Keywords: PARP، پلی مراز (ADP-ribose); RABV, rabies virus; CVS, challenge virus standard-11 strain of fixed rabies virus; VSV, vesicular stomatitis virus; AIF, apoptosis-inducing factor; cyto c, cytochrome c; PARP, poly (ADP-ribose) polymerase; LDH, lactate dehydrogenase; TOMM20, translocase o
مقالات ISI PARP، پلی مراز (ADP-ribose) (ترجمه نشده)
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Keywords: PARP، پلی مراز (ADP-ribose); NSCLC; NCI-H460; Apoptosis; Flavonoid; TrifolinNSCLC, non-small cell lung cancer; MOMP, mitochondrial outer membrane permeabilization; PARP, poly (ADP-ribose) polymerase; Bax, Bcl-2-associated X protein; FasL, Fas ligand; FADD, Fas-associated protein with
Molybdenum induces pancreatic β-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress-triggered pathways
Keywords: PARP، پلی مراز (ADP-ribose); Mo, molybdenum; DM, diabetes mellitus; MMP, mitochondrial membrane potential; PARP, poly (ADP-ribose) polymerase; ER, endoplasmic reticulum; UPR, unfolded protein response; eIF, eukaryotic initiation factor; AFT, activation transcription factor; XBP, X-bo
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells
Keywords: PARP، پلی مراز (ADP-ribose); Aurora A kinase; Colorectal cancer; Aminopyridine derivatives; ApoptosisHTRF, homogeneous, time-resolved fluorescence; TR-FRET, time resolved-fluorescence resonance energy transfer; PARP, Poly (ADP-ribose) polymerase; CDC2, cell division cycle protein 2
Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+2 – and oxidative stress-induced apoptosis
Keywords: PARP، پلی مراز (ADP-ribose); Anti-proliferation; Apoptosis; β-Cryptoxanthin; Caco-2 cells; PhytosterolsMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PARP, poly (ADP-ribose) polymerase; PI, propidium iodide; Ps mix, phytosterols mixture; RONS, reactive oxygen nitr
Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro
Keywords: PARP، پلی مراز (ADP-ribose); TRAIL; Breast cancer; Cytotoxicity; Fenretinide; Chemotherapy4-HPR, Fenretinide; ROS, Reactive oxygen species; TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand; ATP, Adenosine-5′-triphosphate; PARP, Poly (ADP-ribose) polymerase; FADD, Fas as
Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3
Keywords: PARP، پلی مراز (ADP-ribose); DAPI, diamidino-2-phenylindole; MAPK, mitogen activated protein kinase; PARP, poly (ADP-ribose) polymerase; STAT3, signal transducer and activator of transcription 3Apoptosis; Fas; Luteolin; Paclitaxel; STAT3
Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells
Keywords: PARP، پلی مراز (ADP-ribose); Bcl, B-cell lymphoma; Bax, Bcl-2-associated X protein; GKA, glucokinase activator; GSK, glycogen synthase kinase; IRS-2, insulin receptor substrate-2; PARP, poly (ADP-ribose) polymerase; VDAC, voltage-dependent anion-selective channel protein; TFAM, mitoc
Diethylcarbamazine inhibits NF-κB activation in acute lung injury induced by carrageenan in mice
Keywords: PARP، پلی مراز (ADP-ribose); NO, nitric oxide; iNOS, inducible nitric oxide synthase; PGE2, prostaglandin E2; COX-2, cyclooxygenase-2; PARP, poly (ADP-ribose) polymerase; NF-κB, nuclear transcription factor-κB; MAPKs, mitogen-activated protein kinasesDiethylcarbamazine; Nuclear trans
Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways
Keywords: PARP، پلی مراز (ADP-ribose); ROS, reactive oxygen species; MAPKs, mitogen-activated protein kinases; JNK, c-Jun N-terminal kinase; ERK, extracellular signal-related kinase; Nrf2, nuclear-factor-E2-related factor 2; PARP, poly (ADP-ribose) polymerase; NAC, N-acetylcysteine; ER stress,
Diabetic retinopathy: Neuron protection as a therapeutic target
Keywords: PARP، پلی مراز (ADP-ribose); BNDF, brain derived neurotrophic factor; DR, diabetic retinopathy; DMO, diabetic macular oedema; ERG, electroretinogram; EPO, Erythropoietin; GABA, gamma-amminobytyric acid; GrB, granzyme B; PARP, poly (ADP-ribose) polymerase; Pp38MAPK, phosphorylated p38
Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis
Keywords: PARP، پلی مراز (ADP-ribose); DNMT1, DNA methyltransferase 1; PARP, Poly (ADP-ribose) polymerase; RING, Really Interesting New Gene; SRA, SET and RING-finger associated domain; TTD, tandem tudor domain; UHRF1, ubiquitin-like containing PHD and RING finger domains, 1; VEGF, vascular en
Celecoxib antagonizes the cytotoxic effect of cisplatin in human gastric cancer cells by decreasing intracellular cisplatin accumulation
Keywords: PARP، پلی مراز (ADP-ribose); COX, cyclooxygenase; CTR1, copper transporter 1; NSAIDs, nonsteroidal anti-inflammatory drugs; PGE2, Prostaglandin E2; PARP, poly (ADP-ribose) polymerase; siRNA, small interference RNA; SC-236, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]ben
Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro
Keywords: PARP، پلی مراز (ADP-ribose); AA, aristolochic acid; LD50, median lethal dose; NRK52E, normal rat renal proximal tubular epithelial cells; PARP, poly (ADP-ribose) polymerase; 3-MA, 3-methyl adenine; Atg, autophagy-related gene; LC3, microtubule-associated protein light chain 3Aristolo
Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma
Keywords: PARP، پلی مراز (ADP-ribose); HCC, hepatocellular carcinoma; PP2A, protein phosphatase 2A; CIP2A, cancerous inhibitor of PP2A; PI3 K, phosphatidylinositol-3-kinase; PDK1, phosphatidylinositol-3-kinase dependent 1; PARP, poly (ADP-ribose) polymerase; DMEM, Dulbecco's modified Eagle's m
Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
Keywords: PARP، پلی مراز (ADP-ribose); 4-HT, 4-hydroxy-tamoxifen; DMEM, Dulbecco Minimal Essential Medium; DMSO, Dimethyl sulfoxide; FACS, Fluorescence-activated cell sorting; Fr, Frondoside A; PARP, Poly (ADP-ribose) polymerase; RIPA, Radioimmunoprecipitation assay buffer; SA-β-Gal, Senescenc
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A
Keywords: PARP، پلی مراز (ADP-ribose); HCC, hepatocellular carcinoma; PP2A, protein phosphatase 2A; CIP2A, cancerous inhibitor of PP2A; PI3K, phosphatidylinositol-3-kinase; PDK1, phosphatidylinositol-3-kinase dependent 1; PARP, poly (ADP-ribose) polymerase; DMEM, Dulbecco’s modified Eagle’s me
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines
Keywords: PARP، پلی مراز (ADP-ribose); HR, homologous recombination; DSBs, double-strand breaks; MAPK, mitogen-activated protein kinases; JNK, c-Jun N-terminal kinases; PARP, poly (ADP-ribose) polymerase; MTS, [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetraz
DAPk1 inhibits NF-κB activation through TNF-α and INF-γ-induced apoptosis
Keywords: PARP، پلی مراز (ADP-ribose); DAPk1, death-associated protein kinase 1; TNF-α, Tumor necrosis factor alpha; IFN-γ, Interferon-gamma; siRNA, short interfering RNA; PARP, poly (ADP-ribose) polymerase; FADD, Fas-associated protein with death domain; TRADD, TNFR-associated death domain pr
Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis
Keywords: PARP، پلی مراز (ADP-ribose); BAT, brown adipose tissue; BSA, bovine serum albumin; CIDE, cell death-inducing DNA fragmentation α-like effector; FBS, fetal bovine serum; FFA, free fatty acid; HRP, horseradish peroxidase; PARP, poly (ADP-ribose) polymerase; siRNA, small interfering RNA
Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1
Keywords: PARP، پلی مراز (ADP-ribose); STZ, Streptozotocin; DZ, Diazoxide; FoxO1, Forkhead box other transcription factors; iNOS, Inducible nitric oxide synthase; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; PARP, Poly (ADP-ribose) polymerase; AIF, Apoptosis-inducing factorDiabetic cardiom
Involvement of oxidative stress-induced ERK/JNK activation in the Cu2+/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells
Keywords: PARP، پلی مراز (ADP-ribose); DM, diabetes mellitus; PDTC, pyrrolidine dithiocarbamate; LPO, lipid peroxidation; GSH, glutathione; PARP, poly (ADP-ribose) polymerase; NAC, N-acetylcysteine; MAPKs, mitogen-activated protein kinases; ERK, extracellular signal-regulated kinases; JNK, c-j
Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells
Keywords: PARP، پلی مراز (ADP-ribose); ROS, reactive oxygen species; PARP, poly (ADP-ribose) polymerase; LC3, microtuble-associated protein 1 light chain 3; AMPK, AMP-activated protein kinase; PJS, Peutz–Jeghers syndrome; EMEM, Eagle's minimal essential medium; FBS, Fetal bovine serum; DPQ, 3,
Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury
Keywords: PARP، پلی مراز (ADP-ribose); LPO, lipid peroxidation; PARP, poly (ADP-ribose) polymerase; NAC, N-acetylcysteine; MAPKs, mitogen-activated protein kinases; ERK, extracellular signal-regulated kinases; JNK, c-Jun N-terminal kinases; MMP, mitochondrial membrane potential; ROS, reactive
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
Keywords: PARP، پلی مراز (ADP-ribose); TRAIL, TNF-related apoptosis-inducing ligand; IAP, inhibitor of apoptosis protein; cIAP-1, cellular inhibitor of apoptosis 1; cIAP-2, cellular inhibitor of apoptosis 2; XIAP, X-linked inhibitor of apoptosis; PARP, poly (ADP-ribose) polymerase; SMAC, secon
N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death
Keywords: PARP، پلی مراز (ADP-ribose); BCS, bathocuproinedisulfonic acid; NAC, N-acetylcysteine; MTS, (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium); PARP, poly (ADP-ribose) polymerase; ROS, reactive oxygen species; SOD, superoxide dismutase; TM, tet
Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells
Keywords: PARP، پلی مراز (ADP-ribose); METH, methamphetamine; DA, dopamine; ROS, reactive oxygen species; RA, retinoic acid; 3-MA, 3-methyladenine; PARP, poly (ADP-ribose) polymerase; GFP, green fluorescent protein; FITC, fluorescein isothiocyanateDifferentiated SH-SY5Y cell; Methamphetamine;
Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
Keywords: PARP، پلی مراز (ADP-ribose); AE, aloe-emodin; NPC, human nasopharyngeal carcinoma; PARP, poly (ADP-ribose) polymerase; siRNA, small interfering RNA; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; CsA, cyclosporine A; FADD, Fas-associated death domain; AIF, apopt
UVC-induced apoptosis in Dubca cells is independent of JNK activation and p53Ser-15 phosphorylation
Keywords: PARP، پلی مراز (ADP-ribose); UVC, Ultraviolet C; MAPK, mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; ATF2, activating transcription factor 2; AP-1, Activator Protein 1; PARP, Poly (ADP-Ribose) Polymerase; PI3K, Phosphoinositide 3-kinaseApoptosis; p53Ser-15 phosphory
Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity
Keywords: PARP، پلی مراز (ADP-ribose); WEPN, water extracts from pine needle; DCF-DA, 2′,7′-dichlorofluorescin diacetate; DPPH, 1,1diphenyl-2-picryl hydrazyl; ROS, reactive oxygen species; EBB, ethidium bromide binding; PARP, poly (ADP-ribose) polymerase; PBS, phosphate-buffered salinePine nee
Vascular endothelial growth factor protects motoneurons from serum deprivation–induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition
Keywords: PARP، پلی مراز (ADP-ribose); apoptosis; neuroprotection; neurotrophic factors; spinal cord; stress kinaseALS, amyotrophic lateral sclerosis; FUDR, fluorodeoxyuridine; L-15, Leibowitz's 15; MAPK, mitogen-activated protein kinase; PARP, poly (ADP-ribose) polymerase; PBS, phosphate-buff
The in vitro and in vivo apoptotic effects of Mahonia oiwakensis on human lung cancer cells
Keywords: PARP، پلی مراز (ADP-ribose); MOE, Mahonia oiwakensis extract; PARP, poly (ADP-ribose) polymerase; SCLC, small-cell lung carcinoma; NSCLC, non-small-cell lung carcinoma; MTT, 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide; HPLC, high-pressure liquid chromatograms; DMSO,
Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage
Keywords: PARP، پلی مراز (ADP-ribose); Bc, Bromocriptine; ERK, Extracellular Signal Regulated Kinase; JNK, Stress Related c-jun NH2-terminal kinase; MAPK, Mitogen Activated Protein Kinase; PARP, poly (ADP-ribose) polymerase; PCD, Programmed Cell Death; P-ERK1/2, phosphorylated ERK1/2; PKCδ, Pr
Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation
Keywords: PARP، پلی مراز (ADP-ribose); AZT, azidothymidine3′-azido-3′-deoxythymidine; ROS, reactive oxygen species; PAR, poly (ADP-ribose); PARG, poly (ADP-ribose) (PAR) glycohydrolase; PARP, poly (ADP-ribose) polymerase; AST, asparatate aminotransferase; ALT, alanine aminotransferase; MN, mic
Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa
Keywords: PARP، پلی مراز (ADP-ribose); Apaf-1, apoptosis protease-activating factor-1; FasL, fas ligand; HESL, hexane extract of Saussurea lappa; HSP 60, heat shock protein 60; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; PARP, poly (ADP-ribose) polymerase; t-Bid, truncat
Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes
Keywords: PARP، پلی مراز (ADP-ribose); NAD, nicotinamide adenine dinucleotide; NADH, reduced nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, reduced nicotinamide adenine dinucleotide phosphate; PARP, poly (ADP-ribose) polymerase; Nam, nicotinamide;
Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis
Keywords: PARP، پلی مراز (ADP-ribose); LLC, Lewis lung carcinoma; PARP, poly (ADP-ribose) polymerase; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; PCNA, proliferating cell nuclear antigenIsorhamnetin; Quercetin; Apoptosis; Mitochondria; Caspases
Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses
Keywords: PARP، پلی مراز (ADP-ribose); DSB, double-stranded break; HR, homologous recombination; NHEJ, non-homologous end joining; PARP, poly (ADP-ribose) polymerase; RIP, replication-initiated processing; tAML, therapy-related secondary acute myeloid leukemia; TIP, transcription-initiated pro
Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily
Keywords: PARP، پلی مراز (ADP-ribose); EGFP, enhanced green fluorescence protein; PAGE, polyacrylamide gel electrophoresis; PARP, poly (ADP-ribose) polymerase; PBS, phosphate-buffered saline; SDS, sodium dodecyl sulfate; si, small interference.Mst1; TRAIL; Caspase; MAPK
Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression
Keywords: PARP، پلی مراز (ADP-ribose); CDKs, cyclin-dependent kinases; ERK, extracellular-related protein kinase; IKK, IκB kinase; JNK, C-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; PARP, poly (ADP-ribose) polymerase; PI3K, phosphoinositide 3-kinaseSurfactin; Anti-cancer eff
Bradykinin enhances reactive oxygen species generation, mitochondrial injury, and cell death induced by ATP depletion—A role of the phospholipase CCa2+ pathway
Keywords: PARP، پلی مراز (ADP-ribose); ARF, acute renal failure; B2R, bradykinin B2 receptor; DHE, dihydroethidium; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; I/R, ischemia/reperfusion; PARP, poly (ADP-ribose) polymerase; PLC, phospholipase C; ROS, reactive oxygen speciesBradykinin;
Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle
Keywords: PARP، پلی مراز (ADP-ribose); AIF, Apoptosis inducing factor; Apaf-1, Apoptotic protease activation factor-1; ARC, Apoptosis repressor with caspase recruitment domain; ELISA, Enzyme-Linked Immunosorbent Assay; HSP, Heat shock protein; PARP, poly (ADP-ribose) polymerase; TNFα, Tumor ne
Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1
Keywords: PARP، پلی مراز (ADP-ribose); Ac-IETD, Ac-Ile-Glu-Thr-Asp-CHO; Ann V, Annexin V; aSMase, acid sphingomyelinase; β-CD, β-cyclodextrin; Desi, desipramine; FB1, fumonisin B1; Gal-1, galectin-1; PARP, poly (ADP-ribose) polymerase; PDBu, phorbol dibutyrate; PS, phosphatidylserine; PTK, pro
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck
Keywords: PARP، پلی مراز (ADP-ribose); EGF, epidermal growth factor; GSK-3, glycogen synthase kinase-3; HNSCC, squamous cell carcinomas of the head and neck; MTT, thiazolyl blue tetrazolium bromide; p, phosphorylated; PARP, poly (ADP-ribose) polymerase; PI-3K, phosphatidylinositol 3-kinase; SC