کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2832332 | 1163836 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways](/preview/png/2832332.png)
Classical BCR signaling requires a number of signalosome mediators that are bypassed when BCR signaling follows an alternate pathway produced by prior exposure of B cells to IL-4. The two pathways, classical and alternate, co-exist in IL-4-treated B cells. Here we report that operation of the IL-4-induced alternate pathway in combination with the classical pathway changes the nature of the B cell response to BCR engagement so that the cytokine, osteopontin (Opn), is produced and secreted. Although Opn expression by B cells has not previously been noted, anti-Ig-induced secretion by IL-4-treated B cells amounts to levels comparable to those secreted by activated T cells. However, unlike T cell Opn expression, B cell expression of Opn is not mediated by T-Bet. Because elevated levels of IL-4 occur in association with severe illness, and because Opn is strongly associated with autoimmunity, these results suggest that the IL-4-induced alternate BCR signaling pathway may participate in the pathophysiology of autoimmune dyscrasias.
Journal: Molecular Immunology - Volume 46, Issue 4, February 2009, Pages 587–591