دانلود مقالات ISI درباره Park8 + ترجمه فارسی

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition

Keywords: Park8; Dardarin; Pharmacodynamics; Pharmacokinetics; Small-molecule inhibitor; LRRK2; Leucine-rich repeat kinase 2; PD; Parkinson disease; ATP; adenosine-tri phosphate; DTT; dithiothreitol; HSC70; Heat-shock cognate 70; Rab; Ras gene from rat brain, or Ra

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro

Keywords: PARK8; ROCO4; Dardarin; Enzyme kinetics; Manganese; Nucleotide-binding pocket;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Expanding perspectives on the significance of mitophagy in cancer

Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; ASC; apoptosis-associated speck-like protein containing a CARD; ATM; ataxia telangiectasia mutated; BCL-2; breakpoint cluster locus-2; BCL-XL; BCL2-like 1 long; BNIP3; BCL2 interacting protein 3;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of novel variants in LRRK2 gene in patients with Parkinson's disease in Serbian population

Keywords: Parkinson's disease; Genetics; LRRK2; PARK8; Late onset; Mutation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Keywords: LRRK2; Kinase; Parkinsonism; Parkinson's disease; Adenovirus; Neurodegeneration; PARK8; Nigrostriatal

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Keywords: Parkinson's disease; LRRK2; PARK8; Dopaminergic; Nuclear envelope; Transgenic; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Keywords: PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Cognitive dysfunction in Tunisian LRRK2 associated Parkinson's disease

Keywords: Parkinson's disease; PARK8; LRRK2 gene; G2019S mutation; Neuropsychological study;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

LRRK2 I2020T mutation is associated with tau pathology

Keywords: LRRK2; I2020T mutation; Pathology; Tau; PARK8

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Reduced LRRK2-positive neurons in the striatum of Parkinson's disease patients hypothesize a retrograde disease mechanism?

Keywords: LRRK2; Parkinson's disease; Immunohistochemistry; PARK8; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson’s disease: A meta-analysis

Keywords: Parkinson’s disease (PD); LRRK2; PARK8; Variant; Meta-analysis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations

Keywords: Leucine-rich repeat kinase 2; Akt1; Parkinson's disease; PARK8;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson’s disease

Keywords: Parkinson’s disease; LRRK2; G2019S; PARK8; Review

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

Keywords: dardarin; PARK8; Parkinson disease; neurodegeneration; serine/threonine kinaseLRRK2, leucine-rich repeat kinase 2; PD, Parkinson disease; GTPase, guanosine triphosphatase; ETD, electron transfer dissociation; CID, collision-induced dissociation; WT, wild

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation

Keywords: Leucine-rich repeat kinase 2; B-1 cells; B-2 cells; Parkinson's disease; PARK8; Downregulation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

Keywords: Parkinson's disease; Leucine-rich repeat kinase 2; PARK8; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2

Keywords: Inhibitors; Kinase; LRRK2; Parkinson’s disease; PARK8; Substrates

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

I2020T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson’s disease, has a higher intracellular degradation rate than the wild-type molecule

Keywords: Parkinson’s disease; Leucine-rich repeat kinase 2; PARK8; Degradation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

Keywords: Nigral degeneration; PARK8; PET11C-DTBZ, 11C-α-dihydrotetrabenazine; GCI, glial cytoplasmic inclusion; HY, Hoehn and Yahr scale; 123I-MIBG, 123I-meta-iodobenzylguanidine; MAPKKK, mitogen-activated protein kinase kinase kinase; MSA-P, multiple system atrop

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

The biology and pathobiology of LRRK2: Implications for Parkinson's disease

Keywords: LRRK2; PARK8; Dardarin; Parkinsonism; GTPase; Kinase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Research ReportLocalization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

Keywords: Parkinson's disease (PD); Parkinsonism; PARK8; Dardarin; Lewy body (LB); Dementia with Lewy bodies (DLB);

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

LRRK2 G2019S mutation and Parkinson's disease: A clinical, neuropsychological and neuropsychiatric study in a large Italian sample

Keywords: Parkinson; Park8; LRRK2; G2019S mutation; Neuropsychological study

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه