کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1950585 | 1055664 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
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کلمات کلیدی
Hspperoxisome proliferator-activated receptor-γ coactivator-1αNeuro-2aIKKβWST-1N2aIκBαPUFAsPGC-1αPKCpKaPCNIRSPPARERKTLCFBSEPANF-κBLPSJnkc-Jun N-terminal kinase - C-Jun N-terminal kinaseIκB kinase β - IkB kinase βMAPK - MAPKROS - ROSMitochondrial dysfunction - اختلال در عملکرد میتوکندریmild cognitive impairment - اختلال شناختی خفیفEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکsaturated free fatty acids - اسیدهای چرب آزاد اشباع شدهinflammation - التهاب( توروم) insulin receptor substrate - انسولین بستر گیرندهOleate - اولیتهinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینAlzheimer's disease - بیماری آلزایمرtriglyceride - تریگلیسریدtumor necrosis factor-α - تومور نکروز عامل αDHA - دوکوساهگزائنوئیک اسیدdiacylglycerol - دیسیل گلیسیرینDAG - روزfetal bovine serum - سرم جنین گاوpalmitate - طلاییTNF-α - فاکتور نکروز توموری آلفاnuclear factor-κB - فاکتور هسته ای κBLipopolysaccharides - لیپوپلی ساکارید هاInsulin resistance - مقاومت به انسولینMCI - همراه اولHeat shock protein - پروتئین شوک حرارتprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenthin layer chromatography - کروماتوگرافی لایه نازکextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیReactive oxygen species - گونههای فعال اکسیژنperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells](/preview/png/1950585.png)
چکیده انگلیسی
Elevated circulating levels of saturated free fatty acids (sFFAs; e.g. palmitate) are known to provoke inflammatory responses and cause insulin resistance in peripheral tissue. By contrast, mono- or poly-unsaturated FFAs are protective against sFFAs. An excess of sFFAs in the brain circulation may also trigger neuroinflammation and insulin resistance, however the underlying signaling changes have not been clarified in neuronal cells. In the present study, we examined the effects of palmitate on mitochondrial function and viability as well as on intracellular insulin and nuclear factor-κB (NF-κB) signaling pathways in Neuro-2a and primary rat cortical neurons. We next tested whether oleate preconditioning has a protective effect against palmitate-induced toxicity. Palmitate induced both mitochondrial dysfunction and insulin resistance while promoting the phosphorylation of mitogen-activated protein kinases and nuclear translocation of NF-κB p65. Oleate pre-exposure and then removal was sufficient to completely block subsequent palmitate-induced intracellular signaling and metabolic derangements. Oleate also prevented ceramide-induced insulin resistance. Moreover, oleate stimulated ATP while decreasing mitochondrial superoxide productions. The latter were associated with increased levels of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Inhibition of protein kinase A (PKA) attenuated the protective effect of oleate against palmitate, implicating PKA in the mechanism of oleate action. Oleate increased triglyceride and blocked palmitate-induced diacylglycerol accumulations. Oleate preconditioning was superior to docosahexaenoic acid (DHA) or linoleate in the protection of neuronal cells against palmitate- or ceramide-induced cytotoxicity. We conclude that oleate has beneficial properties against sFFA and ceramide models of insulin resistance-associated damage to neuronal cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 7, July 2014, Pages 1402-1413
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 7, July 2014, Pages 1402-1413
نویسندگان
Bumsup Kwon, Han-Kyu Lee, Henry W. Querfurth,