Correlation between PAI-1, leptin and ferritin with HOMA in HIV/AIDS patients
Keywords: PAI-1; Leptin; Ferritin; HOMA; HIV/AIDS patients;
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A new assay for global fibrinolysis capacity (GFC): Investigating a critical system regulating hemostasis and thrombosis and other extravascular functions
Keywords: Global fibrinolytic capacity; t-PA; PAI-1; Thrombosis; Matrix degradation;
Role of miRNAs in cell signaling of cancer associated fibroblasts
Keywords: ATG; autophagy related; CAF; cancer associated fibroblasts; CCL; C-C motif chemokine ligand; CDK2; cyclin-dependentkinase 2; CXCL; chemokine(C-X-C motif) ligand; DRAM; damage-regulated autophagy modulator; ECM; extracellular matrix; EMT; epithelialto mese
Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
Keywords: ANCOVA; analysis of covariance; CANA; canagliflozin; CANVAS; CANagliflozin cardioVascular Assessment Study; CI; confidence interval; CRP; C-reactive protein; GLIM; glimepiride; HDL-C; high-density lipoprotein cholesterol; IL-6; interleukin-6; LDL-C; low-d
Constitutive DPP4 activity, inflammation, and microvascular reactivity in subjects with excess body weight and without diabetes
Keywords: ADA; American Diabetes Association; AUC; area uder the curve; BMI; body mass index; CD26; cluster of differentiation 26; DPP4; dipeptidyl peptidase 4; EDTA; ethylenediamine tetraacetic acid; FPG; fasting plasma glucose; GIP; glucose-dependent insulinotrop
New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices
Keywords: CAD; coronary artery disease; CHF; congestive heart failure; DCM; dilated cardiomyopathy; HF; heart failure; LV; left ventricle; LVAD; left ventricular-assist device; PAI-1; plasminogen activator inhibitor-1; SMCA; single-molecule counting assay; TGF-β1;
uPA/uPAR signaling in rheumatoid arthritis: Shedding light on its mechanism of action
Keywords: uPA/uPAR; AMPK; β1/β3 integrin; Survivin; PAI-1; Rheumatoid arthritis;
Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis
Keywords: Pulmonary fibrosis; CXCR4; PAI-1; siRNA; Intratracheal administration;
Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences
Keywords: AHA; American Heart Association; AEPCOS; Androgen Excess PCOS Society; apoB; apolipoprotein B; apoA-I; apolipoprotein A-I; CAD; coronary artery disease; CHD; coronary heart disease; CI; confidence interval; CIMT; carotid artery intima-media thickness; CRP
Effects of grape consumption on biomarkers of inflammation, endothelial function, and PBMC gene expression in obese subjects
Keywords: Grape; Polyphenol; Postprandial; Endothelial function; Inflammation; Gene expression; CRP; C-Reactive Protein; CVD; cardiovascular disease; ET-1; endothelin-1; GP; polyphenol-rich whole grape powder; HFHC; high fat high carbohydrate; HOMA-IR; homeostatic
Adipocytes spectrum - From homeostasia to obesity and its associated pathology
Keywords: Acrp30 (AdipoQ); adiponectin gene; AdipoR; adiponectin receptor; AGE; angiotensinogen; ALP; alkaline phosphatase; Ang II; angiotensin II; Angptl2; angiopoietin-like protein-2; Aqp7; aquaporin-7; aP2; adipocyte-specific fatty acid binding protein 2 gene; A
Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) in diabetic foot syndrome
Keywords: Diabetic foot syndrome; PAI-1; tPA;
PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer
Keywords: PAI-1; microRNAs; miR-34a; Stat3; NSCLC; Metastasis;
Short communicationsÏ-3 polyunsaturated fatty acid supplementation ameliorates lipopolysaccharide-induced behavioral deficits and modulates neurotrophic factors in rats: Focus on tPA/PAI-1 system and BDNF-TrkB signaling
Keywords: BDNF; brain-derived neurotrophic factor; LPS; lipopolysaccharide; NGF; nerve growth factor; PAI-1; plasminogen activator inhibitor-1; PUFA; polyunsaturated fatty acid; tPA; tissue plasmogen activator; SSRI; selective serotonin reuptake inhibitor; TrkB; tr
Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice
Keywords: Acaudina molpadioides; Fucoidan; Renal fibrosis; Kidney protection; Transforming growth factor-β1; Am-FUC; fucoidan from Acaudina molpadioides; CAT; catalase; DKD; diabetic kidney disease; ECM; extracellular matrix; GBM; glomerular basement membrane; GPX
Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice
Keywords: NAFLD; non-alcoholic fatty liver disease; WAT; white adipose tissue; ND; normal diet; HD; high-fat diet; RP; red paprika-supplemented diet; CS; capsanthin-supplemented diet; TG; triacylglycerol; TC; total cholesterol; HDL; high-density lipoprotein; NEFA;
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
Keywords: TMPRSS2; Influenza virus; Coronavirus; Therapeutics; ARE; androgen receptor element; AEBSF; 4-(2-Aminomethyl)benzenesulfonyl fluoride hydrochloride; BHH; Bromhexine hydrochloride; CoV; coronavirus; DESC1; serine protease DESC1; EST; (2S,3S)-trans-Epoxysuc
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
Keywords: clinical trial; COPD; EETs; endothelial function; smokers; soluble epoxide hydrolase inhibitor; CYP; cytochrome P450; DHET; dihydroxyepoxyeicosatrienoic acid; EC50; half maximal effective concentration; EDHF; endothelium-derived hyperpolarizing factor; EE
Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AP; apple polyphenols; APC; apple procyanidins; AST; aspartate aminotransferase; BMI; body mass index; CVD; cardiovascular diseases; DPP-4; dipeptidyl peptidase-4; FPG; fasting plasma glucose; GLP-
Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes
Keywords: Type 1 diabetes mellitus; Diabetic autonomic neuropathy; Heat-Shock Protein 27; Macrophage Migration Inhibition Factors; PAI-1;
Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
Keywords: ACE; angiotensin converting enzyme; ADAM; a disintegrin and metalloproteinase; AKI; acute kidney injury; ANGII; angiotensin II; AT1; angiotensin II receptor type 1; AMPKα; AMP-activated protein kinase α; α-SMA; α-smooth muscle actin; CKD; chronic kidn
Modulation of plasminogen activator inhibitor-1 (PAI-1) by the naphthoquinone shikonin
Keywords: PAI-1; PAI-1 inhibitor; Thrombolysis; Fibrinolysis; Pharmacology
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis
Keywords: AT-1; angiotensin II type 1 receptor; VSMC; vascular smooth muscle cell; TGF-β1; transforming growth factor-β1; Ang-II; angiotensin II; ECM; extracellular matrix; CKD; chronic kidney disease; eNOS; endothelial nitric oxide synthase; UUO; unilateral uret
Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression
Keywords: TGF-β; transforming growth factor-β; CA; carnosic acid; α-SMA; α-smooth muscle actin; COLI; collagen I; FN; fibronectin; PAI-1; plasminogen activator inhibitor-1; Nox4; NADPH oxidase 4; ROS; reactive oxygen species; Nrf2; nuclear factor erythroid-2 re
The contribution of different adipose tissue depots to plasma plasminogen activator inhibitor-1 (PAI-1) levels
Keywords: BMI; body mass index; CT; computed tomography; IL-1; interleukin-1; IL-6; interleukin-6; NRF; National Research Foundation; MetS; metabolic syndrome; mRNA; messenger ribonucleic acid; PAI-1; plasminogen activator inhibitor-1; PAI-1act; PAI-1 activity; PAI
Annexin V homodimer protects against ischemia reperfusion-induced acute lung injury in lung transplantation
Keywords: diannexin; primary graft dysfunction; ischemia reperfusion injury; apoptosis; CK18-M30; caspase-cleaved cytokeratin 18; DN group; Diannexin group; IRI; ischemia reperfusion injury; PAI-1; plasminogen activator inhibitor-1; PGD; primary graft dysfunction;
Chemical composition and “in vitro” anti-inflammatory activity of Vitis vinifera L. (var. Sangiovese) tendrils extract
Keywords: CAD; coronary artery disease; CVD; cardiovascular disease; DPPH; diphenylpicrylhydrazyl; HPLC-DAD; high-performance liquid chromatography with diode-array detection; IRAK-1; IL-1 receptor-associated kinase 1; LPS; lipopolysaccharide; MIRAKIL; biomarkers a
Bovine lactoferrin suppresses high-fat diet induced obesity and modulates gut microbiota in C57BL/6J mice
Keywords: bLF; bovine lactoferrin; Gapdh; glyceraldehyde 3-phosphate dehydrogenase; HF; mice fed with high-fat diet through the study; HF-bLF; mice fed with high-fat diet and meanwhile received oral administration of 100âmg/kg BW of bLF for 12 weeks; IL-1β; inte
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa
Keywords: PAI-1; plasminogen activator inhibitor 1; uPA; urokinase plasminogen activator; KO; knockout; EMT; epithelial-to-mesenchymal transition; PPI; proton pump inhibitor; H. pylori; Helicobacter pylori; ECL; enterochromaffin-like; HK; H+K+-ATPase beta subunit;
Carbamylated Low-Density Lipoproteins Induce a Prothrombotic State Via LOX-1
Keywords: aggregation; arterial thrombosis; chronic kidney disease; platelets; vascular smooth muscle cells; AoSMC; aortic smooth muscle cell; CKD; chronic kidney disease; cLDL; carbamylated low-density lipoprotein; HAEC; human aortic endothelial cell; LDL; low-de
Inhibition of coagulation proteases Xa and IIa decreases ischemia-reperfusion injuries in a preclinical renal transplantation model
Keywords: α-SMA; α-smooth muscle actin; DCD; donors deceased after cardiac death; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HAEC; human aortic endothelial cell; HES; hematoxylin-eosin-s
In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients
Keywords: Vanadium; TGF-β; Epithelial mesenchymal transition; Cancer stem cells; Antitumor activity synergism; TGF-β; transforming growth factor beta; EMT; epithelial mesenchymal transition; MMP-2; matrix metalloproteinase 2; ROS; reactive oxygen species; CSC; ca
TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
Keywords: Eosinophil; esophagitis; SerpinE1; remodeling; fibrosis; TGF-β1; BZH; Basal zone hyperplasia; EoE; Eosinophilic esophagitis; LP; Lamina propria; LRP1; Lipoprotein receptor-related protein 1; MMP; Matrix metalloproteinases; PAI-1; Plasminogen activator
The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration
Keywords: bFGF; basic Fibroblast Growth Factor; NF-κB; nuclear factor kappa B; c-JNK; Jun N-terminal kinase; PI3 K; phosphatidylinositol 3-kinase; FGFR; fibroblast growth factor receptor; RNA-Seq; RNA-Sequencing; IκB-α; inhibitor of nuclear factor kappa B-alpha;
MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene
Keywords: MnTE-2-PyP; p300; PAI-1; HIF-1β; CREB;
Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS
Keywords: alveolar fluid clearance; ARDS phenotype; lung morphology; mechanical ventilation; rage; AT; alveolar type; ES; effect size; PAI-1; plasminogen activator inhibitor-1; ROC; receiver operating characteristic; SAPS II; simplified acute physiology scores; sRA
MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell
Keywords: PAI-1; plasminogen activator inhibitor-1; ROS; reactive oxygen species; HRE; hypoxia-response element; SOD1; superoxide dismutase 1; HIF-1; hypoxia-inducible factor-1; CREB; cAMP response element-binding protein; ChIP; chromatin immunoprecipitation; ARNT;
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population
Keywords: THRGFs, thrombophilic genetic factors; HCC, hepatocellular carcinoma; PVT, portal vein thrombosisGenetic mutation; PAI-1; Plasminogen activator inhibitor-type 1; MTHFR C677T; MTHFR; Methylenetetrahydrofolate reductase; V Leiden 506Q; Prothrombin 20210A; P
Receptor-associated protein promotes t-PA expression, reduces PAI-1 expression and improves neurorecovery after acute ischemic stroke
Keywords: RAP; t-PA; PAI-1; Acute ischemic stroke; Neurorecovery; Hemorrhagic transformation;
Regular ArticleTGF-β1 prevents blood-brain barrier damage and hemorrhagic transformation after thrombolysis in rats
Keywords: BBB; blood-brain barrier; HT; hemorrhagic transformation; rt-PA; recombinant tissue plasminogen activator; TGF-β1; transforming growth factor-beta1; MCAO; middle cerebral artery occlusion; PAI-1; plasminogen activator inhibitor type-1; MMP; matrix meta
Adiponectin, leptin, interleukin-6 and HbA1c in the prediction of incident type 2 diabetes: A nested case-control study in Asian Indian men with impaired glucose tolerance
Keywords: AUC; area under curve; BMI; body mass index; CI; confidence interval; CVD; cardiovasular disease; CVS; coefficients of variations; ELISA; enzyme-linked immunosorbent assay; EPIC; European prospective investigation into cancer and nutrition; HDL-chol; high
Gasomediators (·NO, CO, and H2S) and their role in hemostasis and thrombosis
Keywords: ADP; adenosine diphosphate; CAT; cysteine aminotransferase; CBS; cystathionine β-synthase; cGMP; cyclic guanosine monophosphate; CO; carbon monoxide; CORM; CO-releasing molecule; CSE; cystathionine γ-lyase; GC-MS; gas chromatography-mass spectrometry; e
Hantavirus infection-induced thrombocytopenia triggers increased production but associates with impaired aggregation of platelets except for collagen
Keywords: HCPS; hantavirus cardiopulmonary syndrome; PUUV; Puumala virus; NE; nephropathia epidemica; AKI; acute kidney injury; ADAMTS13; a thrombospondin type 1 domain 13; PAI-1; plasminogen activator inhibitor 1; HTNV; Hantaan virus; MPV; mean platelet volume; IP
A microfluidic cell culture system for monitoring of sequential changes in endothelial cells after heat stress
Keywords: Microfluidic cell culture system; Microchip; Endothelial cells; Heat-shock response; PAI-1;
The association of clot lysis time with total obesity is partly independent from the association of PAI-1 with central obesity in African adults
Keywords: ADP; air-displacement plethysmography; ANCOVA; analysis of co-variance; ANOVA; analysis of variance; BIA; bioelectrical impedance analysis; BMI; body mass index; CLT; clot lysis time; CLTs; clot lysis times; CI; confidence intervals; PAI-1; plasminogen ac
Deleterious effects of benomyl and carbendazim on human placental trophoblast cells
Keywords: MMPs; matrix metalloproteinases; TIMPs; tissue inhibitors of MMPs; uPA; urokinase plasminogen activator; PAI-1; plasminogen activator inhibitor-1; Benomyl; Carbendazim; Benzimidazole fungicides; Placenta; Trophoblast; HTR-8 cells; Toxicity;
N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury
Keywords: AHR; airway hyperresponsiveness; ALI; acute lung injury; BAL; bronchoalveolar lavage; Cl2; chlorine; ERS; respiratory elastance; DEX; dexamethasone (low-dose); G; tissue resistance; H; tissue elastance; HDEX; dexamethasone (high-dose); i.p.; intraperitone
ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts
Keywords: bFGF; ERK5; PAI-1; Fibroblasts; Pulmonary fibrosis
Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice
Keywords: Inflammation; Atherosclerosis; Oxidative stress; Txnip; thioredoxin interacting protein; WT; wild type; VSMC; vascular smooth muscle cells; TKO; Txnip knockout; Trx; thioredoxin; DHE; dihydroethidium; Eh; redox potential; Eâ²0; midpoint potential; ROS; r