دانلود مقالات ISI درباره Pcsk9 + ترجمه فارسی

RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form

Keywords: CTR; control; CRISPR; clustered regularly interspaced short palindromic repeats; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; HPRT; hypoxanthine-guanine phosphoribosyltransferase; LDL-C; low-density lipoprotein cholesterol; LDLR; low-de

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A cholesterol-lowering VLP vaccine that targets PCSK9

Keywords: PCSK9; Vaccine; Virus-like particles; LDL Cholesterol;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis

Keywords: miR-27a; LDLR; PCSK9; LRP6; LDLRAP1; Cholesterol homeostasis; Atherosclerosis; LDL; low-density lipoprotein; LDL-C; LDL cholesterol; LDLR; LDL receptor; PCSK9; proprotein convertase subtilisin/kexin type 9; LRP6; LDLR-related protein 6; LDLRAP1; LDLR-adap

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

PCSK9 inhibitors: Novel therapeutic agents for the treatment of hypercholesterolemia

Keywords: PCSK9; Proprotein Convertase Subtilisin/Kexin type 9; Alirocumab; Evolocumab; Bococizumab;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both : A 2 × 2 Factorial Mendelian Randomization Study

Keywords: ezetimibe; genetic association; PCSK9; statinsCHD, coronary heart disease; HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; LDL-C, low-density lipoprotein cholesterol; MI, myocardial infarction; NPC1L1, Niemann-Pick C1-Like 1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels

Keywords: High fructose diet; PCSK9; LDL receptor; Hamsters; Dyslipidemia;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection

Keywords: HCV; hepatitis C virus; HCVpp; HCV pseudotyped particles; HCVcc; cell culture produced HCV virions; VSVpp; vesicular stomatitis virus pseudotyped particles; HDV; hepatitis delta virus; SKI-1/S1P; subtilisin/hexin-isoenzyme-1/site-1 protease; SRE; sterol r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial

Keywords: Lipid-lowering drugs; Clinical trials; PCSK9; Lipoproteins; Monoclonal antibodies;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans

Keywords: Apolipoprotein B100; low-density lipoproteins; PCSK9; adipose tissue; type II diabetes mellitus; obesity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

AMG 145, a Monoclonal Antibody Against PCSK9, Facilitates Achievement of National Cholesterol Education Program–Adult Treatment Panel III Low-Density Lipoprotein Cholesterol Goals Among High-Risk Patients : An Analysis From the LAPLACE–TIMI 57 Trial (LDL-

Keywords: cholesterol; LDL; PCSK9; statinsApoB, apolipoprotein B; CAD, coronary artery disease; CHD, coronary heart disease; CV, cardiovascular; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NCEP-ATP III, National Choleste

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewSorting an LDL receptor with bound PCSK9 to intracellular degradation

Keywords: Degradation; Cathepsin; Endosome; LDL receptor; PCSK9;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

PCSK9 levels in abdominally obese men: Association with cardiometabolic risk profile and effects of a one-year lifestyle modification program

Keywords: PCSK9; Physical activity; Nutrition; Obesity; Insulin resistance;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels

Keywords: Chronic kidney disease; Hemodialysis; PCSK9; LDL-C; Statin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Relation of circulating PCSK9 concentration to fibrinogen in patients with stable coronary artery disease

Keywords: PCSK9; Fibrinogen; Coronary artery disease; C-reactive protein; Inflammation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Effect of Nicotinic acid/Laropiprant in the lipoprotein(a) concentration with regard to baseline lipoprotein(a) concentration and LPA genotype

Keywords: Lp(a); Lipoprotein(a); Apo(a); Apolipoprotein(a); LDL; Low density lipoprotein; LPA; apolipoprotein(a) gene; NA; Nicotinic acid; HDL; High density lipoprotein; PCR; Polymerase Chain Reaction; BMI; Body Mass Index; HOMA-IR; Homeostasis Model of Assessment-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques

Keywords: Cholesteryl ester transfer protein; Anacetrapib; Rhesus macaques; Lipoproteins; PCSK9

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial

Keywords: Alirocumab; Ezetimibe; Hypercholesterolemia; PCSK9; Phase 3 clinical trial; Statin intolerance; Muscle symptoms; Statin myopathy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation

Keywords: Homozygous familial hypercholesterolemia (Homo-FH); Heterozygous-FH (Hetero-FH); LDL-receptor; PCSK9;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Having excess levels of PCSK9 is not sufficient to induce complex formation between PCSK9 and the LDL receptor

Keywords: LDL receptor; LDL; PCSK9; IDOL; Human hepatocyte-like C3A cells

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

PCSK9 inhibition for the treatment of hypercholesterolemia: Promises and emerging challenges

Keywords: PCSK9; Hypercholesterolemia; LDL cholesterol; LDL receptor; Monoclonal antibodies

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Risk prediction with proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment

Keywords: PCSK9; Coronary artery disease; Risk prediction; Triglycerides; Statins

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Anti-PCSK9 Monotherapy for Hypercholesterolemia: The MENDEL-2 Randomized, Controlled Phase III Clinical Trial of Evolocumab

Keywords: evolocumab; dyslipidemia; monotherapy; PCSK9 inhibition; AE; adverse event(s); CV; cardiovascular; HDL-C; high-density lipoprotein cholesterol; LDL-C; low-density lipoprotein cholesterol; Lp(a); lipoprotein; PCSK9; proprotein convertase subtilisin/kexin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Reduction in Lipoprotein(a) With PCSK9 Monoclonal Antibody Evolocumab (AMG 145): A Pooled Analysis of More Than 1,300 Patients in 4 Phase II Trials

Keywords: dyslipidemia; evolocumab; lipoprotein(a); PCSK9 inhibition; CVD; cardiovascular disease; LDL; low-density lipoprotein; PCSK9; proprotein convertase subtilisin/kexin type 9; Q2W; every 2 weeks; Q4W; every 4 weeks; SC; subcutaneous; UC LDL-C; low-density l

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism

Keywords: CETP inhibitors; LDL receptor; PCSK9; SREBP2; Hyperlipidemia;

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2014 سفارش ترجمه

Emerging LDL therapies: Using human genetics to discover new therapeutic targets for plasma lipids

Keywords: Familial hypercholesterolemia; Genetics; LDL cholesterol; PCSK9; Sequencing;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Beyond LDL-C lowering: Distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

Keywords: PCSK9; Biomarker; Lipidomics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Inverse relationship between LDL cholesterol and PCSK9 plasma levels in dyslipidemic cynomolgus monkeys: Effects of LDL lowering by ezetimibe in the absence of statins

Keywords: Non-human primate; Dyslipidemia; Ezetimibe; PCSK9;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the PCSK9 pathway

Keywords: PCSK9; Monoclonal antibodies; Hypercholesterolaemia; Cardiovascular; Safety;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Proprotein convertase subtilisin/kexin type 9 potentially influences cholesterol uptake in macrophages and reverse cholesterol transport

Keywords: PCSK9; Reverse cholesterol transport; Low-density lipoprotein receptor; Atherosclerosis

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Hipercolesterolemias genéticas

Keywords: Hipercolesterolemia familiar; Hiperlipidemia familiar combinada; PCSK9; Sitosterolemia; Genética; Colesterol LDLFamilial hypercholesterolemia; Familial combined hyperlipidemia; PCSK9; Sitosterolemia; Genetics; Cholesterol LDL

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis

Keywords: atherosclerosis; LDL cholesterol; LDL receptor; PCSK9; proprotein convertase subtilisin/kexin type 9ARH, autosomal recessive hypercholesterolemia protein; EGF-A, epidermal growth factor-like repeat homology domain; ENaC, epithelial (Na+) channel; LDL-C, l

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Plasma Lipoprotein-associated Phospholipase A2 Is Inversely Correlated with Proprotein Convertase Subtilisin-kexin Type 9

Keywords: Low-density lipoprotein cholesterol; Lp-PLA2; PCSK9

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: A population-based study in Greece

Keywords: CHD; coronary heart disease; CAD; coronary artery disease; MI; myocardial infarction; GRS; genetic risk score; OR; odds ratio; CI; confidence interval; SNP; single nucleotide polymorphism; MIA3; melanoma inhibitory activity family, member 3; PCSK9; propro

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration

Keywords: PCSK9; LDL cholesterol; Periodontitis; Chronic inflammation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels

Keywords: LDLR; β-VLDL; Smooth muscle cells; Macrophages; PCSK9

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

Keywords: Familial hypercholesterolemia; PCSK9; LDL-C; Mutations;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy

Keywords: dyslipidemia; statins; gene variants; pharmacogenetics; treatment efficacy; CELSR2/PSRC1/SORT1; CILP2/PBX4; PCSK9; APOB

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy

Keywords: apolipoprotein-B; hypercholesterolemia; low-density lipoprotein cholesterol; PCSK9; safety; SAR236553/REGN727; statinAE, adverse event; Apo, apolipoprotein; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LDLR, low

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters

Keywords: PCSK9; LDLR; SREBP; HNF1α; PPARα; LXR; LDL-cholesterol; Fasting; Golden Syrian hamsters;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver

Keywords: PCSK9; proprotein convertase subtilisin/kexin type 9; LDLR; low-density lipoprotein receptor; LDLc; low-density lipoprotein cholesterol; HCD; high cholesterol diet; TC; total cholesterol; WT; wild type; qPCR; quantitative polymerase chain reaction; LPDS;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Short communicationA novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene

Keywords: Autosomal recessive hypercholesterolemia; Low density lipoprotein receptor adopter protein 1; Familial hypercholesterolemia; PCSK9;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation

Keywords: Ubiquitin; Low-density lipoprotein receptor; PCSK9; Protein degradation

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Spectrum of LDLR gene mutations, including a novel mutation causing familial hypercholesterolaemia, in North-western Greece

Keywords: Apolipoprotein B; Familial hypercholesterolaemia; Low-density lipoprotein receptor gene; PCSK9; North-western Greece

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus:

Keywords: PCSK9; Diabetes mellitus; Insulin resistance; Dyslipidemia;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor

Keywords: Cholesterol; LDL receptor; Mutagenesis; Prodomain; PCSK9;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: Results from a crossover study

Keywords: PCSK9; Bezafibrate; Fenofibrate; Diabetes; Dyslipidemia; Peroxisome proliferator-activated receptor (PPAR); Adiponectin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes

Keywords: Lipoprotein kinetics; PCSK9; Diabetes; LDL catabolism; Apolipoprotein B;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI

Keywords: Pharmacogenetics; Statin; Case-control study; Cholesterol; Myocardial infarction; PCSK9; SCARB1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Array-based resequencing for mutations causing familial hypercholesterolemia

Keywords: FH; familial hypercholesterolemia; PCR; polymerase chain reaction; MLPA; multiple ligation-dependent probe amplification; LDLR; low-density lipoprotein receptor; APOB; apolipoprotein B; PCSK9; proprotein convertase subtilisin/kexin type 9; Familial hyperc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه