کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2072119 | 1078841 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A review on estimation of stochastic differential equations for pharmacokinetic/pharmacodynamic models A review on estimation of stochastic differential equations for pharmacokinetic/pharmacodynamic models](/preview/png/2072119.png)
This paper is a survey of existing estimation methods for pharmacokinetic/pharmacodynamic (PK/PD) models based on stochastic differential equations (SDEs). Most parametric estimation methods proposed for SDEs require high frequency data and are often poorly suited for PK/PD data which are usually sparse. Moreover, PK/PD experiments generally include not a single individual but a group of subjects, leading to a population estimation approach. This review concentrates on estimation methods which have been applied to PK/PD data, for SDEs observed with and without measurement noise, with a standard or a population approach. Besides, the adopted methodologies highly differ depending on the existence or not of an explicit transition density of the SDE solution.
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Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 7, 30 June 2013, Pages 929–939