کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8310861 | 1538653 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gasomediators (·NO, CO, and H2S) and their role in hemostasis and thrombosis
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کلمات کلیدی
CBSO2−••NOPAI-2CO-releasing moleculeCORMTxA2PAI-1VSMCPKGPDInNOSADPeNOSiNOSH2SCATCSEcGMPMSTt-PAGC-MS - کروماتوگرافی گازی-طیف سنج جرمی3-mercaptopyruvate sulfurtransferase - 3-merkaptopyruvate sulfurransferasecystathionine γ-lyase - cystationine γ-lyaseONOO− - ONOO-u-PA - U-PAadenosine diphosphate - آدنوزین دی فسفاتsuperoxide anion - آنیون سوپر اکسیدThrombosis - ترومبوزThromboxane A2 - ترومبوکسیان A2Vascular smooth muscle cells - سلول های عضلانی صاف عروقیinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالneuronal nitric oxide synthase - سنتاز اکسید نیتریک عصبیHydrogen sulfide - سولفید هیدروژنcysteine aminotransferase - سیتیین آمینوترانسفرازcystathionine β-synthase - سیستاتیونین β-سنتازPlatelet activating factor - عامل فعال کننده پلاکتtissue plasminogen activator - فعال کننده بافتی پلاسمینوژنurokinase plasminogen activator - فعال کننده پلاسمینوژن یوروکینازcarbon monoxide - منوکسیدکربنPlasminogen activator inhibitor-1 - مهار کننده فعال کننده پلاسمینوژن-1Plasminogen activator inhibitor-2 - مهار کننده فعال کننده پلاسمینوژن-2cyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایNitric oxide - نیتریک اکسیدPAF - نیروی هوایی پاکستانheme oxygenase - همگام اکسژنازHemostasis - هِموستاز، خونایستیprotein disulfide isomerase - پروتئین دیسولفید ایزومرازprotein kinase G - پروتئین کیناز GPeroxynitrite - پروکسی نیتریتGas Chromatography-Mass Spectrometry - گاز کروماتوگرافی-اسپکترومتری جرمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Hemostasis is a group of mechanisms used to prevent the outflow of blood from its vessels, and to ensure its liquidity and flow within them. The system incorporates aspects of the blood vessel wall (mainly the intima), the clotting process, together with its factors (i.e. fibrinogen) and coagulation inhibitors, as well as fibrinolysis, blood platelets and the phagocyte system. The modulation of hemostasis is associated with the pathogenesis of cardiovascular diseases, such as thrombosis. The study examines the action of three selected gasomediators, nitric oxide (
- NO), carbon monoxide (CO) and hydrogen sulfide (H2S), on hemostasis and thrombosis, although these gasses are also involved in a multitude of other physiological functions.
- NO inhibits blood platelet activation, relaxes blood vessels and, as a free radical chain, may rapidly react with superoxide anion (O2â
- ) in blood platelets to form peroxynitrite (ONOOâ). ONOOâ is a reactive nitrating and nitrosating agent which induces oxidative/nitrative stress in blood platelets and plasma. Moreover, ONOOâ changes the structure and function of fibrinogen and proteins associated with fibrinolysis. Recently, proteomic studies have provided unequivocal evidence that human platelets lack any expression of nitric oxide synthase isoforms. Other studies have demonstrated that CO and H2S, reduce blood platelet reactivity. Moreover, H2S has been reported to demonstrate anticoagulatory activity, and CO may act not only as an anticoagulant, but also aprocoagulant. This review article summarizes current knowledge of the biological roles of gasomediators (NO, CO, H2S) in hemostasis and in cardiovascular diseases.
- NO), carbon monoxide (CO) and hydrogen sulfide (H2S), on hemostasis and thrombosis, although these gasses are also involved in a multitude of other physiological functions.
- NO inhibits blood platelet activation, relaxes blood vessels and, as a free radical chain, may rapidly react with superoxide anion (O2â
- ) in blood platelets to form peroxynitrite (ONOOâ). ONOOâ is a reactive nitrating and nitrosating agent which induces oxidative/nitrative stress in blood platelets and plasma. Moreover, ONOOâ changes the structure and function of fibrinogen and proteins associated with fibrinolysis. Recently, proteomic studies have provided unequivocal evidence that human platelets lack any expression of nitric oxide synthase isoforms. Other studies have demonstrated that CO and H2S, reduce blood platelet reactivity. Moreover, H2S has been reported to demonstrate anticoagulatory activity, and CO may act not only as an anticoagulant, but also aprocoagulant. This review article summarizes current knowledge of the biological roles of gasomediators (NO, CO, H2S) in hemostasis and in cardiovascular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 445, 20 May 2015, Pages 115-121
Journal: Clinica Chimica Acta - Volume 445, 20 May 2015, Pages 115-121
نویسندگان
Beata Olas,