کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116428 | 1084908 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death](/preview/png/2116428.png)
چکیده انگلیسی
A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the “ROS generators”.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 298, Issue 2, 8 December 2010, Pages 186–194
Journal: Cancer Letters - Volume 298, Issue 2, 8 December 2010, Pages 186–194
نویسندگان
Jie Zheng, Jessica R. Lou, Xiao-Xi Zhang, Doris M. Benbrook, Marie H. Hanigan, Stuart E. Lind, Wei-Qun Ding,