کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10586692 | 981395 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships](/preview/png/10586692.png)
چکیده انگلیسی
A novel facile synthesis led to pyridine-2-one target structures of which first series with varying substituents have been yielded and biologically characterized as novel multidrug resistance (MDR) modulators inhibiting P-glycoprotein (P-gp). Structure-activity relationships prove a dependency of the MDR-modulating properties from the kind and positioning of hydrogen bond acceptor functions within the molecular skeleton. Cyano functions turned out as biologically effective substituents for a potential hydrogen bonding to the protein target structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 21, 1 November 2011, Pages 6309-6315
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 21, 1 November 2011, Pages 6309-6315
نویسندگان
Sören Krawczyk, Monika Otto, Alexander Otto, Claudius Coburger, Martin Krug, Marianne Seifert, Volkmar Tell, Joséf Molnár, Andreas Hilgeroth,