Keywords: AD; Alzheimer's disease; DA; dopamine; DAergic; dopaminergic; hMAO-A; human monoamine oxidase A; hMAO-B; human monoamine oxidase B; HRP; horseradish peroxidase; IC50; the half maximal inhibitory concentration; i.p.; intraperitoneal; Ki; inhibition const
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Keywords: Aβ; amyloid beta; AβO; Aβ oligomer; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AGEs; advanced glycation end products; AND; age-related neurological disorder; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; BDNF;
Keywords: TCM; Traditional Chinese Medicine; OTC; over-the-counter; i.v.; intravenous; i.p.; interaperitoneal; p.o.; orally; FDA; Food and Drug Administration; NSAIDs; non-steroidal anti-inflammatory drugs; PG; prostaglandin; TNFα; tumor necrosis factor alpha; IL;
Keywords: 1H NMR; proton nuclear magnetic resonance spectroscopy; MS; mass spectrometry; GCMS; gas chromatography-mass spectrometry; UPLC; ultraperformance liquid chromatography; ESI-QTOFMS; electrospray ionization-quadrupole time-of-flight mass spectrometry; PCA
Keywords: AMPT; α-methyl-para-tyrosine methyl ester; ANOVA; one-way analysis of variance; 5-HT; serotonin; i.p.; intraperitoneally; MFST; modified forced swimming test; PCPA; p-chlorophenylalanine methyl ester; p.o.; per oral; S.E.M; standard error of mean; s.c.;
Keywords: ACE; angiotensin-converting enzyme; BA; block advance; BV; blood vessels; C; control; CP; capsula; D; diosgenin treated; DAB; diaminobenzidine; HPA; hypothalamic-pituitary-adrenal; HRP; horseradish peroxidase; M; medulla; NO; nitric oxide; PBS; phosphate
Keywords: ACN; acetonitrile; br; broad; Cbz; N-benzyloxycarbonyl; DMAP; 4-dimethylaminopyridine; DMSO; dimethyl sulfoxide; ED50; median effective dose; HPLC; high performance liquid chromatography; LC-MS/MS; liquid chromatography tandem mass spectrometry; MeOH; met
Keywords: Agmatine; Antidepressants; Central nervous system; Depression; Neuroprotection; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARE; antioxidant response element; BDNF; brain-derived-neurotrophic factor; BBB; blood-brain barrier; CRE; cAMP
Keywords: Hemostasis; Fucoidan; Hemophilia; NMR; Structure; Screening; NASP; non-anticoagulant sulfated polysaccharide; TFPI; tissue factor pathway inhibitor; TF; tissue factor; s.c.; subcutaneous; p.o.; per os (oral); Mw; molecular weight; polyD; polydispersity; O
Keywords: [123I]-β-CIT; 123I-labelled 2b-carbomethoxy-3b-(4-iodophenyl) tropane; 5-HIAA; 5-hydroxyindoleacetic acid; 5-HT; 5-hydroxytryptamine, serotonin; 5-HTT; serotonin transporter; ADHD; attention deficit hyperactivity disorder; AMPH; amphetamine; ATS; ampheta
Keywords: Pyrrolizidine alkaloids; Risk assessment; Herbals; Margin of exposure; Herbal medicinal products; Safety; Carcinogenicity; Mutagenicity; ANZFA; The Australia New Zealand Food Authority; BfR; Federal Institute for Risk Assessment; BMDL10; benchmark dose lo
Keywords: ABR; auditory brainstem response; CF; characteristic frequency; CI; cochlear implant; CS; cochleostomy; DS; Durelon⢠seal; EAS; electro-acoustic stimulation; i.m.; intramuscular; MS; muscle seal; NS; no seal; p.o.; per os; Pt; platinum; RWM; round windo
Keywords: NO; nitric oxide; p.o.; per os; Tmax; maximum time; AUC0-inf; area under curve (time 0Â >Â infinite); CMC; carboxymethyl cellulose; NMR; nuclear magnetic resonance; Cmax; maximum concentration; AUC0-t; area under curve (time 0Â >Â last time); Nicorand
Keywords: ANOVA; one-way analysis of variance; CCA; common carotid artery; ECA; external carotid artery; GSH-Px; glutathione peroxidase; H&E; hematoxylin and eosin; HPLC; high performance liquid chromatography; ICA; internal carotid artery; iNOS; inducible nitric o
Keywords: BBB; blood-brain barrier; CAD; Charged Aerosol Detector; CM; chitosan-microsphere; CP; compritol; CTS; cryptotanshinone; DGLC; Double gradient liquid chromatograph; DH-Ppt; dehydrogynated protopanaxatriol; DSS; danshensu; F; bioavailability; FA; ferulic
Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved
Keywords: AA; Arachidonic Acid; ABST; 2,2â²-Azino-Bis(3-ethylbenzothiazoline-6-Sulfonic Acid); COX; Cyclooxygenase; DAMP; Damage-Associated Molecular Pattern; DMSO; Dimethyl Sulfoxide; DPPH; 2,2-Diphenyl-1-Picryl-Hydrazyl-Hydrate; EORO; Essential oil of Rosmarinus
Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp
Keywords: Tamarind or TI; Tamarindus indica; MF; mount frequency; IF; Intromission frequency; ML; mount latency; IL; intromission latency; R. Time; Retention time; p.o.; per oral; GCMS; Gas chromatography Mass spectroscopy; ANOVA; Analysis of Variance; SEM; Standar
Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat
Keywords: CNS; central nervous system; DMF; dimethyl fumarate; PTZ; pentylenetetrazole; VPA; sodium valproate; Nrf2; nuclear factor erythroid-2 related factor 2; GPx; glutathione peroxidase; SOD; superoxide dismutase; GSH; reduced glutathione; HO-1; heme oxygenase
Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene
Keywords: NMYR; N-methyl-l-tyrosine-l-arginine; PENK; preproenkephalin; POMC; proopiomelanocortin; Leu-Arg; l-leucine-l-arginine; NMLR; N-methyl-l-Leucine-l-arginine; WT; wild-type; KO; knockout; DAMGO; [D-Ala2, N-Methyl-Phe4, Gly5-ol] enkephalin; MOPr; μ opioid r
Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact
Keywords: Herb-drug interaction; Lamotrigine; Paullinia cupana; Rats; AED; antiepileptic drug; AUC; area under the concentration-time curve; AUC0-24; AUC from time zero to 24â¯h; AUC0-t; AUC from time zero to the last measurable concentration; AUC0-â; AUC from t
The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β
Keywords: Naringenin; Gout arthritis; Pain; Inflammation; NFκB; Inflammasome; ABTS; 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate; ALT; alanine transaminase; ASC; apoptosis-associated speck-like protein containing a CARD; AST; aspartate transaminase; BMDMs; bone
Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic Ã-cell damage in diabetic rats
Keywords: Bcl-2; B-cell lymphoma 2; BSA; bovine serum albumin; b.w.; body weight; CAT; catalase; DAB; 3,3â²-diaminobenzidine; DM; diabetes mellitus; ELISA; enzyme-linked immunosorbent assay; FBG; fasting blood glucose; GSH-Px; gutathione peroxidase; H&E; hematoxyl
D-pinitol attenuates cisplatin-induced nephrotoxicity in rats: Impact on pro-inflammatory cytokines
Keywords: Nephrotoxicity; D-pinitol; Cisplatin; Sutherlandia fruitcence; ATP; adenosine triphosphate; cGMP; cyclic guanosine monophosphate; DNA; deoxyribonucleic acid; eNOS; endothelial nitric oxide synthase; ERK; extracellular-signal-regulated kinases; H2O2; Hydro
Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: Chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity
Keywords: AEJg; aqueous extract of Jatropha gossypiifolia; AEJm; aqueous extract of Jatropha mollissima; ATCC; American type culture collection; ANOVA; analysis of variance; AUC0-120Â min; area under the time-course curves after 120Â min; BeV; Bothrops erythromel
Morinda officinalis How. - A comprehensive review of traditional uses, phytochemistry and pharmacology
Keywords: MO; Morinda officinalis How.; HNMR; nuclear magnetic resonance spectroscopy; IR; infrared spectroscopy; MS; mass spectrometry; 1HNMR; urine nuclear magnetic resonance 1H; TCM; traditional Chinese medicine; SFDA; State Food and Drug Administration; i.p.; i
Bioconversion of alkaloids to high-value chemicals: Comparative analysis of newly isolated lupanine degrading strains
Keywords: Lupanine; Quinolizidine alkaloids; Biodegradation; Bioconversion; Toxicity assessment; M9; Minimal microbial growth medium; GC; Gas chromatography; EC50; Half maximal effective concentration; ITS; Internal transcribed spacer sequence; NCBI; National Cente
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
Keywords: Wnt signaling pathway; Hedgehog signaling pathway; Porcupine; Smoothened; Antagonist; Stem cell; Cancer therapy; AUC; area under the plasma time-concentration curve; BCC; basal cell carcinoma; BPO; benzoyl peroxide; CL; clearance; CSC; cancer stem cells;
Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AST; aspartate transaminase; CAT; catalase; CCL4; carbon tetrachloride; CK; casein kinase; DMN; dimethylnitrosamine; DPPH; 2,2-diphenyl-1-picrylhydrazyl; GSH; glutathione; HPRI; hepa
Oral N-acetylcysteine in the treatment of obsessive-compulsive disorder: A systematic review of the clinical evidence
Keywords: N-acetylcysteine; Obsessive-compulsive disorder; Nutraceutical; ACC; anterior cingulate cortex; BAI; Beck Anxiety Inventory; CBT; cognitive-behavioral therapy; CGI-I; clinical global impression-severity; CSTC; cortico-striato-thalamo-cortical; dACC;
Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice
Keywords: Apoptosis; Cell proliferation; Depression; Emotional behavior; Olfactory bulbectomy; Neuroinflammation; ANOVA; analysis of variance; Bax; Bcl-2-associated protein X; Bcl-2; B cell lymphoma/leukemia gene 2; BDNF; brain-derived neurotrophic factor; BrdU; 5-
Pregabalin as adjunct in a multimodal pain therapy after traumatic foot amputation - A case report of a 4-year-old girl
Keywords: ATLS; advanced trauma life support; i.v.; intravenous; K-wire; Kirschner wire; NSAIDs; Nonsteroidal Anti-Inflammatory Drugs; OR; operating room; PCA-pump; patient controlled analgesia pump; p.o.; per os; PLP; Phantom limb pain; pt; post trauma; q8Â h; eve
Provision of food and water in rodent whole body plethysmography safety pharmacology respiratory studies - Impact on animal welfare and data quality
Keywords: bpm; breaths per minute; ICH; International Conference on Harmonisation; p.o.; oral gavage administration; MV; minute volume; f; respiratory rate; S.E.M.; standard error of the mean; TV; tidal volume; WBP; whole body plethysmography; Food; Water; Whole-bo
The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim
Keywords: FST; forced swimming test; i.c.v.; intra cerebro ventricular; p.o.; oral route; i.p.; intraperitoneally; s.c.; subcutaneous; Antidepressant; Estradiol; Folic acid; Forced swimming test;
Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics
Keywords: ED50; Effective dose producing 50% receptor occupancy; g; Gram; i.v.; Intravenous; p.o.; Per oral; Kg; Kilogram; min; Minute; mL; Millilitre; mg; Milligram; μg; Microgram; ng; Nanogram; rpm; Rotations per minute; RO; Receptor Occupancy; CNS; Central nerv
Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation
Keywords: Barringtonia racemosa; lecythidaceae; bartogenic acid; anti-inflammatory; delayed type hypersensitivity; BREAF; Barringtonia racemosa ethyl acetate fraction; DTH; Delayed type hypersensitivity; p.o.; Per oral;
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Keywords: ACEA; arachidonyl-2â²-chloroethylamide; AEA; N-arachidonoylethanolamide, anandamide; APN; aminopeptidase N; BNI; nor-binaltorphimine; CCI; chronic constrictive injury; CYP; cyprodime; DENKI; dual enkephalinase inhibitor; DOR; delta opioid receptor; ENK;
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti
Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel
Keywords: 2â²SPTX; 2â²-O-succinyl-paclitaxel; AUC; area under the concentrationtime curve; BSA; bovine serum albumin; CMC; critical micelle concentration; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; DSC; differential scanning calorimetry;
Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology
Keywords: ALP; alkalinephosphatase; BBB; blood-brain barrier; BMC; bone mineral content; BMD; bone mineral density; BW; body weight; CKD; chronic kidney disease; Col; collagen; CSF; cerebrospinal fluid; CT; calcitonin; DREE; dried Rehmanniae Radix alcohol extract
Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound β-caryophyllene in in vivo models
Keywords: β-caryophyllene; Croton campestris; Essential oil; Inflammation; Mice; AA; Arachidonic acid; ANOVA; Analysis of variance; CEUA; Animal Research Ethics Committee; COX; Cyclooxygenase; EOCC; Essential oil of Croton campestris; GC-MS; Gas chromatography-m
AC-3933, a benzodiazepine partial inverse agonist, improves memory performance in MK-801-induced amnesia mouse model
Keywords: AC-3933; 5-(3-methoxyphenyl)-3-(5-methyl-1, 2, 4-oxadiazol-3-yl)-1, 6-naphthyridin-2(1H)-one; ACh; acetylcholine; AD; Alzheimer's disease; FG-7142; β-carboline-3-carboxylic acid methyl amide; i.p.; intraperitoneally; NMDA; N-methyl-d-aspartate; p.o.; per
β-Asarone modulate adipokines and attenuates high fat diet-induced metabolic abnormalities in Wistar rats
Keywords: HFD; high fat diet; FFA; free fatty acid; AC; Acorus calamus; IAEC; institutional animal ethics committee; INSA; indian national science academy; DTNB; 5,5â²dithiobis (2-nitrobenzoic acid); HDL; high density lipoprotein; p.o.; peroral; BMI; body mass ind
Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain
Keywords: APN; Aminopeptidase N; BBB; blood-brain barrier; CCI; Chronic constrictive injury; DENKI; Dual ENKephalinase Inhibitor; DOP; delta opioid receptor; DRG; Dorsal Rood Ganglion; i.c.v.; intracerebroventricular; MOP; mu opioid receptor; NEP; Neprilysin; PKC;
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain
Keywords: 17-AAG; 17-Allylamino-17-demethoxygeldanamycin; Cmpd; compound; CNS; central nervous system; fEPSP; evoked postsynaptic field potential; HSF1; heat-shock factor 1; HSP; heat-shock protein; Occ50; 50% occupancy; p.o.; peroral dosing; HSP70; HSP90; Occupanc
The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment
Keywords: AChEI; acetylcholinesterase inhibitor; AD; Alzheimer's disease; ANOVA; analysis of variance; CA1; Cornu Ammonis 1; DMSO; dimethylsulfoxide; DPZ; donepezil, 5-HT, 5-hydroxytryptamine; GABA; gamma-aminobutyric acid; i.p.; intraperitoneal; LED; lowest effe
Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
Keywords: CITES; the Convention on International Trade in Endangered Species of Wild Fauna and Flora; IUCN; International Union for Conservation of Nature and Natural Resources; O2â¢â¾; superoxide anion; HOâ¢; hydroxyl radical; ABTS; 2,2â²-azinobis-(3-ethylbenz
Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context
Keywords: Paracetamol; FAAH; Analgesia; Brain; AM404; N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide; DMSO; dimethyl sulfoxide; FAAH; fatty acid amide hydrolase; i.c.v.; intracerebroventricular; i.p.; intraperitoneal; i.pl.; intra-plantar; PCR; polymerase cha
Combination of low dose major n3 PUFAs in fresh water mussel lipid is an alternative of EPA-DHA supplementation in inflammatory conditions of arthritis and LPS stimulated macrophages
Keywords: ACP; acid phosphatase; ALP; alkaline phosphatase; ALA; α-linolenic acid; DAPI; 4â²,6-diamidino-2-phenylindole; DHA; docosahexaenoic acid; DMSO; dimethyl sulphoxide; DPA; docosapentaenoic acid; DCFH-DA; 2â²,7â² dichloro dihydro fluorescin diacetate; EP
Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model
Keywords: AD; Alzheimer׳s disease; Aβ; amyloid β; AChE; acetylcholinesterase; ANOVA; analysis of variance; ANSM; Agence Nationale de Sécurité des Médicaments (French); APP; amyloid precursor protein; b-APP; b-amyloid precursor protein; ATCI; acetylthiocholine