TNF-α knockdown alleviates palmitate-induced insulin resistance in C2C12 skeletal muscle cells
Keywords: طلایی; TNF-α; Short hairpin RNA; Insulin resistance; Knockdown; Palmitate
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Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK
Keywords: طلایی; Palmitate; Apoptosis; Autophagy; ROS; JNK; p38 MAPK;
Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes
Keywords: طلایی; Pancreatic α cells; Type 2 diabetes; Apoptosis; Metabolic stress; Palmitate; Bcl2l1; ER stress
Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation
Keywords: طلایی; JLDG; Jinlida granule; TCM; traditional Chinese medicine; ACC; acetyl-coA carboxylase; FAS; fatty acid synthase; CPT-1; carnitine acyl transferase 1; AMPK; AMP activated protein kinase; pAMPK; phospho-AMP activated protein kinase; SREBP-1c; sterol regulat
Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules
Keywords: طلایی; Insulin resistance; Free fatty acids; Palmitate; Ubiquitin; Proteasome
Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway
Keywords: طلایی; Non-alcoholic fatty liver; Non-alcoholic steatohepatitis; MicroRNAs; MicroRNA-451; Cab39/MO25; Inflammation; AMPK; adenosine monophosphate activated protein kinase; DEGs; differentially expressed genes; GEO; gene expression omnibus; GOBPs; gene ontology b
NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - But not palmitate-induced toxicity
Keywords: طلایی; NDRG2; N-myc downstream-regulated gene 2; MRFs; myogenic regulatory factors; Cdk; cyclin-dependent kinase; Rb; retinoblastoma; Myf5; myogenic factor 5; MyoD; myogenic differentiation; p27; p27 kip1; p21; p21 waf1/cip1; Akt; thymoma viral proto-oncogene; P
Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells
Keywords: طلایی; Lipoapoptosis; SHIP2; Palmitate; ROS; Akt; FOXO-1; Liver; HepG2; Apoptosis;
Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes
Keywords: طلایی; Palmitate; Musclin; ER stress; Unfolded protein response (UPR); PERK;
Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance
Keywords: طلایی; Adipokines; Chenodeoxycholic acid; Insulin resistance; Palmitate; High fat diet;
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
Keywords: طلایی; Caveolin-1; Palmitate; Reactive oxygen species; Tyrosine-14; Apoptosis; Beta cell;
Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes
Keywords: طلایی; Palmitate; Docosahexaenoic acid; Muscle atrophy; Proteolysis; Macroautophagy; FoxO3
CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation
Keywords: طلایی; CTRP5; AMPK; Palmitate; Insulin resistance; IRS-1;
Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes
Keywords: طلایی; MicroRNA; miR-29a; Palmitate; Insulin resistance; IRS-1; Saturated fatty acid
Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells
Keywords: طلایی; MicroRNA; MiR-195; Saturated fatty acid; Palmitate; Insulin resistance; Insulin receptor; Insulin receptor substrate-1;
Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells
Keywords: طلایی; AICAR; AICA riboside; AMPK; AMP-activated protein kinase; EGCG; epigallocatechin gallate; eNOS; endothelial nitric oxide synthase; ER stress; endoplasmic reticulum stress; ÎÏm; mitochondrial membrane potential; Mito Q; mitoquinone mesylate; NLRP3; NOD-l
Research reportXanthohumol improved cognitive flexibility in young mice
Keywords: طلایی; Palmitoylation; Reversal trials; Aging; Memory; Palmitate;
Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor
Keywords: طلایی; PPARβ/δ; peroxisome proliferator-activated receptor β/δ; GLP-1R; glucagon-like peptide-1 receptor; GW; GW501516; PA; palmitate; qPCR; quantitative polymerase chain reaction; SREBP-1c; sterol regulatory element binding protein-1c; GSIS; glucose-stimula
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
Keywords: طلایی; AD; Alzheimer's disease; DAG; diacylglycerol; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; HSP; heat shock protein; IFN; interferon; IκBα; inhibitory κBα; IKKβ; IκB kinas
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
Keywords: طلایی; ABAF; anti-bacterial, anti-fungal; ANOVA; analysis of variance; AS160; Akt substrate of 160Â kDa; BSA; bovine serum albumin; CM; conditioned medium; CXCL2; Chemokine (C-X-C motif) ligand 2; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulphox
Palmitate induces SHIP2 expression via the ceramide-mediated activation of NF-κB, and JNK in skeletal muscle cells
Keywords: طلایی; Palmitate; Insulin resistance; C2C12; Ceramide; SHIP2;
Saturated fatty acid palmitate induces extracellular release of histone H3: A possible mechanistic basis for high-fat diet-induced inflammation and thrombosis
Keywords: طلایی; High-fat diet; Palmitate; ROS; JNK; Histone H3; Inflammation;
Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)
Keywords: طلایی; Aspalathus linearis; Rooibos; Aspalathin; Glucose uptake; Palmitate; Insulin resistance; T2D; type 2 diabetes; IR; insulin resistance; FFAs; free fatty acids; DAG; diacylglycerol; IRS1; insulin receptor substrate 1; PKC θ; protein kinase C theta; AKT; pr
Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells
Keywords: طلایی; Palmitate; Nur77; Sp1; ZBP89; Pancreatic β-cell;
Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages
Keywords: طلایی; Fatty acid; Inflammation; EPA; Palmitate;
Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate
Keywords: طلایی; Arterial; Venous; 11CO2; Metabolite; Acetate; Palmitate
Calcium hydroxy palmitate: Possible precursor phase in calcium precipitation by palmitate
Keywords: طلایی; Calcium precipitation; Palmitate; Calcium hydroxy palmitate; Solubility product
Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB
Keywords: طلایی; Kaempferol; Palmitate; β-cells; Islets; cAMP; CREB; PDX-1
Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis
Keywords: طلایی; Apoptosis; Geniposide; Glucagon-like peptide 1 receptor (GLP-1R); Palmitate;
Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE)
Keywords: طلایی; Glucolipotoxicity; High glucose; Palmitate; SMILE; Beta cell dysfunction;
Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells
Keywords: طلایی; Palmitate; RIP1; Necrosis; Macrophage death; Free fatty acids;
Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet
Keywords: طلایی; Fatty acids; Palmitate; Palmitic acid; Atherosclerosis; Plaque stability
Research ArticleCdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes
Keywords: طلایی; Palmitate; Small GTPases; MAP3K; JNK; NAFLD; SFA; saturated free fatty acids; JNK; c-Jun NH2-terminal kinase; Cdc42; cell division cycle protein 42; Rac1; ras-related C3 botulinum toxin substrate 1; NAFLD; non-alcoholic fatty liver disease; IRE1; inositol
Research ArticleA hedgehog survival pathway in 'undead' lipotoxic hepatocytes
Keywords: طلایی; NASH; non-alcoholic steatohepatitis; SHH; sonic hedgehog; FFA; free fatty acids; PA; palmitate; LPC; lysophosphatidylcholine; JNK; c-Jun N-terminal kinase; shRNA; short-hairpin RNA; MPH; mouse primary hepatocytes; DAPI; 4â²,6-diamidine-2'-phenylindole
Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes
Keywords: طلایی; Flavonoids; Insulin resistance; Palmitate; Obesity;
Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB
Keywords: طلایی; NIDDM; non-insulin-dependent diabetes mellitus; FGF-21; fibroblast growth factor 21; HSMMs; human skeletal muscle myotubes; PA; palmitate; PBS; phosphate-buffered saline; 2-NBDG; 2-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino-2-deoxyglucose; AMV; avian mye
Palmitate enhances the differentiation of mouse embryonic stem cells towards white adipocyte lineages
Keywords: طلایی; Obesity; Adipocytes; Palmitate; Subcutaneous fat; Sex steroid hormones;
Endoplasmic reticulum stress-mediated inhibition of NSMase2 elevates plasma membrane cholesterol and attenuates NO production in endothelial cells
Keywords: طلایی; NO; nitric oxide; ER; endoplasmic reticulum; BAEC; bovine aortic endothelial cells; eNOS; endothelial nitric oxide synthase; NSMase or NSM; neutral sphingomyelinase; SREBP-2; sterol-responsive element-binding protein; Tm; tunicamycin; Pm; palmitate; RNAi;
Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis
Keywords: طلایی; BCECF-AM; 2â²,7â²-bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetrakis(acetoxymethyl) ester; BSA; bovine serum albumin; CVD; cardiovascular disease; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²,-tetramethylindocarbocyanine perchlorate; FA; fatty acid; FFA; fre
Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
Keywords: طلایی; FFA; free fatty acid; PDX1; pancreatic and duodenal homeobox 1; GSIS; glucose-stimulated insulin secretion; JNK; Jun N-terminal kinase; SIRT1; sirtuin 1; PGC-1; peroxisome proliferator-activated receptor gamma coactivator 1; NeuroD; neurogenic differentia
Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells
Keywords: طلایی; AA; arachidonic acid; DHA; docosahexanoic acid; PERK; protein kinase RNA-like endoplasmic reticulum kinase; β-Cell; Lipotoxicity; Palmitate; Palmitoleate; Cytoprotection; ER stress;
Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons
Keywords: طلایی; NPY; Clock gene; Palmitate; AMPK; Hypothalamus; Neurons
Short-term effects of palmitate and 2-bromopalmitate on the lipolytic activity of rat adipocytes
Keywords: طلایی; Adipocytes; Lipolysis; ATP; Palmitate; 2-Bromopalmitate
Ghrelin inhibits insulin resistance induced by glucotoxicity and lipotoxicity in cardiomyocyte
Keywords: طلایی; Ghrelin; Glucose; Palmitate; Insulin resistance; PI3-kinase/AKT pathway; Cardiomyocyte
Cysteine aggravates palmitate-induced cell death in hepatocytes
Keywords: طلایی; Cysteine; Palmitate; ER stress; HepG2; JNK
Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity
Keywords: طلایی; APC; antigen presenting cell; bSP; bovine surfactant protein; DPPC; 1,2-dipalmitoyl-phosphatidylcholine from egg yolk; HAv; hemagglutinin vaccine; SP; surfactant protein; PA; palmitate; PG; phosphatidylglycerol; SSF; synthetic Surfacten; St; Surfacten; An
Cellular and Molecular NeuroscienceResearch PaperPalmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways
Keywords: طلایی; palmitate; ceramide; apoptosis; Schwann cells; peripheral neuropathy; obesity; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma protein-2; BSA; bovine serum albumin; CHOP; CCAAT/enhancer-binding protein homologous protein; DAPI; 4,6-diamidino-2-p
Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells
Keywords: طلایی; Free fatty acid; Inflammation; Insulin resistance; Macrophage; Palmitate; Protein tyrosine phosphatase 1B2-DG, 2-deoxy-d-[3H]glucose; BSA, bovine serum albumin; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; FFA, free fatty acid; HRP,
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation
Keywords: طلایی; Insulin secretion; CD36; INS-1; Palmitate; Oleate; Carnitine palmitoyltransferase I
Palmitate-induced changes in protein expression of insulin secreting INS-1E cells
Keywords: طلایی; Two-dimensional gel electrophoresis; β-cell; Lipotoxicity; Diabetes; Oleate; Palmitate; Insulin