In vitro pharmacodynamic modelling of anidulafungin against Candida spp.
Keywords: فارماکودینامیک; Pharmacodynamic; In vitro; Modelling; Anidulafungin; Candida
مقالات ISI فارماکودینامیک (ترجمه نشده)
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Strategies for the treatment of polymyxin B-resistant Acinetobacter baumannii infections
Keywords: فارماکودینامیک; Acinetobacter baumannii; Resistant; Polymyxin B; Antimicrobial combination; Pharmacodynamic
Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial
Keywords: فارماکودینامیک; aspirin; coronary artery disease; P2Y12 receptor; ACS; acute coronary syndrome; ADP; adenosine diphosphate; bid; twice a day; LTA; light transmittance aggregometry; MI; myocardial infarction; PD; pharmacodynamic; PK; pharmacokinetic; PRI; platelet reactiv
PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data
Keywords: فارماکودینامیک; AIC; Akaike information criterion; BSV; between subject variability; BLQ; below the limit of quantification; CV; cardiovascular; ECG; electrocardiogram; hERG; human ether-a-go-go-related gene channel; hCav1.2; human cardiac calcium channel; hNav1.5; human
New agents for the treatment of drug-resistant Mycobacterium tuberculosis
Keywords: فارماکودینامیک; Mtb; Mycobacterium tuberculosis; TB; Tuberculosis; MDR-TB; Multidrug-resistant tuberculosis; RIF; Rifampicin; INH; Isoniazid; PZA; Pyrazinamide; ETH; Ethambutol; WHO; World Health Organization; CYP; Cytochrome P450; ADME; Absorption, distribution, metabol
Sulpiride microemulsions as antipsychotic nasal drug delivery systems: In-vitro and pharmacodynamic study
Keywords: فارماکودینامیک; Microemulsion; Phase diagram; Sulpiride; Nasal transport; Pharmacodynamic; Solubility;
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
Keywords: فارماکودینامیک; Kynurenine; Kynurenic acid; Inhibitor; Huntington's disease; Quinolinic acid; Pharmacodynamic; Neurodegeneration; Q175; R6/2;
FondaKIDS II: Long-term follow-up data of children receiving fondaparinux for treatment of venous thromboembolic events
Keywords: فارماکودینامیک; CHLA; Children's Hospital Los Angeles; CVC; central venous catheter; DVT; deep vein thrombosis; HIT; heparin-induced thrombocytopenia; IRB; Institutional Review Board; LMWH; low molecular weight heparin; PD; pharmacodynamic; PE; pulmonary embolus; PK; p
The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice
Keywords: فارماکودینامیک; PK; pharmacokinetic; IV; intravenous; PD; pharmacodynamic; AUC; area under the concentration-time curve; Cmax; maximum concentration; IC50; 50% inhibitory concentration; IC95; 95% inhibitory concentration; T>IC95; time that drug concentration exceeds IC
An LC–MS/MS method for the simultaneous determination of goserelin and testosterone in rat plasma for pharmacokinetic and pharmacodynamic studies
Keywords: فارماکودینامیک; Goserelin; Testosterone; LC–MS/MS; Surrogate analyte; Pharmacokinetic; Pharmacodynamic
Research ArticlePhase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure
Keywords: فارماکودینامیک; PVT; portal vein thrombosis; TPO-R; thrombopoietin receptor; NASH; non-alcoholic steatohepatitis; MELD; model for end-stage liver disease; PK; pharmacokinetic; PD; pharmacodynamic; EOT; end of treatment; AE; adverse events; BMI; body mass index; CTP; Chil
Pharmacokinetic-pharmacodynamic (PK-PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs
Keywords: فارماکودینامیک; Antimicrobial; Antibiotic; Pharmacokinetic; Pharmacodynamic; Monte Carlo simulation; Resistance.;
Safety and Biosimilarity of ior®EPOCIM Compared with Eprex® Based on Toxicologic, Pharmacodynamic, and Pharmacokinetic Studies in the Sprague-Dawley Rat
Keywords: فارماکودینامیک; Erythropoietin; biosimilar; ior®EPOCIM; Eprex®; toxicity; pharmacokinetic; pharmacodynamic; safety; toxicokinetics; bioequivalence;
Effect of Chinese herbs on CYP3A4 activity and expression in vitro
Keywords: فارماکودینامیک; TCM; Traditional Chinese Medicine; PK; pharmacokinetic; CYP3A4; cytochrome P450 3A4; PD; pharmacodynamic; hPXR; human pregnane X receptor; Herb-drug interactions; Pharmacokinetics; Traditional Chinese Medicine; Oldenlandia diffusa; Rehmannia glutinosa;
Cortical responses to amphetamine exposure studied by pCASL MRI and pharmacokinetic/pharmacodynamic dose modeling
Keywords: فارماکودینامیک; pCASL; Amphetamine; Pharmacological MRI; Pharmacodynamic; CBF; Perfusion;
Pharmacokinetic and Safety Profile of Ivabradine in Healthy Chinese Men: A Phase I, Randomized, Open-Label, Increasing Single- and Multiple-Dose Study
Keywords: فارماکودینامیک; Chinese; ivabradine; pharmacodynamic; pharmacokinetics;
Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry
Keywords: فارماکودینامیک; PK; pharmacokinetic; PD; pharmacodynamic; PK/PD; pharmacokinetic/pharmacodynamic; RES; reticuloendothelial system; EPR effect; enhanced permeability and retention effect; ADMET; absorption, distribution, metabolism, excretion and toxicity; logP; octanolâ
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid
Keywords: فارماکودینامیک; PLGA nanoparticles; In vitro; In vivo; Pharmacokinetic; Pharmacodynamic; Rifampicin; Isoniazid; PEG coated
A review on estimation of stochastic differential equations for pharmacokinetic/pharmacodynamic models
Keywords: فارماکودینامیک; Stochastic differential equations; Pharmacokinetic; Pharmacodynamic; Population approach; Maximum likelihood estimation; Kalman filter; EM algorithm; Hermite expansion; Gauss quadrature; Bayesian estimation
Pharmacodynamic potentiation of antiepileptic drugs’ effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice
Keywords: فارماکودینامیک; Epilepsy; Cholesterol; Statins; Anticonvulsant potency; Pharmacodynamic; AEDs; Drug–drug Interaction
Bronchopulmonary pharmacokinetic and pharmacodynamic profiles of levofloxacin 750 mg once daily in adults undergoing treatment for acute exacerbation of chronic bronchitis
Keywords: فارماکودینامیک; Levofloxacin; Pharmacokinetic; Pharmacodynamic; Fluoroquinolone; AECB; Penetration
Fospropofol: un nuevo profármaco del propofol
Keywords: فارماکودینامیک; Fospropofol; Propofol metabolización; Farmacocinética; Farmacodinamia; Profármaco; Fospropofol; Propofol metabolism; Pharmacokinetic; Pharmacodynamic; Prodrug;
Synergism between clofarabine and decitabine through p53R2: A pharmacodynamic drug-drug interaction modeling
Keywords: فارماکودینامیک; AML; acute myeloid leukemia; PD; pharmacodynamic; IC50; concentration achieving 50% inhibition of cell growth; Emax; maximal response; gamma (γ); measure of the steepness of slope; psi (Ψ); interaction term; Clofarabine; Decitabine; AML; Synergy; Pharma
Basic NeuroscienceCisterna magna cannulated repeated CSF sampling rat model - effects of a gamma-secretase inhibitor on Aβ levels
Keywords: فارماکودینامیک; Aβ; amyloid beta; CNS; central nervous system; CSF; cerebrospinal fluid; GSI; gamma-secretase inhibitor; PD; pharmacodynamic; PK; pharmacokinetic; Cerebrospinal fluid; Cisterna magna cannulation; Repeated CSF sampling; Alzheimer's; gamma-secretase; Amylo
Pharmaceutical nanotechnologyNanostructured lipid carriers (NLC) based topical gel of flurbiprofen: Design, characterization and in vivo evaluation
Keywords: فارماکودینامیک; Nanostructured lipid carriers; Topical gel; Flurbiprofen; Pharmacodynamic; Pharmacokinetic;
Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral γ-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers
Keywords: فارماکودینامیک; avagacestat; Alzheimer's disease; Aβ1–40; gamma-secretase inhibitor; pharmacodynamic; pharmacokinetic; tolerability
Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria
Keywords: فارماکودینامیک; PKU; phenylketonuria; HPA; hyperphenylalaninemia; Phe; phenylalanine; PAL; phenylalanine ammonia lyase; PAH or Pah - gene, PAH or Pah - enzyme; phenylalanine hydroxylase; PD; pharmacodynamic; Av; Anabaena variabilis; ENU2; PKU mouse model Pahenu2/enu2
Understanding Dose Titration: Overactive Bladder Treatment With Fesoterodine as an Example
Keywords: فارماکودینامیک; Dose response; Fesoterodine; Muscarinic antagonists; Overactive bladder; Pharmacodynamic; Pharmacokinetic;
Analysis of two pharmacodynamic biomarkers using acoustic micro magnetic particles on the ViBE bioanalyzer
Keywords: فارماکودینامیک; Preclinical biomarker analysis; Pharmacodynamic; Acoustic micro magnetic particle detection; Tissue culture; Mouse xenograft
Validation of a flow cytometry based G2M delay cell cycle assay for use in evaluating the pharmacodynamic response to Aurora A inhibition
Keywords: فارماکودینامیک; Flow cytometry; Validation; Cell cycle; Pharmacodynamic; Aurora A; Phytohemagglutinin
Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia
Keywords: فارماکودینامیک; AUC(0-â); area under concentration-time curve from t = 0 to last time; CL/F; apparent clearance; Cmax; maximum plasma concentration; CSS; Chaihu-Shugan-San; C-t; concentration-time; FA; ferulic acid; FD; functional dyspepsia; GE; gastric empty
The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Keywords: فارماکودینامیک; Allergic rhinitis; nasal allergen challenge; anti-IL-13; mAb; AR; Allergic rhinitis; AUC; Area under the curve; NAC; Nasal allergen challenge; PD; Pharmacodynamic; SAM; Synthetic absorptive matrix; TNSS; Total nasal symptom scores;
Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies
Keywords: فارماکودینامیک; Seliciclib; Phase I trial; Pharmacokinetic; Pharmacodynamic; Cyclin-dependent kinase; Roscovitine; CYC202
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
Keywords: فارماکودینامیک; Pharmacokinetic; Pharmacodynamic; Noncompartmental analysis; PKSolver; Excel
Combining radio telemetry and automated blood sampling: A novel approach for integrative pharmacology and toxicology studies
Keywords: فارماکودینامیک; Automated blood sampling; Cardiovascular; Stress; Electroencephalogram; Integrative; Pharmacology; Radio telemetry; Renal; Toxicology; Safety pharmacology; Pharmacokinetic; Pharmacodynamic
In Vitro Pharmacodynamic Profile of Loranthus ferrugineus: Evidence for Noncompetitive Antagonism of Norepinephrine-induced Vascular Contraction
Keywords: فارماکودینامیک; aortic rings; double-reciprocal plot; Loranthus ferrugineus; noncompetitve antagonism; norepinephrine; pharmacodynamic;
Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex
Keywords: فارماکودینامیک; Serotonin; Fluoxetine; Norfluoxetine; Pharmacokinetic; Pharmacodynamic; In vivo microdialysis
Psychopharmacology for children: From off label use to registration
Keywords: فارماکودینامیک; Children; Adolescents; Psychopharmacology; Treatment; Pharmacokinetic; Pharmacodynamic
The promises and pitfalls of epigenetic therapies in solid tumours
Keywords: فارماکودینامیک; Epigenetics; DNMTI; HDAC inhibitor; Pharmacodynamic; Biomarker; Solid tumour
Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours
Keywords: فارماکودینامیک; Triptolide; Pharmacokinetic; Pharmacodynamic; Targeted therapy
Novel in vitro pharmacodynamic model simulating ofloxacin pharmacokinetics in the treatment of Pseudomonas aeruginosa biofilm-associated infections
Keywords: فارماکودینامیک; Pharmacodynamic; Model; Pharmacokinetics; Pseudomonas aeruginosa; Biofilm
Population stochastic modelling (PSM)—An R package for mixed-effects models based on stochastic differential equations
Keywords: فارماکودینامیک; Stochastic differential equations (SDEs); State-space models; Mixed-effect; Pharmacokinetic; Pharmacodynamic
PEGylated PPI dendritic architectures for sustained delivery of H2 receptor antagonist
Keywords: فارماکودینامیک; PPI dendrimers; PEGylation; Famotidine; Sustained drug delivery; Pharmacokinetic; Pharmacodynamic
Disposition kinetics of moxifloxacin in lactating ewes
Keywords: فارماکودینامیک; Moxifloxacin; Pharmacokinetic; Pharmacodynamic; Ewes; High performance liquid chromatography
Can pharmacokinetic–pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance?
Keywords: فارماکودینامیک; antibiotic; bacterium; pharmacodynamic; pharmacokinetic; resistance; review
The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs
Keywords: فارماکودینامیک; Dendrimer; Pharmacodynamic; Pharmacokinetic; Complex; Conjugate; Drug delivery system
Farmacocinética y farmacodinamia. Interacciones y efectos secundarios. Comparación con otras equinocandinas
Keywords: فارماکودینامیک; Equinocandinas; Farmacocinética; Farmacodinamia; Interacciones; Equinocandins; Pharmacokinetic; Pharmacodynamic; Drug interactions;
Pharmacological treatment effects on eye movement control
Keywords: فارماکودینامیک; Pharmacologic treatment effects; Saccade eye movements; Pursuit eye movements; Pharmacogenetic; Pharmacodynamic
Synthesis and evaluation of a glibenclamide glucose-conjugate: A potential new lead compound for substituted glibenclamide derivatives as islet imaging agents
Keywords: فارماکودینامیک; Glibenclamide glucose-conjugate; Pharmacodynamic; Insulin secretion; Binding to SUR1
Pharmacodynamic monitoring of the immunosuppressive therapy in patients after heart transplantation: Whole blood flow cytometric analysis of lymphocyte function
Keywords: فارماکودینامیک; Whole blood; Flow cytometry; Lymphocyte function; Immunosuppression; Pharmacodynamic; Pharmacokinetic