کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8544640 | 1561552 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
D-pinitol attenuates cisplatin-induced nephrotoxicity in rats: Impact on pro-inflammatory cytokines
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کلمات کلیدی
eNOSNOSERKcGMPNADPHiNOSi.p.XODIL-1RNSi.v.p.o.NF-κBXanthine oxidase - زانتین اکسیدازd-Pinitol - d-پینیتولDNA - DNA یا اسید دزوکسی ریبونوکلئیکextracellular-signal-regulated kinases - kineases regulated by extracellular-signal-regulatedMAPK - MAPKMitogen activated protein kinases - Mitogen فعال پروتئین کینازNAD+ - NAD +NADP+ - NADP +O2− - O2-OH− - OH-ONOO− - ONOO-ROS - ROSHydrogen peroxide - آب اکسیژنهAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPdeoxyribonucleic acid - اسید deoxyribonucleicoxidized nicotinamide adenine dinucleotide phosphate - اکسید شده نیکوتین آمید آدنین دینکلوتید فسفاتoxidized nicotinamide adenine dinucleotide - اکسید نیکوتین آمید آدنین دینکلوتیدinterleukin-1 - اینترلوکین-1intraperitoneal - داخل صفاقیIntravenous - داخل وریدیper oral - در طول دهانHydroxyl radical - رادیکال هیدروکسیلinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالSuperoxide - سوپر اکسیدcisplatin - سیس پلاتینTumor Necrosis Factor- α - عامل ناکروز تومور- αTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa beta - فاکتور هسته ای کاپا بتاcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایNADH - نادانNAD - نادانNephrotoxicity - نفخ سمیNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازnicotinamide adenine dinucleotide - نیکوتین آمید adenine dinucleotideH2O2 - هیدروژن پراکسیدPeroxynitrite - پروکسی نیتریتreduced nicotinamide adenine dinucleotide - کاهش ninocotinamide adenine dinucleotidereduced nicotinamide adenine dinucleotide phosphate - کاهش نیکوتین آمید آدنین دینکلوتید فسفاتreactive nitrogen species - گونه های واکنش پذیر نیتروژنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: D-pinitol attenuates cisplatin-induced nephrotoxicity in rats: Impact on pro-inflammatory cytokines D-pinitol attenuates cisplatin-induced nephrotoxicity in rats: Impact on pro-inflammatory cytokines](/preview/png/8544640.png)
چکیده انگلیسی
Cisplatin has been widely used as a first-line agent against various forms of solid cancers. However, nephrotoxicity is the major limiting factor for its clinical use. Several clinical and pre-clinical studies have suggested different strategies for the reduction of cisplatin-induced nephrotoxicity. The present study was conducted to investigate the efficacy of D-Pinitol, against cisplatin-induced nephrotoxicity in Swiss albino mice. A single intraperitoneal injection of cisplatin (20â¯mg/kg) was used to induce nephrotoxicity in mice. Administration of cisplatin in mice is linked with elevated oxidative stress, imbalanced biochemical parameters, apoptosis and stimulation of mitogen-activated protein kinase (MAPK) pathway. D-Pinitol is a member of the flavonoid family and a chief constituent of Sutherlandia fruitesecnce. It was administered with saline water (10, 20, 40â¯mg/kg, p.o.) for seven consecutive days after a single dose of cisplatin. At the end of experiment, animals were sacrificed and biochemical parameters in serum and urine were recorded. Kidneys were isolated for the estimation of tumor necrosis factor-alpha, interleukin-1β, interlukin-6 levels and histopathological evaluations. It was noted that D-Pinitol significantly ameliorated biochemical levels of serum and urinary creatinine and blood urea nitrogen. Tissue homogenate levels of TNF-α, IL-6, IL-1β and the renal expression of tissue nitrites were also significantly decreased in D-Pinitol treated mice. These results were supplemented by histopathological findings. This study highlights the potential role of D-Pinitol against cisplatin-induced toxicity, exhibited through favorable alterations in biochemical and histological changes as well as reduction in oxidative stress and cytokine levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 290, 25 June 2018, Pages 6-11
Journal: Chemico-Biological Interactions - Volume 290, 25 June 2018, Pages 6-11
نویسندگان
Nita Vasaikar, Umesh Mahajan, Kalpesh R. Patil, Kapil Suchal, Chandragouda R. Patil, Shreesh Ojha, Sameer N. Goyal,