دانلود مقالات ISI درباره Pcsk9 + ترجمه فارسی

Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Keywords: antisense; BNA; hypercholesterolemia; LNA; PCSK9;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases

Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

PCSK9 Inhibitors

Keywords: cost effectiveness; prevention; society; ICER; incremental cost-effectiveness ratio; LDL-C; low-density lipoprotein cholesterol; MI; myocardial infarction; PCSK9; proprotein convertase subtilisin/kexin type 9; QALY; quality-adjusted life-year; RCT; random

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

How effectively will PCSK9 inhibitors allow retrieval of freedom from apheresis in cardiovascular high risk patients? - Estimates form a large single center

Keywords: Lipoprotein apheresis; Lipids; PCSK9; Lipoprotein(a); LDL-cholesterol;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Oxidized LDL at the crossroads of immunity in non-alcoholic steatohepatitis

Keywords: 25HC; 25-hydroxycholesterol; 27HC; 27-hydroxycholesterol; 4-HNE; 4-hydroxynonenal; CASP-1; Caspase-1; CD36; cluster of differentiation 36; Col1a1; collagen type 1, alpha 1; CONV-R; conventionally raised; CVD; cardiovascular disease; FA; fatty acid; FXR; f

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Hypercholesterolemia: The role of PCSK9

Keywords: LDL; PCSK9; IDOL; LDL receptor; Hypercholesterolemia; Statin; Inhibitors; Metabolic diseases;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Predicting proprotein convertase subtilisin kexin type-9 loss of function mutations using plasma PCSK9 concentration

Keywords: PCSK9; R46L mutation; InsLEU mutation; Sensitivity; Specificity;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Atorvastatin and lovastatin, but not pravastatin, increased cellular complex formation between PCSK9 and the LDL receptor in human hepatocyte-like C3A cells

Keywords: Hypercholesterolemia; PCSK9; LDL receptor; Protein complexes; Statins;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

The efficacy of anti-PCSK9 antibodies: Results from recent trials

Keywords: Alirocumab; Anti-PCSK9 antibodies; Cardiovasvular disease; Evolocumab; PCSK9;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg/dL compared with a novel low-density lipoprotein estimation method

Keywords: LDL-C; Non-HDL-C; ApoB; Lipids; PCSK9; ASCVD;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

How many familial hypercholesterolemia patients are eligible for PCSK9 inhibition?

Keywords: PCSK9; Evolocumab; Alirocumab; LDL target; Lipid lowering therapy; Familial hypercholesterolemia;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Calorically restricted diets decrease PCSK9 in overweight adolescents

Keywords: Dyslipidemia; Nutritional Therapy; Adolescents; PCSK9; Obesity;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys

Keywords: SCAP; LDL-cholesterol; Triglyceride; PCSK9; Diabetic dyslipidemia; RhM; rhesus monkey; DNL; de novo lipogenesis;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

PCSK9 Monoclonal Antibodies in 2016: Current Status and Future Challenges

Keywords: PCSK9 inhibitors; Statins; Lipid lowering therapies; LDL-C; Low-density lipoprotein cholesterol; LDL-R; Low-density lipoprotein receptor; PCSK9; Proprotein Convertase Subtilisin/Kexin type 9; ACS; Acute coronary syndrome; FDA; Food and Drug Administration

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Lipoprotein (a)

Keywords: familial hypercholesterolemia; LDL receptor; lipoprotein(a); PCSK9; primary human hepatocytes;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Statins in Familial Hypercholesterolemia

Keywords: genetic; LDL; PCSK9; prevention; statin;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice

Keywords: Atherosclerosis; Cholesterol-lowering pattern;; PCSK9;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of novel APOB mutations by targeted next-generation sequencing for the molecular diagnosis of familial hypobetalipoproteinemia

Keywords: Familial hypobetalipoproteinemia; Target next generation sequencing; APOB; PCSK9; Molecular diagnosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia

Keywords: Coronary artery calcification; Lipids and lipoprotein metabolism; Hypercholesterolemia; PCSK9; proprotein convertase subtilisin kexin type 9; LDL-C; low-density lipoprotein cholesterol; LDLR; low-density lipoprotein receptor; LLT; lipid lowering therapy;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Dietary high oleic canola oil supplemented with docosahexaenoic acid attenuates plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in participants with cardiovascular disease risk: A randomized control trial

Keywords: Cardiovascular disease; DHA; PCSK9; LDL-C; Randomized control trial;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Statins can exert dual, concentration dependent effects on HCV entry in vitro

Keywords: HCV; Statins; CLDN-1; LDLR; NPC1L1; CD81; PCSK9; Lipids; CholesterolHMG-CoAR, 3-hydroxy-3-methylglutharyl-coenzyme A reductase; PEG-IFN, pegylated interferon; SVR, sustained viral response; LDLR, low density lipoprotein receptor; NPC1L1, Niemann–Pick C1-l

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

PCSK9 in relation to coronary plaque inflammation: Results of the ATHEROREMO-IVUS study

Keywords: PCSK9; Atherosclerosis; Inflammation; Intravascular ultrasound; Prognosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Nonstatins and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Role in Non‐Familial Hypercholesterolemia

Keywords: Ezetimibe; PCSK9 inhibitor; Risk reduction; ASCVD; Atherosclerotic cardiovascular disease; CVD; Cardiovascular disease; DM; Diabetes mellitus; FH; Familial hypercholesterolemia; HDL-C; High-density lipoprotein cholesterol; LDL-C; Low-density lipoprotein c

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A review of PCSK9 inhibition and its effects beyond LDL receptors

Keywords: PCSK9; Alirocumab; Evolocumab; Dyslipidemia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Circulating PCSK9 in patients with type 2 diabetes and related metabolic disorders

Keywords: PCSK9; Type 2 diabetes; Metabolic syndrome; Nuclear magnetic resonance; SNPPCSK9; Diabetes tipo 2; Síndrome metabólico; Resonancia magnética nuclear; SNP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Studies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations

Keywords: Furin; LDL receptor; Mutation; Prodomain; PCSK9;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Impact of a 1-year lifestyle modification program on plasma lipoprotein and PCSK9 concentrations in patients with coronary artery disease

Keywords: PCSK9; Lifestyle; Lipoproteins; Ectopic fat; Coronary artery disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: The ODYSSEY OPTIONS II randomized trial

Keywords: Alirocumab; Ezetimibe; Low-density lipoprotein cholesterol; Monoclonal antibody; PCSK9; Rosuvastatin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I

Keywords: Alirocumab; Cardiovascular risk; LDL-C; PCSK9; Placebo-controlled; Phase III; Randomized;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Culturing of HepG2 cells with human serum improve their functionality and suitability in studies of lipid metabolism

Keywords: CYP; cytochrome P450; LDLR; low density lipoprotein receptor; MTP; microsomal triglyceride transfer protein; PCSK9; proprotein subtilisin/kexin type 9; HepG2; Human serum; FBS; Lipoproteins; Bile acids;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons

Keywords: VLDLR; Wnt; Berberine; ER stress; Lipoprotein receptors; PCSK9;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism

Keywords: ABCA1; ATP-binding cassette transporter isoform A1; APL; alkylphospholipid; apoA1; apolipoprotein A1; CETP; cholesteryl ester transfer protein; CYP7A1; cholesterol 7α-hydroxylase; CYP27; sterol 27-hydroxylase; DHCR7; 7-dehydrocholesterol reductase; ER; e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Up-regulation of Hnf1α gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations

Keywords: HNF1; HNF4; MTP; apoB-100; FASN; PCSK9; CRF;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Determining When to Add Nonstatin Therapy

Keywords: cost; ezetimibe; nonstatins; PCSK9 inhibitors; statins; ARR; absolute risk reduction; ASCVD; atherosclerotic cardiovascular disease; FH; familial hypercholesterolemia; ICER; Institute for Clinical and Economic Review; LDL-C; low-density lipoprotein choles

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

The re-emergence of lipoprotein(a) in a broader clinical arena

Keywords: apo; apolipoprotein; AS; aortic stenosis; CAVS; calcific aortic valve stenosis; CVD; cardiovascular disease; LDL; low-density lipoprotein; LDL-C; low-density lipoprotein cholesterol; Lp(a); lipoprotein(a); OMT; optimal medical therapy; OxPL; oxidized phos

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a)

Keywords: apo; apolipoprotein; CHD; coronary heart disease; d; density; FCR; fractional catabolic rate; GC/MS; gas chromatography/mass spectrometry; IDL; intermediate density lipoprotein (d 1.006-1.019 g/mL); KIV1; kringle IV1; KIV2; kringle IV2; Lp(a); lipoprot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Lupin protein exerts cholesterol-lowering effects targeting PCSK9: From clinical evidences to elucidation of the in vitro molecular mechanism using HepG2 cells

Keywords: Bioactive peptides; HepG2 cells; HNF1-alpha; Lupinus; PCSK9; Plant proteinsFBS, foetal bovine serum; HMGCoAR, 3-hydroxy-3-methylglutaryl coenzyme A reductase; HNF1-alpha, hepatocyte nuclear factor 1 alpha; LDL-C, LDL cholesterol; PCSK9, proprotein convert

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Therapeutic efficacy of PCSK9 monoclonal antibodies in statin-nonresponsive patients with hypercholesterolemia and dyslipidemia: A systematic review and meta-analysis

Keywords: Dyslipidemia; PCSK9; LDL-Cholesterol; Statins; Hypercholesterolemia;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement

Keywords: PCSK9; Smooth muscle cells; Restenosis; Small G proteins; Cell proliferation; Cell migration;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Antisense molecules: A new class of drugs

Keywords: Clinical trial; antisense; small interfering RNA; DNAzyme; therapy; ALS; Amylotrophic lateral sclerosis; AMD; Age-related macular degeneration; CMV; Cytomegalovirus; CNV; Choroidal neovascularization; CVD; Cardiovascular disease; DMD; Duchenne muscular dy

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Proprotein convertase subtilisin/kexin 9 V4I variant with LDLR mutations modifies the phenotype of familial hypercholesterolemia

Keywords: PCSK9; LDL receptor; Variant; Familial hypercholesterolemia; Mutation;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting PCSK9 for therapeutic gains: Have we addressed all the concerns?

Keywords: PCSK9; LDL-C; LDL-receptor; VLDL; PCSK9-Centric lipid lowering; Pleiotropic; Monoclonal antibody; CRISPR-CAS9; Anti-sense oligonucleotide; Peptide-mimetic; Adnectin; Vaccine; Lipoprotein-apheresis;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Advances in therapeutic CRISPR/Cas9 genome editing

Keywords: Cas9; CRISPR-associated protein 9; cccDNA; covalently closed circular DNA; CCR5; chemokine receptor 5; CFTR; cystic fibrosis transmembrane conductance regulator; CRISPRs; clustered regularly interspaced short palindromic repeats; crRNA; CRISPR RNA; Crygc;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Possible involvement of PCSK9 overproduction in hyperlipoproteinemia associated with hepatocellular carcinoma: A case report

Keywords: Hypercholesterolemia; Hypertriglyceridemia; Type III hyperlipoproteinemia; Cholesterol; Liver; Hepatocellular carcinoma; PCSK9; SREBP-2; LDL receptor; Hepatitis B virus;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol

Keywords: ALT; alanine transaminase; ASO; antisense oligonucleotide; apoB; apolipoprotein B; CVD; cardiovascular disease; EGF; epidermal growth factor; LDL-C; low-density lipoprotein cholesterol; MTP; microsomal triglyceride transfer protein; PCSK9; proprotein conv

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans

Keywords: PCSK9; LDL-cholesterol; Testosterone; Estradiol; Gender;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Alginate oligosaccharide enhances LDL uptake via regulation of LDLR and PCSK9 expression

Keywords: AOS; alginate oligosaccharide; CVD; cardiovascular disease; FH; familial hypercholesterolemia; GSK3β; glycogen synthase kinase 3β; HINFP; histone nuclear factor P; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A; HNF; hepatocyte nuclear factor; Insig; in

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticlePCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism

Keywords: PCSK9; proprotein convertase subtilisin-like kexin type 9; HCV; hepatitis C virus; LVP; lipoviral particle; LDLR; low-density lipoprotein receptor; G; genotype; HCV RNA; hepatitis C virus ribonucleic acid; RT-PCR; reverse transcriptase polymerase chain re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Focus on alirocumab: A PCSK9 antibody to treat hypercholesterolemia

Keywords: Alirocumab; PCSK9; Hypercholesterolemia; Statin; Cardiovascular risk; Low-density lipoprotein cholesterol; Monoclonal antibody;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Association of plasma small dense LDL cholesterol with PCSK9 levels in patients with angiographically proven coronary artery disease

Keywords: Coronary artery disease; PCSK9; sdLDL; sdLDL-C; Lipid profile

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه