxyvalerate)
Keywords: OPN، osteopontin; ECM, extracellular matrix; FN1, fibronectin; GAG, glycosaminoglycan; ON, osteonectin; OPN, osteopontin; PHBV, Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate); REU, relative expression units; RNA, ribonucleic acid; TCP, tissue culture plastic; VN, vitro
Osteopontin increases lung cancer cells migration via activation of the αvβ3 integrin/FAK/Akt and NF-κB-dependent pathway
Keywords: OPN، osteopontin; NSCLCs, non-small cell lung cancers; ECM, extracellular matrix; OPN, osteopontin; FAK, focal adhesion kinase; PI3K, phosphatidylinositol 3-kinase; IKK α/β, IκB kinase α/β; NF-κB, nuclear factor-κBOPN; Lung cancer; Integrin; Migration; FAK
Regulation of human bone sialoprotein gene transcription by platelet-derived growth factor-BB
Keywords: OPN، osteopontin; BSP, bone sialoprotein; OPN, osteopontin; PDGF, platelet-derived growth factor; FGF2, fibroblast growth factor 2; FRE, FGF2 response element; bp, base pair(s); nts, nucleotides; PKC, protein kinase C; PKA, cAMP dependent protein kinase; LUC, luciferase; A
Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin
Keywords: OPN، osteopontin; OPN, osteopontin; LF, lactoferrin; ITC, isothermal titration calorimetry; DSC, differential scanning calorimetryLactoferrin; Osteopontin; Immunity; Inflammation; Cytokines; Immunodeficiency diseases; Calcium; Iron; Isothermal titration calorimetry; Differ
Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9
Keywords: OPN، osteopontin; C/EBPα, CCAAT/Enhancer Binding Protein α; ECM, extracellular matrix; HES1, Homolog of Hairy/Enhancer of Split-1; Hex, hematopoietically expressed homeobox factor; HNF, Hepatocyte Nuclear Factor; OPN, osteopontin; PDS, primitive ductal structures; SOX9, SR
Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro
Keywords: OPN، osteopontin; PRDC, Protein related to Dan and Cerberus; BMP, Bone morphogenetic protein; ALP, Alkaline phosphatase; OC, Osteocalcin; OPN, Osteopontin; siRNA, Small interfering RNA; AA, Ascorbic acid; β-GP, β-GlycerophosphateBMP; Antagonist; Osteoblast; Differentiation
Arterial calcification: a tumor necrosis factor-alpha mediated vascular Wnt-opathy
Keywords: OPN، osteopontin; BMP-2, bone morphogenetic protein-2; CKD, chronic kidney disease; DM, diabetes mellitus; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HFD, high fat diet; OPN, osteopontin; OPG, osteoprotegerin; TNF-α, tumor necrosis factor-alpha
Osteopontin functions as an opsonin and facilitates phagocytosis by macrophages of hydroxyapatite-coated microspheres: Implications for bone wound healing
Keywords: OPN، osteopontin; OPN, Osteopontin; IgGs, immunoglobulins; TG2, transglutaminase 2; b-OPN, bovine milk osteopontin; b-IgG, Bovine IgG; BSA, bovine serum albumin; m-IgG, mouse IgG; MSA, mouse serum albumin; FBS, fetal bovine serum; Lamp-1, lysosome-associated membrane prote
Interaction of osteopontin with neutrophil α4β1 and α9β1 integrins in a rodent model of alcoholic liver disease
Keywords: OPN، osteopontin; ALD, Alcoholic liver disease; ASH, Alcoholic steatohepatitis; cOPN, cleaved osteopontin; EtOH, Ethanol; LPS, Lipopolysaccharide; OPN, Osteopontin; RGD, arginine–glycine–aspartateChemokine; Chemokinesis; Ethanol; Inflammation; Neutrophils; Steatohepatitis
Osteopontin: Role in immune regulation and stress responses
Keywords: OPN، osteopontin; OPN, Osteopontin; iOPN, intracellular OPN; sOPN, secreted OPN; DC, dendritic cell; DTH, delayed type hypersensitivity; EAE, experimental allergic encephalomyelitis; HSC, hematopoietic stem cellIntegrins; CD44; Apoptosis; Innate immunity; Cell-mediated imm
Down-Regulation of Osteopontin Suppresses Growth and Metastasis of Hepatocellular Carcinoma Via Induction of Apoptosis
Keywords: OPN، osteopontin; 5-FU, 5-fluorouracil; GFP, green fluorescent protein; MMP, mitochondrial membrane potential; NF-κB, nuclear factor-κB; OPN, osteopontin; shNon, nonsilencing shRNA; shOPN, shRNA targeting OPN; shRNA, short-hairpin RNA; TMRE, tetramethylrhodamine ethylester
Prognostic significance of osteopontin in hepatitis B virus-related hepatocellular carcinoma
Keywords: OPN، osteopontin; OPN, osteopontin; HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, α-fetoprotein; PBS, phosphate-buffered saline; DFS, disease-free survival; OS, overall survivalHepatitis B virus-related hepatocellular carcinoma; Metastasis; Osteopontin; Progn
Effect of traditional Chinese medicine Qin-Dan-Jiang-Ya-Tang on remodeled vascular phenotype and osteopontin in spontaneous hypertensive rats
Keywords: OPN، osteopontin; ECM, extracellular matrix; HE, hematoxylin–eosin; LD, lumen diameter; MMP, matrix metalloproteinase; MT, media thickness; OPN, osteopontin; QDJYT, Qin-Dan-Jiang-Ya-Tang; RGD, arginine-glycine-aspartate; SBP, systolic blood pressure; SHR, spontaneous hyper
Over-expression of TIMP-1 in osteoblasts increases the anabolic response to PTH
Keywords: OPN، osteopontin; BMC, bone mineral content; BMD, bone mineral density; DEXA, dual-energy X-ray absorptiometry; HPRT, hypoxanthine guanine phosphoribosyl transferase; MMP, matrix metalloproteinase; OC, osteocalcin; OPN, osteopontin; PTH, human recombinant PTH fragment 1-34
Effects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application
Keywords: OPN، osteopontin; CF-TP, polyphenol extract of Crataegus pinnatifida; TPA, 12-O-tetradecanoylphorbol-13-acetate; B[a]P, benzo[a]pyrene; OPN, osteopontin; H2O2, hydrogen peroxide; MPO, myeloperoxidase; ODC, ornithine decarboxylase; iNOS, inducible nitric oxide synthase; COX
Assembly of collagen-binding peptide with collagen as a bioactive scaffold for osteogenesis in vitro and in vivo
Keywords: OPN، osteopontin; Bioactive scaffold; Collagen-binding motif peptide; Assembly; Osteopontin; Biomineralization; Bone regenerationCBM, collagen-binding motif; SPR, surface plasmon resonance; BSP, bone sialoprotein; OPN, osteopontin; ECM, extracellular matrix; XRD, X-ray dif
Osteopontin expression in activated glial cells following mechanical- or toxin-induced nigral dopaminergic cell loss
Keywords: OPN، osteopontin; 6-OHDA, 6-hydroxydopamine; LPS, lipopolysaccharide; OPN, osteopontin; PD, Parkinson's disease; SN, substantia nigra; TH, tyrosine hydroxylaseOsteopontin; Substantia nigra; Parkinson's disease; 6-Hydroxydopamine; Rat
Calcospherulites1 isolated from the mineralization front of bone induce the mineralization of type I collagen
Keywords: OPN، osteopontin; BAG-75, Bone acidic glycoprotein-75; BMF, biomineralization foci; BSP, bone sialoprotein; OPN, osteopontin; SEM, scanning electron microscopy; TEM, transmission electron microscopy; EDS, energy dispersive spectroscopy; XRD, X-ray diffraction; PBS, phospha
Regulation of podosomes by integrin αvβ3 and Rho GTPase-facilitated phosphoinositide signaling
Keywords: OPN، osteopontin; Osteoclasts; Integrin αvβ3; Osteopontin; Rho GTPase; Podosomes; Actin ring; Phosphoinositides; Gelsolin; WASP; PI3 kinase; PI4P-5 kinaseABPs, actin-binding proteins; HA, hemagglutinin; OPN, osteopontin; PBD, phosphoinositide-binding domain; PI(4, 5)P2, ph