Keywords: PG، پروستاگلاندین; CVD, cardiovascular disease; CKD, chronic renal disease; eGFR, estimated glomerular filtration rate; ROS, reactive oxidant species; PG, prostaglandin; Hb, hemoglobin; Scr, serum creatinine; MDRD, modification diet of renal disease study; EPO, erythropoiet
مقالات ISI PG، پروستاگلاندین (ترجمه نشده)
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Keywords: PG، پروستاگلاندین; AA, arachidonic acid; IBMX, 3-isobutyl-1-methylxanthine; COX, cyclooxygenase; PG, prostaglandin; PPAR, peroxisome proliferator-activated receptor; L-PGDS, lipocalin-type PGD synthase; 15d-PGJ2, 15-deoxy-Δ12,14-PGJ2; DMEM-HEPES, Dulbecco’s modified Eagle’s
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; (TNF)-α, tumor necrosis factor; ERK, extracellular signal-related kinase; TLR, toll-like receptors (TLRs); MAPK, mitogen activated protein kinase; NF-κB, nuclear factor
Stromal COX-2 signaling are correlated with colorectal cancer: A review
Keywords: PG، پروستاگلاندین; COX-2, prostaglandin-endoperoxide synthase 2; PG, prostaglandin; GSK-3β, glycogen synthase kinase 3β; 15-d-PGJ₂, 15-deoxy-delta(12,14)-prostaglandin J(2); PPARγ, peroxisome proliferator-activated receptor gamma; TNF-α, tumor necrosis factor alpha; IL-1β,
The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under inflammatory conditions in osteoarthritic knee synovial fibroblasts
Keywords: PG، پروستاگلاندین; OAK, osteoarthritis of the knee; COX, cyclooxygenase; LMWF-5A, molecular weight fraction of human serum albumin under 5000 Da; PG, prostaglandin; IL, interleukin; TNF, tumor necrosis factor; qPCR, quantitative real-time polymerase chain reaction; PGE2, pr
Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps
Keywords: PG، پروستاگلاندین; Chronic rhinosinusitis with nasal polyps; IL-5; IL-10; Poly(IC); Toll-like receptorCOX, cyclooxygenase; CRSwNP, chronic rhinosinusitis with nasal polyps; DNPCs, dispersed nasal polyp cells; IFN, interferon; IL, interleukin; PG, prostaglandin; Poly(IC), po
Increased potential for wound activated production of Prostaglandin E2 and related toxic compounds in non-native populations of Gracilaria vermiculophylla
Keywords: PG، پروستاگلاندین; Gracilaria; Metabolomics; Ogonori; Oxylipin; Prostaglandin; Seaweed invasionAA, arachidonic acid; CAP, canonical analysis of principal coordinates; DAD, diode array detector; HETE, hydroxy-eicosatetraenoic acid; MeOH, methanol; PG, prostaglandin; UPLC, ul
Src/Syk/IRAK1-targeted anti-inflammatory action of Torreya nucifera butanol fraction in lipopolysaccharide-activated RAW264.7 cells
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; TNF-α, tumor necrosis factor α; ERK, extracellular signal-related kinase; TLR, Toll-like receptors; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor-κB; AP
Secreted phospholipase A2 and mast cells
Keywords: PG، پروستاگلاندین; Anaphylaxis; Animal model; Lipid mediators; Mast cells; Phospholipase A2AA, arachidonic acid; PG, prostaglandin; PLA2, phospholipase A2; MC, mast cell; BMMC, bone marrow-derived MC; bvPLA2, bee venom PLA2; COX, cyclooxygenase; CTMC, connective-tissue MC;
Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease
Keywords: PG، پروستاگلاندین; Polycystic kidney disease; Acetylsalicylic acid; NDGA; EicosanoidCOX, cyclooxygenase; LOX, lipoxygenase; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid; PKD, polycystic kidney disease; PG, prostaglandin; TX, thromboxane; ESRD, End s
Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease
Keywords: PG، پروستاگلاندین; AMPK, AMP Kinase; cAMP, cyclic adenosine 3’5’-monophosphate; COX, Cyclooxygenase; PAF, Platelet activating factor; PG, Prostaglandin; DP, Prostaglandin D2 receptor; EP, Prostaglandin E2 receptor; PKA, Protein Kinase A; Tx, ThromboxaneAntiplatelet agent; p
The aldo-keto reductases (AKRs): Overview
Keywords: PG، پروستاگلاندین; AKR, aldo-keto reductase; PG, prostaglandin; SDR, short-chain dehydrogenase reductase; nsSNP, non-synonymous single nucleotide polymorphism; SSH, succinic semialdehyde dehydrogenaseHydroxysteroid dehydrogenases; Potassium channels; Steroid 5β-reductase; Q
Evaluation of urinary prostaglandin E2 metabolite as a biomarker in infants with fever due to viral infection
Keywords: PG، پروستاگلاندین; PG, prostaglandin; 15-PGDH, 15-hydroxyprostaglandin dehydrogenase; tetranor-PGEM, 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid; LC-MS/MS, liquid chromatography coupled to tandem mass spectrometry; mPGES-1, Microsomal Prost
Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes
Keywords: PG، پروستاگلاندین; 5-HT, 5-hydroxytryptamine; IL, interleukin; PG, prostaglandin; COX, cyclooxygenase; mPGES, microsomal prostaglandin E synthaseTropisetron; Serotonin; Prostaglandin E2; Cytokines; Cyclooxygenase; Chondrocytes
Phase II Study on the Efficacy and Safety of the EP1 Receptor Antagonist ONO-8539 for Nonneurogenic Overactive Bladder Syndrome
Keywords: PG، پروستاگلاندین; urinary bladder; overactive; receptors; prostaglandin E; EP1 subtype; urination; urinary incontinence; urge; treatment outcomeATP, adenosine triphosphate; LOCF, last observation carried forward; OAB, overactive bladder; PG, prostaglandin; UUI, urgency uri
Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund׳s adjuvant-induced arthritis in Sprague-Dawley rats
Keywords: PG، پروستاگلاندین; DNA, deoxyribonucleic acid; ERK, extracellular signal-regulated kinase; HGB, haemoglobin; HCT, haematocrit; IgG, immunoglobulin G; IL, interleukin; MAPK, mitogen activated protein kinase; NO, nitric oxide; NF-κB, nuclear Factor-κB; PG, prostaglandin; RBC,
Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; TLR, toll-like receptors (TLR); NF-κB, nuclear factor-κB; AP-1, activator protein-1; JNK, c-Jun N-terminal kinase; EIA, enzyme immunoassay; MTT, 3-4,5-dimethylthiazol-2
Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts
Keywords: PG، پروستاگلاندین; AA, arachidonic acid; PG, prostaglandin; PLA2, phospholipase A2; COX, cyclooxygenase; ACSL, acyl-CoA synthetase long-chain family member; cPLA2, cytosolic PLA2; sPLA2, secreted PLA2; iPLA2, Ca2 +-independent PLA2; IL, interleukin; cPGES, cytosolic PGE syn
EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: Pharmacological characterization
Keywords: PG، پروستاگلاندین; PGE2, prostaglandin E2; PG, prostaglandin; GI, gastrointestinal; COX, cyclooxigenase; ICC, interstitial cells of Cajal; NANC, non-adrenergic non-cholinergic; NO, nitric oxide; RMP, resting membrane potential; KO, knockout; IJP, inhibitory junction potenti
Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis
Keywords: PG، پروستاگلاندین; PP1/2A, protein phosphatase 1/2A; PPAR, peroxisome proliferator-activated receptor; C/EBP, CCAAT/enhancer-binding protein; SREBP, sterol regulatory element-binding protein; PG, prostaglandin; COX, cyclooxygenase; MEK, mitogen-activated protein kinase/extr
ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; TNF α, tumor necrosis factor-α; TLR, toll-like receptors; NF-κB, nuclear factor-κB; MTT, 3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PI3K, phosphoinosi
Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment
Keywords: PG، پروستاگلاندین; ACTH, adrenocorticotropic hormone; ANOVA, analysis of variance; BAT, brown adipose tissue; BNST, bed nucleus of the stria terminalis; IR, immunoreactive; LPS, lipopolysaccharide; PG, prostaglandin; PSH, psychological stress-induced hyperthermia; Tc, body
Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis
Keywords: PG، پروستاگلاندین; Th, t helper; RANKL, receptor activator of nuclear factor-kB ligand; IL, interleukin; TNF-α, tumor necrosis factor-α; PG, prostaglandin; OPG, osteoprotegerin; SOFAT, secreted osteoclastogenic factor of activated T cells; PD, probing depth; CAL, clinical a
AP-1 pathway-targeted inhibition of inflammatory responses in LPS-treated macrophages and EtOH/HCl-treated stomach by Archidendron clypearia methanol extract
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; (TNF)-α, tumour necrosis factor; ERK, extracellular signal-related kinase; TLR, Toll-like receptor (TLR); MAPK, mitogen activated protein kinase; NF-κB, nuclear factor-
The inflammatory state of the rat placenta increases in late gestation and is further enhanced by glucocorticoids in the labyrinth zone
Keywords: PG، پروستاگلاندین; Placenta; Inflammation; Prostaglandins; Cytokines; GlucocorticoidsDex, dexamethasone; Ptgs, prostaglandin G/H synthase; Pgdh, 15-hydroxy-prostaglandin dehydrogenase; PG, prostaglandin; Tnf-α, tumor necrosis factor-α; Il, interleukin; Emr-1, EGF module-con
Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase
Keywords: PG، پروستاگلاندین; PGHS, prostaglandin H synthase; GvPGHS, Gracilaria vermiculophylla PGHS; CtPGHS, Coccotylus truncatus PGHS; huPGHS, human PGHS; AA, arachidonic acid; PG, prostaglandin; AEA, arachidonoyl ethanolamide; AG, arachidonoylglycerol; HPETE, hydroperoxyeicosatetr
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide
Keywords: PG، پروستاگلاندین; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; TNF-α, tumor necrosis factor α; ERK, extracellular signal-related kinase; TLR, Toll-like receptors; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor-κB; AP
Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes
Keywords: PG، پروستاگلاندین; PG, prostaglandin; COX, cyclooxygenase; 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; PPARγ, peroxisome proliferator-activated receptor γ; MCP-1, monocyte chemoattractant protein-1; IL-6, interleukin-6; L-PGDS, lipocalin-type PGD synthase; DME-HEPES, Dulbec
The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes
Keywords: PG، پروستاگلاندین; 5-HT, 5-Hydroxytryptamine; IL, interleukin; TNF, tumor necrosis factor; PG, prostaglandin; MMP, matrix metalloprotease; PMA, phorbol myristate acetate; PHA, phytohemagglutinin; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinaseTropisetron; Se
Dietary supplementation with high dose of epigallocatechin-3-gallate promotes inflammatory response in mice
Keywords: PG، پروستاگلاندین; APC, allophycocyanin; Con A, concanavalin A; EGCG, epigallocatechin-3-gallate; FITC, fluorescein isothiocyanate; IFN, interferon; IL, interleukin; MΦ, macrophage; LPS, lipopolysaccharide; PE, phycoerythrin; PG, prostaglandin; Th, T helper; TNF, tumor necr
Role of HCA2 (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin
Keywords: PG، پروستاگلاندین; NA, nicotinic acid; FAE, fumaric acid ester; GPCR, G-protein-coupled receptor; HCA2, hydroxy-carboxylic acid receptor 2; PG, prostaglandin; COX, cyclooxygenase; MMF, monomethyl fumarate; DMF, dimethyl fumarate; cPLA2, cytosolic phospholipase A2; GRK, GPCR
Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats
Keywords: PG، پروستاگلاندین; α-MSH, alpha-melanocyte-stimulating hormone; COX, cyclooxygenase; CRF, corticotropin releasing factor; IL-1β, interleukin-1β; PG, prostaglandin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GI, gastrointestinal; LPS, lipopolysaccharide; NF-κB, nuclear
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ12-PGJ2 acting through PPARγ-dependent and independent pathways
Keywords: PG، پروستاگلاندین; PPAR, peroxisome proliferator-activated receptor; PG, prostaglandin; L-PGDS, lipocalin-type PGD synthase; 15d-PGJ2, 15-deoxy Δ12,14-PGJ2; DMEM, Dulbecco's modified Eagle's medium; TBP, TATA-binding protein; N.C., negative control; SCD, stearoyl-CoA desatu
Tumor necrosis factor (TNF)-α upregulates progesterone receptor-A by activating the NF-κB signaling pathway in human decidua after labor onset
Keywords: PG، پروستاگلاندین; Decidua; TNF-α; PR-A/PR-B ratio; NF-κB; COX-2PR, progesterone receptor; NF-κB, nuclear factor-kappaB; IL, in labor; NIL, not in labor; PG, prostaglandin; ELISA, enzyme-linked immunosorbent assay; PBST, Phosphate Buffered Saline Tween; CRP, C-reactive prot
Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo
Keywords: PG، پروستاگلاندین; BW, body weight; COX, cyclooxygenase; PG, prostaglandin; PGIS, prostacyclin synthase; TX, thromboxane; ROS, reactive oxygen speciesOzone; Insufflation; Cyclooxygenase; Isoprostanes; Prostanoids; Oxidative stress
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation
Keywords: PG، پروستاگلاندین; BL, baseline; COX-1/2, cyclooxygenase-1/2; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PG, prostaglandin; PWL, paw withdrawal latency; S1P, sphingosine-1-phosphate; SPHK, sphingosine kinase; Tx, thromboxaneInflammation; Cyclooxygenase-2; Pro
The distribution of the prostaglandin E receptor type 2 (EP2) in the detrusor of the guinea pig
Keywords: PG، پروستاگلاندین; PG, prostaglandin; PGE2, prostaglandin E2; EP1, prostaglandin E receptor type 1; EP2, prostaglandin E receptor type 2; COX I, cyclo-oxygenase type 1; DO, detrusor overactivity; OAB, overactive bladder syndrome; ICs, interstitial cells; IM-ICs, intramuscle
Proteomic analysis of egg white proteins during the early phase of embryonic development
Keywords: PG، پروستاگلاندین; PG, Prostaglandin; MW, molecular weight; PCBP3, poly (rC) binding protein 3; OTf, ovotransferrin2-DE; Early embryonic development; Egg white proteins; Proteomics
Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug
Keywords: PG، پروستاگلاندین; NSAID; COX-2/COX-1 selectivity; Orally active COX-2 inhibitor; Carrageenan-induced oedema; InflammationAA, arachidonic acid; COX, cyclooxygenase (or endoperoxidase, or prostaglandin G/H synthase, EC 1.14.99.1); PG, prostaglandin; PGH2, prostaglandin H2; P
COX-2 and PGE2-dependent immunomodulation in breast cancer
Keywords: PG، پروستاگلاندین; COX, cyclooxygenase; PG, prostaglandin; mPGES, microsomal prostaglandin E synthase; 15-PGDH, 15-hydroxyprostaglandin dehydrogenase; SLCO2A1, solute carrier organic anion transporter 2A1; APC, antigen-presenting cell; DC, dendritic cell; NK, natural killer
TNF-α stimulates alkaline phosphatase and mineralization through PPARγ inhibition in human osteoblasts
Keywords: PG، پروستاگلاندین; COX, cyclooxygenase; ELISA, enzyme-linked immunosorbent assay; FCS, fetal calf serum; GP, glycerophosphate; IL, interleukin; MSC, mesenchymal stem cell; PG, prostaglandin; NF-κB, nuclear factor-κB; NSAID, non-steroidal anti-inflammatory drug; PGDS, PG D s
Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression
Keywords: PG، پروستاگلاندین; COX, cyclooxygenase; PG, prostaglandin; AKR, aldo–keto reductase; PPAR γ, peroxisome proliferator-activated receptor γ; C/EBP, CCAAT enhancer binding protein; TBP, TATA-binding protein; aP2, fatty acid binding protein 4, adipocytes; EIA, enzyme immunoassa
Quantification of intracellular and extracellular prostanoids stimulated by A23187 by liquid chromatography/electrospray ionization tandem mass spectrometry
Keywords: PG، پروستاگلاندین; COX, cyclooxygenase; IS, internal standard; LC/MS/MS, liquid chromatography/tandem mass spectrometry; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; PG, prostaglandin; TX, thromboxaneProstanoid; LC/MS/MS; Intracellular measurement
A ceramide analog inhibits cPLA2 activity and consequent PGE2 formation in LPS-stimulated macrophages
Keywords: PG، پروستاگلاندین; CERA-1, ceramide analogue-1; PCERA-1, phospho-ceramide analogue-1; AA, arachidonic acid; cPLA2, cytosolic phospholipase A2; PG, prostaglandin; COX, cyclooxygenase; NO, nitric oxide; C1P, ceramide-1-phosphate; S1P, sphingosine-1-phosphate; PC, phosphatidyl
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights
Keywords: PG، پروستاگلاندین; AKR, aldo–keto reductase; CBM, N-(4-chlorobenzoyl)-melatonin; 15dPGJ2, 15-deoxy-Δ12,14-prostaglandin J2; 5α-DHT, 5α-dihydrotestosterone; MPA, medroxyprogesterone acetate; NSAID, non-steroidal anti-inflammatory drug; PG, prostaglandin; PGHS, prostaglandin
Discovery of a novel COX-2 inhibitor as an orally potent anti-pyretic and anti-inflammatory drug: Design, synthesis, and structure–activity relationship
Keywords: PG، پروستاگلاندین; COX, cyclooxygenase (or endoperoxidase, or prostaglandin G/H synthase, EC 1.14.99.1); AA, arachidonic acid; PG, prostaglandin; PGH2, prostaglandin H2; PGG2, prostaglandin G2; PGE2, prostaglandin E2; PGI2, prostacyclin; 6-keto-PGF1α, 6-keto-prostaglandin F
The role of prostacyclin in lung cancer
Keywords: PG، پروستاگلاندین; cAMP, cyclic adenosine 3′,5′-monophosphate; COX, cyclooxygenase; IL, interleukin; NSCLC, non-small cell lung carcinoma; PG, prostaglandin; PGES, PGE synthase; PGFS, PGF2 synthase; PGI2, prostacyclin; PGIS, PGI2 synthase; PPAR, peroxisomal proliferator act
Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template
Keywords: PG، پروستاگلاندین; PG, prostaglandin; COX, cyclooxygenase; NSAID, nonsteroidal anti-inflammatory drug; mPGES-1, microsomal prostaglandin E synthase-1; PGE2, prostaglandin E2; PGI2, prostaglandin I2; PGF2a, prostaglandin F2a; 6-keto PGF1a, 6-keto prostaglandin F1a
The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge
Keywords: PG، پروستاگلاندین; CRTH2; prostaglandin D2; atopic dermatitisAD, Atopic dermatitis; CRTH2, Chemoattractant receptor–homologous molecule expressed on receptor on TH2 cells; DC, Dendritic cell; DP1, Prostaglandin D2 receptor 1; OVA, Ovalbumin; PG, Prostaglandin; WT, Wild-type
Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-κB nuclear localization
Keywords: PG، پروستاگلاندین; UVB, ultraviolet B; HIF, homoisoflavanone; ROS, reactive oxygen species; NAC, N-acetylcysteine; PG, prostaglandin; COX, cyclooxygenase; cPLA2, cytosolic phospholipase A2; AA, arachidonic acid; JNK, c-Jun N-terminal kinase; ERK, extracellular signal-regula