Keywords: P-glycoprotein (P-gp); Fluorescence microscopy; Electrochemical sensor; Chronic myeloid leukemia; Single-wall carbon nanotube;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: Solubility-permeability interplay; Intestinal absorption; Solubility-enabling formulations; Efflux transport; P-glycoprotein (P-gp); D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS);
Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins
Keywords: ABC transporters; P-glycoprotein (P-gp); Cancer; Chemotherapeutic drugs; Multidrug resistance; 7q21 amplicon; Sorcin;
Extending the structureâactivity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors
Keywords: Ningalin B; Multidrug resistance (MDR); P-glycoprotein (P-gp); P-gp chemosensitizer; ATP-Binding cassette (ABC) transporter;
CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy
Keywords: Spinal muscular atrophy (SMA); Survival motor neuron (SMN); P-glycoprotein (P-gp); Blood brain barrier (BBB); Bortezomib; Tariquidar; Proteasome;
Establishment and characterization of an MDCK cell line stably-transfected with chicken Abcb1 encoding P-glycoprotein
Keywords: P-glycoprotein (P-gp); Abcb1; Rhodamine123; MDCK-chAbcb1 cells;
Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors
Keywords: Permethyl ningalin B; Multidrug resistance (MDR); P-glycoprotein (P-gp); P-gp chemosensitizer; ATP-binding cassette (ABC) transporter;
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability
Keywords: Protein kinase C theta (PKCθ); CYP3A4 time-dependent inhibition (TDI); P-glycoprotein (P-gp);
Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation
Keywords: Paris saponin VII; Growth inhibition; Multidrug resistance (MDR); P-glycoprotein (P-gp); Apoptosis;
A novel compound RY10-4 downregulates P-glycoprotein expression and reverses multidrug-resistant phenotype in human breast cancer MCF-7/ADR cells
Keywords: RY10-4; Multidrug-resistance (MDR); P-glycoprotein (P-gp); Reversal effect
Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells
Keywords: Tetrandrine; Fangchinoline; Multidrug resistance (MDR); ABC transporter activity; P-glycoprotein (P-gp);
An investigation of heat shock protein 27 and P-glycoprotein mediated multi-drug resistance in breast cancer using liquid chromatography-tandem mass spectrometry-based targeted proteomics
Keywords: Heat shock protein 27 (HSP27); P-glycoprotein (P-gp); Multi-drug resistance; Phosphorylation; Liquid chromatography-tandem mass spectrometry; Targeted proteomics;
A high-yield route to synthesize the P-glycoprotein radioligand [11C]N-desmethyl-loperamide and its parent radioligand [11C]loperamide
Keywords: [11C]N-Desmethyl-loperamide ([11C]dLop); [11C]Loperamide; P-glycoprotein (P-gp); Automation; Positron emission tomography (PET); Brain imaging;
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp
Keywords: Arylthiazoles; P-glycoprotein (P-gp); MRP1; Tariquidar;
Transcellular transport of aconitine across human intestinal Caco-2 cells
Keywords: Aconitine; Caco-2 cells; P-glycoprotein (P-gp); pH-dependent carrier-mediated transport;
PHII-7 inhibits cell growth and induces apoptosis in leukemia cell line K562 as well as its MDR- counterpart K562/A02 through producing reactive oxygen species
Keywords: Reactive oxygen species; PHII-7; DNA damage; P-glycoprotein (P-gp); Apoptosis; Cell cycle arrest;
Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells – Novel strategies for intracellular drug targeting
Keywords: multidrug resistance (MDR); P-glycoprotein (P-gp); peptide transporter; mitochondria
Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: Novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties
Keywords: Structure–activity relationships (SAR); Multidrug resistance (MDR); P-glycoprotein (P-gp); Inhibitor; Efflux pump inhibition
Personalised MedicineEnhanced brain accumulation of pazopanib by modulating P-gp and Bcrp1 mediated efflux with canertinib or erlotinib
Keywords: Pazopanib; Pharmacokinetics; Brain; P-glycoprotein (P-gp); Breast cancer resistance protein (Bcrp1); Erlotinib; Canertinib;
Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells
Keywords: Gypenoside aglycon; Gynostemma pentaphyllum; Multidrug resistance (MDR); KB/VCR cells; P-glycoprotein (P-gp); Multidrug resistance associated protein 1 (MRP1);
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells
Keywords: P-glycoprotein (P-gp); Multidrug resistance-associated protein 4 (MRP4); Caco-2 cells; Adefovir dipivoxil; 1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3); Vitamin D receptor (VDR)
Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships
Keywords: Structure-activity relationships (SAR); Multidrug resistance (MDR); P-glycoprotein (P-gp); Lead structure; Efflux pump inhibition;
Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure
Keywords: Sodium ferulate; IUGR; Placenta; Oxidative stress; Antioxidative functions; P-glycoprotein (P-gp)
Rapid and simultaneous measurement of midazolam, 1′-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: Application to an in vivo study to simultaneously measure P-glycoprotein and Cytochrome P450 3A activity
Keywords: Midazolam (MDZ); 1′-Hydroxymidazolam (1′-OHMDZ); Digoxin (DG); Liquid chromatography/tandem mass spectrometry (LC–MS/MS); P-glycoprotein (P-gp); Cytochrome P450 3A (CYP3A)
Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum
Keywords: Multidrug resistance (MDR); P-glycoprotein (P-gp); Curcuma wenyujin; Chrysanthemum indicum; MCF-7/ADR cells; A549/Taxol cells
P-glycoprotein limits the absorption of the anti-HIV drug zidovudine through rat intestinal segments
Keywords: Azidothymidine (AZT); Gut sac technique; Intestinal permeation; P-glycoprotein (P-gp)
PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression
Keywords: Multi-drug resistance (MDR); P-glycoprotein (P-gp); PKD2; Paclitaxel
Synthesis and in vivo evaluation of 18F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters
Keywords: Positron emission tomography (PET); Fluorine-18; P-Glycoprotein (P-gp); Breast cancer resistance protein (BCRP); Drug efflux transporter; GF120918 (elacridar); XR9576 (tariquidar)
Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators
Keywords: Structure-activity relationships (SAR); Multidrug resistance (MDR); P-Glycoprotein (P-gp); Multidrug resistance associated protein (MRP); Breast cancer resistant protein (BCRP); Selectivity;
Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells
Keywords: compound of the substituted 1,3-dimethyl-1H-quinoxalin-2-ones QA3; multidrug resistance (MDR); P-glycoprotein (P-gp); ATP; ATPase; PKC; Apoptosis; caspases
2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists
Keywords: ORL1 antagonist; Nociceptin/orphanin FQ; Benzimidazole; P-glycoprotein (P-gp);
Expert Panel report on a study of Splenda in male rats
Keywords: Splenda; Sucralose; Weight gain; Body weight; Gut bacteria; Fecal microflora; P-glycoprotein (P-gp); P450 enzymes; Safety; Drug absorption
Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells
Keywords: Substituted 1,3-dimethyl-1H-quinoxalin-2-ones; K562/A02 cells; P-glycoprotein (P-gp); Multidrug resistance (MDR); Reversal effect;
Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450
Keywords: Polyoxyethylene (40) stearate; Rhodamine 123; Rhodamine 110; P-glycoprotein (P-gp); Cytochrome P450
ABCB1 G2677 Allele Is Associated with High Dose Requirement of Cyclosporin A to Prevent Renal Allograft Rejection in North India
Keywords: ABCB1 gene; P-glycoprotein (P-gp); Cyclosporin A; Renal transplantation
Chloro acridone derivatives as cytotoxic agents active on multidrug-resistant cell lines and their duplex DNA complex studies by electrospray ionization mass spectrometry
Keywords: Acridone; Doxorubicin; Multidrug resistance (MDR); P-glycoprotein (P-gp); Vincristine;
Thyroid hormone receptor mediates human MDR1 gene expression-Identification of the response region essential for gene expression
Keywords: P-glycoprotein (P-gp); TR; Triiodothyronine (T3); Thyroxine (T4); Thyroid hormone response element (TRE); ABCB1;
Identification of the functional vitamin D response elements in the human MDR1 gene
Keywords: Multidrug resistance 1; P-glycoprotein (P-gp); Vitamin D receptor (VDR); 1α,25-Dihydroxyvitamin D3; Vitamin D response element (VDRE)
Functional characterization of peptide transporters in MDCKII–MDR1 cell line as a model for oral absorption studies
Keywords: Madin–Darby canine kidney cells; MDCKII–MDR1; MDCKII–WT; Caco-2 cells; Peptide transporter; P-glycoprotein (P-gp); Gly-Sar; Apical (AP); Basolateral (BL); Uptake; Transport; Permeability
Multidrug resistance protein expression of adult T-cell leukemia/lymphoma
Keywords: Adult T-cell leukemia/lymphoma; Multidrug resistance protein (MDR); Lung resistance-related protein (LRP); Multidrug resistance-associated protein (MRP); P-glycoprotein (P-gp)
Localization of P-glycoprotein at the nuclear envelope of rat brain cells
Keywords: P-Glycoprotein (P-gp); Microglia; Brain microvessel endothelial cells; Subcellular; Nucleus; Drug resistance; Western blot; Immunocytochemistry;
Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats
Keywords: Saquinavir (SQV); P-glycoprotein (P-gp); Single pass intestinal perfusion (SPIP); Intestinal absorption rate constant (ka); Effective intestinal permeability across rat jejunum (Peff); Net water flux (NWF)
Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor
Keywords: MDCKII-MDR1; MDCKII-MRP2; MDCKII-MRP1; MDCKII-Bcrp1; MDCKII-WT; P-glycoprotein (P-gp); Multidrug resistance protein (MRP); Breast cancer resistance protein (BCRP); Lopinavir (LVR); Uptake; Transport; Permeability; Efflux ratio (ER)
Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells
Keywords: Stemona curtisii; Multidrug resistance (MDR); P-glycoprotein (P-gp); Multidrug resistance-associated protein-1 (MRP-1); Chemosensitizer
Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia
Keywords: Acute myeloid leukemia; Refractory/relapse; Tetrandrine; P-glycoprotein (P-gp)
The complexity of intestinal absorption and exsorption of digoxin in rats
Keywords: Digoxin; Brush-border membrane vesicles (BBMV); Carrier-mediated uptake; Organic anion transporting polypeptide (Oatp); P-glycoprotein (P-gp)
Effect of bisphenol A on drug efflux in BeWo, a human trophoblast-like cell line
Keywords: Bisphenol A (BPA); P-glycoprotein (P-gp); BeWo cells; Drug efflux; 17β-estradiol (E2);
Dose dependency in the oral bioavailability of an organic cation model, tributylmethyl ammonium (TBuMA), in rats: Association with the saturation of efflux by the P-gp system on the apical membrane of the intestinal epithelium
Keywords: organic cations (OCs); TBuMA; Ussing chamber; intestinal secretion/transport; nonlinear pharmacokinetics; P-glycoprotein (P-gp); efflux pumps; organic cation transporters (OCT);