دانلود مقالات ISI درباره پچ گیر + ترجمه فارسی

Electrophysiological effect and the gating mechanism of astragaloside IV on l-type Ca2+ channels of guinea-pig ventricular myocytes

Keywords: پچ گیر; AS-IV; l-type Ca2+ channel; Patch-clamp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor

Keywords: پچ گیر; Nicotinic receptor; Patch-clamp; Channel gating; Channel coupling; nAChR; nicotinic acetylcholine receptor; ACh; acetylcholine; α-BTX; alpha-bungarotoxin; LGIC; ligand-gated ion channel; 5-HT3R; serotonin receptor type 3; GABAR; γ-aminobutyric acid rece

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1)

Keywords: پچ گیر; MD-2, myeloid differentiation factor 2 (MD-2); SDM, site-directed mutagenesis; Nav1.4, skeletal muscle voltage-gated sodium channel; TLR4, Toll-like receptor type 4; Trk, tyrosine receptor.Ig-like; CDR1; MD-2; Patch-clamp; Site-directed mutagenesis; Analo

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Glycosylation-dependent activation of epithelial sodium channel by solnatide

Keywords: پچ گیر; Epithelial sodium channel (ENaC); Glycosylation; Patch-clamp; Western blot;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition

Keywords: پچ گیر; Exposure; Flow cell; hERG; ICH S7B; Methods; Patch-clamp; Screening; Solubility; Turbidometry; UV spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Pulmonary, gastrointestinal and urogenital pharmacologyProstaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: A novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channels

Keywords: پچ گیر; Prostaglandin E2; Detrusor; Patch-clamp; Ca2+ imaging;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy

Keywords: پچ گیر; SCN8A; Nav1.6; Epileptic encephalopathy; Exome sequencing; Patch-clamp;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcayji-hes mice

Keywords: پچ گیر; Dystonia; Ataxia; Cerebellum; Purkinje cells; Deep cerebellar nuclei; Patch-clamp; Electrophysiology; Mutant mice;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

The P2X7 receptor: Shifting from a low- to a high-conductance channel - An enigmatic phenomenon?

Keywords: پچ گیر; P2X7R; Ion channel activity; Patch-clamp; Calcium; Second messenger;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Interleukin-1β and interleukin-6 affect electrophysiological properties of thalamic relay cells

Keywords: پچ گیر; AP; action potential; dLGN; dorsal lateral geniculate nucleus; ISI; inter-spike interval; LTS; low threshold calcium spike; Thalamic relay cell; Interleukin; IL-1β; IL-6; Patch-clamp;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors

Keywords: پچ گیر; EDTA; Ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; DMEM; Dulbecco's modified Eagle medium; BES; N,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid; kainate receptors; mutagenesis; patch-clamp; glutamate;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Short CommunicationDopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats

Keywords: پچ گیر; GABAA receptors; Tonic inhibition; Ventrobasal thalamus; Absence epilepsy; Patch-clamp; Dopamine;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Arrhythmogenic effect of a crude extract from sea anemone Condylactis gigantea: Possible involvement of rErg1 channels

Keywords: پچ گیر; Sea anemone; Long QT syndrome type 2; Erg1; Ether-a-go-go-related gene; Patch-clamp; Purification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease

Keywords: پچ گیر; 5-HT; 6-Hydroxydopamine; Electrophysiology; Patch-clamp; PD; In vitro;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

Keywords: پچ گیر; Acetazolamide; Chloride channel mutation; ClC-1 chloride channel; Genotype-phenotype relationship; Myotonia congenita; Non-dystrophic myotonia; Patch-clamp; Transitory weakness;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Focal cerebral ischemia induces the neurogenic potential of mouse Dach1-expressing cells in the dorsal part of the lateral ventricles

Keywords: پچ گیر; aCSF; artificial cerebrospinal fluid; aNSCs; adult neural stem cells; bFGF; basic fibroblast growth factor; BLBP; brain lipid-binding protein; CD; current densities; DAPI; 4,6-diamidino-2-phenylindole; DCX; doublecortin; EDTA; ethylenediaminetetraacetic a

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Modulatory effects of the novel TrkB receptor agonist 7,8-dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro

Keywords: پچ گیر; Flavonoids; BDNF; TrkB receptor; Synaptic transmission; Patch-clamp; Visual cortex

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Cholinergic receptor activation supports persistent firing in layer III neurons in the medial entorhinal cortex

Keywords: پچ گیر; Acetylcholine; Electrophysiology; Patch-clamp; Grid cell; Working memory;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices

Keywords: پچ گیر; Area postrema; Amylin; Patch-clamp; Brain slice; Rat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Which agonist properties are important for the activation of 5-HT3A receptors?

Keywords: پچ گیر; Human 5-HT3A receptor; Agonist; Patch-clamp; Anesthetic; 5-Hydroxytryptamine derivative; Tyramine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

20 Hz membrane potential oscillations are driven by synaptic inputs in collision-detecting neurons in the frog optic tectum

Keywords: پچ گیر; Patch-clamp; Whole-cell recording; Visual system; Synapse; Cellular neurophysiology;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy

Keywords: پچ گیر; Hippocampus; Rat pilocarpine model; Patch-clamp; h-Current; Human; Temporal lobe epilepsy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels

Keywords: پچ گیر; CRAC channel; Ion selectivity; Orai1; STIM1; Patch-clamp; Ca2+ imaging;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Compromised function in the Nav1.2 Dravet syndrome mutation R1312T

Keywords: پچ گیر; Nav1.2; voltage-gated Na+ channel; SCN2A; gene, voltage-gated Na+ channel Nav1.2; SMEI; severe myoclonic epilepsy in infancy; GEFS +; genetic epilepsy with febrile seizures, plus; BFNIS; benign familial neonatal-infantile seizures; OMIM; Online Mendeli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells

Keywords: پچ گیر; Patch-clamp; Current-clamp; 3H glucose uptake; Colony formation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Voltage-dependent inactivation of the plasmodial surface anion channel via a cleavable cytoplasmic component

Keywords: پچ گیر; PSAC; plasmodial surface anion channel; clag; cytoadherence linked antigen; Vm; membrane potential; zg; effective valence of inactivating particle; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; PSAC; Voltage-dependent inactivation; Patch-clam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

A consensus segment in the M2 domain of the hP2X7 receptor shows ion channel activity in planar lipid bilayers and in biological membranes

Keywords: پچ گیر; P2X7 receptor; Ionic channel activity; Peptide single channel activity; Artificial planar lipid bilayer; Patch-clamp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG

Keywords: پچ گیر; VTA; 2-arachidonoylglycerol; Midbrain; Mice; Patch-clamp; Synaptic;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The Stress-Induced Cytokine Interleukin-6 Decreases the Inhibition/Excitation Ratio in the Rat Temporal Cortex via Trans-Signaling

Keywords: پچ گیر; 2-Br-hexadecanoic acid; postsynaptic; Brefeldin A; dynamin inhibitory peptide; foot-shock; γ-aminobutyric acid (GABA); interleukin-6 (IL-6); lipopolysaccharide (LPS); PI3K/AKT; patch-clamp; stress; gp130; rat; temporal cortex; trans-signaling; wortmannin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Nav sodium channel isoforms

Keywords: پچ گیر; CGTX-II; cangitoxin-II; VGSC; voltage-gated sodium channels; Sea anemone; Bunodosoma cangicum; Sodium channels; Inactivation process; Patch-clamp; Toxins selectivity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Positive modulation of δ-subunit containing GABAA receptors in mouse neurons

Keywords: پچ گیر; AA29504; Interneuron; Patch-clamp; Zinc; Marble burying assay;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Age-related increase of sIAHP in prefrontal pyramidal cells of monkeys: relationship to cognition

Keywords: پچ گیر; Slice; Patch-clamp; Voltage-clamp; Potassium channels; Excitability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents

Keywords: پچ گیر; Ca2+-activated K+ channel; After-hyperpolarizing potential; Status epilepticus; Patch-clamp; UCL1684;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Neural precursors (NPCs) from adult L967Q mice display early commitment to “in vitro” neuronal differentiation and hyperexcitability

Keywords: پچ گیر; Neural stem/progenitor cells (NPCs); Motoneuron; Neurodegeneration; Amyotrophic lateral sclerosis; Wobbler mouse; Sodium channel; Hyperexcitability; Patch-clamp;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The GABA(A)ρ receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex

Keywords: پچ گیر; GABAρ; Patch-clamp; TPMPA; Amygdala; Visual cortex

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Neuropharmacology and AnalgesiaInteractions between modulators of the GABAA receptor: Stiripentol and benzodiazepines

Keywords: پچ گیر; Anti-convulsant; Electrophysiology; Diazepam; Clobazam; Norclobazam; Clonazepam; Recombinant; Patch-clamp; Dravet syndrome;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Investigation of morphological and functional changes during neuronal differentiation of PC12 cells by combined Hopping Probe Ion Conductance Microscopy and patch-clamp technique

Keywords: پچ گیر; SICM; SPM; Patch-clamp; Ion channel; Neuron;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

A PDMS microfluidic system with poly(ethylene glycol)/SU-8 based apertures for planar whole cell-patch-clamp recordings

Keywords: پچ گیر; Poly(ethylene glycol); Patch-clamp; Micromolding; Whole cell current recording

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

P2X7 receptors contribute to the currents induced by ATP in guinea pig intestinal myenteric neurons

Keywords: پچ گیر; Small intestine; Enteric neurons; Myenteric plexus; P2X receptors; P2X2 receptors; Patch-Clamp; RT-PCR; (Guinea pig)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome

Keywords: پچ گیر; Long QT syndrome; Kv11.1 channels; Missense mutation; Patch-clamp; HERGAP, action potential; CHO, Chinese hamster ovary cells; Erev, reversal potential; IE637G, current generated by p.E637G Kv11.1 channels; IKr, rapid component of the delayed rectifier K+

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Mechanism of action of lolitrem B, a fungal endophyte derived toxin that inhibits BK large conductance Ca2+-activated K+ channels

Keywords: پچ گیر; Large conductance calcium-activated potassium channel; BK ion channel; Patch-clamp; Paxilline; Lolitrem; BK channel inhibitor; Fungal toxin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Combined Bicarbonate Conductance-Impairing Variants in CFTR and SPINK1 Variants Are Associated With Chronic Pancreatitis in Patients Without Cystic Fibrosis

Keywords: پچ گیر; NAPS2; Pancreas; Polygenic; Risk Factor; Patch-Clamp; Epistasis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A step towards characterisation of electrophysiological profile of torsadogenic drugs

Keywords: پچ گیر; Electrocardiogram; Patch-clamp; Purkinje fibres; QT prolongation; Safety pharmacology; Telemetry

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A minimal isoform of the TMEM16A protein associated with chloride channel activity

Keywords: پچ گیر; CaCC; Ca2+-activated Cl− channel; YFP; yellow fluorescent protein; Chloride channel; Alternative splicing; Intracellular calcium; Patch-clamp;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A use-dependent sodium current modification induced by type I pyrethroid insecticides in honeybee antennal olfactory receptor neurons

Keywords: پچ گیر; Antennal sensilla; Olfactory receptor neurons; Sensory neuron; Electrophysiology; Patch-clamp; Insecticide; Permethrin; Tetramethrin; Ionic current; Bee health; Mode of action; Sodium channel; Para; TipE; State-dependent modification;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina

Keywords: پچ گیر; patch-clamp; phospholipase C; protein kinase C; IP3ACSF, artificial cerebral spinal fluid; BC, bipolar cell; Bis IV, bisindolylmaleimide IV; BKCa, large-conductance Ca2+-activated K+ channels; cAMP, cyclic adenosine monophosphate; [Ca2+]i, intracellular c

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network

Keywords: پچ گیر; Leptin; Insulin; Serotonin; Obesity; Diabetes; Patch-clamp

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Dopamine depresses melanin concentrating hormone neuronal activity through multiple effects on α2-noradrenergic, D1 and D2-like dopaminergic receptors

Keywords: پچ گیر; dopamine; melanin concentrating hormone neurons; patch-clamp; lateral hypothalamus; MCH-GFP transgenic mouse; brain sliceAP, action potential; DA, dopamine; LH, lateral hypothalamus; MCH, melanin concentrating hormone; PFA, perifornical area; α2-NA, α2-no

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Modulators of BK and SK channels alter electrical activity in vitro in single vasopressin neurons isolated from the rat supraoptic nucleus

Keywords: پچ گیر; AVP, arginine vasopressin; GFP, green fluorescent protein; MNC, magnocellular neurosecretory cell; OXT, oxytocin; SON, supraoptic nucleusBK channel; SK channel; Vasopressin neuron; Green fluorescent protein; Patch-clamp; Supraoptic nucleus

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism

Keywords: پچ گیر; Neuropathic pain; Myricetin; Voltage activated potassium channels; Flavonoids; Patch-clamp

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه