HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter
Keywords: T2DM; Gluconeogenesis; FXR antagonist; PGC-1α; Drug lead compound;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Protective roles of fenofibrate against cisplatin-induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction
Keywords: Cisplatin; Fenofibrate; NADPH Oxidase Isoforms; PPAR-α; Ototoxicity; ABR; auditory brainstem responses; ACOX1; peroxisome acyl-coenzyme A oxidase 1; ARF; acute renal failure; AKI; acute kidney injury; B-FABP; brain-type fatty acid binding protein; COX5A1
Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1
Keywords: AMPK; AMP-activated protein kinase; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; CREB; CRE-binding protein; CRTC; CREB-regulated transcription coactivator; G6Pase; glucose 6-phosphatase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy
Keywords: DMD; Duchenne muscular dystrophy; DGC; dystrophin-associated glycoprotein complex; ECM; extracellular matrix; SIRT1; Sirtuin1; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; PPARγ; peroxisome proliferator-activated receptor γ; B
Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
Keywords: AMPK; AMP-activated protein kinase; CaMKKβ; calcium/calmodulin-dependent protein kinase kinase beta; CBF; cerebral blood flow; CCA; common carotid artery; EBSS; glucose-free Earle's balanced salt solution; ECA; external carotid artery; ELISA; cytokine en
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome
Keywords: AMP-activated protein kinase (AMPK); Hutchinson-Gilford progeria syndrome (HGPS); Oocyte; HIV-1 latency; Rapamycin; Metformin; Retinoic acid; Methylene blue; Sulforaphane; Oltipraz; Vitamin D; MG132; Acrosome; Alternative splicing; ULK1; Autophagy; PGC-1Î
Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice
Keywords: EDL; Extensor digitorum longus; FL; Flavan 3-ol; GC; Gastrocnemius; MuRF1; Muscle ring finger-1; p70S6K; p70S6 kinase; PGC-1α; Proliferator-activated receptor gamma coactivator-1 alpha; PI3K; Phosphoinositide 3-kinase; SOL; Soleus; TA; Tibialis anterior;
Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease
Keywords: Parkinson's disease; Mitochondria; PGC-1α; Neuroprotection; Parkin;
Identification of PGC-1α activating constituents in Zingiberaceous crude drugs
Keywords: Kaempferia galanga; Ethyl p-methoxycinnamate; Zingiberaceae; PGC-1α;
Molecular drivers of mitochondrial membrane proliferation in response to cold acclimation in threespine stickleback
Keywords: AGPAT; 1-acylglycerol 3-phosphate acyltransferase; CDP-DAG; cytidine diphosphodiacylglycerol; CDS; cytidine diphosphodiacylglycerol synthase; CL; cardiolipin; DAG; diacylglycerol; EF-1α; elongation factor-1 alpha; G3P; glycerol 3-phosphate; GPAT; glycero
Association of irisin and FNDC5 rs16835198 GÂ >Â T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study
Keywords: ACR; urinary albumin to creatinine ratio; BAT; brown adipose tissues; BMI; body mass index; DM; diabetes mellitus; eGFR; estimated glomerular filtration rate; ELISA; enzyme-linked immunosorbent assay; FNDC5; fibronectin type III domain containing protein
Early intervention with Didang decoction delays macrovascular lesions in diabetic rats through regulating AMP-activated protein kinase signaling pathway
Keywords: Didang decoction; Caspase-3; AMPK; Endothelial cells; PGC-1α;
Mild palmitate treatment increases mitochondrial mass but does not affect EA.hy926 endothelial cells viability
Keywords: Endothelial cells; Inflammatory response; Mitochondrial mass; Palmitate; Reactive oxygen species; BSA; bovine serum albumin; Cu/Zn-SOD (SOD1); copper/zinc superoxide dismutase; eNOS; endothelial nitric oxide synthase; HUVEC; human umbilical vein endotheli
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β
Keywords: Atorvastatin; Myocardial hypertrophy; Apoptosis; C/EBPβ; PGC-1α; (MMP); Mitochondrial membrane potential; (Ang II); Angiotensin II; (C/EBPβ); CCAAT/enhancer-binding protein β; (CCCP); Carbonyl cyanide 3-chlorophenylhydrazone; (DMEM); Dulbecco's modifi
Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved
Keywords: Chronic obstructive pulmonary disease; Curcumin; Mitochondria; PGC-1α; SIRT3;
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
Effects of diet and arginine treatment during the luteal phase on ovarian NO/PGC-1α signaling in ewes
Keywords: Hu sheep; Arginine; PGC-1α; Restriction; Estrous cycle; Gene expression;
Priority CommunicationA Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action
Keywords: Cocaine; Epigenetics; MSN subtype; Nucleus accumbens; PGC-1α; RiboTag;
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells
Keywords: IFNγ; interferon gamma; RIG-I; retinoic acid (RA)-inducible gene-I; SFM; serum free media; ChIP; chromatin immunoprecipitation; NFκB; nuclear factor kappa B; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; PRMT-1; protein
The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway
Keywords: Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1α; NRF1; nuclear respiratory factor 1; NRF2; nuclear respiratory factor 2; CK; creatine kinase; LDH; lactate dehydrogenase; BNP; brain natriuretic peptide; cTnT; car
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
Keywords: ALS; amyotrophic lateral sclerosis; PGC-1α; peroxisome-proliferator activated receptor gamma coactivator)-1α; SOD1; superoxide dismutase 1; SOD3; superoxide dismutase 3; FUS/TLS; fused in sarcoma/translocated in sarcoma; Amyotrophic lateral sclerosis; L
Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice
Keywords: NAFLD; non-alcoholic fatty liver disease; WAT; white adipose tissue; ND; normal diet; HD; high-fat diet; RP; red paprika-supplemented diet; CS; capsanthin-supplemented diet; TG; triacylglycerol; TC; total cholesterol; HDL; high-density lipoprotein; NEFA;
Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
Keywords: AMD; Age Related Macular Degeneration; ANOVA; Analysis of Variance; ARBP; 60S Acidic Ribosomal Protein P0; BEST1; Bestrophin; CAT; Catalase; cDNA; Complementary DNA; CMST; Cell Mito Stress Test; CRABP; Cellular Retinoic Acid Binding Protein; CRALBP; Cellu
Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation
Keywords: Acetylation; GCN5; Mitochondria; SIRT1; Deacetylase; PGC-1α; AMP; adenosine monophosphate; Ca2+; calcium; CBP; CREB-binding protein; Cre-MCK; creatine kinase promoter; CHO; carbohydrate; DAC; deacetylase; ETC; electron transport chain; ExT; endurance exe
Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury
Keywords: Resveratrol; Neuroinflammation; Microglia polarization; PGC-1α;
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis
Keywords: ACM; alcoholic cardiomyopathy; ALDH; aldehyde dehydrogenase; ADH; alcohol dehydrogenase; PKC-β; protein kinase C (PKC)-beta; TCA cycle; tricarboxylic acid; ETC; electron transport chain; RCI; mitochondrial respiratory control index/ratio; FAD+; flavin ad
Sirt1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner
Keywords: KO; knock-out; KI; knock-in; βTrCP; beta-transducin repeat containing E3 ubiquitin protein ligase; RING; really interesting new gene; S; Ser; T; Thr; A; alanine; R; arginine; mSirt1; mouse Sirt1; mSIRT1-KI; mouse Sirt1 knock-in; mSirt1-LKO; mSirt1-liver
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy
Keywords: GTDF; Adiponectin; Adiponectin receptor; Skeletal muscle atrophy; FoxO; PGC-1α; GTDF; 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3â²,4'-tetrahydroxydihydroflavonol; gAd; globular adiponectin; AdipoR; Adiponectin receptor; AMPK; AMP-activated protein kinase
Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner
Keywords: PGC-1α; Aging; Exercise; Muscle; Mitochondria;
Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes
Keywords: Diabetes; PGC-1α; Salicylate; Mitochondria biogenesis; mtDNA;
Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK
Keywords: FNDC5; fibronectin type III domain containing 5; PGC-1α; peroxisome proliferator-activated receptor-γ co-activator 1α; TGF; transforming growth factor; FSTL3; follistatin-like 3; CAD; coronary artery disease; MI; myocardial infarction; PCI; percutaneou
Metabolic roles of poly(ADP-ribose) polymerases
Keywords: ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver
Keywords: PGC-1α; Aging; Exercise; Liver; ER stress; UPR;
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
Keywords: 1-25-diOH D; dihydroxyvitamine D; 25-OH D; 25-hydroxyvitamin D; APO; apolipoprotein; BMI; body mass index; ER; endoplasmic reticulum; FC; free cholesterol; FFAs; free fatty acids; FGF-2; fibroblast growth factor 2; FXRÉ; farnesoid X receptor α; HDL; hig
Honokiol exerts dual effects on browning and apoptosis of adipocytes
Keywords: ACO; peroxisomal acylcoenzyme A oxidase; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; BAX; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Cidea; gene encoding cell death-inducing DFFA-like effector a; Cited1; gene encoding Cbp/p30
High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster
Keywords: PGC-1α; peroxisome proliferator-activated receptor-Ï coactivator 1α; dILPs; Drosophila insulin-like-peptides; TAG; triacylglycerides; mt-TFB1; mitochondrial transcription factor binding protein 1; FSC; follicle stem cells; HSD; high-sucrose-diet; LSD;
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice
Keywords: PGC-1α; peroxisome proliferator-activated receptor gamma co-activator 1α; TFAM; mitochondrial transcription factor A; BDNF; brain-derived neurotrophic factor; ETC; electron transport chain; OC; old control group; OT; old trained group; YC; young control
Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway
Keywords: AMPK; AMP-activated protein kinase; AraA; adenine 9-β-d-arabinofuranoside; ATP-5β; ATP synthase 5β; Cyt B; cytochrome B; CTRP3; C1q/tumor necrosis factor-related protein-3; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; H/R; hypoxia-reoxy
Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation
Keywords: 3-TyrNO2; 3-nitrotyrosine; AβN3(pE); pyroglutamate-Aβ; iAβ; intraneuronal Aβ; BBB; blood-brain barrier; BHI; Bioenergetic Health Index; CRTC; CREB-regulated transcription coactivator; IDE; insulin degrading enzyme; IR; insulin resistance; MetS; metabo
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
Keywords: AMPK; Autophagy; Mitochondriogenesis; NAD+; PGC-1α; SIRT1;
Saponins from stems and leaves of Panax ginseng prevent obesity via regulating thermogenesis, lipogenesis and lipolysis in high-fat diet-induced obese C57BL/6 mice
Keywords: Anti-obesity; Saponins; Panax ginseng; C57BL/6 mice; Haematoxylin and eosin; RT-PCR; aP2; adipocyte fatty acid binding protein 2; ATGL; adipose triglyceride lipase; CD36; cluster of differentiation 36; CPT-1; carnitine O-palmitoyltransferase 1; FFA; free
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats
Keywords: ATG; autophagy-related gene; Bak1; BCL2-antagonist/killer 1; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl2-like 1; Beclin1; BCL2 interaction myosin/moesin like coiled-coil protein 1; Cdkn2A; cyclin-dependent kinase inhibitor 2A; Dapk1; death associated protein k
Involvement of PKCα and ERK1/2 signaling pathways in EGCG's protection against stress-induced neural injuries in Wistar rats
Keywords: 5-HT; 5-hydroxytryptamine or serotonin; AD; Alzheimer's disease; ATP; adenosine triphosphate; BBB; blood-brain barrier; CNS; central nervous system; DA; dopamine; EGCG; epigallocatechin-3-gallate; ERK1/2; extracellular signal-regulated kinase 1/2; GC; g
Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway
Keywords: NaF; Sodium; ROS; Reactive oxygen species; O2â¢â; superoxide; GSH; Glutathione; MDA; Malondialdehyde; Bax; Bcl2-associated X protein; Bcl-2; B-cell CLL/lymphoma 2; GAPDH; Glyceraldehyde-3-Phosphate Dehydrogenase; COXIV; Cytochrome C Oxidase Subunit IV;
MC1R signaling. Intracellular partners and pathophysiological implications
Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; ARRB; β-arrestin; ASIP; agouti signal protein; CBD103; dog β-defensin-3; CREB; cAMP responsive-element binding protein; EDN1; endothelin 1; ER; endoplasmic reticulum; ERK; extracellular signal-reg
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
Effect of sprint training on resting serum irisin concentration - Sprint training once daily vs. twice every other day
Keywords: Irisin; PGC-1α; Myokine; High-intensity interval training; Muscle glycogen;
Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha
Keywords: Parkinson's disease; Monoamine oxidase-B; Reactive oxygen species; Parkin; PGC-1α; Mitochondrial dysfunction;